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 Thursday, April 6, 2006     Volume 16   Number 14  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Images of population, and asian man E-Facts on Public Health Genomics
Adapted from a 45-minute presentation called Genomics for Public Health Practitioners, this e-fact sheet presents quick information about public health genomics.
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CDC Announcements
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New HuGE Review
The long QT syndrome family of cardiac ion channelopathies
Modell, Stephen M. MD, MS; Lehmann, Michael H. MD

 
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New HuGE Review
Association between the Transforming Growth Factor Alpha Gene and Nonsyndromic Oral Clefts

   
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Quantifying the health benefits of genetic tests: The importance of a population perspective
Khoury MJ, Jones K, Grosse SD. Genet Med. (March 2006)
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Researchers Identify Obsessive-compulsive Disorder (OCD) Risk Gene” This reference links to a non-governmental website
(April 2) Medical News Today reports, “Scientists at the National Institutes of Health's (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD).”

“Combo breast cancer treatment works” This reference links to a non-governmental website
(April 6) myDNA reports, “Breast cancer patients with HER2-positive tumors who don't respond to Herceptin (trastuzumab) may benefit from cocktail therapy that includes Herceptin along with one or more PI3K inhibiting agents, say researchers at The University of Texas M. D. Anderson Cancer Center.”

“Gene Therapy Offers Promise Against Arthritis”  This reference links to a non-governmental website
(April 6) HealthCentral.com reports, “For the approximately 2.1 million Americans who suffer from rheumatoid arthritis, treatment has consisted of painkillers and exercise but no cures for this degenerative joint disease.”

“A Genomic Signature Of 254 Genes Predicting Clinical Outcome In Primary Cutaneous Melanoma Identified” This reference links to a non-governmental website
(April 6) Medical News Today reports, “EORTC Melanoma Group researchers have identified a genomic signature predicting clinical outcome in Primary Cutaneous Melanoma, after patients having undergone standard treatment.”

“Gene Test Spots Early Lung Cancers” This reference links to a non-governmental website
(April 4) WEbMD reports, “A test that characterizes tumors by their unique genetic fingerprint may soon help doctors to spot lung cancers earlier, when they're much more treatable, researchers report.”

“Prostate cancer impacts black men” This reference links to a non-governmental website
(April 4) myDNA reports, “Prostate cancer is the most common cancer in men, comprising approximately one-third of all male-specific cancers, according to a recent multicenter study.”

“Studies show glaucoma is genetic” This reference links to a non-governmental website
(April 4) Channel News Asia reports, “For some time now, studies have shown that glaucoma is genetic. But there is more to this than meets the eye, as a new study suggests.”

“Genetic clues to longevity” This reference links to a non-governmental website
(April 4) News-Medical.Net reports, “Many studies show that tweaking a single gene can extend life span in animal models.”

“Researchers narrow search for effective prostate cancer biomarkers” This reference links to a non-governmental website
(April 4) News-Medical.Net reports, “Researchers at Mayo Clinic have narrowed the search for effective prostate cancer biomarkers (genetic variations that point to a specific disease or condition), identifying changes in the expression of genes of the whole genome closely correlated to prostate cancer development and progression.”

“HOXB13 and IL17BR genes predict outcome for breast cancer patients” This reference links to a non-governmental website
(April 4) News-Medical.Net reports, “The 2-gene expression profile of HOXB13 and IL17BR in a woman's breast cancer predicts risk of recurrence in node-negative patients treated with tamoxifen.”

“Team may have found cure for genetic disorder” This reference links to a non-governmental website
(April 3) IOL reports, “A team of German and Swiss doctors on Monday claimed to have found the world's first gene therapy cure for chronic granulomatous disease, a rare and fatal immune system disorder.”

“The silence of the genes” This reference links to a non-governmental website
(April 3) myDNA reports, “Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have developed a new method to identify genes that keep cancer cells active and that could be potential targets of anticancer therapies.”

“Searching for anticancer drugs” This reference links to a non-governmental website
(April 3) myDNA reports, “Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University in Illinois have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anticancer drugs.”

“Translational Derepression & Oncogene Expression In Breast Cancer Cells” This reference links to a non-governmental website
(April 3) Medical News Today reports, “Drs. Anuradha Mehta, Christopher Trotta and Stuart Peltz (PTC Therapeutics) have uncovered a novel mechanism whereby the translation efficiency of oncogenes is increased in cancer cells.”

“Researchers study Cape Verdeans' genetic structure” This reference links to a non-governmental website
(April 3) afrol News reports, “Why do Cape Verdeans have a specific hue to their skin and a tendency toward high blood pressure?”

“Paper Reports Discovery Of Virus Implicated In Genetics Of Prostate Cancer” This reference links to a non-governmental website
(April 3) Medical News Today reports, “The Open Access journal PLoS Pathogens has published an article detailing research that identifies a new retrovirus in the tissue of human prostate tumors.”

“Gene key to infection-fighting immune cells identified” This reference links to a non-governmental website
(April 3) News-Medical.Net reports, “Every time the human body encounters a virus, bacteria or other infectious agent, immune cells called B-lymphocytes multiply in lymph nodes and then swing into action to fight off the intruders.”

“Genomatix technology facilitates de novo identification of new renal disease associated genes” This reference links to a non-governmental website
(April 3) EurekAlert! reports, “Previously unknown molecules and regulatory pathways in human glomerular diseases have been identified by a joint effort of the Medizinische Poliklinik, Munich, the University of Bristol´s Children´s Renal Unit, the German Cancer Research Center, sanofi-aventis, and Genomatix Software GmbH.”

“Weill Cornell experts publish review of genetic medicine” This reference links to a non-governmental website
(April 3) News-Medical.Net reports, “In an article published in the April issue of Nature Reviews Genetics, two experts at the Weill Medical College of Cornell University sum up the achievements, challenges and promise of a burgeoning field: genetic medicine.”

“Genetic disease cripples Indigenous families” This reference links to a non-governmental website
(April 3) News-Medical.Net reports, “Aboriginal people on a remote island off the Northern Territory coast are grappling with a rare genetic disease that's crippling whole families. Machado Joseph Disease is a degenerative condition that kills nerves cells, eventually leaving sufferers totally disabled.”

“Genetic Research Will Drive Computing Needs, Venter Says” This reference links to a non-governmental website
(April 2) Information Week reports, “Craig Venter, whose team mapped the human genome, predicts breakthroughs like vastly deeper understanding of disease and creating species.”

“First Clinical Trial Of Gene Therapy For Muscular Dystrophy Now Under Way” This reference links to a non-governmental website
(April 1) Medical News Today reports, “The first gene therapy human trial in the United States for a form of muscular dystrophy is under way.”

“Researchers Identify New Childhood-onset Epilepsy Disorder And Its Genetic Cause” This reference links to a non-governmental website
(April 1) Medical News Today reports, “Researchers from the Translational Genomics Research Institute (TGen) and the Clinic for Special Children (CSC) in Strasburg, PA, have described a new childhood-onset disorder characterized by severe epilepsy and autistic traits, and identified its genetic basis.”

“Here's proof that smart kids really are different” This reference links to a non-governmental website
(March 31) International Herald Tribune reports, “The brains of highly intelligent children develop in a different pattern from those with more average abilities, researchers said they had found after analyzing a series of imaging scans collected over 17 years.”

“New Gene That Causes Spread Of Cancer Identified, University Of Liverpool” This reference links to a non-governmental website
(March 31) Medical News Today reports, “Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from the University's Cancer and Polio Research Fund Laboratories have discovered an additional member of the S100 family of protein genes - S100P - that causes the spread of cancerous cells from an original tumour to other parts of the body.”

“Genes make you angry?” This reference links to a non-governmental website
(March 30) myDNA reports, “A version of a gene previously linked to impulsive violence appears to weaken brain circuits that regulate impulses, emotional memory and thinking in humans, researchers at the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) have found.”

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Genomics in Scientific Literature
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Policy implications of genetic testing: not just for geneticists anymore
Javitt GH
Adv Chronic Kidney Dis 2006 Apr;13(2):178-82

Modifier genes and sickle cell anemia
Steinberg MH & Adewoye AH
Curr Opin Hematol 2006 May;13(3):131-6

Gene by Environment Interaction in Asthma
Koppelman GH
Curr Allergy Asthma Rep 2006 Mar;6(2):103-11

Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
Domchek SM, et al.
Lancet Oncol 2006 Mar;7(3):223-9

Reporting genetic results in research studies: Summary and recommendations of an NHLBI working group
Bookman EB, et al.
Am J Med Genet A 2006 Mar

Newborn Screening: Complexities in Universal Genetic Testing
Green NS, et al.
Am J Public Health 2006 Mar

The molecular genetics of Marfan syndrome and related disorders
Robinson PN, et al.
J Med Genet 2006 Mar

Familial risks of esophageal cancer among the Turkmen population of the Caspian littoral of Iran
Akbari MR, et al.
Int J Cancer 2006 Mar

Patients' information needs and decision-making processes: What can be learned from genetic counselees?
Shiloh S, et al.
Health Psychol 2006 Mar;25(2):211-9

Applying a cognitive behavioral model of health anxiety in a cancer genetics service
Rimes KA, et al.
Health Psychol 2006 Mar;25(2):171-80

A general population-genetic model for the production by population structure of spurious genotype-phenotype associations in discrete, admixed, or spatially distributed populations
Rosenberg NA & Nordborg M
Genetics 2006 Apr

The genetics of uterine leiomyomata: what clinicians need to know
Stewart EA & Morton CC
Obstet Gynecol 2006 Apr;107(4):917-21

Pharmacogenomics and antidepressant drugs
Binder EB & Holsboer F
Ann Med 2006;38(2):82-94

Risk factors for lung cancer in Iowa women: Implications for prevention
Neuberger JS, et al.
Cancer Detect Prev 2006 Mar

Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease
Gable DR, et al.
Atherosclerosis 2006 Mar

Current concepts on the genetics of hereditary and sporadic colorectal cancer and the role of genetics on the patient management-I. Hereditary colorctal cancer syndromes
Lakatos PL & Lakatos L
Orv Hetil 2006 Feb;147(8):363-8

Factor V Leiden as a common genetic risk factor for venous thromboembolism
Horne MK 3rd & McCloskey DJ
J Nurs Scholarsh 2006;38(1):19-25

Genomics, nutrition, obesity, and diabetes
Johnson RL, et al.
J Nurs Scholarsh 2006;38(1):11-8

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 5, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Condition
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

Behavior Genetics Association 36th Annual Conference
June 20-24, 2006 ~ Storrs, Connecticut
  The Biology of Genomes This reference links to a non-governmental website (last accessed 2/2008)
May 10-14, 2006 ~ Cold Spring Harbor, NY
   
CDC sponsored event
The 2006 CDC Diabetes and Obesity Conference
May 16-19, 2006 ~ Denver, Colorado
   
  Summer Institute in Statistical Genetics This reference links to a non-governmental website
June 12-30, 2006 ~ Seattle, WA
   
New this week 5th European Congress of Biogerontology This reference links to a non-governmental website
September 16-20, 2006 ~ Istanbul, Turkey
   
New this week NCRI Cancer Conference This reference links to a non-governmental website
October 8-11, 2006 ~ Birmingham, UK
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Let's Go Surfing
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Epidemiologist Position - NIH
A tenure-track or tenured investigator is being recruited to join the intramural Epidemiology Branch of the Division of Epidemiology, Statistics and Prevention Research at the National Institute of Child Health and Human Development.

Department of Genetics at the University of Georgia (UGA) This reference links to a non-governmental website
UGA offers graduate and undergraduate degrees in genetics.

Center for Genetics and Society This reference links to a non-governmental website
The Center for Genetics and Society is a nonprofit information and public affairs organization working to encourage responsible uses and effective societal governance of the new human genetic and reproductive technologies.

Human Genetics Commission
This UK government advisory body oversees the new developments in human genetics and how they impact individual lives.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: April 6, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics