A new version of the HuGE Navigator (1.3) has been launched:

• Non-standard common names are widely used for genetic variants in the scientific literature. The Variant Name Mapper  allows researchers to map these different names to the corresponding refSNP (rs) number and vice versa.

• Studies that have examined mitochondrial genetic variants can now be easily identified in the HuGE Literature Finder.  Just type “MITO” into the search query or filter your results by the “Mitochondria genetic association” category. In addition, you can track the progress of HuGE research involving mitochondrial genetic variants using the HuGE Watch. 

• The capacity for downloading query results has been added to the Phenopedia  and Genopedia applications. Just click on the “Download” button on the results page.

HuGENet™ would like to invite researchers to conduct HuGE Field Synopses in their areas of expertise. HuGE Field Synopses provide systematic, updated, and authoritative reviews of genetic associations in a specific area of research such as a disease or closely related health conditions. Authors are encouraged to summarize and grade genetic associations using the interim guidelines for assessing the cumulative evidence on genetic associations developed by HuGENet. For more information, please review the materials from the HuGENet Workshop, “Networks, Genome-Wide Association Studies, and the Knowledge Base on Genetic Variation and Human Health”. 

• Read the recently published field synopsis, Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

Two new HuGE Reviews were registered with HuGENet™ since the last issue of the ‘What's New’:

• The Genomics of Cerebral Palsy – a HuGE Systematic Review by Michael E. O'Callaghan, et al., from the South Australian Cerebral Palsy Research Group.

• Genes involved in the inflammatory pathway and lung cancer risk by Darren R. Brenner and Rayjean J. Hung from the University of Toronto, Canada.
  

> List of completed HuGE Reviews
> List of HuGE Review topics under development

The following publications were written by HuGENet™ collaborators and were added to PubMed in August:

• Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology.

• Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer's Disease

As of August 31, 2008, the HuGE Navigator  contains 36,534 research studies, referencing 4,046 genes, and 1,935 health outcomes/diseases. Both epidemiologic studies and review articles can be found in the database which includes 72 HuGE Reviews and 806 meta-analyses.

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