• An automatic method to generate domain-specific investigator networks using PubMed abstracts
  Wei Yu, Ajay Yesupriya, Anja Wulf, Junfeng Qu, Marta Gwinn, Muin J. Khoury
  BMC medical informatics and decision making 2007; 20;7(1):17

• Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes.
  Georgia Salanti, Julian P. T. Higgins
  Statistics in medicine (June 2007)

• The emergence of biobanks: practical design considerations for large population-based studies of gene-environment interactions.
  Robert L Davis, Muin J. Khoury.
  Community genetics 2007; 10(3):181-5.

• Non-Replication and Inconsistency in the Genome-Wide Association Setting.
  John P. A. Ioannidis
  Human heredity 2007; 64(4):203-213

• Genomics and public health research.
  Muin J. Khoury, Marta Gwinn, M Scott Bowen
  JAMA 2007; 297(21):2347

• Commentary: Rare alleles, modest genetic effects and the need for collaboration.
  H Campbell, T Manolio
  International journal of epidemiology 2007; 36(2):445-8

• Reporting of Systematic Reviews: The Challenge of Genetic Association Studies. (last accessed 2/2008)
  Khoury MJ et al. PLoS Medicine 2007

One new HuGE Review was proposed in June:

• Estrogen receptor alpha and risk factors for cardiovascular disease
  Krista Casazza
  (University of Alabama at Birmingham)

> List of completed HuGE Reviews
> List of HuGE Review topics under development

Handbook for Authors of New HuGE Reviews
HuGENet™ released the first edition of the HuGENet™ Handbook of Systematic
Reviews ((165KB)) in March 2006. All new HuGE reviews should follow the guidance in this document.

As of July 1, 2007, the HuGENet™ website contains 28,254 research studies indexed in the HuGE Published Literature database, referencing 2,924 genes, 993 factors (personal or environmental), and 3,507 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 60 HuGE Reviews and 508 meta-analyses.  Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z.

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

Provides link to non-governmental sites and does not necessarily represent the  views of the Centers for Disease Control and Prevention.