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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
January 31, 2008
Volume 20, No. 5

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Infectious and Parasitic Diseases

Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV  infection in West Africa
Bronowicki JP, et al.
J Hepatol 2008 Jan

The effects of RANTES/CCR5 promoter polymorphisms on HIV disease progression in HIV-infected Koreans
Jang DH, et al.
Int J Immunogenet 2008 Jan

 

Neoplasms

Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients
Sun J, et al.
Prostate 2008 Jan

The androgen receptor CAG and GGN repeat polymorphisms and prostate cancer susceptibility in African-American men: results from the Flint Men's Health Study
Lange EM, et al.
J Hum Genet 2008 Jan

CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia
Taspinar M, et al.
Swiss Med Wkly 2008 Jan;138(1-2):12-7

MBL2 and MASP2 gene polymorphisms in patients with hepatocellular carcinoma
Segat L, et al.
J Viral Hepat 2008 Jan

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the ovarian cancer association consortium pooled analysis
Pearce CL, et al.
Br J Cancer 2008 Jan;98(2):282-8

Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma
Slebos RJ, et al.
Br J Cancer 2008 Jan

Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer
Zhai R, et al.
Clin Cancer Res 2008 Jan;14(2):612-7

Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population
Liu H, et al.
Lung Cancer 2008 Jan

Polymorphism in the Matrix Metalloproteinase-2 Gene Promoter is Associated with Cervical Neoplasm Risk in Mexican Women
Baltazar-Rodriguez LM, et al.
Biochem Genet 2008 Jan

 

Endocrine, Nutritional and Metabolic Diseases

Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2  diabetes patients
Wang J, et al.
Acta Pharmacol Sin 2008 Feb;29(2):252-8

Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes
Stene LC, et al.
Pediatr Diabetes 2008 Feb;9(1):40-5

FTO gene associated with extreme obesity in cases, controls and extremely discordant sister pairs
Price RA, et al.
BMC Med Genet 2008 Jan;9(1):4

No association between common Gly972Arg variant of the insulin receptor substrate-1 and polycystic ovary syndrome in Southern Chilean women
Valdes P, et al.
Clin Chim Acta 2008 Jan

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
Cauchi S, et al.
J Mol Med 2008 Jan

Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result
Holmkvist J, et al.
Diabetologia 2008 Jan

IL-10 gene polymorphism, but not TGF-beta1 gene polymorphisms, is associated with food allergy in a Japanese population
Campos Alberto EJ, et al.
Pediatr Allergy Immunol 2008 Jan

Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes Mellitus in the Women's Health Initiative Observational Study
Hsu YH, et al.
Diabetes 2008 Jan

Association of SGK1 Gene Polymorphisms with Type 2 Diabetes
Schwab M, et al.
Cell Physiol Biochem 2008;21(1-3):151-60


Mental Disorders

Lack of association between the -759C/T polymorphism of the 5-HT2(C) receptor gene and olanzapine-induced weight gain among Korean schizophrenic patients
Park YM, et al.
J Clin Pharm Ther 2008 Feb;33(1):55-60

Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic  stress disorder
Lu AT, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jan

Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
Luo X, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jan

Serotonin transporter gene and adverse life events in adult ADHD
Muller DJ, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jan

Lack of association of the dopamine transporter gene in a French ADHD sample
Wohl M, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jan

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent
Ho MK, et al.
Pharmacogenet Genomics 2008 Jan;18(1):67-75

Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia
Yanagi M, et al.
Schizophr Res 2008 Jan

Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression
Uhr M, et al.
Neuron 2008 Jan;57(2):203-9

alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking
Berrettini W, et al.
Mol Psychiatry 2008 Jan

 

Diseases of the Nervous System and Sense Organs

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease
Poleggi A, et al.
Eur J Neurol 2008 Feb;15(2):173-8

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls
Paisan-Ruiz C, et al.
Hum Mutat 2008 Jan

T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population
Rodrigues F, et al.
Mult Scler 2008 Jan

Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis
Goertsches R, et al.
Mult Scler 2008 Jan

Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2
Bras J, et al.
BMC Neurol 2008 Jan;8(1):1

Genotype-Phenotype correlation of age-related macular degeneration: influence of  complement factor H Polymorphism
Droz I, et al.
Br J Ophthalmol 2008 Jan

Exploring gene-environment interactions in Parkinson's disease
McCulloch CC, et al.
Hum Genet 2008 Jan

Glutathione-S-transferase P1 polymorphism and risk for essential tremor
Martinez C, et al.
Eur J Neurol 2008 Jan

Association between complement factor H gene polymorphisms and neovascular age-related macular degeneration in Koreans
Kim NR, et al.
Invest Ophthalmol Vis Sci 2008 Jan

The LOXL1 Gene Variations are not Associated with Primary Open Angle and Primary  Angle Closure Glaucomas
Chakrabarti S, et al.
Invest Ophthalmol Vis Sci 2008 Jan

 

Diseases of the Circulatory System

Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study
Marcus GM, et al.
Am Heart J 2008 Feb;155(2):303-9

Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension
Lynch AI, et al.
JAMA 2008 Jan;299(3):296-307

Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism and Aortic Calcification. The Rotterdam Study
Teichert M, et al.
Arterioscler Thromb Vasc Biol 2008 Jan

A functional intronic variant in tyrosine hydroxylase (TH) gene confers risk of essential hypertension in northern Chinese Han population
Wang L, et al.
Clin Sci (Lond) 2008 Jan

beta1- and beta2-Adrenergic Receptor Gene Variation, beta-Blocker Use and Risk of Myocardial Infarction and Stroke
Lemaitre RN, et al.
Am J Hypertens 2008 Jan

The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension
Laffer CL, et al.
Hypertension 2008 Jan

Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
Iakoubova OA, et al.
J Am Coll Cardiol 2008 Jan;51(4):435-43

Meta-Analysis of the Association of 4 Angiotensinogen Polymorphisms With Essential Hypertension. A Role Beyond M235T?
Pereira TV, et al.
Hypertension 2008 Jan

Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population
Zhang L, et al.
Pharmacogenet Genomics 2008 Jan;18(1):45-51

The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG)
Sinner MF, et al.
Eur Heart J 2008 Jan

Protective effect of R allele of PON1 gene on the coronary artery disease in the  presence of specific genetic background
Balcerzyk A, et al.
Dis Markers 2008;24(2):81-8

A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population
Polonikov AV, et al.
Dis Markers 2008;24(2):119-26

The P2Y(13) Met-158-Thr Polymorphism, Which Is in Linkage Disequilibrium with the P2Y(12) Locus, Is Not Associated with Acute Myocardial Infarction
Amisten S, et al.
PLoS ONE 2008;3(1):e1462

 

Diseases of the Digestive System

Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding
Blanco G, et al.
Pharmacogenet Genomics 2008 Jan;18(1):37-43

Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population
Hume GE, et al.
Inflamm Bowel Dis 2008 Jan

 

Diseases of the Genitourinary System

MBL2 Genetic Screening in Patients with Recurrent Vaginal Infections
Milanese M, et al.
Am J Reprod Immunol 2008 Feb;59(2):146-51

Association of the macrophage migration inhibitory factor -173*C allele with childhood nephrotic syndrome
Vivarelli M, et al.
Pediatr Nephrol 2008 Jan

Polymorphism of the interleukin-10 gene in polycystic ovary syndrome
Karadeniz M, et al.
Int J Immunogenet 2008 Jan

Specific Podocin Mutations Correlate with Age of Onset in Steroid-Resistant Nephrotic Syndrome
Hinkes B, et al.
J Am Soc Nephrol 2008 Jan

 

Complications of Pregnancy, Childbirth, and the Puerperium

Lack of consistent association between endothelial nitric oxide synthase gene polymorphisms, homocysteine levels and recurrent pregnancy loss in tunisian women
Zammiti W, et al.
Am J Reprod Immunol 2008 Feb;59(2):139-45

Combined inherited thrombophilia and adverse pregnancy outcome
Androutsopoulos G, et al.
Clin Exp Obstet Gynecol 2007;34(4):236-8

 

Diseases of the Skin and Subcutaneous Tissue

Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis
Nair RP, et al.
J Invest Dermatol 2008 Jan

 

Diseases of the Musculoskeletal System and Connective Tissue

Effects of hormone replacement therapy on bone mineral density in Turkish patients with or without COL1A1 Sp1 binding site polymorphism
Simsek M, et al.
J Obstet Gynaecol Res 2008 Feb;34(1):73-7

Association of LY9 in UK and Canadian SLE families
Graham DS, et al.
Genes Immun 2008 Jan

Genetic determinants of basal C-reactive protein expression in Filipino systemic  lupus erythematosus families
Rhodes B, et al.
Genes Immun 2008 Jan

A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with  susceptibility to systemic lupus erythematosus in Japanese population
Oishi T, et al.
J Hum Genet 2008 Jan

 

Congenital Anomalies

Familial non-syndromic cleft lip and palate--analysis of the IRF6 gene and clinical phenotypes
Pegelow M, et al.
Eur J Orthod 2008 Jan

Genes in glucose metabolism and association with spina bifida
Davidson CM, et al.
Reprod Sci 2008 Jan;15(1):51-8

Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: A Dutch case-control study
Verkleij-Hagoort AC, et al.
Mol Genet Metab 2008 Jan

 

Certain Conditions Originating in the Perinatal Period

Adverse Birth Outcomes Associated with Maternal Smoking and Polymorphisms in the  N-Nitrosamine-Metabolizing Enzyme Genes NQO1 and CYP2E1
Sasaki S, et al.
Am J Epidemiol 2008 Jan

 

Injury and Poisoning

Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery
Kim YJ, et al.
J Toxicol Environ Health A 2008 Jan;71(5):333-41

Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden
Paiva L, et al.
Pharmacogenet Genomics 2008 Jan;18(1):1-10

Genetic polymorphism in cell cycle control genes and susceptibility of chromosomal damage in vinyl chloride monomer exposed workers
Qiu YL, et al.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007 Nov;25(11):649-53

 

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Page last reviewed: January 31, 2008 (archived document)
Content Source: National Office of Public Health Genomics