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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
July 12, 2007
Volume 19, No. 2

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Polymorphisms of the COL1A2, CYP1A1 and HS1,2 Ig enhancer genes in the Tuaregs from Libya
Martinez-Labarga C, et al.
Ann Hum Biol 2007 Jul-2007 Aug;34(4):425-36

 

Infectious and Parasitic Diseases

Association of interleukin-18 gene polymorphism (-607A/A genotype) with susceptibility to chronic hepatitis B virus infection
Hirankarn N, et al.
Tissue Antigens 2007 Aug;70(2):160-3

Association of Interleukin-8 Polymorphism and Immunoglobulin G Anti-Toxin A in Patients With Clostridium difficile-Associated Diarrhea
Jiang ZD, et al.
Clin Gastroenterol Hepatol 2007 Jul

Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients
Ribeiro CS, et al.
Mem Inst Oswaldo Cruz 2007 Jul;102(4):435-40

 

Neoplasms

Functional -1562 C-to-T polymorphism in matrix metalloproteinase-9 (MMP-9) promoter is associated with the risk for oral squamous cell carcinoma in younger male areca users
Tu HF, et al.
J Oral Pathol Med 2007 Aug;36(7):409-14

Interleukin-1beta gene in esophageal, gastric and colorectal carcinomas
Ito H, et al.
Oncol Rep 2007 Aug;18(2):473-81

Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development
Zabaleta J, et al.
Cancer Immunol Immunother 2007 Jul

The low frequency of defective TPMT alleles in Turkish population: A study on pediatric patients with acute lymphoblastic leukemia
Tumer TB, et al.
Am J Hematol 2007 Jul

Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan
Wang YH, et al.
J Cancer Res Clin Oncol 2007 Jul

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
Tomlinson I, et al.
Nat Genet 2007 Jul

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
Zanke BW, et al.
Nat Genet 2007 Jul

Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck
Li C, et al.
Cancer 2007 Jul

Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies
Ostrovsky O, et al.
Leukemia 2007 Jul

PAI-1 -675 4G/5G polymorphism as a prognostic biomarker in breast cancer
Lei H, et al.
Breast Cancer Res Treat 2007 Jul

Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population
Jung HY, et al.
J Hum Genet 2007 Jul

Human leukocyte class I antigen alleles A2 and A11 are not associated with nasopharyngeal carcinoma in West Malaysia
Lee LK, et al.
Singapore Med J 2007 Jul;48(7):632-4

Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk
Bethke L, et al.
BMC Cancer 2007 Jul;7(1):123

Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
Berndt SI, et al.
Carcinogenesis 2007 Jul

Polymorphisms of Fractalkine receptor CX3CR1 and plasma levels of its ligand CX3CL1 in colorectal cancer patients
Dimberg J, et al.
Int J Colorectal Dis 2007 Jul

CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer
Boccia S, et al.
J Cancer Res Clin Oncol 2007 Jul

COX2 genetic variation, NSAIDs, and advanced prostate cancer risk
Cheng I, et al.
Br J Cancer 2007 Jul

Genetic analysis of the GRM1 gene in human melanoma susceptibility
Ortiz P, et al.
Eur J Hum Genet 2007 Jul

Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers
Costa DB, et al.
Lung Cancer 2007 Jul

A common genetic risk factor for colorectal and prostate cancer
Haiman CA, et al.
Nat Genet 2007 Jul

Glutathione S-transferase polymorphisms, cruciferous vegetable intake, and cancer risk in the Central and Eastern European Kidney Cancer Study
Moore L, et al.
Carcinogenesis 2007 Jul

Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer
Ruzzo A, et al.
Clin Chem Lab Med 2007 Jul;45(7):822-8

The p73 polymorphisms are not associated with susceptibility to esophageal squamous cell carcinoma in a high incidence region of China
Ge H, et al.
Dis Esophagus 2007;20(4):290-6

 

Endocrine, Nutritional and Metabolic Diseases

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis
Thomson G, et al.
Tissue Antigens 2007 Aug;70(2):110-27

Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
Leak TS, et al.
Mol Genet Metab 2007 Jul

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity
Bouatia-Naji N, et al.
BMC Med Genet 2007 Jul;8(1):44

Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women
Ando T, et al.
Am J Clin Nutr 2007 Jul;86(1):25-32

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men
Dahlgren A, et al.
Diabetologia 2007 Jul

Replication and Identification of Novel Variants at TCF7L2 Associated with Type 2 Diabetes in Hong Kong Chinese
Ng MC, et al.
J Clin Endocrinol Metab 2007 Jul

Candidate genes and growth curves for adiposity in African- and European-American youth
Podolsky RH, et al.
Int J Obes (Lond) 2007 Jul

Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls
Luan X, et al.
Eur J Endocrinol 2007 Jul;157(1):113-8

 

Diseases of the Blood & Blood-Forming Organ Disorders

Thrombophilic mutations among Southern Iranian patients with sickle cell disease: high prevalence of factor V Leiden
Rahimi Z, et al.
J Thromb Thrombolysis 2007 Jul

 

Mental Disorders

Study on the interrelationship between 5-HTTLPR/G-protein beta3 subunit (C825T) polymorphisms and depressive disorder
Cao MQ, et al.
Psychiatr Genet 2007 Aug;17(4):233-8

Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample
Sakai JT, et al.
Psychiatr Genet 2007 Aug;17(4):207-14

Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population
Watanabe Y, et al.
Psychiatry Clin Neurosci 2007 Aug;61(4):364-9

Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Iwasaki S, et al.
Psychiatr Genet 2007 Aug;17(4):215-20

Association of SOX10 with schizophrenia in the Japanese population
Maeno N, et al.
Psychiatr Genet 2007 Aug;17(4):227-31

Association analysis of GRK3 gene promoter variants in cocaine abuse
Guindalini C, et al.
Psychiatr Genet 2007 Aug;17(4):239-42

Tobacco smoking and the ADRA2A C-1291G polymorphism
Prestes AP, et al.
J Neural Transm 2007 Jul

Dysbindin (DTNBP1) and the Biogenesis of Lysosome-Related Organelles Complex 1 (BLOC-1): Main and Epistatic Gene Effects Are Potential Contributors to Schizophrenia Susceptibility
Morris DW, et al.
Biol Psychiatry 2007 Jul

Variants of the peroxisome proliferator-activated receptor {gamma}- and {beta}-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children
Cecil JE, et al.
Am J Clin Nutr 2007 Jul;86(1):167-73

Polymorphisms of androgen receptor gene in childhood and adolescent males with first-onset major depressive disorder and association with related symptomatology
Su QR, et al.
Int J Neurosci 2007 Jul;117(7):903-17

Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
Cornelis MC, et al.
Am J Clin Nutr 2007 Jul;86(1):240-4

The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
Lavretsky H, et al.
Int J Geriatr Psychiatry 2007 Jul

 

Diseases of the Nervous System and Sense Organs

Investigation of potential gene-gene interactions between apoe and reln contributing to autism risk
Ashley-Koch AE, et al.
Psychiatr Genet 2007 Aug;17(4):221-6

Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
Andersson ME, et al.
Int J Mol Med 2007 Aug;20(2):233-9

An association study of two functional promotor polymorphisms in the myeloperoxidase (MPO) gene in multiple sclerosis
Lundmark F, et al.
Mult Scler 2007 Jul;13(6):697-700

Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy
Syed AA, et al.
Clin Endocrinol (Oxf) 2007 Jul

The role of VLA4 polymorphisms in multiple sclerosis: An association study
Andreoli V, et al.
J Neuroimmunol 2007 Jul

Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia
Helbecque N, et al.
Neurobiol Aging 2007 Jul

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease
Belbin O, et al.
Hum Mol Genet 2007 Jul

No association of TDP-43 with sporadic frontotemporal dementia
Schumacher A, et al.
Neurobiol Aging 2007 Jul

Investigation on Mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian Multiple Sclerosis Patients
Ahari SE, et al.
Cell Mol Neurobiol 2007 Jul

No association of common VCP variants with sporadic frontotemporal dementia
Schumacher A, et al.
Neurobiol Aging 2007 Jul

Effect of CAG repeat length on psychiatric disorders in Huntington's disease
Vassos E, et al.
J Psychiatr Res 2007 Jul

FcRL3 and multiple sclerosis pathogenesis: Role in autoimmunity?
Martinez A, et al.
J Neuroimmunol 2007 Jul

Mitochondrial complex I gene variant associated with early age at onset in spinocerebellar ataxia type 2
Simon DK, et al.
Arch Neurol 2007 Jul;64(7):1042-4

Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma
Woo SJ, et al.
Eye 2007 Jul

Screen for excess FMR1 premutation alleles among males with parkinsonism
Kraff J, et al.
Arch Neurol 2007 Jul;64(7):1002-6

Diseases of the Circulatory System

Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men
Ohlin B, et al.
J Hypertens 2007 Aug;25(8):1613-9

High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 gene
Ott C, et al.
J Hypertens 2007 Aug;25(8):1627-32

Scavenger receptor class B type I polymorphisms and peripheral arterial disease
Ritsch A, et al.
Metabolism 2007 Aug;56(8):1135-41

A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension
Moreno MU, et al.
J Hypertens 2007 Aug;25(8):1620-6

ACE Gene Polymorphism in Peripheral Vascular Disease*
Basar Y, et al.
Horm Metab Res 2007 Jul;39(7):534-7

Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men
Pellikka M, et al.
J Thromb Thrombolysis 2007 Jul

Endothelin-converting enzyme-1b C-338A polymorphism is associated with the increased risk of coronary artery disease in Chinese population
Wang LS, et al.
Clin Chim Acta 2007 Jun

FXIII Gene Val34Leu Polymorphism in Turkish Children with Cerebral Infarct
Akar N, et al.
J Child Neurol 2007 Feb;22(2):222-4

 

Diseases of the Respiratory System

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
Moffatt MF, et al.
Nature 2007 Jul

DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
Olesen R, et al.
Genes Immun 2007 Jul

IL13 Promoter Polymorphism -1112C/T Modulates the Adverse Effect of Tobacco Smoking on Lung Function
Sadeghnejad A, et al.
Am J Respir Crit Care Med 2007 Jul

 

Diseases of the Digestive System

Investigation of NOD1/CARD4 variation in Inflammatory Bowel Disease using a haplotype-tagging strategy
Van Limbergen J, et al.
Hum Mol Genet 2007 Jul

Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Gene Polymorphisms in Patients With Chronic Periodontitis
Gurkan A, et al.
J Periodontol 2007 Jul;78(7):1256-63

Association of Variants of the Interleukin-23 Receptor Gene With Susceptibility to Pediatric Crohn's Disease
Baldassano RN, et al.
Clin Gastroenterol Hepatol 2007 Jul

 

Diseases of the Genitourinary System

Relationship of angiotensin-converting enzyme gene polymorphism with nephropathy associated with Type 2 diabetes mellitus in Asian Indians
Movva S, et al.
J Diabetes Complications 2007 Jul-2007 Aug;21(4):237-41

Association of VEGF-1499C-->T polymorphism with diabetic nephropathy in type 1 diabetes mellitus
McKnight AJ, et al.
J Diabetes Complications 2007 Jul-2007 Aug;21(4):242-5

 

Complications of Pregnancy, Childbirth, and the Puerperium

Increased activating killer immunoglobulin-like receptor genes and decreased specific HLA-C alleles in couples with recurrent spontaneous abortion
Wang S, et al.
Biochem Biophys Res Commun 2007 Jul

 

Diseases of the Skin and Subcutaneous Tissue

IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans
Namkung JH, et al.
Allergy 2007 Aug;62(8):934-42

Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis
Macaluso F, et al.
Exp Dermatol 2007 Aug;16(8):692-8

 

Diseases of the Musculoskeletal System and Connective Tissue

Physical Activity, Cdx-2 Genotype, and BMD
Gentil P, et al.
Int J Sports Med 2007 Jul

Association of FLT3 Polymorphisms With Low BMD and Risk of Osteoporotic Fracture in Postmenopausal Women
Koh JM, et al.
J Bone Miner Res 2007 Jul

Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis
Rueda B, et al.
Cytokine 2007 Jul

Interaction between Angiotensin Converting Enzyme Insertion/Deletion Genotype and Exercise Training on Knee Extensor Strength in Older Individuals
Giaccaglia V, et al.
Int J Sports Med 2007 Jul

The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study
Jacq L, et al.
Arthritis Res Ther 2007 Jul;9(4):R63

The interferon-gamma receptor gene polymorphisms (Val14Met and Gln64Arg) are not associated with systemic lupus erythematosus in Chinese patients
Yao X, et al.
Arch Dermatol Res 2007 Jul

Mannose-Binding Lectin is a Disease-Modifying Factor in North American Patients with Systemic Lupus Erythematosus
Piao W, et al.
J Rheumatol 2007 Jul;34(7):1506-13

 

Congenital Anomalies

Non-Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C > T: A meta-analysis
Amorim MR, et al.
Am J Med Genet A 2007 Jul

Maternal Smoking During Early Pregnancy, GSTP1 and EPHX1 Variants, and Risk of Isolated Orofacial Clefts
Ramirez D, et al.
Cleft Palate Craniofac J 2007 Jul;44(4):366-73

 

Certain Conditions Originating in the Perinatal Period

Associations among genetic susceptibility, DNA damage, and pregnancy outcomes of expectant mothers exposed to environmental tobacco smoke
Wu FY, et al.
Sci Total Environ 2007 Jul

STOX1 gene in pre-eclampsia and intrauterine growth restriction
Berends A, et al.
BJOG 2007 Jul

 

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Page last reviewed: July 12, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics