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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 31, 2006
Volume 17, No. 9

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Infectious and Parasitic Diseases

Cytokine gene polymorphisms can alter the effect of Bacillus Calmette-Guerin (BCG) immunotherapy
Basturk B, et al.
Cytokine 2006 Aug

A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria
Awandare GA, et al.
Genes Immun 2006 Aug

The association between cytokine gene polymorphisms and the outcomes of chronic HBV infection
Li C, et al.
Hepatol Res 2006 Aug

Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran
Ranjbar M, et al.
World J Gastroenterol 2006 Aug;12(31):5044-7

Monocyte Chemoattractant Protein 1 (MCP-1) Gene Polymorphism Is Not Associated with Severe and Cerebral Malaria in Thailand
Dechkum N, et al.
Jpn J Infect Dis 2006 Aug;59(4):239-44

Association of genetic polymorphism of low-density lipoprotein receptor with chronic viral hepatitis C infection in Han Chinese
Li H, et al.
J Med Virol 2006 Aug;78(10):1289-95

IL-1 gene polymorphism and periodontal status of HIV Brazilians on highly active antiretroviral therapy
de S Goncalves L, et al.
AIDS 2006 Aug;20(13):1779-81

Polymorphism of interferon-gamma gene at position +874 and clinical characteristics of chronic hepatitis C
Dai CY, et al.
Transl Res 2006 Sep;148(3):128-33

CCR5Delta32 mutation does not influence the susceptibility to HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C
Goyal A, et al.
World J Gastroenterol 2006 Aug;12(29):4721-6

 

Neoplasms

Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population
Slanger TE, et al.
Cancer Causes Control 2006 Oct;17(8):1025-31

An association between glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma
Miller DP, et al.
Cancer 2006 Aug

No Association Between the Polymorphisms in Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Promoter Regions and Colorectal Cancer in Chinese
Xu E, et al.
Dis Colon Rectum 2006 Aug

Polymorphisms in the caspase-8 gene and the risk of lung cancer
Son JW, et al.
Cancer Genet Cytogenet 2006 Sep;169(2):121-7

Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
Kiemeney LA, et al.
Eur J Cancer 2006 Aug

The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor-related survival in neoadjuvant treated locally advanced gastric cancer
Ott K, et al.
Int J Cancer 2006 Aug

Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China
Zhang Y, et al.
Int J Cancer 2006 Aug

Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants
Pinto-Correia AL, et al.
World J Gastroenterol 2006 Aug;12(31):5033-6

Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer
Theodoropoulos G, et al.
World J Gastroenterol 2006 Aug;12(31):5037-43

Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians
Gu J, et al.
Carcinogenesis 2006 Aug

Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk
Acar H, et al.
Cancer Genet Cytogenet 2006 Sep;169(2):89-93

 

Endocrine, Nutritional and Metabolic Diseases

Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
Zhang C, et al.
Diabetes 2006 Sep;55(9):2645-8

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q
Zeggini E, et al.
Diabetes 2006 Sep;55(9):2541-8

A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus
Ng DP, et al.
Diabetes 2006 Sep;55(9):2660-3

Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance
Damcott CM, et al.
Diabetes 2006 Sep;55(9):2654-9

Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
Scott LJ, et al.
Diabetes 2006 Sep;55(9):2649-53

Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk
Groves CJ, et al.
Diabetes 2006 Sep;55(9):2640-4

New Polymorphism of ENPP1 (PC-1) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals
Bochenski J, et al.
Diabetes 2006 Sep;55(9):2626-30

Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns
Bonnycastle LL, et al.
Diabetes 2006 Sep;55(9):2534-40

Relationships of Serum Ferritin, Transferrin Saturation, and HFE Mutations and Self-Reported Diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
Acton RT, et al.
Diabetes Care 2006 Sep;29(9):2084-9

Apolipoprotein B signal peptide polymorphism : distribution and influence on lipid parameters in Tunisian population
Kallel A, et al.
Physiol Res 2006 Aug

Faecal elastase-1 concentration in cystic fibrosis patients with CFTR I1234V mutation
Abdel Rahman H, et al.
Acta Paediatr 2006 Sep;95(9):1066-9

Decline in Neurophysiological Function After 7 Years in an Adolescent Diabetic Cohort and the Role of Aldose Reductase Gene Polymorphisms
Thamotharampillai K, et al.
Diabetes Care 2006 Sep;29(9):2053-7

P-selectin gene genotypes or haplotypes and cardiovascular complications in type 2 diabetes mellitus
Zalewski G, et al.
Nutr Metab Cardiovasc Dis 2006 Sep;16(6):418-25

Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes
Das SK, et al.
Diabetes 2006 Sep;55(9):2631-9

 

Diseases of the Blood & Blood-Forming Organ Disorders

Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with
hemophilia A

Astermark J, et al.
Blood 2006 Aug

 

Mental Disorders

Early Family Environment, Current Adversity, the Serotonin Transporter Promoter Polymorphism, and Depressive Symptomatology
Taylor SE, et al.
Biol Psychiatry 2006 Aug

An Experimental Study of Catechol-O-Methyltransferase Val(158)Met Moderation of Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition
Henquet C, et al.
Neuropsychopharmacology 2006 Aug

Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication
Zai G, et al.
Psychopharmacology (Berl) 2006 Aug

Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression
Hickie IB, et al.
J Affect Disord 2006 Aug

Variations in the Vesicular Monoamine Transporter 1 Gene (VMAT1/SLC18A1) are Associated with Bipolar I Disorder
Lohoff FW, et al.
Neuropsychopharmacology 2006 Aug

 

Diseases of the Nervous System and Sense Organs

Apolipoprotein E epsilon4 Allele Is Associated with Vascular Dementia
Baum L, et al.
Dement Geriatr Cogn Disord 2006 Aug;22(4):301-5

Genetic risk profiles for Alzheimer's disease: Integration of APOE genotype and variants that up-regulate inflammation
Licastro F, et al.
Neurobiol Aging 2006 Aug

SMN1 gene, but not SMN2, is a risk factor for sporadic ALS
Corcia P, et al.
Neurology 2006 Aug

Detection of Mutations in Genes Associated with Hearing Loss Using a Microarray-Based Approach
Siemering K, et al.
J Mol Diagn 2006 Sep;8(4):483-9

Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes
Stogmann E, et al.
Neurogenetics 2006 Aug

Association between presenilin 1 intronic polymorphism and late onset Alzheimer's disease in the North Chinese population
Jia L, et al.
Brain Res 2006 Aug

Analysis of CFH, TLR4, and APOE Polymorphism in India Suggests the Tyr402His Variant of CFH to be a Global Marker for Age-Related Macular Degeneration
Kaur I, et al.
Invest Ophthalmol Vis Sci 2006 Sep;47(9):3729-35

Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra
Akbas N, et al.
Neurosci Lett 2006 Aug

Evaluation of MMP3 and TIMP1 as Candidate Genes for High Myopia in Young Taiwanese Men
Liang CL, et al.
Am J Ophthalmol 2006 Sep;142(3):518-20

Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-asians
Duranceaux NC, et al.
Alcohol Clin Exp Res 2006 Sep;30(9):1470-8

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration
Li M, et al.
Nat Genet 2006 Aug

A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse
Cevoli S, et al.
Eur J Neurol 2006 Sep;13(9):1009-13

Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration
Borroni B, et al.
BMC Neurol 2006 Aug;6(1):31

Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
The Games Collaborative Group
J Neuroimmunol 2006 Aug

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
Maller J, et al.
Nat Genet 2006 Aug

 

Diseases of the Circulatory System

Anti-inflammatory effects of atorvastatin: Modulation by the T-786C polymorphism in the endothelial nitric oxide synthase gene
Souza-Costa DC, et al.
Atherosclerosis 2006 Aug

Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage
Martinez-Gonzalez NA & Sudlow CL
J Neurol Neurosurg Psychiatry 2006 Aug

Gene polymorphism and requirement for vasopressor infusion after cardiac surgery
Ryan R, et al.
Ann Thorac Surg 2006 Sep;82(3):895-901

The risk of dialysis access thrombosis is related to the transforming growth factor-{beta}1 production haplotype and is modified by polymorphisms in the plasminogen activator inhibitor-type 1 gene
Lazo-Langner A, et al.
Blood 2006 Aug

Associations between Two Single Nucleotide Polymorphisms of Adiponectin Gene and Coronary Artery Diseases
Jung CH, et al.
Endocr J 2006 Aug

GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease
Connelly JJ, et al.
PLoS Genet 2006 Aug;2(8)

Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients
Kalita J, et al.
Neurol India 2006 Sep;54(3):260-3

Angiotensin-converting enzyme gene polymorphisms and prognosis in chronic thromboembolic pulmonary hypertension
Tanabe N, et al.
Circ J 2006 Sep;70(9):1174-9

A monocyte chemoattractant protein-1 gene polymorphism is associated with occult ischemia in a high-risk asymptomatic population
Kim MP, et al.
Atherosclerosis 2006 Aug

 

Diseases of the Respiratory System

Allelic Polymorphisms in the Interleukin-4 Promoter Regions and Their Association with Bronchial Asthma among the Russian Population
Gervaziev YV, et al.
Int Arch Allergy Immunol 2006 Aug;141(3):257-64

Polymorphisms in the Muscarinic Receptor 1 Gene Confer Susceptibility to Asthma in Japanese Subjects
Maeda Y, et al.
Am J Respir Crit Care Med 2006 Aug

Sequence, Haplotype and Association Analysis of ADR{beta}2 in Multi-Ethnic Asthma Case/Control Subjects
Hawkins GA, et al.
Am J Respir Crit Care Med 2006 Aug

Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan
Ku MS, et al.
J Microbiol Immunol Infect 2006 Aug;39(4):297-301

Distribution of CTLA-4 Polymorphisms in Allergic Asthma
Jasek M, et al.
Int Arch Allergy Immunol 2006 Aug;141(3):223-9

Association of Inducible Nitric Oxide Synthase (iNOS) with Asthma Severity, Total Serum IgE and Blood Eosinophil Levels
Batra J, et al.
Thorax 2006 Aug

G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome
Pulkkinen V, et al.
Ann Med 2006;38(5):357-66

Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study
Hall IP, et al.
Lancet 2006 Aug;368(9537):771-9

 

Diseases of the Digestive System

Association of TNF-alpha/LTA polymorphisms with Crohn's disease in Koreans
Yang SK, et al.
Cytokine 2006 Aug

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility
Jones DC, et al.
Genes Immun 2006 Aug

Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps
Goode EL, et al.
Carcinogenesis 2006 Aug

 

Diseases of the Genitourinary System

Synergistic effect of interleukin-6 promoter (IL6 -634C/G) and intercellular adhesion molecule-1 (ICAM-1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women
Kitawaki J, et al.
Am J Reprod Immunol 2006 Oct;56(4):267-74

Influence of ACE I/D gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease: a meta-analysis
Pereira TV, et al.
Nephrol Dial Transplant 2006 Aug

Circadian Pharmacokinetics of Mycophenolic Acid and Implication of Genetic Polymorphisms for Early Clinical Events in Renal Transplant Recipients
Satoh S, et al.
Transplantation 2006 Aug;82(4):486-93

 

Complications of Pregnancy, Childbirth, and the Puerperium

A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans
Wang H, et al.
Proc Natl Acad Sci U S A 2006 Aug

Which Thrombophilic Gene Mutations are Risk Factors for Recurrent Pregnancy Loss?
Goodman CS, et al.
Am J Reprod Immunol 2006 Oct;56(4):230-6

 

Diseases of the Musculoskeletal System and Connective Tissue

SHBG gene promoter polymorphisms in men are associated with serum SHBG, androgen and androgen metabolite levels and hip BMD
Eriksson AL, et al.
J Clin Endocrinol Metab 2006 Aug

The effect of 3435C>T MDR1 gene polymorphism on rheumatoid arthritis treatment with disease-modifying antirheumatic drugs
Drozdzik M, et al.
Eur J Clin Pharmacol 2006 Aug

Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population
Hwang JY, et al.
Osteoporos Int 2006 Aug

 

Congenital Anomalies

The C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene (MTHFR), Maternal Use of Folic Acid Supplements, and Risk of Isolated Clubfoot: A Case-Parent-Triad Analysis
Sharp L, et al.
Am J Epidemiol 2006 Aug

Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida
Rat E, et al.
Birth Defects Res A Clin Mol Teratol 2006 Aug;76(6):491-8

 

Certain Conditions Originating in the Perinatal Period

The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection
Hauge Opdal S, et al.
Acta Paediatr 2006 Sep;95(9):1129-32

 

 

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