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Rocky Mountain Spotted Fever (Rickettsia
rickettsii) (RMSF)
1996 Case Definition
Clinical description
A tickborne febrile illness most commonly characterized
by acute onset and usually accompanied by myalgia, headache,
and petechial rash (on the palms and soles in two thirds of the
cases)
Laboratory criteria for diagnosis
- Fourfold or greater rise in antibody titer
to Rickettsia rickettsii antigen by immunofluorescence
antibody (IFA), complement fixation (CF), latex agglutination
(LA), microagglutination (MA), or indirect hemagglutination
antibody (IHA) test in acute- and convalescent-phase specimens
ideally taken greater than or equal to 3 weeks apart, or
- Positive polymerase chain reaction assay to R.
rickettsii, or
- Demonstration of positive immunofluorescence
of skin lesion (biopsy) or organ tissue (autopsy), or
- Isolation of R. rickettsii from clinical
specimen
Case classification
Probable: a clinically
compatible case with a single IFA serologic titer of greater
than or equal to 64 or a single CF titer of greater than or equal
to 16 or other supportive serology (fourfold rise in titer or
a single titer greater than or equal to 320 by Proteus OX-19
or OX-2, or a single titer greater than or equal to 128 by an
LA, IHA, or MA test)
Confirmed: a clinically compatible case
that is laboratory confirmed
See also:
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