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An acute illness with a) discrete onset of symptoms (such as nausea, vomiting, abdominal pain and diarrhea) and b) jaundice or abnormal serum aminotransferase levels
Laboratory criteria for diagnosis
Serum alanine aminotransferase levels greater than 7 times the upper limit of normal,
and
IgM antibody to hepatitis A virus (IgM anti-HAV) negative (if done)
and
IgM antibody to hepatitis B core antigen (IgM anti-HBc) negative, or if not done, hepatitis B surface antigen (HBsAg) negative,
and
Antibody to hepatitis C virus (anti-HCV) positive, verified by an additional more specific assay.
Case classification:
Confirmed: a case that meets the clinical case definition and is laboratory confirmed
Comment:
See also:
References
6. Kuo G, Choo Q-L, Alter HJ, et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 1989;244:362-4.
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