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Cholera (Vibrio cholerae)
1990 Case Definition
Clinical description
An illness characterized by diarrhea and/or vomiting.
Severity is variable.
Laboratory criteria for diagnosis
- Isolation of toxigenic (cholera toxin-producing) Vibrio
cholerae 01 from stool or vomitus, or
- Significant rise in vibriocidal or antitoxic
antibodies in acute- and early convalescent-phase sera, or
- Significant fall in vibriocidal antibodies
in early and late convalescent-phase sera among persons not
recently vaccinated
Case classification
Confirmed: a clinically
compatible illness that is laboratory confirmed
Comment
When other cases are known to be occurring, a less
than fourfold rise in titer between acute- and convalescent-phase
serum may be considered significant. Likewise, a less than fourfold
fall between early and late convalescent-phase sera may be important
in these circumstances. Only confirmed cases should be reported
to the NNDSS. Illnesses due to strains of V. cholerae other
than toxigenic V. cholerae 01 should not be reported
as cases of cholera.
See also:
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