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2007 Case Definition*Clinical descriptionStreptococcus pneumoniae causes many clinical syndromes, depending on the site of infection (e.g., acute otitis media, pneumonia, bacteremia, or meningitis). Starting in 2000, a conjugate pneumococcal vaccine is recommended for prevention of pneumococcal disease in the pediatric population. Laboratory criteria for diagnosisIsolation of S. pneumoniae from a normally sterile site (e.g., blood, cerebrospinal fluid, or, less commonly, joint, pleural, or pericardial fluid) Case classificationConfirmed: a clinically compatible case in a child less than five years of age caused by laboratory-confirmed culture of S. pneumoniae from a normally sterile site *CommentThe difference between this case definition and the previous case definition for this condition is the inclusion of new case classifications for reporting purposes. Case classifications for Drug Resistant Streptococcus pneumoniae (DRSP) and Invasive Pneumococcal Disease (IPD) are modified as listed below:
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