The 2002 Grantees' Meeting for the HIV RFA Programs

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Etiology of Cardiovascular Complications in HIV Infection
Endothelial Dysfunction in HIV Infection
Cardiovascular Complications from Cocaine Abuse in HIV Infection
Genesis of Cardiomyopathy with HIV Infection and Alcohol Abuse

May 2-3, 2002

[Meeting Summary], [Recommendations], [Roster]

Agenda

Thursday, May 2, 2002

8:00 a.m.	Registration and Poster Setup
8:30 a.m.	Welcome and Introduction Lan-Hsiang Wang, NHLBI Jag Khalsa, NIDA Sandra Colombini Hatch, NHLBI
8:40 a.m.	Lance Terada (1) University of Texas Southwestern Effect of HIV Tat on Endothelial Cell Function
9:00 a.m.	Mitchell Finkel (16) West Virginia University P38 MAP Kinase Regulates Negative Inotropic Effect of HIV gp120 on Cardiac Myocytes through Troponin I Phosphorylation
9:20 a.m.	Jian-Feng Wang (3) Beth Israel Deaconess Medical Center Functional Studies of HIV-Tat Effects on Endothelium
9:40 a.m.	Winnie Henderson (4) Oregon Health Sciences University HIV-1 vpu and tat Modulate Endothelial Cell-B Lymphoma Cell Interactions: Implications for AIDS-Associated Non-Hodgkin's Lymphoma
10:00 a.m.	Break
10:20 a.m.	John Ho (5) Cornell University HIV-1 Activates Innate Immune Cells via Toll-Like Receptor 2
10:40 a.m.	Emily D. Overholser (6) Johns Hopkins University Mechanisms of Endothelial Cell Dysfunction in SIV Infection
11:00 a.m.	Lingjun Zhao (7) Saint Louis University Medical Center Regulation of Myosin Light Chain Phosphorylation by HIV-1 Vpr
11:20 a.m.	Changyi Chen (8) Baylor College of Medicine HIV-1 gp120 Down-Regulates Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells
11:40 a.m.	Kwang Sik Kim (9) Johns Hopkins University Gp120 Induces Cytotoxicity of Human Brain Microvascular Endothelial Cells
12:00 p.m.	Lunch
1:00 p.m.	Poster Session (Atrium) Posters will be displayed from 8:30 a.m. until 5 p.m. Poster presenters with odd numbers will be present from 1 p.m. to 1:50 p.m. Poster presenters with even numbers will be present from 1:50 p.m. to 2:40 p.m. Harris McFerrin (2)--poster presentation only Tulane University Molecular Mechanism of Tat-Induced Angiogenesis
2:40 p.m.	Break
3:00 p.m.	Douglas Larson (10) University of Arizona Dilated Cardiomyopathy in Murine Acquired Immunodeficiency Syndrome (MAIDS)
3:20 p.m.	Ronald Watson (11) University of Arizona Selenium Supplementation Decreases Coxsackievirus Heart Disease During Murine AIDS
3:40 p.m.	J. Bruce Sundstrom (12) Emory University An in vitro Model for Investigating the Role of Mast Cells in Mechanisms of Increased Fibrosis Associated with AIDS-Related Cardiomyopathies
4:00 p.m.	Debasis Mondal (13) Tulane University Synergistic Effects of Cocaine and the Inflammatory Cytokines in Modulating Vascular Endothelial Cell Function
4:20 p.m.	Guha Krishnaswamy (14) East Tennessee State University Role of the Inflammatory Network in Cocaine and HIV-Mediated Atherogenesis
4:40 p.m.	Shenghan Lai (17) Johns Hopkins University Association of Cocaine Use With Coronary Calcification in Injecting Drug Users in Baltimore
5:00 p.m.	Recommendations for Future Directions Ronald Watson
5:20 p.m.	Conclusion of Today's Program
5:20 - 5:40 p.m.	Remove posters from poster boards

Friday, May 3, 2002

8:30 a.m.	Milan Fiala (15) University of California Los Angeles (A) Human Immunodeficiency Virus Type 1 Enters Brain and Coronary Endothelia by Macropinocytosis Dependent upon Lipid Rafts. (B) Cocaine Binds to a G-Protein Coupled Receptor, Signals and Restructures Coronary Artery Endothelial Cells.
8:50 a.m.	John Bauer (18) Ohio State University Cocaine Induced Cardiotoxicity in Mice
9:10 a.m.	Roy Sutliff (19) Emory University Cocaine Administration Increases LV Mass in HIV-1 Transgenic Mice
9:30 a.m.	Sonia Flores (20) University of Colorado Evidence of Inflammation in Tat-Transgenic Mice
9:50 a.m.	John Bauer (21) Ohio State University Mechanistic Studies of Retrovirus Related Cardiac Dysfunction: the Murine AIDS Model and Human HIV Infection
10:10 a.m.	Douglas Wallace (22) Emory University Ethanol and AIDS Cardiomyopathy: A Mitochondrial Connection?
10:30 a.m.	Break
10:50 a.m.	Paul Jolicoeur (23) Clinical Research Institute of Montreal Studies of Cardiac Disease in HIV-1 Transgenic Mice
11:10 a.m.	William Lewis (24) Emory University Combined Antiretroviral Therapy Causes Cardiomyopathy and Elevates Plasma Lactate in Transgenic AIDS Mice
11:30 a.m.	Richard Shannon (25) New England Regional Primate Research Center Cellular Pathways Involved in Myocardial Injury in Simian AIDS: Role of Cytokines, Inducible Nitric Oxide, and CD95
11:50 a.m.	Milan Fiala (26) University of California Los Angeles HIV-1 Envelope Protein gp120 Induces Cardiomyocyte Apoptosis and Is Associated with HIV-1 Cardiomyopathy
12:10 a.m.	Neil Bowles (27) Baylor College of Medicine The Pathogenesis of Heart Disease in HIV-Infected Children
12:30 p.m.	Closing Remarks
12:40 p.m.	Adjournment Of Meeting

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