Baek, S.J., Wilson, L.C., Hsi, L.C., Eling, T.E. Troglitazone, a Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPARγ. J. Biol. Chem., 278: 5845-5853, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12475986)
Newman, D., Morito, S., Koo, J.S., Kim, K., Baek, S.J., Eling, T., and Jetten, A.M. Differential Regulation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene in Normal Human Tracheobronchial Epithelial and Lung Carcinoma Cells by Retinoids. Mol. Pharmacol., 63: 557-564, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12606762)
Wilson, L.C., Baek, S.J., Call, A., Eling, T.E. Nonsteroidal Anti-Inflammatory Drug-Activated Gene (NAG-1) is Induced by Genistein Through the Expression of p53 in Colorectal Cancer Cells. Int. J. Cancer, 105: 747-753, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12767058)
Nixon, J.B., Kamitani, H., Baek, S.J., Eling, T.E. Evaluation of Eicosanoids and NSAIDs as PPARγ Ligands in Colorectal Carcinoma Cells. Prostaglandins Leukot Essent Fatty Acids, 68: 323-330, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12711249)
Amin, R., Kamitani, H., Sultana, H., Taniura, S., Islam, A., Sho, A., Ishibashi, M., Eling, T.E. and Watanabe, T. Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells. Neurol Res., 25:370-376, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12870263)
Bottone, Jr., F.B., Martinez, J.M., Collins, J.B., Afshari , C.A., and Eling,T.E. Gene Modulation by the Cyclooxygenase Inhibitor, Sulindac Sulfide, in Human Colorectal Carcinoma Cells: Possible Link to Apoptosis. J. Biol. Chem., 278:25790-25801, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12734198)
Nixon, J.B., Kim, K., Lamb, P.W., Bottone, Jr., F.B. and Eling, T.E., 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. Prostaglandins. Leuk. Essent. Fatty Acids, 70, 7-15, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14643174)
Lee, C., Jang, Y., Sun-Ju.Y, Her, Moon, Y., Baek, S., Eling, E. Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-β activity through the inhibition of Smad signaling pathway. Exp. Cell Res.289: 335-341, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14499634)
Bottone, Jr., F.B., Martinez, J.M., Alston-Mills, B. and Eling, T.E. Gene Modulation by Cox-1 and Cox-2 Specific Inhibitors in Human Colorectal Carcinoma Cancer Cells. Carcinogenesis, 25: 349-357, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14633654)
Wang, T.,Qin, L., Liu,Y., Wilson, B., Eling, T.E., Langenbach, R., Taniura, S., and Hong, J. Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J. Neurochem. 88:939-947, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14756815)
Baek, S., Kim, J., Nixon, J.B., DiAugustine, R.P. and Eling, T.E. Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene, EGR-1. J. Biol. Chem. 279:6883-6892, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14662774)
Jain AK, Moore SM, Yamaguchi K, Eling TE, Baek SJ. Selective Nonsteroidal Anti-inflammatory Drugs Induce Thymosin Beta-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells. J Pharmacol. Exp Ther.311:885-91, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15292456)
Baek SJ, Kim JS, Jackson FR, Eling TE, McEntee MF, Lee SHE Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Carcinogenesis: 25, 2425-2432, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15308587)
Martinez JM, Baek SJ, Mays DM, Tithof PK, Eling TE, Walker NJ. EGR1 Is a Novel Target for AhR Agonists in Human Lung Epithelial Cells. Toxicol. Sci. 82: 429-435, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15342960)
Ishibashi M, Bottone FG, Taniura S, Kamitani H, Watanabe T, and Eling TE, The Cyclooxygenase Inhibitor Indomethacin Modulates Gene Expression and Represses the Extracellular Matrix Protein Laminin γ1 in Human Glioblastoma Cells. Exp. Cell Res.302:244-252, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15561105)
Kim JS, Yoon J, Kim JK, Baek SJ, Eling TE, Leeg WJ, Ryug J, Leea JG, Jong-Bum Yooa J. Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys. Res. Comm. 325:1298-1303,2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15555568)
Yamaguchi, K., Lee, S., Eling, T., and Baek, S., Identification of Nonsteroidal Anti-Inflammatory Drug-activated gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3β pathway. J. Biol. Chem. 279: 49617-49623, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15377673)
Seung Joon Baek, Jong-Sik Kim, Scott M. Moore, Seong-Ho Lee, Jeanelle Martinez, and Thomas E. Eling, Cycloxygenase inhibitors induce the expression of the tumor suppressor gene, EGR-1 which results in the up-regulation of NAG-1, an anti-tumorigenic protein. Mol. Pharm: 67: 356-364, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15509713)
Seung-Ho Lee, Jing-Sik Kim, Kiyoshi Yamaguchi. Thomas E. Eling and Seung Joon Baek. Indole-3-carbinol and 3,3’-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem. Biophy. Res. Comm. 328: 63-69, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15670751)
Minsub Shim and Thomas E. Eling, PKC-dependent Regulation of NAG-1/PLAB/MIC-1 Expression in LNCaP Prostate Carcinoma Cells. J. Biol. Chem.280: 18636-18642, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15757899)
Frank G. Bottone, Jr., Yuseok Moon, Jong Sik Kim, Brenda Alston-Mills, Minako Ishibashi, and Thomas E. Eling, The anti-invasive activity of Cox inhibitors are regulated by the transcription factor Activating Transcription Factor 3 (ATF3). Mol. Canc. Ther. 4: 693-703, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15897233)
Jong-Sik Kim, Seung Joon Baek, Tina Sali and Thomas Eling. The conventional NSAID sulindac sulfide arrests ovarian cancer cell growth through NAG-1/MIC-1/GDF-15. Mole Can. Ther. 4: 487-493, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15767558)
House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol Genomics, 21:351-361, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15888570)
Frank G. Bottone, Jr., Yuseok Moon, Brenda Alston-Mills, and Thomas E. Eling. Transcriptional Regulation of Activating Transcription Factor 3 (ATF3) Involves the Early Growth Response-1 (Egr-1) Gene. J. Pharmacol. Exp. Ther.315, 668-677, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16079301)
Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling, Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. J. Pharmacol. Exp Ther.315, 788-795, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16081677)
Krishnamurthy Malathi, Jayashree Paranjapee, Elena Bulanova, Minsub Shim, Jeanna M. Guenther-Johnson,Thomas Eling, Bryan Williams and Robert H. Silverman, A transcriptional signaling pathway in IFN system mediated by 2’-5’-oligoadenylate activation of RNase L. Proc. Nat. Acad. Sci. 102, 14533-14538, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16203993)
Kim, JS, Baek, SJ, Bottone, FG Jr, Sali, T, and Eling TE, Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cells. Mol. Cancer Res 9, 511-517, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16179498)
Yuseok Moon, Frank G. Bottone, Jr., Michael F. McEntee, and Thomas E. Eling, Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by Thrombospondin-1 via the early growth response gene, Egr-1. Mol Cancer Ther. 4,1551-8, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16227405)
Ryuji Okazaki, Yuseok Moon, Toshiyuki Norimura, and Thomas Eling. Ionizing Radiation Enhances the Expression of the Nonsteroidal Anti-inflammatory Drug-Activated Gene (NAG1) by Increasing the Expression of TP53 in Human Colon Cancer Cells Radiation Res. 165, 125-130, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16435911)
Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, and Baek SJ. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27:972-81, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16286461)
Baek SJ and Eling TE. Changes in gene expression contribute to cancer prevention by COX inhibitors. Prog. Lipid Res. 45:1-16, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16337272)
Martinez JM, Sali T, Okazaki R, Anna C, Hollingshead M, Hose C, Monks A, Walker NJ, Baek SJ, and Eling TE. Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharmacol. Exp Ther. 318:899-906, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16714403)
Yamaguchi K, Lee SH, Eling TE, and Baek SJ. A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol Cancer Ther. 5:1352-61, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16731769)
Lambert JR, Kelly JA, Shim M, Huffer WE, Nordeen SK, Baek SJ, Eling TE, and Lucia MS. Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell Physiol. 208 566-574, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16741990)
Baek S, Okazaki R, Lee S, Martinez J, Kim J, Yamaguchi K,. Mishina Y, Martin D, Shoieb A, McEntee M, and Eling. T. Nonsteroidal anti-inflammatory drug activated gene-1 overexpression in transgenic mice suppresses intestinal neoplasia. Gastroenterology, 131(5): 1553-60, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17101328)
Lee C., Bottone, F., Krahn,J., Li, L., Mohrenweiser,H., Cook, M., Petrovich, R., Bell, D., Eling,T., and Zeldin, D., Identification and Functional Characterization of Polymorphisms in Human Cyclooxygenase-1 (PTGS1), Pharmacogenetics and Genomics, 17(2): 145-60, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17301694)
Kambe A., Iguchi G., Moon Y. Kamitani H., Watanabe, T. and Eling T. Suppression of the Prostaglandin EP4 Receptor Expression by Troglitazone requires Phosphorylated Sp-1. Cancer Research, Submitted.
Eling TE, Baek SJ, Shim M, Lee CH. NSAID activated gene (NAG-1), a modulator of tumorigenesis. Journal of biochemistry and molecular biology 2006 39(6):649-655. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17129398)
Kambe A, Iguchi G, Moon Y, Kamitani H, Watanabe T, Eling TE. Regulation of EP4 expression via the Sp-1 transcription factor: Inhibition of expression by anti-cancer agents. Biomedica biochimica acta 2008 1783(6):1211-1219. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18346464)
Moon Y, Kim JI, Yang H, Eling TE. Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life sciences 2008 82(11-12):591-599. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18261746)
Shim M, Eling TE. Vitamin E succinate (VES) induces NAG-1 expression in a p38 kinase-dependent mechanism. Molecular cancer therapeutics 2008 7(4):961-971. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18413810)
|