Avi Shamay : NIDDK

Scientific Programs

Avi Shamay

Dr. Avi Shamay arrived in our lab in 1989 to explored the hormone-controlled regulation of milk protein genes in mamamry tissue during pregnancy and lactation. Specifically he studied the control of the whey acidic protein (WAP) gene in transgenic mice and pigs in collaboration with Bob Wall from the USDA.

Avi left our laboratory in 1992 to take a position at the Volcani Institute in Israel where is is currently a staff scientist.

Publications while in LGP

PubMed search

1. Wall, R.J., Rexroad, C., Shamay, A., McKnight, R.A. and Hennighausen, L. (1995) Synthesis and secretion of the mouse whey acidic protein in the mammary gland and milk of transgenic sheep. Transgenic Research 5, 67-72.

2. Furth, P.A., Shamay, A. and Hennighausen, L. (1995) Gene transfer into mammalian cells by jet injection. Hybridoma 14, 149-152.

3. Furth, P.A., Shamay, A., Wall, J.R. and Hennighausen, L. (1992) Gene transfer into somatic tissues using jet injection. Anal. Biochem. 205, 365-368.

4. McKnight, R.A., Shamay, A., Sankaran, L., Wall, R.J. and Hennighausen, L. (1992) Matrix attachment regions impart position independent regulation of a tissue specific gene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 89, 6943-6947.

5. Shamay, A., Pursel, V.G., Wilkinson, J.E., Wall, R.J., and Hennighausen, L. (1992) Expression of the mouse whey acidic protein gene in transgenic pigs impairs mammary development. Transgenic Res. 1, 124-132.

6. Shamay, A., Pursel, V.G., Wall, R.J. and Hennighausen, L. (1992) Induction of lactogenesis in transgenic virgin pigs: Evidence for gene and integration site specific hormonal regulation. Mol. Endocrinology 6, 191-197.

7. Burdon, T., Wall, R.J., Shamay, A., Smith, G.H. and Hennighausen, L. (1991). Overexpression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary development and a milchlos phenotype. Mech. of Development 36, 67-74.

8. Shamay, A., Pursel, V., McKnight, R., Alexander, L., Beattie, C., Hennighausen, L., and Wall, R.J. (1991). Production of the whey acidic protein in transgenic pigs during lactation. J. Anim. Sci. 69, 4552-4562.

9. Wall, R.J., Pursel, V.G., Shamay, A., McKnight, R.A., Pittius, C.W., and Hennighausen, L. (1991). High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine. Proc. Natl. Acad. Sci. USA 88, 1696-1700.

10. Hennighausen, L., Shamay, A., Furth, P.A., McKnight, R.A., Rexroad, C.E. Jr, Pursel, V.G., and Wall, R.J. (1992) Transgenic animals as bioreactors for therapeutic and nutritional proteins. In E.F. Wagner and F. Theuring (eds.) Transgenic animals as model systems for human diseases, Springer Verlag, Berlin, 129-142.

11. McKnight, R.A., Burdon, T., Pursel, V.G., Shamay, A ., Wall, R.J. and Hennighausen, L. (1991). The whey acidic protein. In R.B Dickson and M.E. Lippman (eds.) Breast Cancer: Molecular and Cellular Biology, Kluwer Academic Publishers, Boston, 399-412.

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