| Title: |
Systems approach to death-survival signaling in mammalian cells [electronic resource] / Peter K. Sorger. |
| Variant Title: |
Title from title screen: Systems biology of a life-death decision |
| Author(s)/Name(s): |
Sorger, Peter K. |
| Publisher: |
[Bethesda, Md. : National Institutes of Health, 2007] |
| Related Names: |
National Institutes of Health (U.S.) |
| Language: |
eng |
| Electronic Links: |
http://videocast.nih.gov/launch.asp?13705 |
| MeSH Subjects: |
Apoptosis --physiology |
|
Cell Survival --physiology |
|
Tumor Necrosis Factors --metabolism |
|
Receptors, Tumor Necrosis Factor --metabolism |
|
Intercellular Signaling Peptides and Proteins |
|
Signal Transduction |
|
Lectures |
| Summary: |
(CIT): Our lab studies the mammalian signaling circuits that determine the choice between alternate cell fates of continued proliferation or programmed cell death. We focus on pathways activated by binding of EGF, IGF1 and hepatocyte growth factor (HGF) proliferation-survival factors and the TNF, TRAIL and FAS death ligands to their receptors on human and murine cells. We approach these topics from a systems perspective in which measurement and experimental manipulations with RNAi, drugs and knock-in mutations are combined with high throughput measurement and mathematical modeling at levels of abstraction that vary from purely statistical to explicitly mechanistic I will describe recent work on the core apoptosis pathways that regulate executioner caspases, proteases that dismantle dying cells. Caspase normally switch from off to on in an all-or-none process that enforces an unambiguous choice between life and death. |
| Notes: |
Title from screen banner (viewed May 16, 2007). |
|
Streaming video (1 hr., 9 min., 43 sec. : sd., col.). |
|
Mode of access: World Wide Web. |
|
Open-captioned. |
| NLM Unique ID: |
101303652 |
| Other ID Numbers: |
(DNLM)CIT:13705 |
