Selected Publications

NTP Pathology Group

Monographs/Reviews

1. Mac Law and Susan Elmore (2008) Mechanisms of Cell Death. Edited by Robert C. Smart and Ernest Hodgson in : Molecular and Biochemical Toxicology, 4,^th Edition. John Wiley & Sons, Inc. Hoboken, New Jersey. Chapter 16, pages 287-317.
2. Alexandra E. Petiet, Matthew H. Kaufman, Matthew M. Goddeeris, Jeffrey Brandenburg, Susan A. Elmore, and G. Allan Johnson (2008). High-resolution magnetic resonance histology of the embryonic and neonatal mouse: A 4D atlas and morphologic database. PNAS 105, 12331-12336. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18713865?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
3. Elmore, S. A. and Travlos, G. S. (2008; submitted). Chemically Induced Histopathological Changes of the Bone Marrow. Toxicology of the blood and bone marrow – 2^nd edition Edited by Jacques Descotes in: Target Organ Toxicology Series (Series Editors John A Thomas, A Wallace Hayes and Donald E Gardner, CRC Press/Taylor and Francis.
4. Elmore, S. A., Nyska, A. and Tischler, A. S. (2008). The Adrenal Medulla as a Target Organ in Toxicologic Studies of Rats and Mice. Edited by Philip Harvey, David Everett and Christopher Springall in: Target Organ Toxicology Series Vol 26 (Series Editors A Wallace Hayes, John A Thomas and Donald E Gardner, Informa Healthcare.
5. Tischler, A. S., Nyska, A. and Elmore, S. A. (2008, submitted). Toxic Responses of the Adrenal Medulla in: Volume 11 of Comprehensive Toxicology, 2nd Edition Edited by I. Glenn Sipes, Charlene A. McQueen and A. Jay Gandolfi. Elsevier, New York, NY.
6. Elmore SA. (2007) Apoptosis: a review of programmed cell death. Toxicologic pathology 4 (495-516). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17562483)
7. Peckham, J.C. and Thomassen, R.W. (2007).The Dog: pathology. In: Animal Models in Toxicology (S.C. Gad, Ed.), pp. 588-645. Taylor & Francis Group, LLC, Boca Raton, Fl.
8. Peckham, J.C (2007).The Guinea Pig: pathology. In: Animal Models in Toxicology (S.C. Gad, Ed.), pp 371-400. Taylor & Francis Group, LLC, Boca Raton, Fl.
9. Peckham, J.C. (2007).The Rabbit: pathology. In: Animal Models in Toxicology (S.C. Gad, Ed.), pp. 449-475. Taylor & Francis Group, LLC, Boca Raton, Fl.
10. Cesta MF. (2006). Normal structure, function, and histology of the spleen. Toxicol Pathol 34(5), 455-465.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067939)
11. Cesta MF. (2006). Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicol Pathol 34(5), 599-608.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067945)
12. Elmore, S. A. (2007). Apoptosis: a review of programmed cell death (invited review). Toxicol Pathol 35 (1-22).
13. Elmore, S. A. (2006). Enhanced histopathology of mucosa-associated lymphoid tissue. Toxicol Pathol 34, 687-96.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067953)
14. Elmore, S. A. (2006). Enhanced histopathology of the bone marrow. Toxicol Pathol 34, 666-86.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067952)
15. Elmore, S. A. (2006). Enhanced histopathology of the thymus. Toxicol Pathol 34, 656-65.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067951)
16. Elmore, S. A. (2006). Enhanced histopathology of the spleen. Toxicol Pathol 34, 648-55.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067950)
17. Elmore, S. A. (2006). Enhanced histopathology of the lymph nodes. Toxicol Pathol 34, 634-47.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067949)
18. Elmore, S. A. (2006). Histopathology of the lymph nodes. Toxicol Pathol 34, 425-54.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067938)
19. Malarkey, DE and Maronpot, RR. (2005). Carcinogenesis. In Encyclopedia of Toxicology; 2nd edition; Edited by Philip Wexler; Academic press, San Diego. pp 445-466.

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Toxicological Pathology

1. K. Yoshizawa, A. Heatherly, D. E. Malarkey, N. J. Walker and A. Nyska (2007). A critical comparison of murine pathology and epidemiological data of TCDD, PCB126, and PeCDF. Toxicologic Pathology 35(7): 865-879. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Heatherly%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)
2. Stout MD, Kissling GE, Suárez FA, Malarkey DE, Herbert RA, Bucher JR. 2008 Influence of Helicobacter hepaticus Infection on the Chronic Toxicity and Carcinogenicity of Triethanolamine in B6C3F1 Mice. Toxicol Pathol. 36(6):783-794. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Su%C3%A1rez%20FA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)
3. Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC. Inhaled Multi-walled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma. Am J Respir Cell Mol Biol. 2008 Sep 11. [Epub ahead of print] [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18787175?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
4. Hardisty JF, Elwell MR, Ernst H, Greaves P, Kolenda-Roberts H, Malarkey DE, Mann PC, Tellier PA. (2007) Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicologic Pathology 35(7):928-941. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18098039)
5. Kissling, G, Malarkey, DE, Hejtmancik, MR, Vallant, MK, Smith, CA, Herbert, RA, and Boorman, GA. Evaluation of dichloroacetic acid for carcinogenicity in genetically modified TgAC and p53 haploinsufficient mice. Tox Sci (in press).
6. Carcinogenesis studies of Benzophenone in Rats and Mice. Rhodes, M. C., Bucher, J. R., Peckham, J. C., Kissling, G. E., Hejtmancik, M. R., and Chhabra, R. S. (2007) Food and Chemical Toxicology, 45(5): 843-851.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17187913)
7. Kissling GE, Malarkey DE, Vallant MK, Johnson JD, Hejtmancik MR, Herbert RA, Boorman GA. (2006) Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2-3: 89-99. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16996724)
8. Elmore, S., Lanning, L., Allison, N., Vallant, M., and Nyska, A. (2006). The transduction of rat submandibular glands by an adenoviral vector carrying the human growth hormone gene is associated with limited and reversible changes at the infusion site. Toxicol Pathol 34: 385-92.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16844666)
9. Zheng, C., Voutetakis, A., Kok, M. R., Goldsmith, C. M., Smith, G. B., Elmore, S., Nyska, A., Vallant, M., Irwin, R. D., and Baum, B. J. (2006). Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland. Oral Dis 12: 137-44.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16476034)
10. Malarkey, DE , Johnson, K, Ryan,, L, Boorman, G and Maronpot, RR.(2005). New insights into functional aspects of liver morphology. Tox Path 33(1): 27-34.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15805053)
11. Lewis, DN, Nyska, M, Johnson, K, Malarkey, DE, Ward, S, Streiker, M, Peddada, S, Shabat, S, Nyska, A. (2005). 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth plate suppression. Tox Path 33(2): 272-282.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15902971)
12. Walker, DM, Malarkey, DE, Seilkop, SK, Ruecker, FA, Funk, KA, Wolfe MJ, Treanor, CP, Foley, JF, Hahn, FF, Hardisty, JF, and VE Walker (2007). Transplacental carcinogenicity of 3-azido-3-deoxythymidine in B6C3F1 mice and F344 rats. Environmental and Molecular Mutagenesis 48(3-4):283-98.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17358026)
13. Nyska A, Jokinen, Brix, Sells, Wyde, Orzech, Haseman, Flake, and Walker. (2004) Exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds. Environ Health Perspect 112: 903-909.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15175180)
14. Doi, A. M., Peckham, J. C., Chou, B. J., Dill, J. A., Renne, R. A., Grumbein, S. L., and Chhabra, R., S. (2004) Development of a2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC, Inhalation Toxicology 16(5): 247-257.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15371178)

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Animal Models of Environmental Diseases

1. Stout MD, Kissling GE, Suárez FA, Malarkey DE, Herbert RA, Bucher JR. Influence of helicobacter hepaticus infection and diet on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice. Toxicologic pathology 2008 36(6):783-794. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18812577)
2. Morrison JP, Satoh H, Foley J, Horton JL, Dunnick JK, Kissling GE , Malarkey DE. N-ethyl-N-nitrosourea (ENU)-induced meningiomatosis and meningioma in p16INK4a/p19ARF tumor suppressor gene deficient mice. Toxicologic Pathology 2007 35(6):838-845. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17943659)
3. Trempus, C. J., Morris, R. J., Elmore, A., Ehinger, M., Bortner, C. D., Ito, M., Cotsarelis G., Peckham, J., Flagler, N., Kissling, G., Humble, M. M., King, L. C., Adams, L. D., Desai, D., Amin, S., and Tennant, R. W. (2007) CD34 Expression by Hair Follicle Stem Cells is Required for Skin Tumor Development in Mice. Cancer Research 67(9):4173-4181.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17483328)
4. Wakamatsu N, Hong HL, Devereux TR, Sills RC. (2007) Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Toxicologic Pathology, 35:75-80.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17325975)
5. Dang, H, Trempus, C, Malarkey, DE, Wei, S, Humble, M, Morris, RJ, and Tennant, RW. (2006). Identification of genes and gene ontology processes critical to skin papilloma development iin Tg.AC transgenic mice. Molecular Carcinogenesis Feb;45(2):126-140.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16329151)
6. Emmen, J. M., Couse, J. F., Elmore, S. A., Yates, M. M., Kissling, G. E., and Korach, K. S. (2005). In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology 146, 2817-26.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15731357)
7. Mangum JB, Turpin EA, Antao-Menezes A, Cesta MF, Bermudez E, Bonner JC. (2006). Single-Walled Carbon Nanotube (SWCNT)-Induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part Fibre Toxicol (in press).  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17134509)

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Toxicogenomics/Proteomics

1. Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biol. 2008;9(6):R100. Epub 2008 Jun 20. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18570634?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
2. Gerrish, K and Malarkey DE. 2007. Genomic profiles of liver injury. Chapter in Hepatotoxicity: From genomics to in-vitro and in-vivo, S Sahu, editor.
3. P. R. Bushel, A. N. Heinloth, J. Li, L. Huang, J. W. Chou, G. A. Boorman, D. E. Malarkey, C. D. Houle, S. M. Ward, R. E. Wilson, R. D. Fannin, M. W. Russo, P. B. Watkins, R. W. Tennant and R. S. Paules (2007). Blood gene expression signatures predict exposure levels. Proceedings of the National Academy of Sciences of the United States of America 104(46): 18211-18216. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17984051?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
4. Lobenhofer, EK, Boorman, GA, Phillips, KL, Heinloth, AN, Malarkey, DE, Blackshear, PE, Houle, C, Parker, JS, and Hurban, P. (2006). Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation. Tox Path 34(7):921-928.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17178692)
5. Malarkey, DE, Parker, JS, Turman, CA, Scott, AM, Paules, RS and Maronpot, RR. (2005). Microarray data analysis of mouse neoplasia. Tox Path 33(1): 127-135.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15805064)
6. Boorman, G, Blackshear, PE. Parker, JS, Lobenhofer, EK, Malarkey, DE, Vallant, M, Gerkin, DK, and Irwin, RD. (2005). Hepatic gene expression changes throughout the day in the Fisher rat: Implications for toxicogenomics experiments. Tox Sci 86(1):185-193.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15814895)
7. Irwin, RD, Boorman GA, Cunningham, ML, Heinloth, AN, Malarkey, DE, and Paules, R. (2004). Application of toxicogenomics to toxicology: Basic concepts in the analysis of microarray data. Tox Path 32(Suppl. 1):72-83.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15209406)

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