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Home » About the NTP » NTP Quarterly Newsletter » March 1996 Liaison Mailout
1) NTP Board of Scientific Counselor's Meeting Schedule
2) Chronic Studies Scheduled to Start in FY96
3) Request for Chemical Nominations
4) NTP Adds New Databases to NTP Web Site
5) Recently Published NTP Reports
6) Update: Biennial Report on Carcinogens (BRC)
7) NTP Board of Scientific Counselors' Technical Reports Review Subcommittee Minutes and Summary of Technical Reports-- December 5, 1995
8) NTP Workshop Report on Validation and Regulatory Acceptance of Alternative Toxicological Test Methods
9) NTP Mailing List Survey Responses
NTP Board of Scientific Counselors' Meeting Schedule |
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The Board is scheduled to meet April 17, and October 22, 1996. A preliminary agenda for the April meeting includes: discussion of research partnerships in transgenic models, new research initiatives on environmental hormones and 'dioxin-like' chemicals, activities in alternative methods to animal research, report on the review of the criteria for the Biennial Report on Carcinogens (BRC), status reports on interagency collaborative studies with NIOSH and NCTR, and concept proposals in the areas of chemical disposition and reproductive toxicity. Information regarding the October 22nd meeting will be provided in a future UPDATE.
The recently established Biennial Report on Carcinogens (BRC) Subcommittee will have its first meeting May 7-8, 1996. The preliminary agenda for the meeting will include a discussion of the recent review of the criteria for listing substances in the BRC; the revised process for preparing the Report and the review responsibilities of the subcommittee, and a presentation of information on select chemicals previously identified for listing in the Eighth or Ninth BRCs to define data requirements for making recommendations regarding listing (see BRC Update).
The Technical Reports Review Subcommittee will be held December 11-12, 1996. Technical reports tentatively scheduled for this review are: 3'-azido-3'-deoxythymidine (AZT)/interferon (IFN), chloroprene, cobalt sulfate, ethylbenzene, isobutyraldehyde, oxazepam, polyvinyl alcohol, primaclone, tetrahydrofuran theophylline. All meetings will be held in the Conference Center, Building 101, South Campus, NIEHS. For information please contact Dr. Larry Hart (919) 541-3971.
Chronic Studies Scheduled to Start in Fiscal Year 1996 |
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Acrylonitrile | o-Nitrotoluene |
Citral | p-Nitrotoluene |
p,p'-Dichlorodiphenyl Sulfone | Riddelliine |
Indium Phosphide | Urethane + Ethanol (Combination)(3 studies) (NCTR) |
Methacrylonitrile | Vanadium Pentoxide |
Naphthalene |
Request for Chemical Nominations |
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NTP is soliciting recommendations for chemicals and chemical classes to be tested for toxicity. Chemicals are tested for any or all of the following health-related effects, including reproductive and developmental toxicity, carcinogenicity, genetic toxicity, immunotoxicity, neurotoxicity, general toxicity, chemical metabolism and disposition, mechanistic studies and clarification of structure activity relationships. The results of the NTP studies are used by other Federal and State agencies and private sector organizations. The results also are available to the public, and are published in the open scientific literature.
Nominating sources are asked to indicate the chemical or agent of interest, particular toxicity studies suggested, and the rationale for nomination. Nominators are also asked to provide available background data on production, use, exposure, environmental occurrence; and extent of existing toxicological data in a supporting summary document. However, we do not wish to discourage anyone from nominating a chemical or agent that could pose a health hazard. The Program will obtain literature and other background data when such support is not available to the nominator.
We encourage anyone who is aware of a chemical or agent that could pose a health hazard to nominate that chemical or agent for studies by the NTP. NTP staff will consider each nomination as it is received and assess the need for studies relative to other nominations. The nominator will be informed of the status of each nomination as decisions are reached.
Please send nominations and relevant information to: Dr. E. Zeiger, Chemical Selection Office, P.O. Box 12233, Research Triangle Park, NC 27709 (919)541-4482.
NTP Adds New Databases to NTP Web Site |
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Recently Published NTP Reports |
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NTP Technical Report on the Toxicology and Carcinogenesis Studies of Diethylphthalate (CAS No. 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CAS No. 131-11-3) in Male Swiss (CD-1®) Mice. (TR-429) - May 1995
NTP Technical Report on the Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CAS No. 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). (TR-436) - May 1995
NTP Technical Report on the Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CAS No. 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies). (TR-438) - July 1995
NTP Technical Report on the Toxicology and Carcinogenesis Studies of Methylphenidate Hydrochloride (CAS No. 298-59-9) in F344/N Rats and B6C3F1 Mice (Feed Studies). (TR-439) - July 1995
NTP Technical Report on Initiation/Promotion Study of o-Benzyl-p-Chlorophenol (CAS No.120-32-1) in Swiss (CD-1®:) Mice (Mouse Skin Study). (TR-444) - May 1995
NTP Technical Report on the Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice. (TOX-30) - May 1995
NTP Technical Report on the Toxicity Studies of Methylene bis(thiocyanate), (CAS No. 6317-18-6) Administered by Gavage to F344/N Rats and B6C3F1 Mice. (TOX-32) - January 1995
NTP Technical Report on the Toxicity Studies of Cadmium Oxide (CAS No. 1306-19-0) Administered by Inhalation to F344/N Rats and B6C3F1 Mice. (TOX-39) - May 1995
NTP Technical Report on the Toxicity Studies of 1,3-Diphenylguanidine (CAS No. 102-06-7) Administered in Feed to F344/N Rats and B6C3F1 Mice. (TOX-42) - September 1995
To request NTP documents contact:
Central Data ManagementUpdate: Biennial Report on Carcinogens (BRC) |
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The criteria are being revised based on these recommendations, and it is expected that the revised criteria will be provided to the NTP Board Subcommittee when they have their first meeting on May 7-8, 1996.
NTP Board of Scientific Counselors' Technical Reports Review Subcommittee Meeting and Summary of Technical Reports -- December 5, 1995 |
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The Subcommittee, predominantly composed of scientists from outside the Federal government, provides peer review of the draft technical reports of NTP long-term (usually two-year) toxicology and carcinogenesis studies and short-term toxicity studies. The Subcommittee reviewed and accepted the conclusions for carcinogenic activity as written for six two-year study reports: D & C Yellow No. 11; molybdenum trioxide; nitromethane; phenolphthalein; sodium xylenesulfonate; and tetrafluoroethylene. A review summary, primary uses, and other information about the six studies are given in the table that follows. Copies of the draft reports, summary minutes of the Report Reviews, and final reports (when available) may be obtained from:
Central Data Management,
MD: E1-02,
P.O. Box 12233,
Research Triangle Park, NC 27709
CHEMICAL
CAS NUMBER |
TECHNICAL
REPORT NUMBER |
PRIMARY USES |
ROUTE/
EXPOSURE LEVELS |
REVIEW SUMMARY |
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D & C YELLOW NO. 11
8003-22-3 |
TR-463 | Color additive used in cosmetics and externally applied to drugs. Contaminant of D&C Yellow 10, a compound which FDA is currently considering for approval for contact lenses. | Dosed-Feed (NIH-07): Rats: 0, 0.05, 0.17, OR 0.5%; 60/GROUP | The Subcommittee accepted with one abstention the conclusions as written, some evidence of carcinogenic activity, for male and female F344 rats. |
MOLYBDENUM TRIOXIDE
1313-27-5 |
TR-462 | In manufacture of molybdenum metals; corrosion inhibitor; catalyst; chemical analysis reagent; alloying agent in steel; agricultural chemical; component of ceramics, enamel & pigments. | Inhalation (AIR): Rats &Mice: 10, 30, OR 100 MG/M3; 50/SEX/SPECIES/GROUP | The Subcommittee accepted unanimously the conclusions as written, equivocal evidence of carcinogenic activity, for male rats, no evidence of carcinogenic activity, for female rats, and some evidence of carcinogenic activity, for male and female B6C3F1 mice. |
NITROMETHANE
75-52-5 |
TR-461 | Fuel additive and propellant. Cellulosic compound solvent. Intermediate for nitro and amino alcohols. | Inhalation (AIR): Rats: 0, 94, 188, OR 375 PPM; 50/GROUP. Mice: 0, 188, 375, OR 750PPM; 50/GROUP | The Subcommittee accepted unanimously the conclusions as written, no evidence of carcinogenic activity, for male rats, and clear evidence of carcinogenic activity, for female rats and male and female mice. |
PHENOLPHTHALEIN
77-09-8 |
TR-465 | Laboratory reagent. Dyes. Cathartic drug in laxatives. | Dosed-Feed (NIH-07): Rats: 0, 1.2, 2.5, OR 5%. Mice 0, 0.3, 0.6, OR 1.2% (50/SEX/SPECIES/GROUP) | The Subcommittee accepted with one abstention the conclusions as written, clear evidence of carcinogenic activity, for male rats and male and female mice, and some evidence of carcinogenic activity, for female rats. |
SODIUM XYLENE SULFONATE
1300-72-7 |
TR-464 | Hydrotrope in liquid detergents, shampoos, degreasing compounds. Used in textile, paper, and leather industries. | Topical (ETHANOL): Rats: 0, 60, 120, OR 240 MG/KG. Mice: 0, 182, 364, OR 727 MG/KG (50/SEX/GROUP) | The Subcommittee accepted the conclusions as written, no evidence of carcinogenic activity, for male and female rats and male and female mice. |
TETRAFLUOROETHYLENE
116-14-3 |
TR-450 | Monomer for polytetrafluoroethylene polymers. Preparation of propellants for food product aerosols. Chemical intermediate. | Inhalation (AIR): Mice & Female Rats: 0, 312, 625, OR 1250. Male Rats: 0, 156, 312,OR 625 PPM; 50/GROUP | The Subcommittee accepted unanimously the conclusions as written, clear evidence of carcinogenic activity, for male and female rats and male and female mice. |
NTP Workshop Report on Validation and Regulatory Acceptance of Alternative Toxicological Test Methods |
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The goals of the ICCVAM Report are to:
The Groups generally agreed that the criteria and guidance for validation and regulatory acceptance of new testing methods provided in the draft report would be useful to both government and non-government scientists, including regulatory scientists. Suggestions were provided to improve the clarity and format of the document. Other selected workshop recommendations included:
Following the NTP Workshop, the Organization for Economic Cooperation and Development (OECD) conducted a Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods in Solna, Sweden, on January 22-24, 1996. The draft ICCVAM Report and the draft NTP Workshop Report served as background working documents. An OECD Workshop Report will be available in late spring and it is anticipated that an OECD Guidance Document will be developed to serve as an international reference on this subject.
Mailing List Survey |
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Web page last updated on December 17, 2007
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.