| | This journal provides immediate access to some articles. Commentaries Scaling of growth: Plants and animals are not so different John Damuth PMCID: PMC33381 H1N1-influenza as Lazarus: Genomic resurrection from the tomb of
an unknown Joshua Lederberg PMCID: PMC33382 The disintegration of a molecule: The role of gelsolin in FAF,
familial amyloidosis (Finnish type) Robert C. Robinson, Senyon Choe, and Leslie D. Burtnick PMCID: PMC33383 Was “molecular opportunism” a factor in the evolution of
different photosynthetic light-harvesting pigment systems? Beverley R. Green PMCID: PMC33384 PEDF: Raising both hopes and questions in controlling
angiogenesis Gerald J. Chader PMCID: PMC33385 Making sense out of nonsense Margaret E. Saks PMCID: PMC33386 Perspective Special Feature: Planetary exploration in the time of astrobiology: Protecting
against biological contamination John D. Rummel PMCID: PMC33387 Review Special Feature: Constraints on nebular dynamics and chemistry based on
observations of annealed magnesium silicate grains in comets and in
disks surrounding Herbig Ae/Be stars Hugh G. M. Hill, Carol A. Grady, Joseph A. Nuth, III, Susan L. Hallenbeck, and Michael L. Sitko PMCID: PMC33388 Special Features Special Feature: Planetary exploration in the time of astrobiology: Protecting
against biological contamination John D. Rummel PMCID: PMC33387 Special Feature: Use of spacecraft data to derive regions on Mars where liquid
water would be stable Brad Lobitz, Byron L. Wood, Maurice M. Averner, and Christopher P. McKay PMCID: PMC30104 Special Feature: Extraterrestrial amino acids in Orgueil and Ivuna: Tracing the
parent body of CI type carbonaceous chondrites Pascale Ehrenfreund, Daniel P. Glavin, Oliver Botta, George Cooper, and Jeffrey L. Bada PMCID: PMC30105 Special Feature: Organic protomolecule assembly in igneous minerals Friedemann Freund, Aaron Staple, and John Scoville PMCID: PMC30106 Special Feature: Oxygen isotope ratios of PO4: An inorganic indicator
of enzymatic activity and P metabolism and a new biomarker in the
search for life Ruth E. Blake, Jeffrey C. Alt, and Anna M. Martini PMCID: PMC30107 Special Feature: Keeping Mars warm with new super greenhouse gases M. F. Gerstell, J. S. Francisco, Y. L. Yung, C. Boxe, and E. T. Aaltonee PMCID: PMC30108 Special Feature: A novel microbial habitat in the mid-ocean ridge subseafloor Melanie Summit and John A. Baross PMCID: PMC30109 Special Feature: Truncated hexa-octahedral magnetite crystals in ALH84001:
Presumptive biosignatures Kathie L. Thomas-Keprta, Simon J. Clemett, Dennis A. Bazylinski, Joseph L. Kirschvink, David S. McKay, Susan J. Wentworth, Hojatollah Vali, Everett K. Gibson, Jr., Mary Fae McKay, and Christopher S. Romanek PMCID: PMC30110 Special Feature: The origin of atmospheric oxygen on Earth: The innovation of
oxygenic photosynthesis G. C. Dismukes, V. V. Klimov, S. V. Baranov, Yu. N. Kozlov, J. DasGupta, and A. Tyryshkin PMCID: PMC30111 Special Feature: Chains of magnetite crystals in the meteorite ALH84001: Evidence
of biological origin E. Imre Friedmann, Jacek Wierzchos, Carmen Ascaso, and Michael Winklhofer PMCID: PMC30112 Special Feature: Constraints on nebular dynamics and chemistry based on
observations of annealed magnesium silicate grains in comets and in
disks surrounding Herbig Ae/Be stars Hugh G. M. Hill, Carol A. Grady, Joseph A. Nuth, III, Susan L. Hallenbeck, and Michael L. Sitko PMCID: PMC33388 Physical Sciences Astronomy Special Feature: Use of spacecraft data to derive regions on Mars where liquid
water would be stable Brad Lobitz, Byron L. Wood, Maurice M. Averner, and Christopher P. McKay PMCID: PMC30104 Chemistry Special Feature: Extraterrestrial amino acids in Orgueil and Ivuna: Tracing the
parent body of CI type carbonaceous chondrites Pascale Ehrenfreund, Daniel P. Glavin, Oliver Botta, George Cooper, and Jeffrey L. Bada PMCID: PMC30105 Special Feature: Organic protomolecule assembly in igneous minerals Friedemann Freund, Aaron Staple, and John Scoville PMCID: PMC30106 Solvent effects on the energy landscapes and folding kinetics of
polyalanine Yaakov Levy, Joshua Jortner, and Oren M. Becker PMCID: PMC30113 On the acidity and reactivity of HNO in aqueous solution and
biological systems Michael D. Bartberger, Jon M. Fukuto, and K. N. Houk PMCID: PMC30114 Geology Special Feature: Oxygen isotope ratios of PO4: An inorganic indicator
of enzymatic activity and P metabolism and a new biomarker in the
search for life Ruth E. Blake, Jeffrey C. Alt, and Anna M. Martini PMCID: PMC30107 Geophysics Special Feature: Keeping Mars warm with new super greenhouse gases M. F. Gerstell, J. S. Francisco, Y. L. Yung, C. Boxe, and E. T. Aaltonee PMCID: PMC30108 Biological Sciences Applied Biological Sciences Delineating developmental and metabolic pathways in
vivo by expression profiling using the RIKEN set of 18,816
full-length enriched mouse cDNA arrays Rika Miki, Koji Kadota, Hidemasa Bono, Yosuke Mizuno, Yasuhiro Tomaru, Piero Carninci, Masayoshi Itoh, Kazuhiro Shibata, Jun Kawai, Hideaki Konno, Sachihiko Watanabe, Kenjiro Sato, Yumiko Tokusumi, Noriko Kikuchi, Yoshiyuki Ishii, Yohei Hamaguchi, Itaru Nishizuka, Hitoshi Goto, Hiroyuki Nitanda, Susumu Satomi, Atsushi Yoshiki, Moriaki Kusakabe, Joseph L. DeRisi, Michael B. Eisen, Vishwnath R. Iyer, Patrick O. Brown, Masami Muramatsu, Hiroshi Shimada, Yasushi Okazaki, and Yoshihide Hayashizaki PMCID: PMC30115 Active site mutant transgene confers tolerance to human
β-glucuronidase without affecting the phenotype of MPS VII mice William S. Sly, Carole Vogler, Jeffrey H. Grubb, Mi Zhou, Jinxing Jiang, Xiao Yan Zhou, Shunji Tomatsu, Yanhua Bi, and Elizabeth M. Snella PMCID: PMC30116 pRB induces Sp1 activity by relieving inhibition mediated
by MDM2 Teresa Johnson-Pais, Catherine Degnin, and Mathew J. Thayer PMCID: PMC30117 Nanohedra: Using symmetry to design self assembling protein
cages, layers, crystals, and filaments Jennifer E. Padilla, Christos Colovos, and Todd O. Yeates PMCID: PMC30118 Mutated plant lectin library useful to identify different cells Mijung Yim, Takashi Ono, and Tatsuro Irimura PMCID: PMC30119 Biochemistry On the acidity and reactivity of HNO in aqueous solution and
biological systems Michael D. Bartberger, Jon M. Fukuto, and K. N. Houk PMCID: PMC30114 Distinct roles for the N- and C-terminal regions in the
cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from
cabbage butterfly, against mammalian cells Takashi Kanazawa, Masahiko Watanabe, Yuko Matsushima-Hibiya, Takuo Kono, Noriaki Tanaka, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi PMCID: PMC30120 The nitrite reductase from Pseudomonas aeruginosa:
Essential role of two active-site histidines in the catalytic and
structural properties Francesca Cutruzzolà, Kieron Brown, Emma K. Wilson, Andrea Bellelli, Marzia Arese, Mariella Tegoni, Christian Cambillau, and Maurizio Brunori PMCID: PMC30121 A short segment within the cytoplasmic domain of the neural cell
adhesion molecule (N-CAM) is essential for N-CAM-induced NF-κB activity in astrocytes Edward B. Little, Kathryn L. Crossin, Leslie A. Krushel, Gerald M. Edelman, and Bruce A. Cunningham PMCID: PMC30122 Supernatant protein factor, which stimulates the conversion of
squalene to lanosterol, is a cytosolic squalene transfer protein
and enhances cholesterol biosynthesis Norihito Shibata, Makoto Arita, Yuko Misaki, Naoshi Dohmae, Koji Takio, Teruo Ono, Keizo Inoue, and Hiroyuki Arai PMCID: PMC30123 Polar residues drive association of polyleucine
transmembrane helices Fang Xiao Zhou, Helen J. Merianos, Axel T. Brunger, and Donald M. Engelman PMCID: PMC30124 Identification in mice of two isoforms of the cysteinyl
leukotriene 1 receptor that result from alternative splicing Akiko Maekawa, Yoshihide Kanaoka, Bing K. Lam, and K. Frank Austen PMCID: PMC30125 Arabidopsis cyt1 mutants are deficient in a
mannose-1-phosphate guanylyltransferase and point to a requirement
of N-linked glycosylation for cellulose biosynthesis Wolfgang Lukowitz, Todd C. Nickle, David W. Meinke, Robert L. Last, Patricia L. Conklin, and Christopher R. Somerville PMCID: PMC30126 From the Cover:
Twenty-first aminoacyl-tRNA synthetase–suppressor tRNA pairs for
possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria Anne K. Kowal, Caroline Köhrer, and Uttam L. RajBhandary PMCID: PMC30127 Viral capsid mobility: A dynamic conduit for inactivation Klas Broo, Jing Wei, Dawn Marshall, Fred Brown, Thomas J. Smith, John E. Johnson, Anette Schneemann, and Gary Siuzdak PMCID: PMC30128 Increased mitochondrial oxidative stress in the Sod2
(+/−) mouse results in the age-related decline of mitochondrial
function culminating in increased apoptosis Jason E. Kokoszka, Pinar Coskun, Luke A. Esposito, and Douglas C. Wallace PMCID: PMC30129 The human mitochondrial deoxynucleotide carrier and its role in
the toxicity of nucleoside antivirals Vincenza Dolce, Giuseppe Fiermonte, Michael J. Runswick, Ferdinando Palmieri, and John E. Walker PMCID: PMC30130 Gene elements that affect the longevity of rbcL
sequence-containing transcripts in Chlamydomonas
reinhardtii chloroplasts Mahipal Singh, Alexander Boutanaev, Paola Zucchi, and Lawrence Bogorad PMCID: PMC30131 TRM1, a YY1-like suppressor of rbcS-m3 expression
in maize mesophyll cells Tao Xu, Marc Purcell, Paola Zucchi, Tim Helentjaris, and Lawrence Bogorad PMCID: PMC30132 Contributions of distinct quaternary contacts to cooperative
operator binding by Mnt repressor Arie Berggrun and Robert T. Sauer PMCID: PMC30133 Mammalian inositol polyphosphate multikinase synthesizes inositol
1,4,5-trisphosphate and an inositol pyrophosphate Adolfo Saiardi, Eiichiro Nagata, Hongbo R. Luo, Akira Sawa, Xiaojiang Luo, Adele M. Snowman, and Solomon H. Snyder PMCID: PMC30134 Structural determinants of oxidative folding in proteins Ervin Welker, Mahesh Narayan, William J. Wedemeyer, and Harold A. Scheraga PMCID: PMC30135 Zinc metallothionein imported into liver mitochondria
modulates respiration Bin Ye, Wolfgang Maret, and Bert L. Vallee PMCID: PMC30136 Fatty acids and hypolipidemic drugs regulate peroxisome
proliferator-activated receptors α- and γ-mediated gene
expression via liver fatty acid binding protein: A signaling
path to the nucleus Christian Wolfrum, Carola M. Borrmann, Torsten Börchers, and Friedrich Spener PMCID: PMC30137 Biophysics Recent improvements in prediction of protein structure by global
optimization of a potential energy function Jarosław Pillardy, Cezary Czaplewski, Adam Liwo, Jooyoung Lee, Daniel R. Ripoll, Rajmund Kaźmierkiewicz, Stanisław Ołdziej, William J. Wedemeyer, Kenneth D. Gibson, Yelena A. Arnautova, Jeff Saunders, Yuan-Jie Ye, and Harold A. Scheraga PMCID: PMC30138 Destabilization of Ca2+-free gelsolin may not be
responsible for proteolysis in Familial Amyloidosis of Finnish Type Gayathri Ratnaswamy, Mary E. Huff, Andrew I. Su, Severine Rion, and Jeffery W. Kelly PMCID: PMC30139 Capabilities of liposomes for topological transformation Fumimasa Nomura, Miki Nagata, Takehiko Inaba, Haruka Hiramatsu, Hirokazu Hotani, and Kingo Takiguchi PMCID: PMC30140 Dynamics and orientation of
N+(CD3)3-bromoacetylcholine bound
to its binding site on the nicotinic acetylcholine receptor P. T. F. Williamson, J. A. Watts, G. H. Addona, K. W. Miller, and A. Watts PMCID: PMC30141 Two different neurodegenerative diseases caused by proteins with
similar structures Huaping Mo, Richard C. Moore, Fred E. Cohen, David Westaway, Stanley B. Prusiner, Peter E. Wright, and H. Jane Dyson PMCID: PMC30142 Transverse relaxation-optimized NMR spectroscopy with the outer
membrane protein OmpX in dihexanoyl phosphatidylcholine micelles César Fernández, Koba Adeishvili, and Kurt Wüthrich PMCID: PMC30143 An unusual pathway of excitation energy deactivation in
carotenoids: Singlet-to-triplet conversion on an ultrafast timescale in
a photosynthetic antenna Claudiu C. Gradinaru, John T. M. Kennis, Emmanouil Papagiannakis, Ivo H. M. van Stokkum, Richard J. Cogdell, Graham R. Fleming, Robert A. Niederman, and Rienk van Grondelle PMCID: PMC30144 The role of structure, energy landscape, dynamics, and allostery
in the enzymatic function of myoglobin Hans Frauenfelder, Benjamin H. McMahon, Robert H. Austin, Kelvin Chu, and John T. Groves PMCID: PMC30145 An amyloid-forming peptide from the yeast prion Sup35 reveals a
dehydrated β-sheet structure for amyloid Melinda Balbirnie, Robert Grothe, and David S. Eisenberg PMCID: PMC30146 Cell Biology Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits
cadherin/p120 association, and regulates stability and
function of the cadherin/catenin adhesion complex Lia Baki, Philippe Marambaud, Spiros Efthimiopoulos, Anastasios Georgakopoulos, Paul Wen, Wen Cui, Junichi Shioi, Eduard Koo, Masayuki Ozawa, Victor L. Friedrich, Jr., and Nikolaos K. Robakis PMCID: PMC30147 An isolated, surface-expressed I domain of the integrin αLβ2
is sufficient for strong adhesive function when locked in the open
conformation with a disulfide bond Chafen Lu, Motomu Shimaoka, Mazen Ferzly, Claus Oxvig, Junichi Takagi, and Timothy A. Springer PMCID: PMC30148 Locking in alternate conformations of the integrin αLβ2 I
domain with disulfide bonds reveals functional relationships among
integrin domains Chafen Lu, Motomu Shimaoka, Qun Zang, Junichi Takagi, and Timothy A. Springer PMCID: PMC30149 INAUGURAL ARTICLE by a Recently Elected Academy Member: Organellar relationships in the Golgi region of the pancreatic
beta cell line, HIT-T15, visualized by high resolution electron
tomography Brad J. Marsh, David N. Mastronarde, Karolyn F. Buttle, Kathryn E. Howell, and J. Richard McIntosh PMCID: PMC30150 Kinetics of protein import into isolated Xenopus
oocyte nuclei Thomas Radtke, Dirk Schmalz, Elias Coutavas, Tarik M. Soliman, and Reiner Peters PMCID: PMC30151 ARF-GEP100, a guanine nucleotide-exchange protein for
ADP-ribosylation factor 6 Akimasa Someya, Makoto Sata, Kazuyo Takeda, Gustavo Pacheco-Rodriguez, Victor J. Ferrans, Joel Moss, and Martha Vaughan PMCID: PMC30152 Identification of the endogenous smooth muscle myosin
phosphatase-associated kinase Justin A. MacDonald, Meredith A. Borman, Andrea Murányi, Avril V. Somlyo, David J. Hartshorne, and Timothy A. J. Haystead PMCID: PMC30153 FKBP12, the 12-kDa FK506-binding protein, is a physiologic
regulator of the cell cycle Bahman Aghdasi, Keqiang Ye, Adam Resnick, Alex Huang, Hyo Chol Ha, Xin Guo, Ted M. Dawson, Valina L. Dawson, and Solomon H. Snyder PMCID: PMC30154 Analysis of endoplasmic reticulum trafficking signals by
combinatorial screening in mammalian cells Noa Zerangue, Michael J. Malan, Sharon R. Fried, Paul F. Dazin, Yuh Nung Jan, Lily Yeh Jan, and Blanche Schwappach PMCID: PMC30155 Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate
revealed by a genetically encoded, fluorescent indicator Akira Honda, Stephen R. Adams, Carolyn L. Sawyer, Varda Lev-Ram, Roger Y. Tsien, and Wolfgang R. G. Dostmann PMCID: PMC30156 IL-4 inhibits osteoclast formation through a direct action on
osteoclast precursors via peroxisome proliferator-activated receptor
γ1 Amy C. Bendixen, Nirupama K. Shevde, Krista M. Dienger, Timothy M. Willson, Colin D. Funk, and J. Wesley Pike PMCID: PMC30157 Activation and targeting of extracellular signal-regulated
kinases by β-arrestin scaffolds Louis M. Luttrell, Francine L. Roudabush, Eric W. Choy, William E. Miller, Michael E. Field, Kristen L. Pierce, and Robert J. Lefkowitz PMCID: PMC30158 Identification and dissection of an enhancer controlling
epithelial gene expression in skin Satrajit Sinha and Elaine Fuchs PMCID: PMC30159 Developmental Biology Production of zebrafish germ-line chimeras from embryo
cell cultures Chunguang Ma, Lianchun Fan, Rosemarie Ganassin, Niels Bols, and Paul Collodi PMCID: PMC30160 An efficient system for conditional gene expression in embryonic
stem cells and in their in vitro and in
vivo differentiated derivatives Ludovic Vallier, Jimmy Mancip, Suzy Markossian, Agnès Lukaszewicz, Colette Dehay, Daniel Metzger, Pierre Chambon, Jacques Samarut, and Pierre Savatier PMCID: PMC30161 Ecology Special Feature: A novel microbial habitat in the mid-ocean ridge subseafloor Melanie Summit and John A. Baross PMCID: PMC30109 Plant growth in elevated CO2 alters mitochondrial
number and chloroplast fine structure Kevin L. Griffin, O. Roger Anderson, Mary D. Gastrich, James D. Lewis, Guanghui Lin, William Schuster, Jeffrey R. Seemann, David T. Tissue, Matthew H. Turnbull, and David Whitehead PMCID: PMC30162 Effects of elevated atmospheric CO2 concentration on
leaf dark respiration of Xanthium strumarium in
light and in darkness Xianzhong Wang, James D. Lewis, David T. Tissue, Jeffrey R. Seemann, and Kevin L. Griffin PMCID: PMC30163 Paleoclimate and Amerindians: Evidence from stable isotopes and
atmospheric circulation Marjorie Brooks Lovvorn, George C. Frison, and Larry L. Tieszen PMCID: PMC30164 Predator-induced stress makes the pesticide carbaryl more deadly
to gray treefrog tadpoles (Hyla versicolor) Rick A. Relyea and Nathan Mills PMCID: PMC30165 Evolution Special Feature: Truncated hexa-octahedral magnetite crystals in ALH84001:
Presumptive biosignatures Kathie L. Thomas-Keprta, Simon J. Clemett, Dennis A. Bazylinski, Joseph L. Kirschvink, David S. McKay, Susan J. Wentworth, Hojatollah Vali, Everett K. Gibson, Jr., Mary Fae McKay, and Christopher S. Romanek PMCID: PMC30110 Special Feature: The origin of atmospheric oxygen on Earth: The innovation of
oxygenic photosynthesis G. C. Dismukes, V. V. Klimov, S. V. Baranov, Yu. N. Kozlov, J. DasGupta, and A. Tyryshkin PMCID: PMC30111 Estimation of divergence times from multiprotein sequences for a
few mammalian species and several distantly related organisms Masatoshi Nei, Ping Xu, and Galina Glazko PMCID: PMC30166 Phylogeny of genes for secretion NTPases: Identification of the
widespread tadA subfamily and development of a diagnostic key for gene classification Paul J. Planet, Scott C. Kachlany, Rob DeSalle, and David H. Figurski PMCID: PMC30167 Positive Darwinian selection drives the evolution of several
female reproductive proteins in mammals Willie J. Swanson, Ziheng Yang, Mariana F. Wolfner, and Charles F. Aquadro PMCID: PMC30168 Genetics Role of the F-box protein Skp2 in lymphomagenesis Esther Latres, Roberto Chiarle, Brenda A. Schulman, Nikola P. Pavletich, Angel Pellicer, Giorgio Inghirami, and Michele Pagano PMCID: PMC30169 Genomic and genetic dissection of an archaeal regulon Nitin S. Baliga, Sean P. Kennedy, Wailap Victor Ng, Leroy Hood, and Shiladitya DasSarma PMCID: PMC30170 Targeted disruption of the Kcnq1 gene produces a
mouse model of Jervell and Lange– Nielsen Syndrome Mathew C. Casimiro, Björn C. Knollmann, Steven N. Ebert, Jay C. Vary, Jr., Anne E. Greene, Michael R. Franz, Alexander Grinberg, Sing Ping Huang, and Karl Pfeifer PMCID: PMC30171 Somatic mosaicism in Fanconi anemia: Evidence of genotypic
reversion in lymphohematopoietic stem cells John J. Gregory, Jr., John E. Wagner, Peter C. Verlander, Orna Levran, Sat Dev Batish, Cindy R. Eide, Amy Steffenhagen, Betsy Hirsch, and Arleen D. Auerbach PMCID: PMC30172 Spectral karyotyping suggests additional subsets of colorectal
cancers characterized by pattern of chromosome rearrangement Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David Bicknell, Walter F. Bodmer, Mark J. Arends, Andrew H. Wyllie, and Paul A. W. Edwards PMCID: PMC30173 Establishment of medaka (Oryzias latipes)
transgenic lines with the expression of green fluorescent protein
fluorescence exclusively in germ cells: A useful model to monitor
germ cells in a live vertebrate Minoru Tanaka, Masato Kinoshita, Daisuke Kobayashi, and Yoshitaka Nagahama PMCID: PMC30174 Interaction of a transcriptional repressor with the RNA
polymerase II holoenzyme plays a crucial role in repression Zafar Zaman, Aseem Z. Ansari, Sang Seok Koh, Richard Young, and Mark Ptashne PMCID: PMC30175 A genomic approach to gene fusion technology Tina K. Van Dyk, Yan Wei, Michael K. Hanafey, Maureen Dolan, Mary Jane G. Reeve, J. Antoni Rafalski, Lucia B. Rothman-Denes, and Robert A. LaRossa PMCID: PMC30176 Immunology Defective localization of the NADPH phagocyte oxidase to
Salmonella-containing phagosomes in tumor necrosis
factor p55 receptor-deficient macrophages Andrés Vázquez-Torres, Giamila Fantuzzi, Carl K. Edwards, III, Charles A. Dinarello, and Ferric C. Fang PMCID: PMC30177 Impaired survival of T helper cells in the absence of CD4 Julie Strong, Qi Wang, and Nigel Killeen PMCID: PMC30178 Spontaneous retinopathy in HLA-A29 transgenic mice Yann Szpak, Jean-Claude Vieville, Thierry Tabary, Marie-Christine Naud, Martine Chopin, Catherine Edelson, Jacques H. M. Cohen, Jean Dausset, Yvonne de Kozak, and Marika Pla PMCID: PMC30179 Requirement for natural killer T (NKT) cells in the induction of
allograft tolerance Ken-ichiro Seino, Katashi Fukao, Kenzo Muramoto, Kazuhiko Yanagisawa, Yasutsugu Takada, Shigeru Kakuta, Yoichiro Iwakura, Luc Van Kaer, Kazuyoshi Takeda, Toshinori Nakayama, Masaru Taniguchi, Hisashi Bashuda, Hideo Yagita, and Ko Okumura PMCID: PMC30180 BLNK mediates Syk-dependent Btk activation Yoshihiro Baba, Shoji Hashimoto, Masato Matsushita, Dai Watanabe, Tadamitsu Kishimoto, Tomohiro Kurosaki, and Satoshi Tsukada PMCID: PMC30181 Lack of a role for transforming growth factor-β in cytotoxic T
lymphocyte antigen-4-mediated inhibition of T cell activation Timothy J. Sullivan, John J. Letterio, Andreas van Elsas, Mizuko Mamura, Jocea van Amelsfort, Shellyann Sharpe, Barbara Metzler, Cynthia A. Chambers, and James P. Allison PMCID: PMC30182 Medical Sciences Prevention of ischemia-induced retinopathy by the natural ocular
antiangiogenic agent pigment epithelium-derived factor Veronica Stellmach, Susan E. Crawford, Wei Zhou, and Noël Bouck PMCID: PMC30183 Genetic disruption of PPARδ decreases the
tumorigenicity of human colon cancer cells Ben Ho Park, Bert Vogelstein, and Kenneth W. Kinzler PMCID: PMC30184 Predominant role of endothelial nitric oxide synthase in vascular
endothelial growth factor-induced angiogenesis and
vascular permeability Dai Fukumura, Takeshi Gohongi, Ananth Kadambi, Yotaro Izumi, Jennifer Ang, Chae-Ok Yun, Donald G. Buerk, Paul L. Huang, and Rakesh K. Jain PMCID: PMC30185 Reduction of atherosclerosis in apolipoprotein E knockout mice by
activation of the retinoid X receptor Thierry Claudel, Mark D. Leibowitz, Catherine Fiévet, Anne Tailleux, Brandee Wagner, Joyce J. Repa, Gérard Torpier, Jean-Marc Lobaccaro, James R. Paterniti, David J. Mangelsdorf, Richard A. Heyman, and Johan Auwerx PMCID: PMC30186 Whole-body and intravital optical imaging of angiogenesis in
orthotopically implanted tumors Meng Yang, Eugene Baranov, Xiao-Ming Li, Jin Wei Wang, Ping Jiang, Lingna Li, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman PMCID: PMC30187 NO chemical events in the human airway during the immediate and
late antigen-induced asthmatic response Raed A. Dweik, Suzy A. A. Comhair, Benjamin Gaston, Frederik
B. J. M. Thunnissen, Carol Farver, Mary Jane Thomassen, Mani Kavuru, Jeffrey Hammel, Husam M. Abu-Soud, and Serpil C. Erzurum PMCID: PMC30188 Trichostatin A reverses skewed expression of CD154,
interleukin-10, and interferon-γ gene and protein expression in lupus
T cells Nilamadhab Mishra, Doris R. Brown, Irene M. Olorenshaw, and Gary M. Kammer PMCID: PMC30189 Cardiovascular abnormalities with normal blood pressure in tissue
kallikrein-deficient mice Pierre Meneton, May Bloch-Faure, Albert A. Hagege, Hartmut Ruetten, Wei Huang, Sonia Bergaya, Debbie Ceiler, Doris Gehring, Isabelle Martins, Georges Salmon, Chantal M. Boulanger, Jürg Nussberger, Bertrand Crozatier, Jean-Marie Gasc, Didier Heudes, Patrick Bruneval, Tom Doetschman, Joël Ménard, and François Alhenc-Gelas PMCID: PMC30190 Top-down morphogenesis of colorectal tumors Ie-Ming Shih, Tian-Li Wang, Giovanni Traverso, Kathy Romans, Stanley R. Hamilton, Shmuel Ben-Sasson, Kenneth W. Kinzler, and Bert Vogelstein PMCID: PMC30191 High-sensitivity array analysis of gene expression for the early
detection of disseminated breast tumor cells in peripheral blood Katherine J. Martin, Edgard Graner, Yi Li, Laura M. Price, Brian M. Kritzman, Marcia V. Fournier, Esther Rhei, and Arthur B. Pardee PMCID: PMC30192 An NO derivative of ursodeoxycholic acid protects against
Fas-mediated liver injury by inhibiting caspase activity Stefano Fiorucci, Andrea Mencarelli, Barbara Palazzetti, Piero Del Soldato, Antonio Morelli, and Louis J. Ignarro PMCID: PMC30193 Anti-PSCA mAbs inhibit tumor growth and metastasis formation and
prolong the survival of mice bearing human prostate cancer xenografts Douglas C. Saffran, Arthur B. Raitano, Rene S. Hubert, Owen N. Witte, Robert E. Reiter, and Aya Jakobovits PMCID: PMC30194 The surface variant antigens of Plasmodium
falciparum contain cross-reactive epitopes Benoit Gamain, Louis H. Miller, and Dror I. Baruch PMCID: PMC30195 DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells,
binds to human and simian immunodeficiency viruses and activates infection in trans Stefan Pöhlmann, Elizabeth J. Soilleux, Frédéric Baribaud, George J. Leslie, Lesley S. Morris, John Trowsdale, Benhur Lee, Nicholas Coleman, and Robert W. Doms PMCID: PMC30196 Adeno-associated viral vector-mediated gene transfer results in
long-term enzymatic and functional correction in multiple organs of
Fabry mice Sung-Chul Jung, Ina P. Han, Advait Limaye, Ruian Xu, Monique P. Gelderman, Patricia Zerfas, Kamala Tirumalai, Gary J. Murray, Matthew J. During, Roscoe O. Brady, and Pankaj Qasba PMCID: PMC30197 Antibodies to human fetal erythroid cells from a nonimmune phage
antibody library Michael A. Huie, Mei-Chi Cheung, Marcus O. Muench, Baltazar Becerril, Yuet W. Kan, and James D. Marks PMCID: PMC30198 Chronic elevation of plasma thioredoxin: Inhibition of
chemotaxis and curtailment of life expectancy in AIDS Hajime Nakamura, Stephen C. De Rosa, Junji Yodoi, Arne Holmgren, Pietro Ghezzi, Leonard A. Herzenberg, and Leonore A. Herzenberg PMCID: PMC30199 Alkaline-mediated differential interaction (AMDI): A simple
automatable single-nucleotide polymorphism assay Sylvia Bartlett, Josef Straub, Susan Tonks, Rush Spencer Wells, Julia G. Bodmer, and Walter F. Bodmer PMCID: PMC30200 Mechanisms underlying losses of heterozygosity in human
colorectal cancers Sam Thiagalingam, Steve Laken, James K. V. Willson, Sanford D. Markowitz, Kenneth W. Kinzler, Bert Vogelstein, and Christoph Lengauer PMCID: PMC30201 A genetic model provides evidence that the receptor for atrial
natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular
myocyte hypertrophy Ichiro Kishimoto, Kristen Rossi, and David L. Garbers PMCID: PMC30202 Mouse strain differences determine severity of iron accumulation
in Hfe knockout model of hereditary hemochromatosis Robert E. Fleming, Christopher C. Holden, Shunji Tomatsu, Abdul Waheed, Elizabeth M. Brunt, Robert S. Britton, Bruce R. Bacon, Derry C. Roopenian, and William S. Sly PMCID: PMC30203 Transcriptome of a mouse kidney cortical collecting duct cell
line: Effects of aldosterone and vasopressin Maya Robert-Nicoud, Marjorie Flahaut, Jean-Marc Elalouf, Marie Nicod, Miguel Salinas, Marcelle Bens, Alain Doucet, Patrick Wincker, François Artiguenave, Jean-Daniel Horisberger, Alain Vandewalle, Bernard C. Rossier, and Dmitri Firsov PMCID: PMC30204 Microbiology Special Feature: Chains of magnetite crystals in the meteorite ALH84001: Evidence
of biological origin E. Imre Friedmann, Jacek Wierzchos, Carmen Ascaso, and Michael Winklhofer PMCID: PMC30112 Evaluation of the role of heterogeneous nuclear ribonucleoprotein
A1 as a host factor in murine coronavirus discontinuous transcription
and genome replication Xiaolan Shen and Paul S. Masters PMCID: PMC30205 Subcellular localization of acetyl-CoA carboxylase in the
apicomplexan parasite Toxoplasma gondii J. Jelenska, M. J. Crawford, O. S. Harb, E. Zuther, R. Haselkorn, D. S. Roos, and P. Gornicki PMCID: PMC30206 Expression of the Anabaena hetR gene from a
copper-regulated promoter leads to heterocyst differentiation
under repressing conditions William J. Buikema and Robert Haselkorn PMCID: PMC30207 Programmed cell death mediated by ced-3 and
ced-4 protects Caenorhabditis
elegans from Salmonella
typhimurium-mediated killing Alejandro Aballay and Frederick M. Ausubel PMCID: PMC30208 Comparative genomics of the restriction-modification systems in
Helicobacter pylori Lee-Fong Lin, Janos Posfai, Richard J. Roberts, and Huimin Kong PMCID: PMC30209 From the Cover:
Sequence of the 1918 pandemic influenza virus nonstructural gene
(NS) segment and characterization of recombinant viruses
bearing the 1918 NS genes Christopher F. Basler, Ann H. Reid, Jody K. Dybing, Thomas A. Janczewski, Thomas G. Fanning, Hongyong Zheng, Mirella Salvatore, Michael L. Perdue, David E. Swayne, Adolfo García-Sastre, Peter Palese, and Jeffery K. Taubenberger PMCID: PMC30210 QscR, a modulator of quorum-sensing signal synthesis and
virulence in Pseudomonas aeruginosa Sudha A. Chugani, Marvin Whiteley, Kimberly M. Lee, David D'Argenio, Colin Manoil, and E. P. Greenberg PMCID: PMC30211 Effect of rabies virus infection on gene expression in
mouse brain Mikhail Prosniak, D. Craig Hooper, Bernhard Dietzschold, and Hilary Koprowski PMCID: PMC30212 Neurobiology Synergistic contributions of cyclin-dependant kinase 5/p35 and
Reelin/Dab1 to the positioning of cortical neurons in the
developing mouse brain Toshio Ohshima, Masaharu Ogawa, Veeranna, Motoyuki Hirasawa, Glenn Longenecker, Koichi Ishiguro, Harish C. Pant, Roscoe O. Brady, Ashok B. Kulkarni, and Katsuhiko Mikoshiba PMCID: PMC30213 Internal initiation of translation of five dendritically
localized neuronal mRNAs Jason K. Pinkstaff, Stephen A. Chappell, Vincent P. Mauro, Gerald M. Edelman, and Les A. Krushel PMCID: PMC30214 Coinciding early activation of the human primary visual cortex
and anteromedial cuneus Simo Vanni, Topi Tanskanen, Mika Seppä, Kimmo Uutela, and Riitta Hari PMCID: PMC30215 Characteristics of glycine receptors expressed by embryonic rat
brain mRNAs Guadalupe García-Alcocer, Jesús García-Colunga, Ataúlfo Martínez-Torres, and Ricardo Miledi PMCID: PMC30216 Point mutant mice with hypersensitive α4 nicotinic receptors
show dopaminergic deficits and increased anxiety Cesar Labarca, Johannes Schwarz, Purnima Deshpande, Sigrid Schwarz, Mark W. Nowak, Carlos Fonck, Raad Nashmi, Paulo Kofuji, Hong Dang, Wenmei Shi, Melihat Fidan, Baljit S. Khakh, Zhoufeng Chen, Barbara J. Bowers, Jim Boulter, Jeanne M. Wehner, and Henry A. Lester PMCID: PMC30217 Morphological abnormalities in the brains of estrogen receptor
β knockout mice Ling Wang, Sandra Andersson, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC30218 Theory for normal and impaired experience-dependent
plasticity in neocortex of adult rats Lubica Beňušková, Velayudhan Rema, Michael Armstrong-James, and Ford F. Ebner PMCID: PMC30219 Tonic nicotinic modulation of serotoninergic transmission in the
spinal cord Matilde Cordero-Erausquin and Jean-Pierre Changeux PMCID: PMC30220 Activity-dependent CREB phosphorylation: Convergence of a fast,
sensitive calmodulin kinase pathway and a slow,
less sensitive mitogen-activated protein kinase pathway Gang-Yi Wu, Karl Deisseroth, and Richard W. Tsien PMCID: PMC30221 An orchestrated gene expression component of neuronal programmed
cell death revealed by cDNA array analysis Lillian W. Chiang, Jill M. Grenier, Laurence Ettwiller, Lorayne P. Jenkins, Dave Ficenec, John Martin, Fenyu Jin, Peter S. DiStefano, and Andrew Wood PMCID: PMC30222 Localization and regulation of GLUTx1 glucose transporter in the
hippocampus of streptozotocin diabetic rats Lawrence P. Reagan, Naira Gorovits, Elena K. Hoskin, Stephen E. Alves, Ellen B. Katz, Claudia A. Grillo, Gerardo G. Piroli, Bruce S. McEwen, and Maureen J. Charron PMCID: PMC30223 In vivo evidence for a cochlear amplifier in the
hair-cell bundle of lizards Geoffrey A. Manley, Des L. Kirk, Christine Köppl, and Graeme K. Yates PMCID: PMC30224 β-Neuregulin-1 is required for the in vivo
development of functional Ca2+-activated
K+ channels in parasympathetic neurons Jill S. Cameron, Laurence Dryer, and Stuart E. Dryer PMCID: PMC30225 Bax ablation prevents dopaminergic neurodegeneration in the
1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of
Parkinson's disease Miquel Vila, Vernice Jackson-Lewis, Slobodanka Vukosavic, Ruth Djaldetti, Gabriel Liberatore, Daniel Offen, Stanley J. Korsmeyer, and Serge Przedborski PMCID: PMC30226 Urocortin II: A member of the corticotropin-releasing factor
(CRF) neuropeptide family that is selectively bound by type 2
CRF receptors T. M. Reyes, K. Lewis, M. H. Perrin, K. S. Kunitake, J. Vaughan, C. A. Arias, J. B. Hogenesch, J. Gulyas, J. Rivier, W. W. Vale, and P. E. Sawchenko PMCID: PMC30227 Brain 5α-dihydroprogesterone and allopregnanolone synthesis in
a mouse model of protracted social isolation Erbo Dong, Kinzo Matsumoto, Veska Uzunova, Ikuko Sugaya, Hiroki Takahata, Hiroaki Nomura, Hiroshi Watanabe, Erminio Costa, and Alessandro Guidotti PMCID: PMC30228 Pharmacology Coupling of histamine H3 receptors to neuronal
Na+/H+ exchange: A novel protective mechanism in myocardial ischemia Randi B. Silver, Christina J. Mackins, Neil C. E. Smith, Irina L. Koritchneva, Kara Lefkowitz, Timothy W. Lovenberg, and Roberto Levi PMCID: PMC30229 Effects of nitric oxide-releasing aspirin versus aspirin on
restenosis in hypercholesterolemic mice Claudio Napoli, Giuseppe Cirino, Piero Del Soldato, Raffaella Sorrentino, Vincenzo Sica, Mario Condorelli, Aldo Pinto, and Louis J. Ignarro PMCID: PMC30230 Ryanodine receptor point mutant E4032A reveals an allosteric
interaction with ryanodine James D. Fessenden, Lili Chen, Yaming Wang, Cecilia Paolini, Clara Franzini-Armstrong, Paul D. Allen, and Isaac N. Pessah PMCID: PMC30231 Physiology Inhibition of caspase 1 reduces human myocardial ischemic
dysfunction via inhibition of IL-18 and IL-1β Benjamin J. Pomerantz, Leonid L. Reznikov, Alden H. Harken, and Charles A. Dinarello PMCID: PMC30232 Calmodulin kinase is a molecular switch for cardiac
excitation –contraction coupling Yuejin Wu, Roger J. Colbran, and Mark E. Anderson PMCID: PMC30233 Defective trafficking and function of KATP channels
caused by a sulfonylurea receptor 1 mutation associated with persistent
hyperinsulinemic hypoglycemia of infancy Etienne A. Cartier, Lisa R. Conti, Carol A. Vandenberg, and Show-Ling Shyng PMCID: PMC30234 Reconstitution and functional comparison of purified GlpF and
AqpZ, the glycerol and water channels from
Escherichia coli Mario J. Borgnia and Peter Agre PMCID: PMC30235 Altered ubiquitination and stability of aquaporin-1 in
hypertonic stress Virginia Leitch, Peter Agre, and Landon S. King PMCID: PMC30236 Plant Biology Galactose-extended glycans of antibodies produced by
transgenic plants Hans Bakker, Muriel Bardor, Jos W. Molthoff, Véronique Gomord, Ingrid Elbers, Lucas H. Stevens, Wilco Jordi, Arjen Lommen, Loïc Faye, Patrice Lerouge, and Dirk Bosch PMCID: PMC30237 One ring or two? Determination of ring number in carotenoids by
lycopene ![[var epsilon]](corehtml/pmc/pmcents/epsiv.gif) -cyclases Francis X. Cunningham, Jr. and Elisabeth Gantt PMCID: PMC30238 Chlorophyll and carotenoid binding in a simple red algal
light-harvesting complex crosses phylogenetic lines Beatrice Grabowski, Francis X. Cunningham, Jr., and Elisabeth Gantt PMCID: PMC30239 KAT1 is not essential for stomatal opening Alexander Szyroki, Natalya Ivashikina, Petra Dietrich, M. Rob G. Roelfsema, Peter Ache, Birgit Reintanz, Rosalia Deeken, Matthias Godde, Hubert Felle, Ralf Steinmeyer, Klaus Palme, and Rainer Hedrich PMCID: PMC30240 From the Cover:
Invariant scaling relationships for interspecific plant biomass
production rates and body size Karl J. Niklas and Brian J. Enquist PMCID: PMC30241 Population Biology Metapopulation extinction caused by mutation accumulation Kevin Higgins and Michael Lynch PMCID: PMC30242 Social Sciences Social Sciences Lifespan depends on month of birth Gabriele Doblhammer and James W. Vaupel PMCID: PMC30243 |
