| | This journal provides immediate access to some articles. Commentaries The energetics of structural change in maltose-binding protein David E. Wemmer Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12529–12530. Published online 2003 October 20. doi: 10.1073/pnas.2335923100.PMCID: PMC240646 Detecting elusive surface atoms with atomic force microscopy Mark C. Hersam and Yip-Wah Chung Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12531–12532. Published online 2003 October 20. doi: 10.1073/pnas.2335865100.PMCID: PMC240647 Convergent evolution of bright coloration and toxicity in frogs Kyle Summers Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12533–12534. Published online 2003 October 20. doi: 10.1073/pnas.2335928100.PMCID: PMC240648 The single capillary and the active brain Gordon M. Shepherd Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12535–12536. Published online 2003 October 20. doi: 10.1073/pnas.2336089100.PMCID: PMC240649 Using nonequilibrium measurements to determine macromolecule free-energy differences Ronald F. Fox Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12537–12538. Published online 2003 October 20. doi: 10.1073/pnas.2336065100.PMCID: PMC240650 Physical Sciences Applied Physical Sciences From the Cover: Revealing the hidden atom in graphite by low-temperature atomic force microscopy Stefan Hembacher, Franz J. Giessibl, Jochen Mannhart, and Calvin F. Quate Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12539–12542. Published online 2003 September 22. doi: 10.1073/pnas.2134173100.PMCID: PMC240651 Chemistry DNA-mediated charge transport for DNA repair Elizabeth M. Boon, Alison L. Livingston, Nikolas H. Chmiel, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12543–12547. Published online 2003 October 14. doi: 10.1073/pnas.2035257100.PMCID: PMC240652 Combinatorial discovery of two-photon photoremovable protecting groups Michael C. Pirrung, Wolfgang H. Pieper, Krishna P. Kaliappan, and Mugunthu R. Dhananjeyan Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12548–12553. Published online 2003 October 13. doi: 10.1073/pnas.2131115100.PMCID: PMC240653 Geology Branched aliphatic alkanes with quaternary substituted carbon atoms in modern and ancient geologic samples Fabien Kenig, Dirk-Jan H. Simons, David Crich, James P. Cowen, Gregory T. Ventura, Tatiana Rehbein-Khalily, Todd C. Brown, and Ken B. Anderson Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12554–12558. Published online 2003 October 9. doi: 10.1073/pnas.1735581100.PMCID: PMC240654 Ancient maize from Chacoan great houses: Where was it grown? Larry Benson, Linda Cordell, Kirk Vincent, Howard Taylor, John Stein, G. Lang Farmer, and Kiyoto Futa Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13111–13115. Published online 2003 October 16. doi: 10.1073/pnas.2135068100.PMCID: PMC240753 Mathematics Signature quantization Victor Guillemin, Shlomo Sternberg, and Jonathan Weitsman Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12559–12560. Published online 2003 October 20. doi: 10.1073/pnas.1735527100.PMCID: PMC398041 The Nagata automorphism is wild Ivan P. Shestakov and Ualbai U. Umirbaev Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12561–12563. Published online 2003 October 20. doi: 10.1073/pnas.1735483100.PMCID: PMC240656 Physics From the Cover: Bias and error in estimates of equilibrium free-energy differences from nonequilibrium measurements Jeff Gore, Felix Ritort, and Carlos Bustamante Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12564–12569. Published online 2003 October 3. doi: 10.1073/pnas.1635159100.PMCID: PMC240657 Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins O. Miyashita, J. N. Onuchic, and P. G. Wolynes Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12570–12575. Published online 2003 October 17. doi: 10.1073/pnas.2135471100.PMCID: PMC240658 Coloration strategies in peacock feathers Jian Zi, Xindi Yu, Yizhou Li, Xinhua Hu, Chun Xu, Xingjun Wang, Xiaohan Liu, and Rongtang Fu Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12576–12578. Published online 2003 October 13. doi: 10.1073/pnas.2133313100.PMCID: PMC240659 Statistics Predicting protein functions from redundancies in large-scale protein interaction networks Manoj Pratim Samanta and Shoudan Liang Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12579–12583. Published online 2003 October 17. doi: 10.1073/pnas.2132527100.PMCID: PMC240660 Biological Sciences Applied Biological Sciences Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF association Niharika Nath, Khosrow Kashfi, Jie Chen, and Basil Rigas Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12584–12589. Published online 2003 October 17. doi: 10.1073/pnas.2134840100.PMCID: PMC240661 Biochemistry DNA-mediated charge transport for DNA repair Elizabeth M. Boon, Alison L. Livingston, Nikolas H. Chmiel, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12543–12547. Published online 2003 October 14. doi: 10.1073/pnas.2035257100.PMCID: PMC240652 The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy Norbert Schülke, Olga A. Varlamova, Gerald P. Donovan, Dangshe Ma, Jason P Gardner, Donna M. Morrissey, Robert R. Arrigale, Cenchen Zhan, Amy J. Chodera, Kenneth G. Surowitz, Paul J. Maddon, Warren D. W. Heston, and William C. Olson Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12590–12595. doi: 10.1073/pnas.1735443100.PMCID: PMC240662 A plant virus replication system to assay the formation of RNA pseudotriloop motifs in RNA–protein interactions P. C. Joost Haasnoot, John F. Bol, and René C. L. Olsthoorn Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12596–12600. Published online 2003 October 20. doi: 10.1073/pnas.2135413100.PMCID: PMC240663 Processive phosphorylation of alternative splicing factor/splicing factor 2 Brandon E. Aubol, Sutapa Chakrabarti, Jacky Ngo, Jennifer Shaffer, Brad Nolen, Xiang-Dong Fu, Gourisankar Ghosh, and Joseph A. Adams Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12601–12606. Published online 2003 October 10. doi: 10.1073/pnas.1635129100.PMCID: PMC240664 Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvβ2-subunit Olga Sokolova, Alessio Accardi, David Gutierrez, Adrian Lau, Mike Rigney, and Nikolaus Grigorieff Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12607–12612. Published online 2003 October 20. doi: 10.1073/pnas.2235650100.PMCID: PMC240665 Capture of an intermediate in the catalytic cycle of l-aspartate-β-semialdehyde dehydrogenase Julio Blanco, Roger A. Moore, and Ronald E. Viola Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12613–12617. Published online 2003 October 14. doi: 10.1073/pnas.1634958100.PMCID: PMC240666 Active sites of thioredoxin reductases: Why selenoproteins? Stephan Gromer, Linda Johansson, Holger Bauer, L. David Arscott, Susanne Rauch, David P. Ballou, Charles H. Williams, Jr., R. Heiner Schirmer, and Elias S. J. Arnér Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12618–12623. Published online 2003 October 20. doi: 10.1073/pnas.2134510100.PMCID: PMC240667 Hypothalamic malonyl-CoA as a mediator of feeding behavior Zhiyuan Hu, Seung Hun Cha, Shigeru Chohnan, and M. Daniel Lane Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12624–12629. Published online 2003 October 7. doi: 10.1073/pnas.1834402100.PMCID: PMC240668 AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins Visvanathan Ramamurthy, Melanie Roberts, Focco van den Akker, Gregory Niemi, T. A. Reh, and James B. Hurley Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12630–12635. Published online 2003 October 10. doi: 10.1073/pnas.2134194100.PMCID: PMC240669 Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases Siiri E. Iismaa, Sara Holman, Merridee A. Wouters, Laszlo Lorand, Robert M. Graham, and Ahsan Husain Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12636–12641. Published online 2003 October 17. doi: 10.1073/pnas.1635052100.PMCID: PMC240670 Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice Zhongqiu Zhang, Manabu Futamura, Haris G. Vikis, Min Wang, Jie Li, Yian Wang, Kun-Liang Guan, and Ming You Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12642–12647. doi: 10.1073/pnas.2133947100.PMCID: PMC240671 Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit Hu Pan, Sanjay Agarwalla, Demetri T. Moustakas, Janet Finer-Moore, and Robert M. Stroud Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12648–12653. Published online 2003 October 17. doi: 10.1073/pnas.2135585100.PMCID: PMC240672 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a Nikolaus Schiering, Stefan Knapp, Marina Marconi, Maria M. Flocco, Jean Cui, Rita Perego, Luisa Rusconi, and Cinzia Cristiani Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12654–12659. Published online 2003 October 14. doi: 10.1073/pnas.1734128100.PMCID: PMC240673 Contrasting patterns of expression of transcription factors in pancreatic α and β cells Jie Wang, Gene Webb, Yun Cao, and Donald F. Steiner Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12660–12665. Published online 2003 October 13. doi: 10.1073/pnas.1735286100.PMCID: PMC240674 The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA Meisheng Zhou, Longwen Deng, Fatah Kashanchi, John N. Brady, Aaron J. Shatkin, and Ajit Kumar Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12666–12671. Published online 2003 October 20. doi: 10.1073/pnas.1835726100.PMCID: PMC240675 Biophysics From the Cover: Bias and error in estimates of equilibrium free-energy differences from nonequilibrium measurements Jeff Gore, Felix Ritort, and Carlos Bustamante Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12564–12569. Published online 2003 October 3. doi: 10.1073/pnas.1635159100.PMCID: PMC240657 Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins O. Miyashita, J. N. Onuchic, and P. G. Wolynes Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12570–12575. Published online 2003 October 17. doi: 10.1073/pnas.2135471100.PMCID: PMC240658 Principles of cell-free genetic circuit assembly Vincent Noireaux, Roy Bar-Ziv, and Albert Libchaber Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12672–12677. Published online 2003 October 14. doi: 10.1073/pnas.2135496100.PMCID: PMC240676 Fast protein folding kinetics Jack Schonbrun and Ken A. Dill Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12678–12682. Published online 2003 October 20. doi: 10.1073/pnas.1735417100.PMCID: PMC240677 Energetics of hydrogen bonds in peptides Sheh-Yi Sheu, Dah-Yen Yang, H. L. Selzle, and E. W. Schlag Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12683–12687. Published online 2003 October 14. doi: 10.1073/pnas.2133366100.PMCID: PMC240678 Damped elastic recoil of the titin spring in myofibrils of human myocardium Christiane A. Opitz, Michael Kulke, Mark C. Leake, Ciprian Neagoe, Horst Hinssen, Roger J. Hajjar, and Wolfgang A. Linke Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12688–12693. Published online 2003 October 16. doi: 10.1073/pnas.2133733100.PMCID: PMC240679 DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a Kylie J. Walters, Patrycja J. Lech, Amanda M. Goh, Qinghua Wang, and Peter M. Howley Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12694–12699. Published online 2003 October 13. doi: 10.1073/pnas.1634989100.PMCID: PMC240680 From the Cover: The energetic cost of domain reorientation in maltose-binding protein as studied by NMR and fluorescence spectroscopy Oscar Millet, Rhea P. Hudson, and Lewis E. Kay Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12700–12705. Published online 2003 October 6. doi: 10.1073/pnas.2134311100.PMCID: PMC240681 Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli José Luis Vázquez-Ibar, Lan Guan, Maja Svrakic, and H. Ronald Kaback Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12706–12711. Published online 2003 October 17. doi: 10.1073/pnas.1835645100.PMCID: PMC240682 Cell Biology Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture Yang Hong, Larry Ackerman, Lily Yeh Jan, and Yuh-Nung Jan Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12712–12717. Published online 2003 October 20. doi: 10.1073/pnas.2135347100.PMCID: PMC240683 Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation Yu-Wen Zhang, Yanli Su, Olga V. Volpert, and George F. Vande Woude Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12718–12723. Published online 2003 October 10. doi: 10.1073/pnas.2135113100.PMCID: PMC240684 Dynamic structures in Escherichia coli: Spontaneous formation of MinE rings and MinD polar zones Kerwyn Casey Huang, Yigal Meir, and Ned S. Wingreen Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12724–12728. Published online 2003 October 20. doi: 10.1073/pnas.2135445100.PMCID: PMC240685 Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery Yunyun Su, Shinji Ishikawa, Masayuki Kojima, and Bo Liu Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12729–12734. Published online 2003 October 16. doi: 10.1073/pnas.2133261100.PMCID: PMC240686 A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery Amy L. Hitchcock, Kathryn Auld, Steven P. Gygi, and Pamela A. Silver Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12735–12740. Published online 2003 October 13. doi: 10.1073/pnas.2135500100.PMCID: PMC240687 Developmental Biology Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds Shulamit Levenberg, Ngan F. Huang, Erin Lavik, Arlin B. Rogers, Joseph Itskovitz-Eldor, and Robert Langer Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12741–12746. Published online 2003 October 15. doi: 10.1073/pnas.1735463100.PMCID: PMC240688 Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a Gonçalo Castelo-Branco, Joseph Wagner, Francisco J. Rodriguez, Julianna Kele, Kyle Sousa, Nina Rawal, Hilda Amalia Pasolli, Elaine Fuchs, Jan Kitajewski, and Ernest Arenas Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12747–12752. Published online 2003 October 13. doi: 10.1073/pnas.1534900100.PMCID: PMC240689 Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis Mira C. Puri and Alan Bernstein Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12753–12758. Published online 2003 October 6. doi: 10.1073/pnas.2133552100.PMCID: PMC240690 Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation Yao Yao, Wei Li, Junwei Wu, Ursula A. Germann, Michael S. S. Su, Keisuke Kuida, and Diane M. Boucher Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12759–12764. Published online 2003 October 17. doi: 10.1073/pnas.2134254100.PMCID: PMC240691 Ecology Biodiversity as spatial insurance in heterogeneous landscapes Michel Loreau, Nicolas Mouquet, and Andrew Gonzalez Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12765–12770. Published online 2003 October 20. doi: 10.1073/pnas.2235465100.PMCID: PMC240692 Helical Lévy walks: Adjusting searching statistics to resource availability in microzooplankton Frederic Bartumeus, Francesc Peters, Salvador Pueyo, Cèlia Marrasé, and Jordi Catalan Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12771–12775. Published online 2003 October 17. doi: 10.1073/pnas.2137243100.PMCID: PMC240693 Mixotrophs combine resource use to outcompete specialists: Implications for aquatic food webs Jörg Tittel, Vera Bissinger, Barbara Zippel, Ursula Gaedke, Elanor Bell, Andreas Lorke, and Norbert Kamjunke Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12776–12781. Published online 2003 October 20. doi: 10.1073/pnas.2130696100.PMCID: PMC240694 Evolution Fitness consequences of a regulatory polymorphism in a seasonal environment Amy M. Suiter, Otmar Bänziger, and Antony M. Dean Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12782–12786. Published online 2003 October 10. doi: 10.1073/pnas.2134994100.PMCID: PMC240695 Alu elements and hominid phylogenetics Abdel-Halim Salem, David A. Ray, Jinchuan Xing, Pauline A. Callinan, Jeremy S. Myers, Dale J. Hedges, Randall K. Garber, David J. Witherspoon, Lynn B. Jorde, and Mark A. Batzer Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12787–12791. Published online 2003 October 15. doi: 10.1073/pnas.2133766100.PMCID: PMC240696 From the Cover: Multiple, recurring origins of aposematism and diet specialization in poison frogs Juan Carlos Santos, Luis A. Coloma, and David C. Cannatella Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12792–12797. Published online 2003 October 10. doi: 10.1073/pnas.2133521100.PMCID: PMC240697 The complexity of alternative splicing of hagoromo mRNAs is increased in an explosively speciated lineage in East African cichlids Yohey Terai, Naoko Morikawa, Koichi Kawakami, and Norihiro Okada Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12798–12803. Published online 2003 October 20. doi: 10.1073/pnas.2132833100.PMCID: PMC240698 Synchronous coadaptation in an ancient case of herbivory Judith X. Becerra Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12804–12807. Published online 2003 October 10. doi: 10.1073/pnas.2133013100.PMCID: PMC240699 Evolution of eusociality and the soldier caste in termites: Influence of intraspecific competition and accelerated inheritance Barbara L. Thorne, Nancy L. Breisch, and Mario L. Muscedere Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12808–12813. Published online 2003 October 10. doi: 10.1073/pnas.2133530100.PMCID: PMC240700 Differential regulation of symmetry genes and the evolution of floral morphologies Lena C. Hileman, Elena M. Kramer, and David A. Baum Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12814–12819. Published online 2003 October 10. doi: 10.1073/pnas.1835725100.PMCID: PMC240701 Evolution of the yeast protein interaction network Hong Qin, Henry H. S. Lu, Wei B. Wu, and Wen-Hsiung Li Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12820–12824. Published online 2003 October 13. doi: 10.1073/pnas.2235584100.PMCID: PMC240702 Probable extirpation of a breeding colony of Short-tailed Albatross (Phoebastria albatrus) on Bermuda by Pleistocene sea-level rise Storrs L. Olson and Paul J. Hearty Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12825–12829. Published online 2003 October 17. doi: 10.1073/pnas.1934576100.PMCID: PMC240703 Proteorhodopsin genes are distributed among divergent marine bacterial taxa José R. de la Torre, Lynne M. Christianson, Oded Béjà, Marcelino T. Suzuki, David M. Karl, John Heidelberg, and Edward F. DeLong Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12830–12835. Published online 2003 October 17. doi: 10.1073/pnas.2133554100.PMCID: PMC240704 Worker policing without genetic conflicts in a clonal ant A. Hartmann, J. Wantia, J. A. Torres, and J. Heinze Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12836–12840. Published online 2003 October 13. doi: 10.1073/pnas.2132993100.PMCID: PMC240705 Genetics An endogenous retroviral long terminal repeat is the dominant promoter for human β1,3-galactosyltransferase 5 in the colon Catherine A. Dunn, Patrik Medstrand, and Dixie L. Mager Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12841–12846. Published online 2003 October 8. doi: 10.1073/pnas.2134464100.PMCID: PMC240706 Adaptive mutation: General mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac E. Susan Slechta, Kim L. Bunny, Elisabeth Kugelberg, Eric Kofoid, Dan I. Andersson, and John R. Roth Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12847–12852. Published online 2003 October 14. doi: 10.1073/pnas.1735464100.PMCID: PMC240707 Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells Jason H. Bielas and John A. Heddle Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12853–12858. Published online 2003 October 20. doi: 10.1073/pnas.2235595100.PMCID: PMC240708 Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin Sugiko Watanabe, Takaya Ichimura, Naoyuki Fujita, Shu Tsuruzoe, Izuru Ohki, Masahiro Shirakawa, Michio Kawasuji, and Mitsuyoshi Nakao Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12859–12864. Published online 2003 October 10. doi: 10.1073/pnas.2131819100.PMCID: PMC240709 Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition Sophie Tessé, Aurora Storlazzi, Nancy Kleckner, Silvana Gargano, and Denise Zickler Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12865–12870. Published online 2003 October 16. doi: 10.1073/pnas.2034282100.PMCID: PMC240710 Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer Michael M. Vilenchik and Alfred G. Knudson Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12871–12876. Published online 2003 October 17. doi: 10.1073/pnas.2135498100.PMCID: PMC240711 Twin concordance and sibling recurrence rates in multiple sclerosis C. J. Willer, D. A. Dyment, N. J. Risch, A. D. Sadovnick, G. C. Ebers, and The Canadian Collaborative Study Group Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12877–12882. Published online 2003 October 20. doi: 10.1073/pnas.1932604100.PMCID: PMC240712 Immunology Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies Lars Hangartner, Beatrice M. Senn, Birgit Ledermann, Ulrich Kalinke, Peter Seiler, Etienne Bucher, Raphaël M. Zellweger, Katja Fink, Bernhard Odermatt, Kurt Bürki, Rolf M. Zinkernagel, and Hans Hengartner Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12883–12888. Published online 2003 October 20. doi: 10.1073/pnas.2135542100.PMCID: PMC240713 Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens Anne L. Ackerman, Christoph Kyritsis, Robert Tampé, and Peter Cresswell Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12889–12894. Published online 2003 October 15. doi: 10.1073/pnas.1735556100.PMCID: PMC240714 RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells Tomonori Eto, Kazuo Kinoshita, Kiyotsugu Yoshikawa, Masamichi Muramatsu, and Tasuku Honjo Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12895–12898. Published online 2003 October 14. doi: 10.1073/pnas.2135587100.PMCID: PMC240715 Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor David M. Koelle, Zhi Liu, Christopher L. McClurkan, Randal C. Cevallos, Jeffrey Vieira, Nancy A. Hosken, Clement A. Meseda, Devon C. Snow, Anna Wald, and Lawrence Corey Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12899–12904. Published online 2003 October 17. doi: 10.1073/pnas.2131705100.PMCID: PMC240716 A genetic lesion that arrests plasma cell homing to the bone marrow Loren D. Erickson, Ling-Li Lin, Biyan Duan, Laurence Morel, and Randolph J. Noelle Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12905–12910. Published online 2003 October 10. doi: 10.1073/pnas.2131686100.PMCID: PMC240717 Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI Jiro Kitaura, Jinming Song, Mindy Tsai, Koichi Asai, Mari Maeda-Yamamoto, Attila Mocsai, Yuko Kawakami, Fu-Tong Liu, Clifford A. Lowell, B. George Barisas, Stephen J. Galli, and Toshiaki Kawakami Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12911–12916. Published online 2003 October 20. doi: 10.1073/pnas.1735525100.PMCID: PMC240718 Medical Sciences Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy Guido Bocci, Giulio Francia, Shan Man, Jack Lawler, and Robert S. Kerbel Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12917–12922. Published online 2003 October 15. doi: 10.1073/pnas.2135406100.PMCID: PMC240719 mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo Chang-Hyuk Kwon, Xiaoyan Zhu, Junyuan Zhang, and Suzanne J. Baker Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12923–12928. Published online 2003 October 8. doi: 10.1073/pnas.2132711100.PMCID: PMC240720 Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age Jörg J. Jacoby, April Kalinowski, Mu-Gen Liu, Samuel S.-M. Zhang, Qian Gao, Gui-Xuan Chai, Lan Ji, Yoshiki Iwamoto, En Li, Michael Schneider, Kerry S. Russell, and Xin-Yuan Fu Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12929–12934. Published online 2003 October 17. doi: 10.1073/pnas.2134694100.PMCID: PMC240721 The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss Feng X. Li, Jing W. Zhu, Jeffery S. Tessem, Joshua Beilke, Marileila Varella-Garcia, Jan Jensen, Christopher J. Hogan, and James DeGregori Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12935–12940. Published online 2003 October 17. doi: 10.1073/pnas.2231861100.PMCID: PMC240722 The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum Shuren Ma, Seymour Lieberman, Gerard M. Turino, and Yong Y. Lin Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12941–12943. Published online 2003 October 16. doi: 10.1073/pnas.2235344100.PMCID: PMC240723 Treatment of Helicobacter gastritis with IL-4 requires somatostatin Yana Zavros, Sivaprakash Rathinavelu, John Y. Kao, Andrea Todisco, John Del Valle, Joel V. Weinstock, Malcolm J. Low, and Juanita L. Merchant Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12944–12949. Published online 2003 October 10. doi: 10.1073/pnas.2135193100.PMCID: PMC240724 Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero Regine Choe, Turgut Durduran, Guoqiang Yu, Mark J. M. Nijland, Britton Chance, Arjun G. Yodh, and Nirmala Ramanujam Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12950–12954. Published online 2003 October 16. doi: 10.1073/pnas.1735462100.PMCID: PMC240725 Identification of T cell-signaling pathways that stimulate latent HIV in primary cells David G. Brooks, Philip A. Arlen, Lianying Gao, Christina M. R. Kitchen, and Jerome A. Zack Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12955–12960. Published online 2003 October 20. doi: 10.1073/pnas.2233345100.PMCID: PMC240726 A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2 Georgia L. Wiesner, Denise Daley, Susan Lewis, Christine Ticknor, Petra Platzer, James Lutterbaugh, Melissa MacMillen, Boris Baliner, Joseph Willis, Robert C. Elston, and Sanford D. Markowitz Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12961–12965. Published online 2003 October 17. doi: 10.1073/pnas.2132286100.PMCID: PMC240727 Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome Anna Richards, Elizabeth J. Kemp, M. Kathryn Liszewski, Judith A. Goodship, Anne K. Lampe, Ronny Decorte, M. Hamza Müslümanogğlu, Salih Kavukcu, Guido Filler, Yves Pirson, Leana S. Wen, John P. Atkinson, and Timothy H. J. Goodship Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12966–12971. Published online 2003 October 17. doi: 10.1073/pnas.2135497100.PMCID: PMC240728 HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation Kimdar Sherefa Kemal, Brian Foley, Harold Burger, Kathryn Anastos, Howard Minkoff, Christina Kitchen, Sean M. Philpott, Wei Gao, Esther Robison, Susan Holman, Carolyn Dehner, Suzanne Beck, William A. Meyer, III, Alan Landay, Andrea Kovacs, James Bremer, and Barbara Weiser Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12972–12977. Published online 2003 October 13. doi: 10.1073/pnas.2134064100.PMCID: PMC240729 Microbiology The small RING finger protein Z drives arenavirus budding: Implications for antiviral strategies Mar Perez, Rebecca C. Craven, and Juan C. de la Torre Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12978–12983. Published online 2003 October 16. doi: 10.1073/pnas.2133782100.PMCID: PMC240730 The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism Elizabeth Waters, Michael J. Hohn, Ivan Ahel, David E. Graham, Mark D. Adams, Mary Barnstead, Karen Y. Beeson, Lisa Bibbs, Randall Bolanos, Martin Keller, Keith Kretz, Xiaoying Lin, Eric Mathur, Jingwei Ni, Mircea Podar, Toby Richardson, Granger G. Sutton, Melvin Simon, Dieter Söll, Karl O. Stetter, Jay M. Short, and Michiel Noordewier Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12984–12988. Published online 2003 October 17. doi: 10.1073/pnas.1735403100.PMCID: PMC240731 Genetic requirements for mycobacterial survival during infection Christopher M. Sassetti and Eric J. Rubin Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12989–12994. Published online 2003 October 20. doi: 10.1073/pnas.2134250100.PMCID: PMC240732 Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus Boyd Yount, Kristopher M. Curtis, Elizabeth A. Fritz, Lisa E. Hensley, Peter B. Jahrling, Erik Prentice, Mark R. Denison, Thomas W. Geisbert, and Ralph S. Baric Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12995–13000. Published online 2003 October 20. doi: 10.1073/pnas.1735582100.PMCID: PMC240733 Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system Sarah A. Stanley, Sridharan Raghavan, William W. Hwang, and Jeffery S. Cox Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13001–13006. Published online 2003 October 13. doi: 10.1073/pnas.2235593100.PMCID: PMC240734 Induction of crossreactive antibodies against the Plasmodium falciparum variant protein Sylvie Gratepanche, Benoit Gamain, Joseph D. Smith, Bridget A. Robinson, Allan Saul, and Louis H. Miller Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13007–13012. Published online 2003 October 20. doi: 10.1073/pnas.2235588100.PMCID: PMC240735 Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution Sandra Blaise, Nathalie de Parseval, Laurence Bénit, and Thierry Heidmann Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13013–13018. Published online 2003 October 13. doi: 10.1073/pnas.2132646100.PMCID: PMC240736 Neuroscience The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia Candice E. Junge, Taku Sugawara, Guido Mannaioni, Sudar Alagarsamy, P. Jeffrey Conn, Daniel J. Brat, Pak H. Chan, and Stephen F. Traynelis Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13019–13024. Published online 2003 October 14. doi: 10.1073/pnas.2235594100.PMCID: PMC240737 Cyclothiazide potently inhibits γ-aminobutyric acid type A receptors in addition to enhancing glutamate responses Lunbin Deng and Gong Chen Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13025–13029. Published online 2003 October 8. doi: 10.1073/pnas.2133370100.PMCID: PMC240738 Elevated gene expression levels distinguish human from non-human primate brains Mario Cáceres, Joel Lachuer, Matthew A. Zapala, John C. Redmond, Lili Kudo, Daniel H. Geschwind, David J. Lockhart, Todd M. Preuss, and Carrolee Barlow Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13030–13035. Published online 2003 October 13. doi: 10.1073/pnas.2135499100.PMCID: PMC240739 Glia-independent chains of neuroblasts through the subcortical parenchyma of the adult rabbit brain F. Luzzati, P. Peretto, P. Aimar, G. Ponti, A. Fasolo, and L. Bonfanti Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13036–13041. Published online 2003 October 14. doi: 10.1073/pnas.1735482100.PMCID: PMC240740 Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis Maaria Ikonen, Bingrong Liu, Yuichi Hashimoto, Liqun Ma, Kuk-Wha Lee, Takako Niikura, Ikuo Nishimoto, and Pinchas Cohen Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13042–13047. Published online 2003 October 15. doi: 10.1073/pnas.2135111100.PMCID: PMC240741 Expression of T cell receptor βlocus in central nervous system neurons Josh Syken and Carla J. Shatz Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13048–13053. Published online 2003 October 20. doi: 10.1073/pnas.1735415100.PMCID: PMC240742 Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry John F. Leite, Michael P. Blanton, Mona Shahgholi, Dennis A. Dougherty, and Henry A. Lester Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13054–13059. Published online 2003 October 20. doi: 10.1073/pnas.2133028100.PMCID: PMC240743 Developmental amnesia and its relationship to degree of hippocampal atrophy E. B. Isaacs, F. Vargha-Khadem, K. E. Watkins, A. Lucas, M. Mishkin, and D. G. Gadian Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13060–13063. Published online 2003 October 10. doi: 10.1073/pnas.1233825100.PMCID: PMC240744 Olivo-cerebellar cluster-based universal control system V. B. Kazantsev, V. I. Nekorkin, V. I. Makarenko, and R. Llinás Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13064–13068. Published online 2003 October 9. doi: 10.1073/pnas.1635110100.PMCID: PMC240745 Brain-derived neurotrophic factor-dependent unmasking of “silent” synapses in the developing mouse barrel cortex Chiaki Itami, Fumitaka Kimura, Tomoko Kohno, Masato Matsuoka, Masumi Ichikawa, Tadaharu Tsumoto, and Shun Nakamura Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13069–13074. Published online 2003 October 13. doi: 10.1073/pnas.2131948100.PMCID: PMC240746 A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis Eric H. Schroeter, Ma. Xenia G. Ilagan, Anne L. Brunkan, Silva Hecimovic, Yue-ming Li, Min Xu, Huw D. Lewis, Meera T. Saxena, Bart De Strooper, Archie Coonrod, Taisuke Tomita, Takeshi Iwatsubo, Chad L. Moore, Alison Goate, Michael S. Wolfe, Mark Shearman, and Raphael Kopan Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13075–13080. Published online 2003 October 17. doi: 10.1073/pnas.1735338100.PMCID: PMC240747 Two-photon imaging of capillary blood flow in olfactory bulb glomeruli Emmanuelle Chaigneau, Martin Oheim, Etienne Audinat, and Serge Charpak Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13081–13086. Published online 2003 October 20. doi: 10.1073/pnas.2133652100.PMCID: PMC240748 Trace but not delay fear conditioning requires attention and the anterior cingulate cortex C. J. Han, Colm M. O'Tuathaigh, Laurent van Trigt, Jennifer J. Quinn, Michael S. Fanselow, Raymond Mongeau, Christof Koch, and David J. Anderson Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13087–13092. Published online 2003 October 10. doi: 10.1073/pnas.2132313100.PMCID: PMC240749 Physiology β-Adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15 Joanne T. Hulme, Teddy W.-C. Lin, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13093–13098. Published online 2003 October 20. doi: 10.1073/pnas.2135335100.PMCID: PMC240750 Plant Biology MADS box genes control vernalization-induced flowering in cereals Ben Trevaskis, David J. Bagnall, Marc H. Ellis, W. James Peacock, and Elizabeth S. Dennis Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13099–13104. Published online 2003 October 13. doi: 10.1073/pnas.1635053100.PMCID: PMC240751 Psychology A modulatory role for facial expressions in prosopagnosia Beatrice de Gelder, Ilja Frissen, Jason Barton, and Nouchine Hadjikhani Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13105–13110. Published online 2003 October 15. doi: 10.1073/pnas.1735530100.PMCID: PMC240752 Social Sciences Anthropology Ancient maize from Chacoan great houses: Where was it grown? Larry Benson, Linda Cordell, Kirk Vincent, Howard Taylor, John Stein, G. Lang Farmer, and Kiyoto Futa Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13111–13115. Published online 2003 October 16. doi: 10.1073/pnas.2135068100.PMCID: PMC240753 Correction Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13116. Published online 2003 October 1. doi: 10.1073/pnas.2235532100.PMCID: PMC305274 Corrects: Florence J. Dallo, et al. Effectiveness of diabetes mellitus screening recommendations. Proc Natl Acad Sci U S A. 2003 September 2; 100(18): 10574–10579. |