| | This journal provides immediate access to some articles. From the Academy Japanese-American Frontiers of Science Symposium Introduction to the Japanese–American Frontiers of
Science Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12402. Published online 2000 October 17. PMCID: PMC34059 Learning and memory Hideyuki Okano, Tomoo Hirano, and Evan Balaban Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12403–12404. Published online 2000 October 17. PMCID: PMC34060 Extrasolar planets Jack J. Lissauer, Geoffrey W. Marcy, and Shigeru Ida Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12405–12406. Published online 2000 October 17. PMCID: PMC34061 Aging mechanisms Yoshiko Takahashi, Makoto Kuro-o, and Fuyuki Ishikawa Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12407–12408. Published online 2000 October 17. PMCID: PMC34062 Mantle dynamics and seismic tomography Toshiro Tanimoto and Thorne Lay Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12409–12410. Published online 2000 October 17. PMCID: PMC34063 Emerging viral diseases Stuart T. Nichol, Jiro Arikawa, and Yoshihiro Kawaoka Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12411–12412. Published online 2000 October 17. PMCID: PMC34064 Commentaries From mouse to human: Fine mapping of quantitative trait loci in a
model organism Mary Sara McPeek Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12389–12390. Published online 2000 October 24. PMCID: PMC34053 Are denatured proteins ever random coils? Robert L. Baldwin and Bruno H. Zimm Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12391–12392. PMCID: PMC34054 Can neural stem cells be used to track down and destroy migratory
brain tumor cells while also providing a means of repairing
tumor-associated damage? Mark Noble Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12393–12395. PMCID: PMC34055 Pausing to decide Maho Niwa and Peter Walter Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12396–12397. Published online 2000 October 31. PMCID: PMC34056 Natural selection and speciation Christopher J. Schneider Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12398–12399. Published online 2000 October 31. PMCID: PMC34057 Anti-inflammatories for cardiovascular disease Jaime L. Masferrer and Philip Needleman Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12400–12401. Published online 2000 October 31. PMCID: PMC34058 Physical Sciences Applied Physical Sciences Remarkable statistical behavior for truncated Burgers–Hopf
dynamics Andrew J. Majda and Ilya Timofeyev Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12413–12417. Published online 2000 October 24. PMCID: PMC18776 Chemistry Emergent mechanical properties of self-assembled polymeric
capsules Ronald K. Castellano, Ross Clark, Stephen L. Craig, Colin Nuckolls, and Julius Rebek, Jr. Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12418–12421. PMCID: PMC18777 Condensed complexes, rafts, and the chemical activity of
cholesterol in membranes Arun Radhakrishnan, Thomas G. Anderson, and Harden M. McConnell Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12422–12427. Published online 2000 October 24. PMCID: PMC18778 Geology Impact of a Permo-Carboniferous high O2 event on the
terrestrial carbon cycle D. J. Beerling and R. A. Berner Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12428–12432. Published online 2000 October 24. PMCID: PMC18779 Geophysics Geophysical, archaeological, and historical evidence support a
solar-output model for climate change Charles A. Perry and Kenneth J. Hsu Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12433–12438. Published online 2000 October 24. PMCID: PMC18780 Mathematics Prime type III factors Dimitri Shlyakhtenko Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12439–12441. Published online 2000 October 31. PMCID: PMC18781 Biological Sciences Biochemistry Single 8-oxo-guanine and 8-oxo-adenine lesions induce marked
changes in the backbone structure of a 25-base DNA strand Donald C. Malins, Nayak L. Polissar, Gary K. Ostrander, and Mark A. Vinson Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12442–12445. Published online 2000 October 31. PMCID: PMC18782 Role of C/EBP homologous protein (CHOP-10) in the programmed
activation of CCAAT/enhancer-binding protein-β
during adipogenesis Qi-Qun Tang and M. Daniel Lane Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12446–12450. Published online 2000 October 24. PMCID: PMC18783 Polymerization of nontemplate bases before transcription
initiation at the 3′ ends of templates by an RNA-dependent RNA polymerase: An activity involved in 3′ end repair of viral RNAs Hancheng Guan and Anne E. Simon Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12451–12456. PMCID: PMC18784 The semaphorin receptor plexin-B1 specifically interacts with
active Rac in a ligand-dependent manner Haris G. Vikis, Weiquan Li, Zhigang He, and Kun-Liang Guan Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12457–12462. Published online 2000 October 17. PMCID: PMC18785 The x-ray structure of d-amino acid oxidase at very
high resolution identifies the chemical mechanism of
flavin-dependent substrate dehydrogenation Stephan Umhau, Loredano Pollegioni, Gianluca Molla, Kay Diederichs, Wolfram Welte, Mirella S. Pilone, and Sandro Ghisla Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12463–12468. PMCID: PMC18786 A unique loop in the DNA-binding crevice of bacteriophage T7 DNA
polymerase influences primer utilization Kajal Chowdhury, Stanley Tabor, and Charles C. Richardson Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12469–12474. Published online 2000 October 24. PMCID: PMC18787 Regulation of the antioxidant response element by protein kinase
C-mediated phosphorylation of NF-E2-related factor 2 H.-C. Huang, Truyen Nguyen, and Cecil B. Pickett Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12475–12480. Published online 2000 October 17. PMCID: PMC18788 Synthesis and characterization of
selenotrisulfide-derivatives of lipoic acid and lipoamide William T. Self, Lin Tsai, and Thressa C. Stadtman Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12481–12486. Published online 2000 October 24. PMCID: PMC18789 Combinatorial peptide libraries reveal the ligand-binding
mechanism of the oligopeptide receptor OppA of Lactococcus lactis Frank J. M. Detmers, Frank C. Lanfermeijer, Rupert Abele, Ralph W. Jack, Robert Tampé, Wil N. Konings, and Bert Poolman Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12487–12492. Published online 2000 October 24. PMCID: PMC18790 2′-Hydroxylation of nicotine by cytochrome P450 2A6 and human
liver microsomes: Formation of a lung carcinogen precursor Stephen S. Hecht, J. Bradley Hochalter, Peter W. Villalta, and Sharon E. Murphy Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12493–12497. Published online 2000 October 24. PMCID: PMC18791 Vigilin binding selectively inhibits cleavage of the vitellogenin
mRNA 3′-untranslated region by the mRNA endonuclease polysomal ribonuclease 1 Kristopher S. Cunningham, Robin E. Dodson, Maria A. Nagel, David J. Shapiro, and Daniel R. Schoenberg Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12498–12502. Published online 2000 October 24. PMCID: PMC18792 Self-organizing biochemical cycles Leslie E. Orgel Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12503–12507. Published online 2000 October 31. PMCID: PMC18793 Unusual DNA structure of the diabetes susceptibility locus
IDDM2 and its effect on transcription by the insulin
promoter factor Pur-1/MAZ Amy Lew, William J. Rutter, and Giulia C. Kennedy Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12508–12512. PMCID: PMC18794 Repression of human papillomavirus oncogenes in HeLa cervical
carcinoma cells causes the orderly reactivation of dormant
tumor suppressor pathways Edward C. Goodwin and Daniel DiMaio Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12513–12518. PMCID: PMC18795 Sequential repression and activation of the CCAAT
enhancer-binding protein-α (C/EBPα) gene during adipogenesis Man-Shiow Jiang and M. Daniel Lane Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12519–12523. Published online 2000 October 24. PMCID: PMC18796 Dimerization and N-terminal domain proximity underlie the
function of the molecular chaperone heat shock protein 90 Ahmed Chadli, Ilham Bouhouche, William Sullivan, Bridget Stensgard, Nancy McMahon, Maria G. Catelli, and David O. Toft Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12524–12529. Published online 2000 October 24. PMCID: PMC18797 Active acetyl-CoA synthase from Clostridium
thermoaceticum obtained by cloning and heterologous expression
of acsAB in Escherichia coli Huay-Keng Loke, George N. Bennett, and Paul A. Lindahl Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12530–12535. Published online 2000 October 24. PMCID: PMC18798 Endogenously expressed estrogen receptor and
coactivator AIB1 interact in MCF-7 human breast cancer cells Minna K. Tikkanen, Damien J. Carter, Alana M. Harris, Hung M. Le, David O. Azorsa, Paul S. Meltzer, and Fern E. Murdoch Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12536–12540. Published online 2000 October 24. PMCID: PMC18799 Chimeric double-stranded RNA-specific adenosine deaminase ADAR1
proteins reveal functional selectivity of double-stranded RNA-binding
domains from ADAR1 and protein kinase PKR Yong Liu, Ming Lei, and Charles E. Samuel Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12541–12546. PMCID: PMC18800 MDM2 inhibits p300-mediated p53 acetylation and activation by
forming a ternary complex with the two proteins Eric Kobet, Xiaoya Zeng, Yong Zhu, David Keller, and Hua Lu Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12547–12552. PMCID: PMC18801 Chimeras of Dictyostelium myosin
II head and neck domains with Acanthamoeba or chicken
smooth muscle myosin II tail domain have greatly increased and
unregulated actin-dependent MgATPase activity Xiong Liu, Shi Shu, Roxanne A. Yamashita, Yuhui Xu, and Edward D. Korn Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12553–12558. Published online 2000 October 31. PMCID: PMC18802 Coevolution of head, neck, and tail domains of myosin
heavy chains Edward D. Korn Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12559–12564. Published online 2000 October 31. PMCID: PMC18803 Biophysics Condensed complexes, rafts, and the chemical activity of
cholesterol in membranes Arun Radhakrishnan, Thomas G. Anderson, and Harden M. McConnell Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12422–12427. Published online 2000 October 24. PMCID: PMC18778 From the Cover: The Flory isolated-pair hypothesis is not valid for polypeptide
chains: Implications for protein folding Rohit V. Pappu, Rajgopal Srinivasan, and George D. Rose Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12565–12570. PMCID: PMC18804 Cell Biology Formation of high molecular weight complexes of mutant
Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic
lateral sclerosis Jennifer A. Johnston, Muffie J. Dalton, Mark E. Gurney, and Ron R. Kopito Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12571–12576. Published online 2000 October 24. PMCID: PMC18805 Phosphorylation near nuclear localization signal regulates
nuclear import of adenomatous polyposis coli protein Fang Zhang, Raymond L. White, and Kristi L. Neufeld Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12577–12582. Published online 2000 October 24. PMCID: PMC18806 Interaction of yeast kinetochore proteins with
centromere–protein/transcription factor Cbf1 Peter Hemmerich, Tanja Stoyan, Gerhard Wieland, Marianne Koch, Johannes Lechner, and Stephan Diekmann Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12583–12588. PMCID: PMC18807 Peripheral Golgi protein GRASP65 is a target of mitotic polo-like
kinase (Plk) and Cdc2 Chin-Yo Lin, Matthew L. Madsen, Frederic R. Yarm, Young-Joo Jang, Xiaoqi Liu, and Raymond L. Erikson Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12589–12594. Published online 2000 October 24. PMCID: PMC18808 Timing of hepatocyte entry into DNA synthesis after partial
hepatectomy is cell autonomous Teresa C. Weglarz and Eric P. Sandgren Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12595–12600. Published online 2000 October 24. PMCID: PMC18809 Genetic mosaic analysis based on Cre recombinase and navigated
laser capture microdissection Melissa H. Wong, Jennifer R. Saam, Thaddeus S. Stappenbeck, Charles H. Rexer, and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12601–12606. Published online 2000 October 24. PMCID: PMC18810 The classical progesterone receptor mediates
Xenopus oocyte maturation through a
nongenomic mechanism Mustafa Bayaa, Ronald A. Booth, Yinglun Sheng, and X. Johné Liu Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12607–12612. Published online 2000 October 24. PMCID: PMC18811 Regulation of β-catenin transformation by the p300
transcriptional coactivator Yongnian Sun, Frank T. Kolligs, Michael O. Hottiger, Rashid Mosavin, Eric R. Fearon, and Gary J. Nabel Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12613–12618. Published online 2000 October 24. PMCID: PMC18812 RNA polymerase III transcription factor TFIIIC2 is overexpressed
in ovarian tumors Andrew G. Winter, George Sourvinos, Simon J. Allison, Kerrie Tosh, Pamela H. Scott, Demetrios A. Spandidos, and Robert J. White Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12619–12624. Published online 2000 October 31. PMCID: PMC18813 PERK mediates cell-cycle exit during the mammalian unfolded
protein response Joseph W. Brewer and J. Alan Diehl Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12625–12630. Published online 2000 October 17. PMCID: PMC18814 Two tandem verprolin homology domains are necessary for a strong
activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP Hideki Yamaguchi, Hiroaki Miki, Shiro Suetsugu, Le Ma, Marc W. Kirschner, and Tadaomi Takenawa Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12631–12636. Published online 2000 October 31. PMCID: PMC18815 Evolution From the Cover: Nonrandom mating in Drosophila melanogaster
laboratory populations derived from closely adjacent ecologically
contrasting slopes at “Evolution Canyon” Abraham Korol, Eugenia Rashkovetsky, Konstantin Iliadi, Pawel Michalak, Yefim Ronin, and Eviatar Nevo Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12637–12642. Published online 2000 October 24. PMCID: PMC18816 Postsegregational killing does not increase plasmid stability but
acts to mediate the exclusion of competing plasmids Tim F. Cooper and Jack A. Heinemann Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12643–12648. Published online 2000 October 31. PMCID: PMC18817 Genetics From the Cover: A method for fine mapping quantitative trait loci in outbred
animal stocks Richard Mott, Christopher J. Talbot, Maria G. Turri, Allan C. Collins, and Jonathan Flint Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12649–12654. Published online 2000 October 24. PMCID: PMC18818 Detection of mutations in transgenic fish carrying a
bacteriophage λcII transgene target Richard N. Winn, Michelle B. Norris, Kathryn J. Brayer, Cecilia Torres, and Stacy L. Muller Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12655–12660. Published online 2000 October 17. PMCID: PMC18819 Quantifying genetic and nongenetic contributions to malarial
infection in a Sri Lankan population Margaret J. Mackinnon, D. M. Gunawardena, Jagath Rajakaruna, Sudath Weerasingha, Kamini N. Mendis, and Richard Carter Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12661–12666. Published online 2000 October 17. PMCID: PMC18820 Zidovudine–didanosine coexposure potentiates DNA
incorporation of zidovudine and mutagenesis in human cells Quanxin Meng, Dale M. Walker, Ofelia A. Olivero, Xiaochu Shi, Brendan B. Antiochos, Miriam C. Poirier, and Vernon E. Walker Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12667–12671. Published online 2000 October 31. PMCID: PMC18821 TEP1, the yeast homolog of the human tumor
suppressor gene PTEN/MMAC1/TEP1, is linked to the
phosphatidylinositol pathway and plays a role in the
developmental process of sporulation Jennifer Heymont, Ludmilla Berenfeld, Jennifer Collins, Alexandra Kaganovich, Bradford Maynes, Aaron Moulin, Irina Ratskovskaya, Pak P. Poon, Gerald C. Johnston, Margarita Kamenetsky, John DeSilva, Hong Sun, Gregory A. Petsko, and JoAnne Engebrecht Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12672–12677. PMCID: PMC18822 SOS mutator activity: Unequal mutagenesis on leading and
lagging strands Magdalena Maliszewska-Tkaczyk, Piotr Jonczyk, Malgorzata Bialoskorska, Roel M. Schaaper, and Iwona J. Fijalkowska Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12678–12683. Published online 2000 October 24. PMCID: PMC18823 RaSH, a rapid subtraction hybridization approach for identifying
and cloning differentially expressed genes Hongping Jiang, Dong-chul Kang, Deborah Alexandre, and Paul B. Fisher Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12684–12689. Published online 2000 October 31. PMCID: PMC18824 Identification of human chromosome 22 transcribed sequences with
ORF expressed sequence tags Sandro J. de Souza, Anamaria A. Camargo, Marcelo R. S. Briones, Fernando F. Costa, Maria Aparecida Nagai, Sergio Verjovski-Almeida, Marco A. Zago, Luis Eduardo C. Andrade, Helaine Carrer, Hamza F. A. El-Dorry, Enilza M. Espreafico, Angelita Habr-Gama, Daniel Giannella-Neto, Gustavo H. Goldman, Arthur Gruber, Christine Hackel, Edna T. Kimura, Rui M. B. Maciel, Suely K. N. Marie, Elizabeth A. L. Martins, Marina P. Nóbrega, Maria Luisa Paçó-Larson, Maria Inês M. C. Pardini, Gonçalo G. Pereira, João Bosco Pesquero, Vanderlei Rodrigues, Silvia R. Rogatto, Ismael D. C. G. da Silva, Mari C. Sogayar, Maria de Fátima Sonati, Eloiza H. Tajara, Sandro R. Valentini, Marcio Acencio, Fernando L. Alberto, Maria Elisabete J. Amaral, Ivy Aneas, Mário Henrique Bengtson, Dirce M. Carraro, Alex F. Carvalho, Lúcia Helena Carvalho, Janete M. Cerutti, Maria Lucia C. Corrêa, Maria Cristina R. Costa, Cyntia Curcio, Tsieko Gushiken, Paulo L. Ho, Elza Kimura, Luciana C. C. Leite, Gustavo Maia, Paromita Majumder, Mozart Marins, Adriana Matsukuma, Analy S. A. Melo, Carlos Alberto Mestriner, Elisabete C. Miracca, Daniela C. Miranda, Ana Lucia T. O. Nascimento, Francisco G. Nóbrega, Élida P. B. Ojopi, José Rodrigo C. Pandolfi, Luciana Gilbert Pessoa, Paula Rahal, Claudia A. Rainho, Nancy da Ro's, Renata G. de Sá, Magaly M. Sales, Neusa P. da Silva, Tereza C. Silva, Wilson da Silva, Jr., Daniel F. Simão, Josane F. Sousa, Daniella Stecconi, Fernando Tsukumo, Valéria Valente, Heloisa Zalcberg, Ricardo R. Brentani, Luis F. L. Reis, Emmanuel Dias-Neto, and Andrew J. G. Simpson Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12690–12693. PMCID: PMC18825 Immunology Coexpression of the chemokines ELC and SLC by T zone stromal
cells and deletion of the ELC gene in the
plt/plt mouse Sanjiv A. Luther, H. Lucy Tang, Paul L. Hyman, Andrew G. Farr, and Jason G. Cyster Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12694–12699. PMCID: PMC18826 A targeted mutation in the IL-4Rα gene protects mice against
autoimmune diabetes Dorel L. Radu, Nancy Noben-Trauth, Jane Hu-Li, William E. Paul, and Constantin A. Bona Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12700–12704. Published online 2000 October 24. PMCID: PMC18827 Selective requirement for c-Rel during IL-12 P40 gene induction
in macrophages Shomyseh Sanjabi, Alexander Hoffmann, Hsiou-Chi Liou, David Baltimore, and Stephen T. Smale Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12705–12710. Published online 2000 October 31. PMCID: PMC18828 Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size,
reactivity, and function of a primed pool of CD4+ T
cells Michael S. Kuhns, Victoria Epshteyn, Raymond A. Sobel, and James P. Allison Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12711–12716. Published online 2000 October 24. PMCID: PMC18829 Beryllium presentation to CD4+ T cells underlies
disease-susceptibility HLA-DP alleles in chronic beryllium disease Andrew P. Fontenot, Michaelann Torres, William H. Marshall, Lee S. Newman, and Brian L. Kotzin Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12717–12722. Published online 2000 October 24. PMCID: PMC18830 An essential amino acid induces epithelial
β-defensin expression Pascale Fehlbaum, Meena Rao, Michael Zasloff, and G. Mark Anderson Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12723–12728. Published online 2000 October 31. PMCID: PMC18831 Medical Sciences Increased adipose tissue in male and female estrogen receptor-α
knockout mice P. A. Heine, J. A. Taylor, G. A. Iwamoto, D. B. Lubahn, and P. S. Cooke Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12729–12734. PMCID: PMC18832 Aromatase-deficient (ArKO) mice have a phenotype of increased
adiposity Margaret E. E. Jones, Anne W. Thorburn, Kara L. Britt, Kylie N. Hewitt, Nigel G. Wreford, Joseph Proietto, Orhan K. Oz, Brian J. Leury, Kirsten M. Robertson, Shenggen Yao, and Evan R. Simpson Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12735–12740. PMCID: PMC18833 Increased resistance to acetaminophen hepatotoxicity in mice
lacking glutathione S-transferase Pi Colin J. Henderson, C. Roland Wolf, Neil Kitteringham, Helen Powell, Diana Otto, and B. Kevin Park Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12741–12745. Published online 2000 October 31. PMCID: PMC18834 Myocardial extracellular matrix remodeling in transgenic mice
overexpressing tumor necrosis factor α can be modulated by
anti-tumor necrosis factor α therapy Y. Y. Li, Y. Q. Feng, T. Kadokami, C. F. McTiernan, R. Draviam, S. C. Watkins, and A. M. Feldman Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12746–12751. PMCID: PMC18835 Linking immune-mediated arterial inflammation and
cholesterol-induced atherosclerosis in a transgenic mouse model Burkhard Ludewig, Stefan Freigang, Martin Jäggi, Michael O. Kurrer, Yao-Chang Pei, Lenka Vlk, Bernhard Odermatt, Rolf M. Zinkernagel, and Hans Hengartner Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12752–12757. Published online 2000 October 24. PMCID: PMC18836 Bestrophin, the product of the Best vitelliform macular dystrophy
gene (VMD2), localizes to the basolateral
plasma membrane of the retinal pigment epithelium Alan D. Marmorstein, Lihua Y. Marmorstein, Mary Rayborn, Xinxing Wang, Joe G. Hollyfield, and Konstantin Petrukhin Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12758–12763. Published online 2000 October 24. PMCID: PMC18837 Sulindac inhibits neointimal formation after arterial injury in
wild-type and apolipoprotein E-deficient mice Ernane D. Reis, Mercè Roqué, Hayes Dansky, John T. Fallon, Juan J. Badimon, Carlos Cordon-Cardo, Steven J. Shiff, and Edward A. Fisher Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12764–12769. Published online 2000 October 10. PMCID: PMC18838 Increased p53 mutation load in nontumorous human liver of Wilson
disease and hemochromatosis: Oxyradical overload diseases S. Perwez Hussain, Kamran Raja, Paul A. Amstad, Mark Sawyer, Laura J. Trudel, Gerald N. Wogan, Lorne J. Hofseth, Peter G. Shields, Timothy R. Billiar, Christian Trautwein, Thomas Höhler, Peter R. Galle, David H. Phillips, Rodney Markin, Aizen J. Marrogi, and Curtis C. Harris Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12770–12775. Published online 2000 October 24. PMCID: PMC18839 Altered HOX and WNT7A expression in human lung cancer Roser Calvo, James West, Wilbur Franklin, Paul Erickson, Lynne Bemis, Efang Li, Barbara Helfrich, Paul Bunn, Joelle Roche, Elisabeth Brambilla, Rafael Rosell, Robert M. Gemmill, and Harry A. Drabkin Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12776–12781. PMCID: PMC18840 The antiangiogenic agent TNP-470 requires p53 and
p21CIP/WAF for endothelial cell growth arrest Jing-Ruey J. Yeh, Royce Mohan, and Craig M. Crews Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12782–12787. PMCID: PMC18841 Microbiology Identification of alternative splicing and negative splicing
activity of a nonsegmented negative-strand RNA virus, Borna
disease virus Keizo Tomonaga, Takeshi Kobayashi, Byeong- Jae Lee, Makiko Watanabe, Wataru Kamitani, and Kazuyoshi Ikuta Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12788–12793. PMCID: PMC18842 Cooperative subunit interactions within the oligomeric envelope
glycoprotein of HIV-1: Functional complementation of
specific defects in gp120 and gp41 Karl Salzwedel and Edward A. Berger Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12794–12799. Published online 2000 October 24. PMCID: PMC18843 Molecular identification by “suicide PCR” of
Yersinia pestis as the agent of Medieval Black Death Didier Raoult, Gérard Aboudharam, Eric Crubézy, Georges Larrouy, Bertrand Ludes, and Michel Drancourt Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12800–12803. Published online 2000 October 31. PMCID: PMC18844 Neurobiology Sparing of neuronal function postseizure with gene therapy John McLaughlin, Benno Roozendaal, Theodore Dumas, Anurag Gupta, Olusola Ajilore, Joseph Hsieh, Dora Ho, Matthew Lawrence, James L. McGaugh, and Robert Sapolsky Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12804–12809. Published online 2000 October 31. PMCID: PMC18845 Endogenous regulators of G protein signaling proteins
regulate presynaptic inhibition at rat hippocampal synapses Huanmian Chen and Nevin A. Lambert Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12810–12815. Published online 2000 October 24. PMCID: PMC18846 A membrane-associated progesterone-binding protein, 25-Dx, is
regulated by progesterone in brain regions involved in female
reproductive behaviors Christopher J. Krebs, Erich D. Jarvis, Johnny Chan, John P. Lydon, Sonoko Ogawa, and Donald W. Pfaff Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12816–12821. PMCID: PMC18847 Presenilin-1 regulates the neuronal threshold to excitotoxicity
both physiologically and pathologically M. Grilli, E. Diodato, G. Lozza, R. Brusa, M. Casarini, D. Uberti, R. Rozmahel, D. Westaway, P. St
George-Hyslop, M. Memo, and E. Ongini Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12822–12827. PMCID: PMC18848 “Kiss and run” exocytosis at hippocampal synapses Charles F. Stevens and James H. Williams Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12828–12833. Published online 2000 October 24. PMCID: PMC18849 From the Cover: An empirical explanation of color contrast R. Beau Lotto and Dale Purves Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12834–12839. Published online 2000 October 31. PMCID: PMC18850 Amplification of dopaminergic signaling by a positive
feedback loop Akinori Nishi, James A. Bibb, Gretchen L. Snyder, Hideho Higashi, Angus C. Nairn, and Paul Greengard Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12840–12845. Published online 2000 October 24. PMCID: PMC18851 From the Cover: Neural stem cells display extensive tropism for pathology in
adult brain: Evidence from intracranial gliomas Karen S. Aboody, Alice Brown, Nikolai G. Rainov, Kate A. Bower, Shaoxiong Liu, Wendy Yang, Juan E. Small, Ulrich Herrlinger, Vaclav Ourednik, Peter McL. Black, Xandra O. Breakefield, and Evan Y. Snyder Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12846–12851. PMCID: PMC18852 Behavioral insensitivity to restraint stress, absent fear
suppression of behavior and impaired spatial learning in transgenic
rats with hippocampal neuropeptide Y overexpression A. Thorsell, M. Michalkiewicz, Y. Dumont, R. Quirion, L. Caberlotto, R. Rimondini, A. A. Mathé, and M. Heilig Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12852–12857. Published online 2000 October 31. PMCID: PMC18853 Long-term regulation of neuronal high-affinity glutamate and
glutamine uptake in Aplysia Jonathan Levenson, Shogo Endo, Lorna S. Kategaya, Raymond I. Fernandez, David G. Brabham, Jeannie Chin, John H. Byrne, and Arnold Eskin Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12858–12863. Published online 2000 October 24. PMCID: PMC18854 Sensory deprivation without competition yields modest
alterations of short-term synaptic dynamics Gerald T. Finnerty and Barry W. Connors Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12864–12868. Published online 2000 October 31. PMCID: PMC18855 Functional mosaic organization of mouse olfactory
receptor neurons Minghong Ma and Gordon M. Shepherd Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12869–12874. Published online 2000 October 24. PMCID: PMC18856 Statistics of lateral geniculate nucleus (LGN) activity determine
the segregation of ON/OFF subfields for simple cells in visual
cortex Ann B. Lee, Brian Blais, Harel Z. Shouval, and Leon N Cooper Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12875–12879. PMCID: PMC18857 Effects of environmental enrichment on gene expression in the
brain Claire Rampon, Cecilia H. Jiang, Helin Dong, Ya-Ping Tang, David J. Lockhart, Peter G. Schultz, Joe Z. Tsien, and Yinghe Hu Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12880–12884. PMCID: PMC18858 Pharmacology Neuronal death enhanced by
N-methyl-d-aspartate antagonists Chrysanthy Ikonomidou, Vanya Stefovska, and Lechoslaw Turski Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12885–12890. Published online 2000 October 31. PMCID: PMC18859 Cloning and characterization of two splice variants of human
phosphodiesterase 11A Joanna M. Hetman, Nicola Robas, Rhona Baxendale, Mark Fidock, Stephen C. Phillips, Scott H. Soderling, and Joseph A. Beavo Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12891–12895. Published online 2000 October 24. PMCID: PMC18860 Physiology A dibasic motif involved in parathyroid hormone-induced
down-regulation of the type IIa NaPi cotransporter Zoubida Karim-Jimenez, Nati Hernando, Jürg Biber, and Heini Murer Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12896–12901. Published online 2000 October 24. PMCID: PMC18861 Plant Biology LEUNIG, a putative transcriptional corepressor
that regulates AGAMOUS expression during
flower development Joann Conner and Zhongchi Liu Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12902–12907. Published online 2000 October 31. PMCID: PMC18862 The Arabidopsis aldehyde oxidase 3
(AAO3) gene product catalyzes the final step in abscisic
acid biosynthesis in leaves Mitsunori Seo, Anton J. M. Peeters, Hanae Koiwai, Takayuki Oritani, Annie Marion-Poll, Jan A. D. Zeevaart, Maarten Koornneef, Yuji Kamiya, and Tomokazu Koshiba Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12908–12913. Published online 2000 October 24. PMCID: PMC18863 Purification, molecular cloning, and sequence analysis of
sucrose-6F-phosphate phosphohydrolase from plants John E. Lunn, Anthony R. Ashton, Marshall D. Hatch, and Hans W. Heldt Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12914–12919. Published online 2000 October 24. PMCID: PMC18864 Potentiation of pathogen-specific defense mechanisms in
Arabidopsis by β-aminobutyric acid Laurent Zimmerli, Gabor Jakab, Jean-Pierre Métraux, and Brigitte Mauch-Mani Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12920–12925. Published online 2000 October 31. PMCID: PMC18865 Social Sciences Anthropology INAUGURAL ARTICLE by a Recently Elected Academy Member: The transition from quantity to quality: A neglected causal
mechanism in accounting for social evolution Robert L. Carneiro Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12926–12931. Published online 2000 October 24. PMCID: PMC18866 Correction Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12932. PMCID: PMC56149 Corrects: Rong Xiang, et al. An autologous oral DNA vaccine protects against murine melanoma. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5492–5497. |