| | This journal provides immediate access to some articles. Commentaries Transforming growth factor β contributes to progressive
diabetic nephropathy W. Brian Reeves and Thomas E. Andreoli PMCID: PMC33997 Anfinsen comes out of the cage during assembly of the bacterial
pilus Staffan Normark PMCID: PMC33998 Schizophrenia: More dopamine, more D2 receptors Philip Seeman and Shitij Kapur PMCID: PMC33999 Toward a new anti-inflammatory and analgesic agent Domenico Regoli PMCID: PMC34000 Taming combinatorial explosion Peter Schuster PMCID: PMC34001 Physical Sciences Applied Mathematics Production of resistant HIV mutants during antiretroviral therapy Ruy M. Ribeiro and Sebastian Bonhoeffer PMCID: PMC16603 Chemistry Mimicking the antenna-electron transfer properties
of photosynthesis Milan Sykora, Kimberly A. Maxwell, Joseph M. DeSimone, and Thomas J. Meyer PMCID: PMC16604 Euclidean shape-encoded combinatorial chemical libraries Andrew R. Vaino and Kim D. Janda PMCID: PMC16605 Mathematics A pseudo zeta function and the distribution of primes Paul R. Chernoff PMCID: PMC16606 Biological Sciences Agricultural Sciences Absence of toxicity of Bacillus thuringiensis pollen to black swallowtails under field conditions C. L. Wraight, A. R. Zangerl, M. J. Carroll, and M. R. Berenbaum PMCID: PMC16607 Biochemistry From the Cover:
The origin of intermediary metabolism Harold J. Morowitz, Jennifer D. Kostelnik, Jeremy Yang, and George D. Cody PMCID: PMC16608 From the Cover:
PapD-like chaperones provide the missing information for folding of pilin proteins Michelle M. Barnhart, Jerome S. Pinkner, Gabriel E. Soto, Frederic G. Sauer, Sol Langermann, Gabriel Waksman, Carl Frieden, and Scott J. Hultgren PMCID: PMC16609 Amino acid transport System A resembles System N in sequence but differs in mechanism Richard J. Reimer, Farrukh A. Chaudhry, Andrew T. Gray, and Robert H. Edwards PMCID: PMC16610 The protelomerase of temperate Escherichia coli phage N15 has cleaving-joining activity Jan Deneke, Günter Ziegelin, Rudi Lurz, and Erich Lanka PMCID: PMC16611 Regulation of protein function by native metastability Cheolju Lee, Soon-Ho Park, Min-Youn Lee, and Myeong-Hee Yu PMCID: PMC16612 Crystal structure of human stem cell factor: Implication for stem cell factor receptor dimerization and activation Zhongtao Zhang, Rongguang Zhang, Andrzej Joachimiak, Joseph Schlessinger, and Xiang-Peng Kong PMCID: PMC16613 pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F Lluis Fajas, Conception Paul, Olivier Zugasti, Laurent Le Cam, Jolanta Polanowska, Eric Fabbrizio, René Medema, Marie-Luce Vignais, and Claude Sardet PMCID: PMC16614 Nucleotide binding by the erythrocyte transglutaminase/Gh protein, probed with fluorescent analogs of GTP and GDP S. N. Prasanna Murthy and Laszlo Lorand PMCID: PMC16615 BRG-1 is required for RB-mediated cell cycle arrest Matthew W. Strobeck, Karen E. Knudsen, Anne F. Fribourg, Marc F. DeCristofaro, Bernard E. Weissman, Anthony N. Imbalzano, and Erik S. Knudsen PMCID: PMC16616 Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Jennifer L. Harris, Bradley J. Backes, Francesco Leonetti, Sami Mahrus, Jonathan A. Ellman, and Charles S. Craik PMCID: PMC16617 Assembly and activation of site-specific recombination complexes Carol E. A. Peña, J. Michelle Kahlenberg, and Graham F. Hatfull PMCID: PMC16618 The N-terminal domains of histones H3 and H4 are not necessary for chromatin assembly factor-1- mediated nucleosome assembly onto replicated DNA in vitro Kei-ichi Shibahara, Alain Verreault, and Bruce Stillman PMCID: PMC16619 In organello formaldehyde crosslinking of proteins to mtDNA: Identification of bifunctional proteins Brett A. Kaufman, Scott M. Newman, Richard L. Hallberg, Clive A. Slaughter, Philip S. Perlman, and Ronald A. Butow PMCID: PMC16620 tmRNAs that encode proteolysis-inducing tags are found in all known bacterial genomes: A two-piece tmRNA functions in Caulobacter Kenneth C. Keiler, Lucy Shapiro, and Kelly P. Williams PMCID: PMC16621 Escherichia coli CspA-family RNA chaperones are transcription antiterminators Weonhye Bae, Bing Xia, Masayori Inouye, and Konstantin Severinov PMCID: PMC16622 Interaction of the iron–sulfur cluster assembly protein IscU with the Hsc66/Hsc20 molecular chaperone system of Escherichia coli Kevin G. Hoff, Jonathan J. Silberg, and Larry E. Vickery PMCID: PMC16623 Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1 Craig Swanson, John Ross, and Peter K. Jackson PMCID: PMC16624 A DNA enzyme with N-glycosylase activity Terry L. Sheppard, Phillip Ordoukhanian, and Gerald F. Joyce PMCID: PMC16625 Phosphatase activity of histidine kinase EnvZ without kinase catalytic domain Yan Zhu, Ling Qin, Takeshi Yoshida, and Masayori Inouye PMCID: PMC16626 Biophysics On the kinetics of distamycin binding to its target sites on duplex DNA Ramesh Baliga and Donald M. Crothers PMCID: PMC16627 Positive cooperativity without domains or subunits in a monomeric membrane channel Tatiana K. Rostovtseva, Tong-Tong Liu, Marco Colombini, V. Adrian Parsegian, and Sergey M. Bezrukov PMCID: PMC16628 Two mechanisms for termination of individual Ca2+
sparks in skeletal muscle Alain Lacampagne, Michael G. Klein, Christopher W. Ward, and Martin F. Schneider PMCID: PMC16629 Cell Biology Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression Nirupama K. Shevde, Amy C. Bendixen, Krista M. Dienger, and J. Wesley Pike PMCID: PMC16630 Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization Christina M. Grozinger and Stuart L. Schreiber PMCID: PMC16631 Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils Paul J. Muchowski, Gregor Schaffar, Annie Sittler, Erich E. Wanker, Manajit K. Hayer-Hartl, and F. Ulrich Hartl PMCID: PMC16632 Ordered membrane insertion of an archaeal opsin in vivo Heather Dale, Christine M. Angevine, and Mark P. Krebs PMCID: PMC16633 A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation Zhan Xiao, Xuedong Liu, Yoav I. Henis, and Harvey F. Lodish PMCID: PMC16634 Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death Suzanne M. Mandala, Rosemary Thornton, Ismael Galve-Roperh, Samantha Poulton, Courtney Peterson, Ana Olivera, James Bergstrom, Myra B. Kurtz, and Sarah Spiegel PMCID: PMC16635 Modeling the fission yeast cell cycle: Quantized cycle times in wee1− cdc25Δ mutant cells Akos Sveiczer, Attila Csikasz-Nagy, Bela Gyorffy, John J. Tyson, and Bela Novak PMCID: PMC16636 Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2 Jesper Nylandsted, Mikkel Rohde, Karsten Brand, Lone Bastholm, Folmer Elling, and Marja Jäättelä PMCID: PMC16637 Developmental Biology SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans Timothy G. Doyle, Chenhui Wen, and Iva Greenwald PMCID: PMC16638 Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor Elisabeth Dupin, Corinne Glavieux, Pierre Vaigot, and Nicole M. Le Douarin PMCID: PMC16639 From the Cover:
JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila Enrique Martín-Blanco, José C. Pastor-Pareja, and Antonio García-Bellido PMCID: PMC16640 Ecology Establishing a grassland signature in veins: 18O in the leaf water of C3 and C4 grasses Brent R. Helliker and James R. Ehleringer PMCID: PMC16641 Evolution Miocene ungulates and terrestrial primary productivity: Where have all the browsers gone? Christine M. Janis, John Damuth, and Jessica M. Theodor PMCID: PMC16642 Gene genealogies reveal global phylogeographic structure and reproductive isolation among lineages of Fusarium graminearum, the fungus causing wheat scab Kerry O'Donnell, H. Corby Kistler, Beth K. Tacke, and Howard H. Casper PMCID: PMC16643 Natural selection mapping of the warfarin-resistance gene Michael H. Kohn, Hans-Joachim Pelz, and Robert K. Wayne PMCID: PMC16644 Genetics A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme Sergei Kuchin, Isabelle Treich, and Marian Carlson PMCID: PMC16645 Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks Michael J. Singer, Larry D. Mesner, Cynthia L. Friedman, Barbara J. Trask, and Joyce L. Hamlin PMCID: PMC16646 Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens Satoshi Tateishi, Yoshiyuki Sakuraba, Sadaharu Masuyama, Hirokazu Inoue, and Masaru Yamaizumi PMCID: PMC16647 A mutation in Rab27a causes the vesicle transport defects observed in ashen mice Scott M. Wilson, Richard Yip, Deborah A. Swing, T. Norene O'Sullivan, Yuke Zhang, Edward K. Novak, Richard T. Swank, Liane B. Russell, Neal G. Copeland, and Nancy A. Jenkins PMCID: PMC16648 INAUGURAL ARTICLE by a Recently Elected Academy Member: Polymerase η deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair Charles L. Limoli, Erich Giedzinski, William F. Morgan, and James E. Cleaver PMCID: PMC16649 Genome-wide scan for body composition in pigs reveals important role of imprinting Dirk-Jan de Koning, Annemieke P. Rattink, Barbara Harlizius, Johan A. M. van Arendonk, E. W. Brascamp, and Martien A. M. Groenen PMCID: PMC16650 Model selection for quantitative trait locus analysis in polyploids R. W. Doerge and Bruce A. Craig PMCID: PMC16651 Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast Thomas J. Lyons, Audrey P. Gasch, L. Alex Gaither, David Botstein, Patrick O. Brown, and David J. Eide PMCID: PMC16652 Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity Stefanie Urlinger, Udo Baron, Marion Thellmann, Mazahir T. Hasan, Hermann Bujard, and Wolfgang Hillen PMCID: PMC16653 Immunology Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1–MAGE-A1 from a nonimmunized phage-Fab library Patrick Chames, Simon E. Hufton, Pierre G. Coulie, Barbara Uchanska-Ziegler, and Hennie R. Hoogenboom PMCID: PMC16654 Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments Barry P. Sleckman, Craig H. Bassing, Maureen M. Hughes, Ami Okada, Margaux D'Auteuil, Tara D. Wehrly, Barbara B. Woodman, Laurie Davidson, Jianzhu Chen, and Frederick W. Alt PMCID: PMC16655 Medical Sciences Production of resistant HIV mutants during antiretroviral therapy Ruy M. Ribeiro and Sebastian Bonhoeffer PMCID: PMC16603 Mechanism of action of a pestivirus antiviral compound Scott G. Baginski, Daniel C. Pevear, Marty Seipel, Siu Chi Chang Sun, Christopher A. Benetatos, Srinivas K. Chunduru, Charles M. Rice, and Marc S. Collett PMCID: PMC16656 Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter Silvia Santamarina-Fojo, Katherine Peterson, Catherine Knapper, Yang Qiu, Lita Freeman, Jan-Fang Cheng, José Osorio, Alan Remaley, Xiao-Ping Yang, Changting Haudenschild, Catherine Prades, Giovanna Chimini, Eunice Blackmon, Teena Francois, Nicholas Duverger, Edward M. Rubin, Marie Rosier, Patrice Denèfle, Donald S. Fredrickson, and H. Bryan Brewer, Jr. PMCID: PMC16657 Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption R. J. van't Hof, K. J. Armour, L. M. Smith, K. E. Armour, X. Q. Wei, F. Y. Liew, and S. H. Ralston PMCID: PMC16658 In vitro cultivation of human islets from expanded ductal tissue Susan Bonner-Weir, Monica Taneja, Gordon C. Weir, Krystyna Tatarkiewicz, Ki-Ho Song, Arun Sharma, and John J. O'Neil PMCID: PMC16659 Genetic susceptibility to tuberculosis in Africans: A genome-wide scan Richard Bellamy, Nulda Beyers, Keith P. W. J. McAdam, Cyril Ruwende, Robert Gie, Priscilla Samaai, Danite Bester, Mandy Meyer, Tumani Corrah, Matthew Collin, D. Ross Camidge, David Wilkinson, Eileen Hoal-van Helden, Hilton C. Whittle, William Amos, Paul van Helden, and Adrian V. S. Hill PMCID: PMC16660 Identification of Renox, an NAD(P)H oxidase in kidney Miklós Geiszt, Jeffrey B. Kopp, Péter Várnai, and Thomas L. Leto PMCID: PMC16661 Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice Fuad N. Ziyadeh, Brenda B. Hoffman, Dong Cheol Han, M. Carmen Iglesias-de la Cruz, Soon Won Hong, Motohide Isono, Sheldon Chen, Tracy A. McGowan, and Kumar Sharma PMCID: PMC16662 In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle Brendan Lee, Hong Yu, Farook Jahoor, William O'Brien, Arthur L. Beaudet, and Peter Reeds PMCID: PMC16663 Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity Yichen Lu, Rachel Friedman, Nicholas Kushner, Amy Doling, Lawrence Thomas, Neal Touzjian, Michael Starnbach, and Judy Lieberman PMCID: PMC16664 Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity Enzo Nisoli, Luca Briscini, Antonio Giordano, Cristina Tonello, Sarah M. Wiesbrock, K. Teoman Uysal, Saverio Cinti, Michele O. Carruba, and Gökhan S. Hotamisligil PMCID: PMC16665 Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy Vincent C. Emery and Paul D. Griffiths PMCID: PMC16666 Identification and characterization of a newly recognized population of high-Na+, low-K+, low-density sickle and normal red cells Robert M. Bookchin, Zipora Etzion, Martin Sorette, Narla Mohandas, Jeremy N. Skepper, and Virgilio L. Lew PMCID: PMC16667 Microbiology Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis Laurent Coscoy and Don Ganem PMCID: PMC16668 Differences in the polar clustering of the high- and low-abundance chemoreceptors of Escherichia coli S. R. Lybarger and J. R. Maddock PMCID: PMC16669 The transcriptional profile of early to middle sporulation in Bacillus subtilis Paul Fawcett, Patrick Eichenberger, Richard Losick, and Philip Youngman PMCID: PMC16670 Neurobiology A psychophysical dissection of the brain sites involved in color-generating comparisons K. Moutoussis and S. Zeki PMCID: PMC16671 Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival Olimpia Meucci, Alessandro Fatatis, Arthur A. Simen, and Richard J. Miller PMCID: PMC16672 Experience-dependent plasticity in the auditory cortex and the inferior colliculus of bats: Role of the corticofugal system Enquan Gao and Nobuo Suga PMCID: PMC16673 A neuronal network model of macaque primary visual cortex (V1):
Orientation selectivity and dynamics in the input layer 4Cα David McLaughlin, Robert Shapley, Michael Shelley, and D. J. Wielaard PMCID: PMC16674 Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease Mark Turmaine, Aysha Raza, Amarbirpal Mahal, Laura Mangiarini, Gillian P. Bates, and Stephen W. Davies PMCID: PMC16675 Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: Synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein–protein interactions Weiqin Zhao, Sebastiano Cavallaro, Pavel Gusev, and Daniel L. Alkon PMCID: PMC16676 From the Cover:
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia Anissa Abi-Dargham, Janine Rodenhiser, David Printz, Yolanda Zea-Ponce, Roberto Gil, Lawrence S. Kegeles, Richard Weiss, Thomas B. Cooper, J. John Mann, Ronald L. Van Heertum, Jack M. Gorman, and Marc Laruelle PMCID: PMC16677 Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo Rony Azouz and Charles M. Gray PMCID: PMC16678 Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene Cui-Wei Xie, David Sayah, Qi-Sheng Chen, Wei-Zheng Wei, Desmond Smith, and Xin Liu PMCID: PMC16679 Mushroom body defect, a gene involved in the control of neuroblast proliferation in Drosophila, encodes a coiled–coil protein Zhonghui Guan, Antonio Prado, Jörg Melzig, Martin Heisenberg, Howard A. Nash, and Thomas Raabe PMCID: PMC16680 Networks of interneurons with fast and slow γ-aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm John A. White, Matthew I. Banks, Robert A. Pearce, and Nancy J. Kopell PMCID: PMC16681 Acid potentiation of the capsaicin receptor determined by a key extracellular site Sven-Eric Jordt, Makoto Tominaga, and David Julius PMCID: PMC16682 Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors João B. Pesquero, Ronaldo C. Araujo, Paul A. Heppenstall, Cheryl L. Stucky, José A. Silva, Jr., Thomas Walther, Suzana M. Oliveira, Jorge L. Pesquero, Antonio C. M. Paiva, João B. Calixto, Gary R. Lewin, and Michael Bader PMCID: PMC16683 Retrograde axonal transport of herpes simplex virus: Evidence for a single mechanism and a role for tegument E. L. Bearer, X. O. Breakefield, D. Schuback, T. S. Reese, and J. H. LaVail PMCID: PMC16684 Pharmacology Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant Heike Wulff, Mark J. Miller, Wolfram Hänsel, Stephan Grissmer, Michael D. Cahalan, and K. George Chandy PMCID: PMC16685 Physiology Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy F. Lang, K. Klingel, C. A. Wagner, C. Stegen, S. Wärntges, B. Friedrich, M. Lanzendörfer, J. Melzig, I. Moschen, S. Steuer, S. Waldegger, M. Sauter, M. Paulmichl, V. Gerke, T. Risler, G. Gamba, G. Capasso, R. Kandolf, S. C. Hebert, S. G. Massry, and S. Bröer PMCID: PMC16686 Plant Biology CPP1, a DNA-binding protein involved in the expression of a soybean leghemoglobin c3 gene Cristina Cvitanich, Niels Pallisgaard, Kirsten A. Nielsen, Anette Chemnitz Hansen, Knud Larsen, Kaarina Pihakaski-Maunsbach, Kjeld A. Marcker, and Erik Østergaard Jensen PMCID: PMC16687 The histidine kinase-related domain participates in phytochrome B function but is dispensable Leonard Krall and Jason W. Reed PMCID: PMC16688 Galactolipid deficiency and abnormal chloroplast development in the Arabidopsis MGD synthase 1 mutant Paul Jarvis, Peter Dörmann, Charles A. Peto, Jason Lutes, Christoph Benning, and Joanne Chory PMCID: PMC16689 Population Biology Criteria for the control of drug-resistant tuberculosis Christopher Dye and Brian G. Williams PMCID: PMC16690 Psychology The emergence of visual objects in space–time Sergei Gepshtein and Michael Kubovy PMCID: PMC16691 Correction Proc Natl Acad Sci U S A. 2000 July 5; 97(14): 8192. PMCID: PMC56021 Corrects: Mark Achtman, et al. Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. Proc Natl Acad Sci U S A. 1999 November 23; 96(24): 14043–14048. |
