| | This journal provides immediate access to some articles. Commentaries A slippery boundary Andrew G. Clark Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4971–4972. Published online 2003 April 18. doi: 10.1073/pnas.0931310100.PMCID: PMC154279 Low-dose radiation: Thresholds, bystander effects, and adaptive responses William M. Bonner Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4973–4975. Published online 2003 April 18. doi: 10.1073/pnas.1031538100.PMCID: PMC154280 Knockout of the guard cell K+out channel and stomatal movements Julian I. Schroeder Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4976–4977. Published online 2003 April 18. doi: 10.1073/pnas.1031801100.PMCID: PMC154281 Nitroxyl gets to the heart of the matter Martin Feelisch Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4978–4980. Published online 2003 April 18. doi: 10.1073/pnas.1031571100.PMCID: PMC154282 Does clathrin pull the fission trigger? Gilbert Di Paolo and Pietro De Camilli Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4981–4983. Published online 2003 April 18. doi: 10.1073/pnas.0930650100.PMCID: PMC154283 Physical Sciences Applied Physical Sciences Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors Robert J. Chen, Sarunya Bangsaruntip, Katerina A. Drouvalakis, Nadine Wong Shi Kam, Moonsub Shim, Yiming Li, Woong Kim, Paul J. Utz, and Hongjie Dai Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4984–4989. Published online 2003 April 15. doi: 10.1073/pnas.0837064100.PMCID: PMC154284 Chemistry Observation of the cascaded atomic-to-global length scales driving protein motion M. R. Armstrong, J. P. Ogilvie, M. L. Cowan, A. M. Nagy, and R. J. D. Miller Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4990–4994. Published online 2003 April 15. doi: 10.1073/pnas.0936507100.PMCID: PMC154285 INAUGURAL ARTICLE by a Recently Elected Academy Member: A macromolecular delivery vehicle for protein-based vaccines: Acid-degradable protein-loaded microgels Niren Murthy, Mingcheng Xu, Stephany Schuck, Jun Kunisawa, Nilabh Shastri, and Jean M. J. Fréchet Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4995–5000. Published online 2003 April 18. doi: 10.1073/pnas.0930644100.PMCID: PMC154286 Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1 Christian F. W. Becker, Christie L. Hunter, Ralf Seidel, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5075–5080. Published online 2003 April 18. doi: 10.1073/pnas.0831227100.PMCID: PMC154300 Physics Lessons from Kepler and the theory of everything Lincoln Wolfenstein Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5001–5003. Published online 2003 April 17. doi: 10.1073/pnas.0931283100.PMCID: PMC154287 Biological Sciences Agricultural Sciences Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm Shai Morin, Robert W. Biggs, Mark S. Sisterson, Laura Shriver, Christa Ellers-Kirk, Dawn Higginson, Daniel Holley, Linda J. Gahan, David G. Heckel, Yves Carrière, Timothy J. Dennehy, Judith K. Brown, and Bruce E. Tabashnik Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5004–5009. Published online 2003 April 14. doi: 10.1073/pnas.0831036100.PMCID: PMC154288 Applied Biological Sciences Molecular characterization of the 1,3-propanediol (1,3-PD) operon of Clostridium butyricum Céline Raynaud, Patricia Sarçabal, Isabelle Meynial-Salles, Christian Croux, and Philippe Soucaille Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5010–5015. Published online 2003 April 18. doi: 10.1073/pnas.0734105100.PMCID: PMC154289 Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein Michael J. Root and Dean H. Hamer Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5016–5021. Published online 2003 April 17. doi: 10.1073/pnas.0936926100.PMCID: PMC154290 Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris Byung-Kwon Choi, Piotr Bobrowicz, Robert C. Davidson, Stephen R. Hamilton, David H. Kung, Huijuan Li, Robert G. Miele, Juergen H. Nett, Stefan Wildt, and Tillman U. Gerngross Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5022–5027. Published online 2003 April 17. doi: 10.1073/pnas.0931263100.PMCID: PMC154291 Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2 Rebekah R. White, Siqing Shan, Christopher P. Rusconi, Geetha Shetty, Mark W. Dewhirst, Christopher D. Kontos, and Bruce A. Sullenger Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5028–5033. Published online 2003 April 11. doi: 10.1073/pnas.0831159100.PMCID: PMC154292 Glucagon-like peptide 1 (1–37) converts intestinal epithelial cells into insulin-producing cells Atsushi Suzuki, Hiromitsu Nakauchi, and Hideki Taniguchi Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5034–5039. Published online 2003 April 17. doi: 10.1073/pnas.0936260100.PMCID: PMC154293 Biochemistry Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban Michio Asahi, Yuji Sugita, Kazimierz Kurzydlowski, Stella De Leon, Michihiko Tada, Chikashi Toyoshima, and David H. MacLennan Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5040–5045. Published online 2003 April 11. doi: 10.1073/pnas.0330962100.PMCID: PMC154294 Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug–topoisomerase complexes George Hong and Kenneth N. Kreuzer Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5046–5051. Published online 2003 April 18. doi: 10.1073/pnas.0835166100.PMCID: PMC154295 The riboswitch-mediated control of sulfur metabolism in bacteria Vitaly Epshtein, Alexander S. Mironov, and Evgeny Nudler Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5052–5056. Published online 2003 April 17. doi: 10.1073/pnas.0531307100.PMCID: PMC154296 From the Cover: Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses Kai Rothkamm and Markus Löbrich Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5057–5062. Published online 2003 April 4. doi: 10.1073/pnas.0830918100.PMCID: PMC154297 The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism Michael Engel, Torsten Hoffmann, Leona Wagner, Michael Wermann, Ulrich Heiser, Reiner Kiefersauer, Robert Huber, Wolfram Bode, Hans-Ulrich Demuth, and Hans Brandstetter Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5063–5068. Published online 2003 April 10. doi: 10.1073/pnas.0230620100.PMCID: PMC154298 Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding Valérie Campanacci, Audrey Lartigue, B. Martin Hällberg, T. Alwyn Jones, Marie-Therèse Giudici-Orticoni, Mariella Tegoni, and Christian Cambillau Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5069–5074. Published online 2003 April 15. doi: 10.1073/pnas.0836654100.PMCID: PMC154299 Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1 Christian F. W. Becker, Christie L. Hunter, Ralf Seidel, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5075–5080. Published online 2003 April 18. doi: 10.1073/pnas.0831227100.PMCID: PMC154300 γ2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate Maria H. Hamilton, Lana A. Cook, Theodore R. McRackan, Kevin L. Schey, and John D. Hildebrandt Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5081–5086. Published online 2003 April 16. doi: 10.1073/pnas.0831228100.PMCID: PMC154301 Group B streptococcal phospholipid causes pulmonary hypertension Jerri Curtis, Geumsoo Kim, Nancy B. Wehr, and Rodney L. Levine Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5087–5090. Published online 2003 April 17. doi: 10.1073/pnas.0931493100.PMCID: PMC154302 Identifying residue–residue clashes in protein hybrids by using a second-order mean-field approach Gregory L. Moore and Costas D. Maranas Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5091–5096. Published online 2003 April 16. doi: 10.1073/pnas.0831190100.PMCID: PMC154303 Activation of archaeal transcription by recruitment of the TATA-binding protein Mohamed Ouhammouch, Robert E. Dewhurst, Winfried Hausner, Michael Thomm, and E. Peter Geiduschek Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5097–5102. Published online 2003 April 11. doi: 10.1073/pnas.0837150100.PMCID: PMC154304 Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin Jun Wang, Ephrem Tekle, Hammou Oubrahim, John J. Mieyal, Earl R. Stadtman, and P. Boon Chock Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5103–5106. Published online 2003 April 15. doi: 10.1073/pnas.0931345100.PMCID: PMC154305 Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver Tsutomu Kabashima, Takumi Kawaguchi, Brian E. Wadzinski, and Kosaku Uyeda Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5107–5112. Published online 2003 April 8. doi: 10.1073/pnas.0730817100.PMCID: PMC154306 Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate M. Todd Washington, William T. Wolfle, Thomas E. Spratt, Louise Prakash, and Satya Prakash Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5113–5118. Published online 2003 April 11. doi: 10.1073/pnas.0837578100.PMCID: PMC154307 Plasma antioxidant status and cell injury after severe physical exercise Shlomit Chevion, Danny S. Moran, Yuval Heled, Yoav Shani, Gilad Regev, Benny Abbou, Eduard Berenshtein, Earl R. Stadtman, and Yoram Epstein Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5119–5123. Published online 2003 April 17. doi: 10.1073/pnas.0831097100.PMCID: PMC154308 Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells Mujib M. Rahman, Hiroshi Miyamoto, Henry Lardy, and Chawnshang Chang Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5124–5129. Published online 2003 April 16. doi: 10.1073/pnas.0530097100.PMCID: PMC154309 Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase Carolyn R. Hoyal, Abel Gutierrez, Brandon M. Young, Sergio D. Catz, Jun-Hsiang Lin, Philip N. Tsichlis, and Bernard M. Babior Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5130–5135. Published online 2003 April 18. doi: 10.1073/pnas.1031526100.PMCID: PMC154310 Biophysics On schemes of combinatorial transcription logic Nicolas E. Buchler, Ulrich Gerland, and Terence Hwa Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5136–5141. Published online 2003 April 17. doi: 10.1073/pnas.0930314100.PMCID: PMC404558 The molecular basis for the chemical denaturation of proteins by urea Brian J. Bennion and Valerie Daggett Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5142–5147. Published online 2003 April 17. doi: 10.1073/pnas.0930122100.PMCID: PMC154312 Simulating disorder–order transitions in molecular recognition of unstructured proteins: Where folding meets binding Gennady M. Verkhivker, Djamal Bouzida, Daniel K. Gehlhaar, Paul A. Rejto, Stephan T. Freer, and Peter W. Rose Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5148–5153. Published online 2003 April 15. doi: 10.1073/pnas.0531373100.PMCID: PMC154313 The role of side-chain interactions in the early steps of aggregation: Molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35 Jörg Gsponer, Urs Haberthür, and Amedeo Caflisch Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5154–5159. Published online 2003 April 16. doi: 10.1073/pnas.0835307100.PMCID: PMC154314 A defined protein–detergent–lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis Huamin Zhang, Genji Kurisu, Janet L. Smith, and William A. Cramer Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5160–5163. Published online 2003 April 17. doi: 10.1073/pnas.0931431100.PMCID: PMC154315 Cell Biology Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes Vikas K. Goel, Xuerong Li, Huiqing Chen, Shih-Chun Liu, Athar H. Chishti, and Steven S. Oh Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5164–5169. Published online 2003 April 11. doi: 10.1073/pnas.0834959100.PMCID: PMC154316 Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor Heather M. Scobie, G. Jonah A. Rainey, Kenneth A. Bradley, and John A. T. Young Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5170–5174. Published online 2003 April 16. doi: 10.1073/pnas.0431098100.PMCID: PMC154317 From the Cover: Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA T.-G. Iversen, G. Skretting, B. van Deurs, and K. Sandvig Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5175–5180. Published online 2003 April 7. doi: 10.1073/pnas.0534231100.PMCID: PMC154318 Cell spreading controls endoplasmic and nuclear calcium: A physical gene regulation pathway from the cell surface to the nucleus Naoki Itano, Shu-ichi Okamoto, Dongxian Zhang, Stuart A. Lipton, and Erkki Ruoslahti Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5181–5186. Published online 2003 April 17. doi: 10.1073/pnas.0531397100.PMCID: PMC154319 Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells Hervør L. Olsen, Marianne Høy, Wei Zhang, Alejandro M. Bertorello, Krister Bokvist, Kirsten Capito, Alexander M. Efanov, Björn Meister, Peter Thams, Shao-Nian Yang, Patrik Rorsman, Per-Olof Berggren, and Jesper Gromada Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5187–5192. Published online 2003 April 16. doi: 10.1073/pnas.0931282100.PMCID: PMC154320 Cripto forms a complex with activin and type II activin receptors and can block activin signaling Peter C. Gray, Craig A. Harrison, and Wylie Vale Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5193–5198. Published online 2003 April 7. doi: 10.1073/pnas.0531290100.PMCID: PMC154321 Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation Carsten Lambert and Reinhild Prange Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5199–5204. Published online 2003 April 15. doi: 10.1073/pnas.0930813100.PMCID: PMC154322 Acidic pH induces topoisomerase II-mediated DNA damage Hai Xiao, Tsai-Kun Li, Jin-Ming Yang, and Leroy F. Liu Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5205–5210. Published online 2003 April 11. doi: 10.1073/pnas.0935978100.PMCID: PMC154323 Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis Robert A. Screaton, Stephan Kiessling, Owen J. Sansom, Catherine B. Millar, Kathryn Maddison, Adrian Bird, Alan R. Clarke, and Steven M. Frisch Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5211–5216. Published online 2003 April 17. doi: 10.1073/pnas.0431215100.PMCID: PMC154324 Developmental Biology A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3 Wenlin Yuan, Yi Rao, Randal P. Babiuk, John Greer, Jane Y. Wu, and David M. Ornitz Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5217–5222. Published online 2003 April 17. doi: 10.1073/pnas.0730709100.PMCID: PMC154325 The functional analysis of insulator interactions in the Drosophila embryo Parimal Majumder and Haini N. Cai Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5223–5228. Published online 2003 April 16. doi: 10.1073/pnas.0830190100.PMCID: PMC154326 Reversal of developmental restrictions in neural crest lineages: Transition from Schwann cells to glial-melanocytic precursors in vitro Elisabeth Dupin, Carla Real, Corinne Glavieux-Pardanaud, Pierre Vaigot, and Nicole M. Le Douarin Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5229–5233. Published online 2003 April 17. doi: 10.1073/pnas.0831229100.PMCID: PMC154327 Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways Shaolin Shi and Pamela Stanley Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5234–5239. Published online 2003 April 15. doi: 10.1073/pnas.0831126100.PMCID: PMC154328 BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development Marta Kostrouchova, Zdenek Kostrouch, Vladimir Saudek, Joram Piatigorsky, and Joseph Edward Rall Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5240–5245. Published online 2003 April 7. doi: 10.1073/pnas.0730770100.PMCID: PMC154329 Ecology Predicted correspondence between species abundances and dendrograms of niche similarities George Sugihara, Louis-Félix Bersier, T. Richard E. Southwood, Stuart L. Pimm, and Robert M. May Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5246–5251. Published online 2003 April 17. doi: 10.1073/pnas.0831096100.PMCID: PMC154330 Evolution Directional selection has shaped the oral jaws of Lake Malawi cichlid fishes R. Craig Albertson, J. Todd Streelman, and Thomas D. Kocher Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5252–5257. Published online 2003 April 18. doi: 10.1073/pnas.0930235100.PMCID: PMC154331 From the Cover: The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species Mineyo Iwase, Yoko Satta, Yuriko Hirai, Hirohisa Hirai, Hirotami Imai, and Naoyuki Takahata Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5258–5263. Published online 2003 April 2. doi: 10.1073/pnas.0635848100.PMCID: PMC154332 An obligate pollination mutualism and reciprocal diversification in the tree genus Glochidion (Euphorbiaceae) Makoto Kato, Atsushi Takimura, and Atsushi Kawakita Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5264–5267. Published online 2003 April 14. doi: 10.1073/pnas.0837153100.PMCID: PMC154333 The genetic basis of adaptive melanism in pocket mice Michael W. Nachman, Hopi E. Hoekstra, and Susan L. D'Agostino Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5268–5273. Published online 2003 April 18. doi: 10.1073/pnas.0431157100.PMCID: PMC154334 Genetics On schemes of combinatorial transcription logic Nicolas E. Buchler, Ulrich Gerland, and Terence Hwa Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5136–5141. Published online 2003 April 17. doi: 10.1073/pnas.0930314100.PMCID: PMC404558 Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development Casey L. Moulson, Daniel R. Martin, Jesse J. Lugus, Jean E. Schaffer, Anne C. Lind, and Jeffrey H. Miner Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5274–5279. Published online 2003 April 15. doi: 10.1073/pnas.0431186100.PMCID: PMC154335 Hot L1s account for the bulk of retrotransposition in the human population Brook Brouha, Joshua Schustak, Richard M. Badge, Sheila Lutz-Prigge, Alexander H. Farley, John V. Moran, and Haig H. Kazazian, Jr. Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5280–5285. Published online 2003 April 7. doi: 10.1073/pnas.0831042100.PMCID: PMC154336 Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease Fangming Lin, Thomas Hiesberger, Kimberly Cordes, Angus M. Sinclair, Lawrence S. B. Goldstein, Stefan Somlo, and Peter Igarashi Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5286–5291. Published online 2003 April 2. doi: 10.1073/pnas.0836980100.PMCID: PMC154337 Dispersal of NK homeobox gene clusters in amphioxus and humans Graham N. Luke, L. Filipe C. Castro, Kirsten McLay, Christine Bird, Alan Coulson, and Peter W. H. Holland Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5292–5295. Published online 2003 April 18. doi: 10.1073/pnas.0836141100.PMCID: PMC154338 A 1-Mb resolution radiation hybrid map of the canine genome Richard Guyon, Travis D. Lorentzen, Christophe Hitte, Lisa Kim, Edouard Cadieu, Heidi G. Parker, Pascale Quignon, Jennifer K. Lowe, Corinne Renier, Boris Gelfenbeyn, Françoise Vignaux, Hawkins B. DeFrance, Stephanie Gloux, Gregory G. Mahairas, Catherine André, Francis Galibert, and Elaine A. Ostrander Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5296–5301. Published online 2003 April 16. doi: 10.1073/pnas.0831002100.PMCID: PMC154339 A rapidly evolving MYB-related protein causes species isolation in Drosophila Daniel A. Barbash, Dominic F. Siino, Aaron M. Tarone, and John Roote Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5302–5307. Published online 2003 April 14. doi: 10.1073/pnas.0836927100.PMCID: PMC154340 Phage HK022 Nun protein represses translation of phage λ N (transcription termination/translation repression) Hyeong C. Kim, Jian-guang Zhou, Helen R. Wilson, Grigoriy Mogilnitskiy, Donald L. Court, and Max E. Gottesman Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5308–5312. Published online 2003 April 8. doi: 10.1073/pnas.0430995100.PMCID: PMC154341 A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites Timothy J. Haggerty, Karen I. Zeller, Rebecca C. Osthus, Diane R. Wonsey, and Chi V. Dang Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5313–5318. Published online 2003 April 17. doi: 10.1073/pnas.0931346100.PMCID: PMC154342 Immunology Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1) Toshiaki Ara, Yuri Nakamura, Takeshi Egawa, Tatsuki Sugiyama, Kuniya Abe, Tadamitsu Kishimoto, Yasuhisa Matsui, and Takashi Nagasawa Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5319–5323. Published online 2003 April 8. doi: 10.1073/pnas.0730719100.PMCID: PMC154343 An important regulatory role for CD4+CD8αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease Gobardhan Das, Mathew M. Augustine, Jyoti Das, Kim Bottomly, Prabir Ray, and Anuradha Ray Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5324–5329. Published online 2003 April 14. doi: 10.1073/pnas.0831037100.PMCID: PMC154344 Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition Anish Suri, James J. Walters, Osami Kanagawa, Michael L. Gross, and Emil R. Unanue Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5330–5335. Published online 2003 April 7. doi: 10.1073/pnas.0330859100.PMCID: PMC154345 PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells P'ng Loke and James P. Allison Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5336–5341. Published online 2003 April 15. doi: 10.1073/pnas.0931259100.PMCID: PMC154346 Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC Emanual Maverakis, Jonathan Beech, David B. Stevens, Akio Ametani, Laurent Brossay, Peter van den Elzen, Richard Mendoza, Quoc Thai, Luis H. Macias, Doug Ethell, Celia W. Campagnoni, Anthony T. Campagnoni, Alessandro Sette, and Eli E. Sercarz Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5342–5347. Published online 2003 April 21. doi: 10.1073/pnas.0936151100.PMCID: PMC154347 Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering Lara Myers, Chikara Takahashi, Robert S. Mittler, Robert J. Rossi, and Anthony T. Vella Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5348–5353. Published online 2003 April 14. doi: 10.1073/pnas.0837611100.PMCID: PMC154348 Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection Christophe Viret, Xin He, and Charles A. Janeway, Jr. Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5354–5359. Published online 2003 April 16. doi: 10.1073/pnas.0831129100.PMCID: PMC154349 Medical Sciences Virus-like interference in the latency and prevention of Creutzfeldt–Jakob disease Laura Manuelidis and Zhi Yun Lu Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5360–5365. Published online 2003 April 11. doi: 10.1073/pnas.0931192100.PMCID: PMC154350 Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding Andrea E. Prota, Jacquelyn A. Campbell, Pierre Schelling, J. Craig Forrest, Melissa J. Watson, Timothy R. Peters, Michel Aurrand-Lions, Beat A. Imhof, Terence S. Dermody, and Thilo Stehle Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5366–5371. Published online 2003 April 15. doi: 10.1073/pnas.0937718100.PMCID: PMC404559 Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma Nicole Y. Fang, Timothy C. Greiner, Dennis D. Weisenburger, Wing C. Chan, Julie M. Vose, Lynette M. Smith, James O. Armitage, R. Aeryn Mayer, Brian L. Pike, Francis S. Collins, and Joseph G. Hacia Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5372–5377. Published online 2003 April 15. doi: 10.1073/pnas.0831102100.PMCID: PMC154352 Telomere attrition and Chk2 activation in human heart failure Hidemasa Oh, Sam C. Wang, Arun Prahash, Motoaki Sano, Christine S. Moravec, George E. Taffet, Lloyd H. Michael, Keith A. Youker, Mark L. Entman, and Michael D. Schneider Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5378–5383. Published online 2003 April 17. doi: 10.1073/pnas.0836098100.PMCID: PMC154353 Cancer cachexia: Its correlations and causes Harry Rubin Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5384–5389. Published online 2003 April 17. doi: 10.1073/pnas.0931260100.PMCID: PMC154354 Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: Chemoprevention strategies with antioxidants Ayelet M. Samuni, Eric Y. Chuang, Murali C. Krishna, William Stein, William DeGraff, Angelo Russo, and James B. Mitchell Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5390–5395. Published online 2003 April 17. doi: 10.1073/pnas.0930078100.PMCID: PMC154355 Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst Christoph Rader, Subhash C. Sinha, Mikhail Popkov, Richard A. Lerner, and Carlos F. Barbas, III Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5396–5400. Published online 2003 April 17. doi: 10.1073/pnas.0931308100.PMCID: PMC154356 Cancer-related changes in prostate DNA as men age and early identification of metastasis in primary prostate tumors Donald C. Malins, Paul M. Johnson, Edward A. Barker, Nayak L. Polissar, Thomas M. Wheeler, and Katie M. Anderson Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5401–5406. Published online 2003 April 17. doi: 10.1073/pnas.0931396100.PMCID: PMC154357 Delivery of bioactive molecules to mitochondria in vivo Robin A. J. Smith, Carolyn M. Porteous, Alison M. Gane, and Michael P. Murphy Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5407–5412. Published online 2003 April 15. doi: 10.1073/pnas.0931245100.PMCID: PMC154358 Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics M. P. Lutolf, J. L. Lauer-Fields, H. G. Schmoekel, A. T. Metters, F. E. Weber, G. B. Fields, and J. A. Hubbell Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5413–5418. Published online 2003 April 9. doi: 10.1073/pnas.0737381100.PMCID: PMC154359 Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Bryan A. Laffitte, Lily C. Chao, Jing Li, Robert Walczak, Sarah Hummasti, Sean B. Joseph, Antonio Castrillo, Damien C. Wilpitz, David J. Mangelsdorf, Jon L. Collins, Enrique Saez, and Peter Tontonoz Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5419–5424. Published online 2003 April 15. doi: 10.1073/pnas.0830671100.PMCID: PMC154360 Genetic changes occurring in established tumors rapidly stimulate new antibody responses Michael T. Spiotto, Michael A. Reth, and Hans Schreiber Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5425–5430. Published online 2003 April 17. doi: 10.1073/pnas.0930140100.PMCID: PMC154361 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) Seiji Kondo, Ying Lu, Michael Debbas, Athena W. Lin, Ildiko Sarosi, Annick Itie, Andrew Wakeham, JoAnn Tuan, Chris Saris, Gary Elliott, Weili Ma, Samuel Benchimol, Scott W. Lowe, Tak Wah Mak, and Sushil K. Thukral Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5431–5436. Published online 2003 April 17. doi: 10.1073/pnas.0530308100.PMCID: PMC154362 Microbiology Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest Rutilio A. Fratti, Jennifer Chua, Isabelle Vergne, and Vojo Deretic Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5437–5442. Published online 2003 April 17. doi: 10.1073/pnas.0737613100.PMCID: PMC154363 Extracellular polysaccharides mediate pilus retraction during social motility of Myxococcus xanthus Yinuo Li, Hong Sun, Xiaoyuan Ma, Ann Lu, Renate Lux, David Zusman, and Wenyuan Shi Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5443–5448. Published online 2003 April 18. doi: 10.1073/pnas.0836639100.PMCID: PMC154364 A sensitive, versatile microfluidic assay for bacterial chemotaxis Hanbin Mao, Paul S. Cremer, and Michael D. Manson Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5449–5454. Published online 2003 April 18. doi: 10.1073/pnas.0931258100.PMCID: PMC154365 Complete genome sequence of the Q-fever pathogen Coxiella burnetii Rekha Seshadri, Ian T. Paulsen, Jonathan A. Eisen, Timothy D. Read, Karen E. Nelson, William C. Nelson, Naomi L. Ward, Hervé Tettelin, Tanja M. Davidsen, Maureen J. Beanan, Robert T. Deboy, Sean C. Daugherty, Lauren M. Brinkac, Ramana Madupu, Robert J. Dodson, Hoda M. Khouri, Kathy H. Lee, Heather A. Carty, David Scanlan, Robert A. Heinzen, Herbert A. Thompson, James E. Samuel, Claire M. Fraser, and John F. Heidelberg Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5455–5460. Published online 2003 April 18. doi: 10.1073/pnas.0931379100.PMCID: PMC154366 Neuroscience Modular organization of internal models of tools in the human cerebellum Hiroshi Imamizu, Tomoe Kuroda, Satoru Miyauchi, Toshinori Yoshioka, and Mitsuo Kawato Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5461–5466. Published online 2003 April 18. doi: 10.1073/pnas.0835746100.PMCID: PMC154367 Subtask sequencing in the primary visual cortex Pieter R. Roelfsema, Paul S. Khayat, and Henk Spekreijse Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5467–5472. Published online 2003 April 14. doi: 10.1073/pnas.0431051100.PMCID: PMC154368 Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration Peter Teismann, Kim Tieu, Dong-Kug Choi, Du-Chu Wu, Ali Naini, Stéphane Hunot, Miquel Vila, Vernice Jackson-Lewis, and Serge Przedborski Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5473–5478. Published online 2003 April 17. doi: 10.1073/pnas.0837397100.PMCID: PMC154369 A reelin–integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes Erbo Dong, Hector Caruncho, Wen Sheng Liu, Neil R. Smalheiser, Dennis R. Grayson, Erminio Costa, and Alessandro Guidotti Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5479–5484. Published online 2003 April 21. doi: 10.1073/pnas.1031602100.PMCID: PMC154370 γ-Aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: Adult RNA interference and pharmacological evidence Svetlana Dzitoyeva, Nikola Dimitrijevic, and Hari Manev Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5485–5490. Published online 2003 April 11. doi: 10.1073/pnas.0830111100.PMCID: PMC154371 Analysis of gene expression in the developing mouse retina Elva Díaz, Yee Hwa Yang, Todd Ferreira, Kenneth C. Loh, Yasushi Okazaki, Yoshihide Hayashizaki, Marc Tessier-Lavigne, Terence P. Speed, and John Ngai Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5491–5496. Published online 2003 April 17. doi: 10.1073/pnas.0831080100.PMCID: PMC154372 Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas Laurie Carr, Marco Iacoboni, Marie-Charlotte Dubeau, John C. Mazziotta, and Gian Luigi Lenzi Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5497–5502. Published online 2003 April 7. doi: 10.1073/pnas.0935845100.PMCID: PMC154373 N-methyl-d-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses Nataša Savić, Andreas Lüthi, Beat H. Gähwiler, and R. Anne McKinney Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5503–5508. Published online 2003 April 17. doi: 10.1073/pnas.0831035100.PMCID: PMC154374 Selective heteromeric assembly of cyclic nucleotide-gated channels Haining Zhong, Jun Lai, and King-Wai Yau Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5509–5513. Published online 2003 April 16. doi: 10.1073/pnas.0931279100.PMCID: PMC154375 Motion generation by Drosophila mechanosensory neurons M. C. Göpfert and D. Robert Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5514–5519. Published online 2003 March 17. doi: 10.1073/pnas.0737564100.PMCID: PMC154376 Naturalizing consciousness: A theoretical framework Gerald M. Edelman Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5520–5524. Published online 2003 April 17. doi: 10.1073/pnas.0931349100.PMCID: PMC154377 Pharmacology Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation Alan S. Kopin, Edward W. McBride, Ci Chen, Roger M. Freidinger, Duan Chen, Chun-Mei Zhao, and Martin Beinborn Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5525–5530. Published online 2003 April 15. doi: 10.1073/pnas.0831223100.PMCID: PMC154378 Involvement of β3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function Giuseppe Cirino, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca, Ada Popolo, Alessandro Palmieri, Ciro Imbimbo, Ferdinando Fusco, Nicola Longo, Gianfranco Tajana, Louis J. Ignarro, and Vincenzo Mirone Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5531–5536. Published online 2003 April 21. doi: 10.1073/pnas.0931347100.PMCID: PMC154379 From the Cover: Positive inotropic and lusitropic effects of HNO/NO− in failing hearts: Independence from β-adrenergic signaling Nazareno Paolocci, Tatsuo Katori, Hunter C. Champion, Marcus E. St. John, Katrina M. Miranda, Jon M. Fukuto, David A. Wink, and David A. Kass Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5537–5542. Published online 2003 April 18. doi: 10.1073/pnas.0937302100.PMCID: PMC154380 Physiology Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity Matteo E. Mangoni, Brigitte Couette, Emmanuel Bourinet, Josef Platzer, Daniel Reimer, Jörg Striessnig, and Joël Nargeot Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5543–5548. Published online 2003 April 16. doi: 10.1073/pnas.0935295100.PMCID: PMC154381 Plant Biology The Arabidopsis outward K+ channel GORK is involved in regulation of stomatal movements and plant transpiration Eric Hosy, Alain Vavasseur, Karine Mouline, Ingo Dreyer, Frédéric Gaymard, Fabien Porée, Jossia Boucherez, Anne Lebaudy, David Bouchez, Anne-Aliénor Véry, Thierry Simonneau, Jean-Baptiste Thibaud, and Hervé Sentenac Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5549–5554. Published online 2003 April 1. doi: 10.1073/pnas.0733970100.PMCID: PMC154382 From the Cover: Overexpression of barley BAX inhibitor 1 induces breakdown of mlo-mediated penetration resistance to Blumeria graminis Ralph Hückelhoven, Cornelia Dechert, and Karl-Heinz Kogel Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5555–5560. Published online 2003 April 18. doi: 10.1073/pnas.0931464100.PMCID: PMC154383 Cell division pattern influences gene expression in the shoot apical meristem Joanna Wyrzykowska and Andrew Fleming Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5561–5566. Published online 2003 April 17. doi: 10.1073/pnas.0930352100.PMCID: PMC154384 Psychology Speech–sound-selective auditory impairment in children with autism: They can perceive but do not attend R. Čeponienė, T. Lepistö, A. Shestakova, R. Vanhala, P. Alku, R. Näätänen, and K. Yaguchi Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5567–5572. Published online 2003 April 17. doi: 10.1073/pnas.0835631100.PMCID: PMC154385 Corrections Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5573. Published online 2003 April 9. doi: 10.1073/pnas.1030820100.PMCID: PMC154277 Corrects: Sophie Schwartz, et al. Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination. Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17137–17142. Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5573. Published online 2003 April 10. doi: 10.1073/pnas.1031189100.PMCID: PMC154278 Corrects: William E. Williams, et al. Surface gas-exchange processes of snow algae. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 562–566. |