| | This journal provides immediate access to some articles. Editorial Making Back Issues of PNAS Online Free Nicholas R. Cozzarelli PMCID: PMC33965 Commentaries How close are we to implementing gene targeting in animals other
than the mouse? Mario R. Capecchi PMCID: PMC33966 Novel antimicrobial targets from combined pathogen and
host genetics Carl D. Johnson and Leo X. Liu PMCID: PMC33967 A groovy new structure Eva J. Neer and Temple F. Smith PMCID: PMC33968 Perspective Brown dwarfs: At last filling the gap between stars and planets Ben Zuckerman PMCID: PMC33969 Physical Sciences Applied Mathematics Effective dimensional reduction algorithm for eigenvalue problems for thin elastic structures: A paradigm in three dimensions Evgueni E. Ovtchinnikov and Leonidas S. Xanthis PMCID: PMC15490 Applied Physical Sciences Configurations for a proof of principle stellarator experiment P. R. Garabedian PMCID: PMC15491 Chemistry A relation between the principal axes of inertia and ligand binding Jefferson Foote and Anandi Raman PMCID: PMC15493 Computer Sciences From the Cover:
Using lateral capillary forces to compute by self-assembly Paul W. K. Rothemund PMCID: PMC15495 Rational discovery of novel nuclear hormone receptor antagonists Matthieu Schapira, Bruce M. Raaka, Herbert H. Samuels, and Ruben Abagyan PMCID: PMC15503 Geophysics A habitat for psychrophiles in deep Antarctic ice P. Buford Price PMCID: PMC15584 Biological Sciences Agricultural Sciences From the Cover:
Six cloned calves produced from adult fibroblast cells after
long-term culture Chikara Kubota, Hiroshi Yamakuchi, Junichi Todoroki, Kazunori Mizoshita, Norio Tabara, Michele Barber, and Xiangzhong Yang PMCID: PMC15497 Applied Biological Sciences Single-target molecule detection with nonbleaching multicolor optical immunolabels Sheldon Schultz, David R. Smith, Jack J. Mock, and David A. Schultz PMCID: PMC15499 Optimization of the helper-dependent adenovirus system for production and potency in vivo Volker Sandig, Rima Youil, Andrew J. Bett, Laura L. Franlin, Masanobu Oshima, Domenico Maione, Fubao Wang, Michael L. Metzker, Rocco Savino, and C. Thomas Caskey PMCID: PMC15501 Biochemistry Rational discovery of novel nuclear hormone receptor antagonists Matthieu Schapira, Bruce M. Raaka, Herbert H. Samuels, and Ruben Abagyan PMCID: PMC15503 A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes Tony T. Huang, Nobuaki Kudo, Minoru Yoshida, and Shigeki Miyamoto PMCID: PMC15505 CBP/p300 interact with and function as transcriptional coactivators of BRCA1 Gerald M. Pao, Ralf Janknecht, Heinz Ruffner, Tony Hunter, and Inder M. Verma PMCID: PMC15508 Enhanced association of mutant triosephosphate isomerase to red cell membranes and to brain microtubules F. Orosz, G. Wágner, K. Liliom, J. Kovács, K. Baróti, M. Horányi, T. Farkas, S. Hollán, and J. Ovádi PMCID: PMC15510 Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome Carol A. Lange, Tianjie Shen, and Kathryn B. Horwitz PMCID: PMC15511 A family of chromatin remodeling factors related to Williams syndrome transcription factor Daniel A. Bochar, Julie Savard, Weidong Wang, David W. Lafleur, Paul Moore, Jacques Côté, and Ramin Shiekhattar PMCID: PMC15513 Permeation and gating residues in serotonin transporter Jie-Guang Chen and Gary Rudnick PMCID: PMC15515 A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins Heike Lange, Anita Kaut, Gyula Kispal, and Roland Lill PMCID: PMC15518 Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5 Xianbo Zhou, Victoria M. Richon, Richard A. Rifkind, and Paul A. Marks PMCID: PMC15519 Biosynthesis of terpenoids: YchB protein of Escherichia
coli phosphorylates the 2-hydroxy group
of 4-diphosphocytidyl-2C-methyl-d-erythritol Holger Lüttgen, Felix Rohdich, Stefan Herz, Juraithip Wungsintaweekul, Stefan Hecht, Christoph A. Schuhr, Monika Fellermeier, Sylvia Sagner, Meinhart H. Zenk, Adelbert Bacher, and Wolfgang Eisenreich PMCID: PMC15522 Biophysics Charge conductivity in peptides: Dynamic simulations of a bifunctional model supporting experimental data E. W. Schlag, Sheh-Yi Sheu, Dah-Yen Yang, H. L. Selzle, and S. H. Lin PMCID: PMC15524 Electric field effect on cholesterol–phospholipid complexes Arun Radhakrishnan and Harden M. McConnell PMCID: PMC15525 Rapid nanopore discrimination between single polynucleotide molecules Amit Meller, Lucas Nivon, Eric Brandin, Jene Golovchenko, and Daniel Branton PMCID: PMC15527 Cell Biology Localization of a peripheral membrane protein: Gβγ targets GαZ C. Simone Fishburn, Sonia K. Pollitt, and Henry R. Bourne PMCID: PMC15529 Actin coating of secretory granules during regulated exocytosis correlates with the release of rab3D Jack A. Valentijn, Karine Valentijn, Lisa M. Pastore, and James D. Jamieson PMCID: PMC15531 From the Cover:
Peptide-in-groove interactions link target proteins to the β-propeller of clathrin Ernst ter Haar, Stephen C. Harrison, and Tomas Kirchhausen PMCID: PMC15533 Mouse VAP33 is associated with the endoplasmic reticulum and microtubules P. A. Skehel, R. Fabian-Fine, and E. R. Kandel PMCID: PMC15535 Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p W.-T. Walter Lau, Russell W. Howson, Per Malkus, Randy Schekman, and Erin K. O'Shea PMCID: PMC15537 Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway Shunichi Murakami, Mikio Kan, Wallace L. McKeehan, and Benoit de Crombrugghe PMCID: PMC15539 Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity Audrey Claing, Stephen J. Perry, Mircea Achiriloaie, Julia K. L. Walker, Joseph P. Albanesi, Robert J. Lefkowitz, and Richard T. Premont PMCID: PMC15541 The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and
GLUT1 glucose transporters and regulates transporter levels in skeletal
muscle cells Francesco Giorgino, Ottilia de Robertis, Luigi Laviola, Carmela Montrone, Sebastio Perrini, Karen C. McCowen, and Robert J. Smith PMCID: PMC15543 Expression of guanylin in “pars tuberalis-specific cells” and gonadotrophs of rat adenohypophysis Loredana D'Este, Hasan Kulaksiz, Ulrich Rausch, Rosa Vaccaro, Tibor Wenger, Yoshimitsu Tokunaga, Tindaro G. Renda, and Yalcin Cetin PMCID: PMC15545 Genetics Genomic interval engineering of mice identifies a novel modulator of triglyceride production Yiwen Zhu, Miek C. Jong, Kelly A. Frazer, Elaine Gong, Ronald M. Krauss, Jan-Fang Cheng, Dario Boffelli, and Edward M. Rubin PMCID: PMC15548 From the Cover:
Toward a protein–protein interaction map of the budding yeast: A
comprehensive system to examine two-hybrid interactions in all possible
combinations between the yeast proteins Takashi Ito, Kosuke Tashiro, Shigeru Muta, Ritsuko Ozawa, Tomoko Chiba, Mayumi Nishizawa, Kiyoshi Yamamoto, Satoru Kuhara, and Yoshiyuki Sakaki PMCID: PMC15550 Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice Emily V. Howman, Kerry J. Fowler, Ainsley J. Newson, Saara Redward, Andrew C. MacDonald, Paul Kalitsis, and K. H. Andy Choo PMCID: PMC15551 TAF250 is required for multiple developmental events
in Drosophila David A. Wassarman, Norikazu Aoyagi, Lori A. Pile, and Erin M. Schlag PMCID: PMC15553 Recent, extensive, and preferential insertion of members of the miniature inverted-repeat transposable element family Heartbreaker into genic regions of maize Qiang Zhang, John Arbuckle, and Susan R. Wessler PMCID: PMC15555 Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally Gloria Esposito, Gemma Texido, Ulrich A. K. Betz, Hua Gu, Werner Müller, Ulf Klein, and Klaus Rajewsky PMCID: PMC15557 Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes Rachel E. Ellsworth, D. Curtis Jamison, Jeffrey W. Touchman, Stephanie L. Chissoe, Valerie V. Braden Maduro, Gerard G. Bouffard, Nicole L. Dietrich, Stephen M. Beckstrom-Sternberg, Leslie M. Iyer, Lauren A. Weintraub, Marc Cotton, Laura Courtney, Jennifer Edwards, Rachel Maupin, Philip Ozersky, Theresa Rohlfing, Patricia Wohldmann, Tracie Miner, Kimberley Kemp, Jason Kramer, Ian Korf, Kimberlie Pepin, Lucinda Antonacci-Fulton, Robert S. Fulton, Patrick Minx, LaDeana W. Hillier, Richard K. Wilson, Robert H. Waterston, Webb Miller, and Eric D. Green PMCID: PMC15558 Immunology A relation between the principal axes of inertia and ligand binding Jefferson Foote and Anandi Raman PMCID: PMC15493 HIV-1 envelope induces activation of caspase-3 and cleavage of
focal adhesion kinase in primary human CD4+ T cells Claudia Cicala, James Arthos, Andrea Rubbert, Sara Selig, Kathryn Wildt, Oren J. Cohen, and Anthony S. Fauci PMCID: PMC15560 Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM Marianne Boes, Tara Schmidt, Kathrin Linkemann, Britte C. Beaudette, Ann Marshak-Rothstein, and Jianzhu Chen PMCID: PMC15562 Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 Soo-Hyun Kim, Miriam Eisenstein, Leonid Reznikov, Giamila Fantuzzi, Daniela Novick, Menachem Rubinstein, and Charles A. Dinarello PMCID: PMC15564 Medical Sciences Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy Tyler Taigen, Leon J. De Windt, Hae W. Lim, and Jeffery D. Molkentin PMCID: PMC15566 Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides Gunnar K. Gouras, Huaxi Xu, Rachel S. Gross, Jeffrey P. Greenfield, Bing Hai, Rong Wang, and Paul Greengard PMCID: PMC15568 Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases Meng Yang, Eugene Baranov, Ping Jiang, Fang-Xian Sun, Xiao-Ming Li, Lingna Li, Satoshi Hasegawa, Michael Bouvet, Maraya Al-Tuwaijri, Takashi Chishima, Hiroshi Shimada, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman PMCID: PMC15570 A mutation in the alpha 3 chain of type IX collagen causes autosomal dominant multiple epiphyseal dysplasia with mild myopathy Carsten G. Bönnemann, Gerald F. Cox, Frederic Shapiro, Jiann-Jiu Wu, Chris A. Feener, Teryl G. Thompson, Douglas C. Anthony, David R. Eyre, Basil T. Darras, and Louis M. Kunkel PMCID: PMC15572 Antagonistic actions of analogs related to growth hormone-releasing hormone (GHRH) on receptors for GHRH and vasoactive intestinal peptide on rat pituitary and pineal cells in vitro Zoltan Rekasi, Jozsef L. Varga, Andrew V. Schally, Gabor Halmos, Kate Groot, and Tamas Czompoly PMCID: PMC15574 Correction of ornithine accumulation prevents retinal degeneration in a mouse model of gyrate atrophy of the choroid and retina Tao Wang, Gary Steel, Ann H. Milam, and David Valle PMCID: PMC15576 Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster Chang Bai, Brett Connolly, Michael L. Metzker, Catherine A. Hilliard, Xiaomei Liu, Volker Sandig, Avery Soderman, Sheila M. Galloway, Qingyun Liu, Christopher P. Austin, and C. Thomas Caskey PMCID: PMC15578 Genetic reconstruction of individual colorectal tumor histories Jen-Lan Tsao, Yasushi Yatabe, Reijo Salovaara, Heikki J. Järvinen, Jukka-Pekka Mecklin, Lauri A. Aaltonen, Simon Tavaré, and Darryl Shibata PMCID: PMC15581 The kidney is an important site for in vivo phenylalanine-to-tyrosine conversion in adult humans: A metabolic role of the kidney Niels Møller, Shon Meek, Maureen Bigelow, James Andrews, and K. S. Nair PMCID: PMC15583 Microbiology A habitat for psychrophiles in deep Antarctic ice P. Buford Price PMCID: PMC15584 The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages James J. De Voss, Kerry Rutter, Benjamin G. Schroeder, Hua Su, YaQi Zhu, and Clifton E. Barry, III PMCID: PMC15586 A role for Salmonella fimbriae in intraperitoneal infections Robert A. Edwards, Dieter M. Schifferli, and Stanley R. Maloy PMCID: PMC15588 Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation Markus Stein, Rino Rappuoli, and Antonello Covacci PMCID: PMC15590 In vivo HIV-1 infection of CD45RA+CD4+ T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4+ T cell decline Hetty Blaak, Angélique B. van't Wout, Margreet Brouwer, Berend Hooibrink, Egbert Hovenkamp, and Hanneke Schuitemaker PMCID: PMC15592 Neurobiology A hippocampal interneuron associated with the mossy fiber system Imre Vida and Michael Frotscher PMCID: PMC15594 Expression of reelin in adult mammalian blood, liver, pituitary
pars intermedia, and adrenal chromaffin cells Neil R. Smalheiser, Erminio Costa, Alessandro Guidotti, Francesco Impagnatiello, James Auta, Pascale Lacor, Virginia Kriho, and George D. Pappas PMCID: PMC15597 Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing Angel Campos-Barros, Lori L. Amma, Jonathan S. Faris, Ranu Shailam, Matthew W. Kelley, and Douglas Forrest PMCID: PMC15599 Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons Antonio Rodríguez-Moreno, Juan C. López-García, and Juan Lerma PMCID: PMC15601 Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice Weichun Lin, Hugo B. Sanchez, Tom Deerinck, Jacqueline K. Morris, Mark Ellisman, and Kuo-Fen Lee PMCID: PMC15603 Physiology Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide Stephen R. Thom, Donald Fisher, Y. Anne Xu, Kathy Notarfrancesco, and Harry Ischiropoulos PMCID: PMC15604 Plant Biology FIDDLEHEAD, a gene required to suppress epidermal cell interactions in Arabidopsis, encodes a putative lipid biosynthetic enzyme Robert E. Pruitt, Jean-Philippe Vielle-Calzada, Sara E. Ploense, Ueli Grossniklaus, and Susan J. Lolle PMCID: PMC15605 Correction Proc Natl Acad Sci U S A. 2000 February 1; 97(3): 1317. PMCID: PMC55971 Corrects: David A. Fancy, et al. Chemistry for the analysis of protein–protein interactions: Rapid and efficient cross-linking triggered by long wavelength light. Proc Natl Acad Sci U S A. 1999 May 25; 96(11): 6020–6024. |
