| | This journal provides immediate access to some articles. Commentaries Plugging the leaks Daniel A. Goodenough PMCID: PMC33540 No milk today (my Hox have gone away) Denis Duboule PMCID: PMC33541 Development of optimized vectors for gene therapy Gary J. Nabel PMCID: PMC33542 Genetic code origins: Experiments confirm phylogenetic predictions and
may explain a puzzle Paul Schimmel and Lluis Ribas de Pouplana PMCID: PMC33543 Protein kinase A takes center stage in ATP-dependent insulin secretion Thomas A. Blanpied and George J. Augustine PMCID: PMC33544 Extending the size limit of protein nuclear magnetic resonance Hongtao Yu PMCID: PMC33545 The fyn art of N-methyl-d-aspartate
receptor phosphorylation Carlo Sala and Morgan Sheng PMCID: PMC33546 Physical Sciences Chemistry Ultrafast electron diffraction and direct observation of transient structures in a chemical reaction Jianming Cao, Hyotcherl Ihee, and Ahmed H. Zewail PMCID: PMC15137 Biological Sciences Biochemistry Persistence of an alternate chromatin structure at silenced loci in vitro Athar Ansari and Marc R. Gartenberg PMCID: PMC15138 Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching David O’Neill, John Yang, Hediye Erdjument-Bromage, Katherine Bornschlegel, Paul Tempst, and Arthur Bank PMCID: PMC15139 Adenovirus-mediated regulable target gene expression in vivo Mark M. Burcin, Gudrun Schiedner, Stefan Kochanek, Sophia Y. Tsai, and Bert W. O’Malley PMCID: PMC15140 Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro Jennifer N. Cha, Katsuhiko Shimizu, Yan Zhou, Sean C. Christiansen, Bradley F. Chmelka, Galen D. Stucky, and Daniel E. Morse PMCID: PMC15141 Site-directed hydroxyl radical probing of 30S ribosomal subunits by using Fe(II) tethered to an interruption in the 16S rRNA chain Raymond R. Samaha, Simpson Joseph, Bonnie O’Brien, Thomas W. O’Brien, and Harry F. Noller PMCID: PMC15142 Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: Mannan-binding proteindependent cell-mediated cytotoxicity Yong Ma, Kazuhide Uemura, Shogo Oka, Yasunori Kozutsumi, Nobuko Kawasaki, and Toshisuke Kawasaki PMCID: PMC15143 The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression Darius Balciunas, Cecilia Gälman, Hans Ronne, and Stefan Björklund PMCID: PMC15144 Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication Tianlin Ma, Nianxiang Zou, Biing Yuan Lin, Louise T. Chow, and J. Wade Harper PMCID: PMC15145 Chemical ligation of folded recombinant proteins: Segmental isotopic labeling of domains for NMR studies Rong Xu, Brenda Ayers, David Cowburn, and Tom W. Muir PMCID: PMC15146 Myosin I heavy chain kinase: Cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42 Hanna Brzeska, Rachel Young, Ulla Knaus, and Edward D. Korn PMCID: PMC15147 Asparagine and glutamine rotamers: B-factor cutoff and correction of amide flips yield distinct clustering Simon C. Lovell, J. Michael Word, Jane S. Richardson, and David C. Richardson PMCID: PMC15148 A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases Dapeng Zhou, André Dinter, Ricardo Gutiérrez Gallego, Johannis P. Kamerling, Johannes F. G. Vliegenthart, Eric G. Berger, and Thierry Hennet PMCID: PMC15149 Persistent membrane association of activated and depalmitoylated G protein α subunits Chunfa Huang, Joseph A. Duncan, Alfred G. Gilman, and Susanne M. Mumby PMCID: PMC15150 Substrate recognition by class I lysyl-tRNA synthetases: A molecular basis for gene displacement Michael Ibba, Heather C. Losey, Yutaka Kawarabayasi, Hisasi Kikuchi, Shipra Bunjun, and Dieter Söll PMCID: PMC15151 Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair Byung Joon Hwang, James M. Ford, Philip C. Hanawalt, and Gilbert Chu PMCID: PMC15152 Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation Christophe Béraud, William J. Henzel, and Patrick A. Baeuerle PMCID: PMC15153 PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-d-aspartate receptor subunit NR2A Tohru Tezuka, Hisashi Umemori, Tetsu Akiyama, Shigetada Nakanishi, and Tadashi Yamamoto PMCID: PMC15154 The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin Michael Weinreich, Chun Liang, and Bruce Stillman PMCID: PMC15155 The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of α-like DNA polymerases Lin Huang, Keiko Kumura Ishii, Harmon Zuccola, Amy M. Gehring, Charles B. C. Hwang, James Hogle, and Donald M. Coen PMCID: PMC15156 Biophysics Trapping of megabase-sized DNA molecules during agarose gel electrophoresis Sergio Gurrieri, Steven B. Smith, and Carlos Bustamante PMCID: PMC15157 Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcription Barden Chan, Kristin Weidemaier, Wai-Tak Yip, Paul F. Barbara, and Karin Musier-Forsyth PMCID: PMC15158 Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry Matthew Walker, Xue-Zhong Zhang, Wei Jiang, John Trinick, and Howard D. White PMCID: PMC15159 Cell adhesion force microscopy G. Sagvolden, I. Giaever, E. O. Pettersen, and J. Feder PMCID: PMC15160 Kinetic evidence for an on-pathway intermediate in the folding of cytochrome c Yawen Bai PMCID: PMC15161 Evidence for microscopic, long-range hydration forces for a hydrophobic amino acid Alexander Pertsemlidis, Alan K. Soper, Jon M. Sorenson, and Teresa Head-Gordon PMCID: PMC15162 Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: Expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line Markus Eilers, Philip J. Reeves, Weiwen Ying, H. Gobind Khorana, and Steven O. Smith PMCID: PMC15163 Cell Biology A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes Sutapa Mukherjee, Krzysztof Palczewski, Vsevolod Gurevich, Jeffrey L. Benovic, J. Paul Banga, and Mary Hunzicker-Dunn PMCID: PMC15164 A Gsα mutant designed to inhibit receptor signaling through Gs Taroh Iiri, Sean M. Bell, Thomas J. Baranski, Toshiro Fujita, and Henry R. Bourne PMCID: PMC15165 Androgens regulate bone resorption activity of isolated osteoclasts in vitro Larry Pederson, Matthew Kremer, Jeffrey Judd, David Pascoe, Thomas C. Spelsberg, B. Lawrence Riggs, and Merry Jo Oursler PMCID: PMC15166 Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands Kazumasa Morita, Mikio Furuse, Kazushi Fujimoto, and Shoichiro Tsukita PMCID: PMC15167 Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation Chang-rung Chen, Ying-chun Li, Jing Chen, Ming-chin Hou, Piyi Papadaki, and Eric C. Chang PMCID: PMC15168 Developmental Biology Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase Urte Gayko, Vaughn Cleghon, Terry Copeland, Deborah K. Morrison, and Norbert Perrimon PMCID: PMC15169 Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals Elisabeth Verpy, Michel Leibovici, and Christine Petit PMCID: PMC15170 INAUGURAL ARTICLE by a Recently Elected Academy Member: Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo Hailan Zhang and Michael Levine PMCID: PMC15171 Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy Feng Chen and Mario R. Capecchi PMCID: PMC15172 Retinoid X receptors are essential for early mouse development and placentogenesis Olivia Wendling, Pierre Chambon, and Manuel Mark PMCID: PMC15173 MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD Jianrong Lu, Robert Webb, James A. Richardson, and Eric N. Olson PMCID: PMC15174 Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina P. Callaerts, A. M. Munoz-Marmol, S. Glardon, E. Castillo, H. Sun, W.-H. Li, W. J. Gehring, and E. Salo PMCID: PMC15175 Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila Bernd Hauck, Walter J. Gehring, and Uwe Walldorf PMCID: PMC15176 Ecology Experimental demonstration that offspring sex ratio varies with maternal condition R. G. Nager, P. Monaghan, R. Griffiths, D. C. Houston, and R. Dawson PMCID: PMC15177 Evolution New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster James D. Fry, Peter D. Keightley, Stefanie L. Heinsohn, and Sergey V. Nuzhdin PMCID: PMC15178 Microsporidia are related to Fungi: Evidence from the largest subunit of RNA polymerase II and other proteins Robert P. Hirt, John M. Logsdon, Jr., Bryan Healy, Michael W. Dorey, W. Ford Doolittle, and T. Martin Embley PMCID: PMC15179 Genetics Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns Makoto Yoshioka, Pamela M. Vacek, Tina Poseno, Robert Silver, and Barry A. Finette PMCID: PMC15180 Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences Karla A. Henning, Elizabeth A. Novotny, Sheila T. Compton, Xin-Yuan Guan, Pu P. Liu, and Melissa A. Ashlock PMCID: PMC15181 The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family Myriam Peyrard, Eyal Seroussi, Ann-Christin Sandberg-Nordqvist, Ya-Gang Xie, Fei-Yu Han, Ingegerd Fransson, John Collins, Ian Dunham, Maria Kost-Alimova, Stephan Imreh, and Jan P. Dumanski PMCID: PMC15182 Functional dissection of the transmitter module of the histidine kinase NtrB in Escherichia coli Günter Kramer and Verena Weiss PMCID: PMC15183 Development of the arbitrarily primed-representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers Yukinari Yoshida, Toshikazu Ushijima, Satoshi Yamashita, Kohzoh Imai, Takashi Sugimura, and Minako Nagao PMCID: PMC15184 DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1 Reid Huber, R. Scott Hansen, Maria Strazzullo, Gina Pengue, Richard Mazzarella, Michele D’Urso, David Schlessinger, Giuseppe Pilia, Stanley M. Gartler, and Maurizio D’Esposito PMCID: PMC15185 Immunology Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4+CD8+ thymocytes Derk Amsen, Conchi Revilla Calvo, Barbara A. Osborne, and Ada M. Kruisbeek PMCID: PMC15186 Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting Xiujun Sun, Colin D. Funk, Chengjun Deng, Arvind Sahu, John D. Lambris, and Wen-Chao Song PMCID: PMC15187 Copolymer 1 acts against the immunodominant epitope 82–100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, and Michael Sela PMCID: PMC15188 Generation of native bovine mAbs by phage display P. M. O’Brien, R. Aitken, B. W. O’Neil, and M. S. Campo PMCID: PMC15189 cDNA cloning of FRIL, a lectin from Dolichos lablab, that preserves hematopoietic progenitors in suspension culture Gabriella Colucci, Jeffrey G. Moore, Michael Feldman, and Maarten J. Chrispeels PMCID: PMC15190 Mechanisms for induction of acquired host immunity by neutrophil peptide defensins James W. Lillard, Jr., Prosper N. Boyaka, Oleg Chertov, Joost J. Oppenheim, and Jerry R. McGhee PMCID: PMC15191 Medical Sciences Nitric oxide synthase in cardiac sarcoplasmic reticulum Kai Y. Xu, David L. Huso, Ted M. Dawson, David S. Bredt, and Lewis C. Becker PMCID: PMC15192 CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue Michael L. Penn, Jean-Charles Grivel, Birgit Schramm, Mark A. Goldsmith, and Leonid Margolis PMCID: PMC15193 Selective induction of apoptosis by the cytotoxic analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone Daniel C. Danila, Andrew V. Schally, Attila Nagy, and Joseph M. Alexander PMCID: PMC15194 Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice Jochen Seufert, Timothy J. Kieffer, and Joel F. Habener PMCID: PMC15195 Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia Lei Sun, Nyla Heerema, Lisa Crotty, Xian Wu, Christopher Navara, Alexei Vassilev, Martha Sensel, Gregory H. Reaman, and Fatih M. Uckun PMCID: PMC15196 The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival Kristiann M. Dougherty, Julia M. Pearson, Angela Y. Yang, Randal J. Westrick, Mark S. Baker, and David Ginsburg PMCID: PMC15197 Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities József L. Varga, Andrew V. Schally, Valér J. Csernus, Márta Zarándi, Gábor Halmos, Kate Groot, and Zoltán Rékási PMCID: PMC15198 Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo Ruedi Stoffel, Sandra Ziegler, Nico Ghilardi, Birgit Ledermann, Frederic J. de Sauvage, and Radek C. Skoda PMCID: PMC15199 Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants Alison A. McCormick, Monto H. Kumagai, Kathleen Hanley, Thomas H. Turpen, Itzhak Hakim, Laurence K. Grill, Daniel Tusé, Shoshana Levy, and Ronald Levy PMCID: PMC15200 Microbiology A role for RNA helicase A in post-transcriptional regulation of HIV type 1 Junzhou Li, Hengli Tang, Tina-Marie Mullen, Christopher Westberg, Thipparthi R. Reddy, David W. Rose, and Flossie Wong-Staal PMCID: PMC15201 Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis Man-Wah Tan, Shalina Mahajan-Miklos, and Frederick M. Ausubel PMCID: PMC15202 Neurobiology Purification of serine racemase: Biosynthesis of the neuromodulator d-serine Herman Wolosker, Kevin N. Sheth, Masaaki Takahashi, Jean-Pierre Mothet, Roscoe O. Brady, Jr., Christopher D. Ferris, and Solomon H. Snyder PMCID: PMC15203 Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice Naomi Eguchi, Toshiaki Minami, Naoki Shirafuji, Yoshihide Kanaoka, Takashi Tanaka, Akihisa Nagata, Nobuaki Yoshida, Yoshihiro Urade, Seiji Ito, and Osamu Hayaishi PMCID: PMC15204 Failure of spinal cord oligodendrocyte development in mice lacking neuregulin Timothy Vartanian, Gerald Fischbach, and Robert Miller PMCID: PMC15205 Morphological, physiological, and biochemical changes in rhodopsin knockout mice J. Lem, N. V. Krasnoperova, P. D. Calvert, B. Kosaras, D. A. Cameron, M. Nicolò, C. L. Makino, and R. L. Sidman PMCID: PMC15206 Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides Jeffrey P. Greenfield, Julia Tsai, Gunnar K. Gouras, Bing Hai, Gopal Thinakaran, Frederic Checler, Sangram S. Sisodia, Paul Greengard, and Huaxi Xu PMCID: PMC15207 Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems Yukari Date, Yoichi Ueta, Hiroshi Yamashita, Hideki Yamaguchi, Shigeru Matsukura, Kenji Kangawa, Takeshi Sakurai, Masashi Yanagisawa, and Masamitsu Nakazato PMCID: PMC15208 Pseudechetoxin: A peptide blocker of cyclic nucleotide-gated ion channels R. Lane Brown, Tammie L. Haley, Karen A. West, and John W. Crabb PMCID: PMC15209 Physiology Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells Noriko Takahashi, Takashi Kadowaki, Yoshio Yazaki, Graham C. R. Ellis-Davies, Yasushi Miyashita, and Haruo Kasai PMCID: PMC15210 Plant Biology Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistance responses Won Do Heo, Sang Hyoung Lee, Min Chul Kim, Jong Cheol Kim, Woo Sik Chung, Hyun Jin Chun, Kyoung Joo Lee, Chan Young Park, Hyeong Cheol Park, Ji Young Choi, and Moo Je Cho PMCID: PMC15211 Selectable viruses and altered susceptibility mutants in Arabidopsis thaliana Steven A. Whitham, Miki L. Yamamoto, and James C. Carrington PMCID: PMC15212 A cytochrome b5 is required for full activity of flavonoid 3′,5′-hydroxylase, a cytochrome P450 involved in the formation of blue flower colors Nick de Vetten, Jeroen ter Horst, Henk-Peter van Schaik, Albertus de Boer, Joseph Mol, and Ronald Koes PMCID: PMC15213 The evolutionary origin of the protein-translocating channel of chloroplastic envelope membranes: Identification of a cyanobacterial homolog Sigrun Reumann, Jennifer Davila-Aponte, and Kenneth Keegstra PMCID: PMC15214 Population Biology The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple-strain pathogens Neil Ferguson, Roy Anderson, and Sunetra Gupta PMCID: PMC15215 Corrections Proc Natl Acad Sci U S A. 1999 January 19; 96(2): 795. PMCID: PMC55997 Corrects: Hans-Joachim G. Jung, et al. Lignification of plant cell walls: Impact of genetic manipulation. Proc Natl Acad Sci U S A. 1998 October 27; 95(22): 12742–12743. Proc Natl Acad Sci U S A. 1999 January 19; 96(2): 795. PMCID: PMC55998 Corrects: Shun-ichi Nakamura, et al. Requirement of GM2 ganglioside activator for phospholipase D activation. Proc Natl Acad Sci U S A. 1998 October 13; 95(21): 12249–12253. Proc Natl Acad Sci U S A. 1999 January 19; 96(2): 795. PMCID: PMC55999 Corrects: Andrée Dierich, et al. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A. 1998 November 10; 95(23): 13612–13617. Proc Natl Acad Sci U S A. 1999 January 19; 96(2): 795. PMCID: PMC56000 Corrects: Michael D. Sheets, et al. Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens. Proc Natl Acad Sci U S A. 1998 May 26; 95(11): 6157–6162. |
