| | This journal provides immediate access to some articles. Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: A self-replicating ligase ribozyme Natasha Paul and Gerald F. Joyce PMCID: PMC130529 Commentaries Comparative genome analysis of the α-proteobacteria: Relationships between plant and animal pathogens and host specificity Renée M. Tsolis PMCID: PMC130485 A human disease indicator for the effects of recent global climate change Jonathan A. Patz PMCID: PMC130486 Extracting functional information from microarrays: A challenge for functional genomics Michael Q. Zhang PMCID: PMC130487 mRNA decay enzymes: Decappers conserved between yeast and mammals Carolyn J. Decker and Roy Parker PMCID: PMC130488 Oxidized phosphatidylcholines: Pattern recognition ligands for multiple pathways of the innate immune response Stanley L. Hazen and Guy M. Chisolm PMCID: PMC130489 A new regulatory role for the chloroplast ATP synthase Stephen K. Herbert PMCID: PMC130490 Telomerase extracurricular activities Sandy Chang and Ronald A. DePinho PMCID: PMC130491 Physical Sciences Applied Physical Sciences Very high growth rate chemical vapor deposition of single-crystal diamond Chih-shiue Yan, Yogesh K. Vohra, Ho-kwang Mao, and Russell J. Hemley PMCID: PMC130492 Chemistry Doming modes and dynamics of model heme compounds Dennis D. Klug, Marek Z. Zgierski, John S. Tse, Zhenxian Liu, James R. Kincaid, Kazimierz Czarnecki, and Russell J. Hemley PMCID: PMC130493 Molecular basis for the explanation of the exponential growth of polyelectrolyte multilayers C. Picart, J. Mutterer, L. Richert, Y. Luo, G. D. Prestwich, P. Schaaf, J.-C. Voegel, and P. Lavalle PMCID: PMC130494 Donor-bridge-acceptor energetics determine the distance dependence of electron tunneling in DNA Frederick D. Lewis, Jianqin Liu, Wilfried Weigel, Wolfgang Rettig, Igor V. Kurnikov, and David N. Beratan PMCID: PMC130495 Gradients of substrate-bound laminin orient axonal specification of neurons Stephan K. W. Dertinger, Xingyu Jiang, Zhiying Li, Venkatesh N. Murthy, and George M. Whitesides PMCID: PMC130496 Memory effects and oscillations in single-molecule kinetics Marcel O. Vlad, Federico Moran, Friedemann W. Schneider, and John Ross PMCID: PMC130497 Structures of bromoalkanes' photodissociation in solution by means of ultrafast extended x-ray absorption fine-structure spectroscopy D. A. Oulianov, I. V. Tomov, A. S. Dvornikov, and P. M. Rentzepis PMCID: PMC130498 Escaping free-energy minima Alessandro Laio and Michele Parrinello PMCID: PMC130499 Circuits and programmable self-assembling DNA structures Alessandra Carbone and Nadrian C. Seeman PMCID: PMC130502 Geology Low atmospheric CO2 levels during the Permo- Carboniferous glaciation inferred from fossil lycopsids D. J. Beerling PMCID: PMC130500 Trace fossils and substrates of the terminal Proterozoic–Cambrian transition: Implications for the record of early bilaterians and sediment mixing Mary L. Droser, Sören Jensen, and James G. Gehling PMCID: PMC130501 Mathematics Circuits and programmable self-assembling DNA structures Alessandra Carbone and Nadrian C. Seeman PMCID: PMC130502 Physics Classification of scale-free networks Kwang-Il Goh, Eulsik Oh, Hawoong Jeong, Byungnam Kahng, and Doochul Kim PMCID: PMC130503 Statistics Olfactory search at high Reynolds number Eugene Balkovsky and Boris I. Shraiman PMCID: PMC130504 Biological Sciences Anthropology Ötzi's last meals: DNA analysis of the intestinal content of the Neolithic glacier mummy from the Alps Franco Rollo, Massimo Ubaldi, Luca Ermini, and Isolina Marota PMCID: PMC130505 Applied Biological Sciences Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner Gregory N. Bancroft, Vassilios I. Sikavitsas, Juliette van den Dolder, Tiffany L. Sheffield, Catherine G. Ambrose, John A. Jansen, and Antonios G. Mikos PMCID: PMC130506 Telomerase contributes to tumorigenesis by a telomere length-independent mechanism Sheila A. Stewart, William C. Hahn, Benjamin F. O'Connor, Elisa N. Banner, Ante S. Lundberg, Poonam Modha, Hana Mizuno, Mary W. Brooks, Mark Fleming, Drazen B. Zimonjic, Nicholas C. Popescu, and Robert A. Weinberg PMCID: PMC130507 A method for the generation of combinatorial antibody libraries using pIX phage display Changshou Gao, Shenlan Mao, Gunnar Kaufmann, Peter Wirsching, Richard A. Lerner, and Kim D. Janda PMCID: PMC130508 Nanocrystal targeting in vivo Maria E. Åkerman, Warren C. W. Chan, Pirjo Laakkonen, Sangeeta N. Bhatia, and Erkki Ruoslahti PMCID: PMC130509 Prediction of structure and function of G protein-coupled receptors Nagarajan Vaidehi, Wely B. Floriano, Rene Trabanino, Spencer E. Hall, Peter Freddolino, Eun Jung Choi, Georgios Zamanakos, and William A. Goddard, III PMCID: PMC130510 Antiviral and antitumor peptides from insects Sergey Chernysh, S. I. Kim, G. Bekker, V. A. Pleskach, N. A. Filatova, V. B. Anikin, V. G. Platonov, and Philippe Bulet PMCID: PMC130511 Biochemistry One O-linked sugar can affect the coil-to-β structural transition of the prion peptide Pei-Yeh Chen, Chun-Cheng Lin, Yin-Ting Chang, Su-Ching Lin, and Sunney I. Chan PMCID: PMC130512 Mechanism of ABC transporters: A molecular dynamics simulation of a well characterized nucleotide-binding subunit Peter M. Jones and Anthony M. George PMCID: PMC130513 Crystallographic findings on the internally uncoupled and near-rigor states of myosin: Further insights into the mechanics of the motor D. M. Himmel, S. Gourinath , L. Reshetnikova, Y. Shen, A. G. Szent-Györgyi, and C. Cohen PMCID: PMC130514 An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein Ryoko Ando, Hiroshi Hama, Miki Yamamoto-Hino, Hideaki Mizuno, and Atsushi Miyawaki PMCID: PMC130515 Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding Kevin D. Augustijn, Dawn L. Duval, Rainer Wechselberger, Rob Kaptein, Arthur Gutierrez-Hartmann, and Peter C. van der Vliet PMCID: PMC130516 From the Cover:
The hDcp2 protein is a mammalian mRNA decapping enzyme Zuoren Wang, Xinfu Jiao, Anne Carr-Schmid, and Megerditch Kiledjian PMCID: PMC130517 Binding of the Escherichia coli response regulator CheY to its target measured in vivo by fluorescence resonance energy transfer Victor Sourjik and Howard C. Berg PMCID: PMC130518 The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP Bethany A. Janowski PMCID: PMC130519 FlgM gains structure in living cells Matthew M. Dedmon, Chetan N. Patel, Gregory B. Young, and Gary J. Pielak PMCID: PMC130520 Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1 Hirokazu Fukuda, Masato Katahira, Naoto Tsuchiya, Yoshiaki Enokizono, Takashi Sugimura, Minako Nagao, and Hitoshi Nakagama PMCID: PMC130521 Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O  reaction Douglas D. Thomas, Michael Graham Espey, Michael P. Vitek, Katrina M. Miranda, and David A. Wink PMCID: PMC130522 Investigation of Overhauser effects between pseudouridine and water protons in RNA helices Meredith I. Newby and Nancy L. Greenbaum PMCID: PMC130523 Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7 Seung-Joo Lee and Charles C. Richardson PMCID: PMC130524 Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains C. Kiong Ho and Stewart Shuman PMCID: PMC130525 Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis Kevin Walker, Shingo Fujisaki, Robert Long, and Rodney Croteau PMCID: PMC130526 Sequence-specific DNA binding by the vnd/NK-2 homeodomain of Drosophila Lan-Hsiang Wang, Rebecca Chmelik, and Marshall Nirenberg PMCID: PMC130527 Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP) Yong Cang and Gregory Prelich PMCID: PMC130528 INAUGURAL ARTICLE by a Recently Elected Academy Member: A self-replicating ligase ribozyme Natasha Paul and Gerald F. Joyce PMCID: PMC130529 β-Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon Audrey Stevens, Yang Wang, Kirsten Bremer, Jing Zhang, Robert Hoepfner, Michael Antoniou, Daniel R. Schoenberg, and Lynne E. Maquat PMCID: PMC130530 External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator Shinichi Asada, Yongmun Choi, Masaki Yamada, Shao-Chun Wang, Mien-Chie Hung, Jun Qin, and Motonari Uesugi PMCID: PMC130531 Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Daisuke Yabe, Michael S. Brown, and Joseph L. Goldstein PMCID: PMC130532 Biophysics Donor-bridge-acceptor energetics determine the distance dependence of electron tunneling in DNA Frederick D. Lewis, Jianqin Liu, Wilfried Weigel, Wolfgang Rettig, Igor V. Kurnikov, and David N. Beratan PMCID: PMC130495 Olfactory search at high Reynolds number Eugene Balkovsky and Boris I. Shraiman PMCID: PMC130504 Structural rearrangements in single ion channels detected optically in living cells Alois Sonnleitner, Lidia M. Mannuzzu, Susumu Terakawa, and Ehud Y. Isacoff PMCID: PMC130533 Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance Louise J. Brown, Ken L. Sale, Ron Hills, Clement Rouviere, Likai Song, Xiaojun Zhang, and Piotr G. Fajer PMCID: PMC130534 Ultrafast ligand rebinding in the heme domain of the oxygen sensors FixL and Dos: General regulatory implications for heme-based sensors Ursula Liebl, Latifa Bouzhir-Sima, Michel Négrerie, Jean-Louis Martin, and Marten H. Vos PMCID: PMC130535 Can a continuum solvent model reproduce the free energy landscape of a β-hairpin folding in water? Ruhong Zhou and Bruce J. Berne PMCID: PMC130536 From the Cover:
Transitive functional annotation by shortest-path analysis of gene expression data Xianghong Zhou, Ming-Chih J. Kao, and Wing Hung Wong PMCID: PMC130537 In vivo modulation of nonphotochemical exciton quenching (NPQ) by regulation of the chloroplast ATP synthase Atsuko Kanazawa and David M. Kramer PMCID: PMC130538 Intrinsic and extrinsic contributions to stochasticity in gene expression Peter S. Swain, Michael B. Elowitz, and Eric D. Siggia PMCID: PMC130539 Cell Biology Mitochondrial respiratory control is lost during growth factor deprivation Eyal Gottlieb, Sean M. Armour, and Craig B. Thompson PMCID: PMC130540 Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxβ María Isabel Tussié-Luna, Dashzeveg Bayarsaihan, Edward Seto, Frank H. Ruddle, and Ananda L. Roy PMCID: PMC130541 Molecular analysis of microscopic ezrin dynamics by two-photon FRAP Sylvie Coscoy, François Waharte, Alexis Gautreau, Marianne Martin, Daniel Louvard, Paul Mangeat, Monique Arpin, and François Amblard PMCID: PMC130542 Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling Koji Eto, Ronan Murphy, Steve W. Kerrigan, Alessandra Bertoni, Heidi Stuhlmann, Toru Nakano, Andrew D. Leavitt, and Sanford J. Shattil PMCID: PMC130543 Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3 Lori A. Kubasiak, Olga M. Hernandez, Nanette H. Bishopric, and Keith A. Webster PMCID: PMC130544 A resident Golgi protein is excluded from peri-Golgi vesicles in NRK cells Pierre Cosson, Mylène Amherdt, James E. Rothman, and Lelio Orci PMCID: PMC130545 The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes Louise Chang, Rachael D. Adams, and Alan R. Saltiel PMCID: PMC130546 Untangling the wires: A strategy to trace functional interactions in signaling and gene networks Boris N. Kholodenko, Anatoly Kiyatkin, Frank J. Bruggeman, Eduardo Sontag, Hans V. Westerhoff, and Jan B. Hoek PMCID: PMC130547 Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu Wanping Xu, Monica Marcu, Xitong Yuan, Edward Mimnaugh, Cam Patterson, and Len Neckers PMCID: PMC130548 Sphingoid base synthesis is required for oligomerization and cell surface stability of the yeast plasma membrane ATPase, Pma1 Qiongqing Wang and Amy Chang PMCID: PMC130549 p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation Katrin Ramsauer, Iwona Sadzak, Almudena Porras, Andreas Pilz, Angel R. Nebreda, Thomas Decker, and Pavel Kovarik PMCID: PMC130550 Developmental Biology Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility Philippe Gabant, Lesley Forrester, Jennifer Nichols, Thierry Van Reeth, Christelle De Mees, Bernard Pajack, Alistair Watt, Johan Smitz, Henri Alexandre, Claude Szpirer, and Josiane Szpirer PMCID: PMC130551 A heterotrimeric death domain complex in Toll signaling Huaiyu Sun, Benjamin N. Bristow, Guowei Qu, and Steven A. Wasserman PMCID: PMC130552 Diversity, topographic differentiation, and positional memory in human fibroblasts Howard Y. Chang, Jen-Tsan Chi, Sandrine Dudoit, Chanda Bondre, Matt van de Rijn, David Botstein, and Patrick O. Brown PMCID: PMC130553 Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci Alexander Schwendemann and Michael Lehmann PMCID: PMC130554 Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei David Humpherys, Kevin Eggan, Hidenori Akutsu, Adam Friedman, Konrad Hochedlinger, Ryuzo Yanagimachi, Eric S. Lander, Todd R. Golub, and Rudolf Jaenisch PMCID: PMC130555 Quantitative imaging of cis-regulatory reporters in living embryos Ivan J. Dmochowski, Jane E. Dmochowski, Paola Oliveri, Eric H. Davidson, and Scott E. Fraser PMCID: PMC130556 Ecology ENSO and cholera: A nonstationary link related to climate change? Xavier Rodó, Mercedes Pascual, George Fuchs, and A. S. G. Faruque PMCID: PMC130557 Size-dependent life-history traits promote catastrophic collapses of top predators André M. De Roos and Lennart Persson PMCID: PMC130558 Two degrees of separation in complex food webs Richard J. Williams, Eric L. Berlow, Jennifer A. Dunne, Albert-László Barabási, and Neo D. Martinez PMCID: PMC130559 Food-web structure and network theory: The role of connectance and size Jennifer A. Dunne, Richard J. Williams, and Neo D. Martinez PMCID: PMC130560 Corridors affect plants, animals, and their interactions in fragmented landscapes Joshua J. Tewksbury, Douglas J. Levey, Nick M. Haddad, Sarah Sargent, John L. Orrock, Aimee Weldon, Brent J. Danielson, Jory Brinkerhoff, Ellen I. Damschen, and Patricia Townsend PMCID: PMC130561 Linking individuals with ecosystems: Experimentally identifying the relevant organizational scale for predicting trophic abundances Ofer Ovadia and Oswald J. Schmitz PMCID: PMC130562 Evolution Life history consequences of mammal sibling rivalry P. Stockley and G. A. Parker PMCID: PMC130563 From the Cover:
Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity A. Grande-Pérez, S. Sierra, M. G. Castro, E. Domingo, and P. R. Lowenstein PMCID: PMC130564 Acceleration of genomic evolution caused by enhanced mutation rate in endocellular symbionts Takeshi Itoh, William Martin, and Masatoshi Nei PMCID: PMC130565 Hitchhiking mapping: A population-based fine-mapping strategy for adaptive mutations in Drosophila melanogaster Bettina Harr, Max Kauer, and Christian Schlötterer PMCID: PMC130566 Functional coadaptation between cytochrome c and cytochrome c oxidase within allopatric populations of a marine copepod Paul D. Rawson and Ronald S. Burton PMCID: PMC130567 Genetics Genetic diversity and selection in the maize starch pathway Sherry R. Whitt, Larissa M. Wilson, Maud I. Tenaillon, Brandon S. Gaut, and Edward S. Buckler, IV PMCID: PMC130568 Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors Jonathan R. Pollack, Therese Sørlie, Charles M. Perou, Christian A. Rees, Stefanie S. Jeffrey, Per E. Lonning, Robert Tibshirani, David Botstein, Anne-Lise Børresen-Dale, and Patrick O. Brown PMCID: PMC130569 The CENP-A homolog CaCse4p in the pathogenic yeast Candida albicans is a centromere protein essential for chromosome transmission Kaustuv Sanyal and John Carbon PMCID: PMC130570 Significance and statistical errors in the analysis of DNA microarray data James P. Brody, Brian A. Williams, Barbara J. Wold, and Stephen R. Quake PMCID: PMC130571 Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin Christiana DelloRusso, Jeannine M. Scott, Dennis Hartigan-O'Connor, Giovanni Salvatori, Catherine Barjot, Ann S. Robinson, Robert W. Crawford, Susan V. Brooks, and Jeffrey S. Chamberlain PMCID: PMC130572 p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene Shanthi Adimoolam and James M. Ford PMCID: PMC130573 The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion Jay N. Lozier, Amalia Dutra, Evgenia Pak, Nan Zhou, Zhili Zheng, Timothy C. Nichols, Dwight A. Bellinger, Marjorie Read, and Richard A. Morgan PMCID: PMC130574 A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1 Michele Giannattasio, Elena Sommariva, Raffaella Vercillo, Filippo Lippi-Boncambi, Giordano Liberi, Marco Foiani, Paolo Plevani, and Marco Muzi-Falconi PMCID: PMC130575 Immunology Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation Yoh-ichi Seki, Katsuhiko Hayashi, Akira Matsumoto, Noriyasu Seki, Jun Tsukada, John Ransom, Tetsuji Naka, Tadamitsu Kishimoto, Akihiko Yoshimura, and Masato Kubo PMCID: PMC130576 T cells from the tumor microenvironment of patients with progressive myeloma can generate strong, tumor-specific cytolytic responses to autologous, tumor-loaded dendritic cells Madhav V. Dhodapkar, Joseph Krasovsky, and Kara Olson PMCID: PMC130577 Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering Laurent Gauthier, Benjamin Rossi, Florence Roux, Elise Termine, and Claudine Schiff PMCID: PMC130578 A push–pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L Jeffrey D. Ahlers, Igor M. Belyakov, Masaki Terabe, Rima Koka, Debra D. Donaldson, Elaine K. Thomas, and Jay A. Berzofsky PMCID: PMC130579 An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines Eun Sook Hwang, Ian Alexander White, and I-Cheng Ho PMCID: PMC130580 Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells Joachim Lehmann, Jochen Huehn, Maurus de la Rosa, Frank Maszyna, Ute Kretschmer, Veit Krenn, Monika Brunner, Alexander Scheffold, and Alf Hamann PMCID: PMC130581 Medical Sciences Myristoylation as a target for inhibiting HIV assembly: Unsaturated fatty acids block viral budding O. Wolf Lindwasser and Marilyn D. Resh PMCID: PMC130582 From the Cover:
C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids Mi-Kyung Chang, Christoph J. Binder, Michael Torzewski, and Joseph L. Witztum PMCID: PMC130583 Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect Martin O. Bergo, Bryant Gavino, Jed Ross, Walter K. Schmidt, Christine Hong, Lonnie V. Kendall, Andreas Mohr, Margarita Meta, Harry Genant, Yebin Jiang, Erik R. Wisner, Nicholas van Bruggen, Richard A. D. Carano, Susan Michaelis, Stephen M. Griffey, and Stephen G. Young PMCID: PMC130584 Teratogenicity induced by targeting a placental immunoglobulin transporter Mikhail G. Kolonin, Renata Pasqualini, and Wadih Arap PMCID: PMC130585 A molecular profile of a hematopoietic stem cell niche Jason A. Hackney, Pierre Charbord, Brian P. Brunk, Christian J. Stoeckert, Ihor R. Lemischka, and Kateri A. Moore PMCID: PMC130586 Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration Lihua Y. Marmorstein, Francis L. Munier, Yvan Arsenijevic, Daniel F. Schorderet, Precious J. McLaughlin, Daniel Chung, Elias Traboulsi, and Alan D. Marmorstein PMCID: PMC130587 Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator Tamaki Suganuma, Masahiro Kawabata, Tomoko Ohshima, and Masa-Aki Ikeda PMCID: PMC130588 Dominant-negative inhibition of prion replication in transgenic mice Véronique Perrier, Kiyotoshi Kaneko, Jiri Safar, Julie Vergara, Patrick Tremblay, Stephen J. DeArmond, Fred E. Cohen, Stanley B. Prusiner, and Andrew C. Wallace PMCID: PMC130589 Metapopulation dynamics and spatial heterogeneity in cancer Isabel González-García, Ricard V. Solé, and José Costa PMCID: PMC130590 Autologous transplantation of genetically modified iris pigment epithelial cells: A promising concept for the treatment of age-related macular degeneration and other disorders of the eye Irina Semkova, Florian Kreppel, Gerhard Welsandt, Thomas Luther, Jolanta Kozlowski, Hanna Janicki, Stefan Kochanek, and Ulrich Schraermeyer PMCID: PMC130591 Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo W. Pfützner, A. Terunuma, C. L. Tock, E. K. Snead, T. M. Kolodka, M. M. Gottesman, L. Taichman, and J. C. Vogel PMCID: PMC130592 From the Cover:
Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs Katherine Parker Ponder, John R. Melniczek, Lingfei Xu, Margaret A. Weil, Thomas M. O'Malley, Patricia A. O'Donnell, Van W. Knox, Gustavo D. Aguirre, Hamutal Mazrier, N. Matthew Ellinwood, Meg Sleeper, Albert M. Maguire, Susan W. Volk, Robert L. Mango, Jean Zweigle, John H. Wolfe, and Mark E. Haskins PMCID: PMC130593 Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel Jianxin Sun and James K. Liao PMCID: PMC130594 Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia–reperfusion leads to extensive liver repopulation Harmeet Malhi, Giridhar R. Gorla, Adil N. Irani, Pallavi Annamaneni, and Sanjeev Gupta PMCID: PMC130595 High efficiency genetic modification of hair follicles and growing hair shafts Norimitsu Saito, Ming Zhao, Lingna Li, Eugene Baranov, Meng Yang, Yukinori Ohta, Kensei Katsuoka, Sheldon Penman, and Robert M. Hoffman PMCID: PMC130596 Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1 Gad Asher, Joseph Lotem, Leo Sachs, Chaim Kahana, and Yosef Shaul PMCID: PMC130597 Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice Zsolt Vajda, Michael Pedersen, Ernst-Martin Füchtbauer, Karin Wertz, Hans Stødkilde-Jørgensen, Endre Sulyok, Tamás Dóczi, John D. Neely, Peter Agre, Jørgen Frøkiær, and Søren Nielsen PMCID: PMC130598 Microbiology Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax Michele D. Hastings and Carol Hopkins Sibley PMCID: PMC130599 HecA, a member of a class of adhesins produced by diverse pathogenic bacteria, contributes to the attachment, aggregation, epidermal cell killing, and virulence phenotypes of Erwinia chrysanthemi EC16 on Nicotiana clevelandii seedlings Clemencia M. Rojas, Jong Hyun Ham, Wen-Ling Deng, Jeff J. Doyle, and Alan Collmer PMCID: PMC130600 The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts Ian T. Paulsen, Rekha Seshadri, Karen E. Nelson, Jonathan A. Eisen, John F. Heidelberg, Timothy D. Read, Robert J. Dodson, Lowell Umayam, Lauren M. Brinkac, Maureen J. Beanan, Sean C. Daugherty, Robert T. Deboy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, William C. Nelson, Bola Ayodeji, Margaret Kraul, Jyoti Shetty, Joel Malek, Susan E. Van Aken, Steven Riedmuller, Herve Tettelin, Steven R. Gill, Owen White, Steven L. Salzberg, David L. Hoover, Luther E. Lindler, Shirley M. Halling, Stephen M. Boyle, and Claire M. Fraser PMCID: PMC130601 The membrane trafficking protein calpactin forms a complex with bluetongue virus protein NS3 and mediates virus release Andrew R. Beaton, Javier Rodriguez, Y. Krishnamohan Reddy, and Polly Roy PMCID: PMC130602 A signal transduction protein cues proteolytic events critical to Caulobacter cell cycle progression Dean Y. Hung and Lucy Shapiro PMCID: PMC130603 Minimum molecular architectures for transcription and replication of the influenza virus Ayae Honda, Kiyohisa Mizumoto, and Akira Ishihama PMCID: PMC130604 Neuroscience Gradients of substrate-bound laminin orient axonal specification of neurons Stephan K. W. Dertinger, Xingyu Jiang, Zhiying Li, Venkatesh N. Murthy, and George M. Whitesides PMCID: PMC130496 Parallel processing of serial movements in prefrontal cortex Bruno B. Averbeck, Matthew V. Chafee, David A. Crowe, and Apostolos P. Georgopoulos PMCID: PMC130605 Reelin, Disabled 1, and β1 integrins are required for the formation of the radial glial scaffold in the hippocampus Eckart Förster, Albrecht Tielsch, Barbara Saum, Karl Heinz Weiss, Celine Johanssen, Diana Graus-Porta, Ulrich Müller, and Michael Frotscher PMCID: PMC130606 Range image statistics can explain the anomalous perception of length Catherine Q. Howe and Dale Purves PMCID: PMC130607 Timing-dependent limbic-motor synaptic integration in the nucleus accumbens Yukiori Goto and Patricio O'Donnell PMCID: PMC130608 Development of 17O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field Xiao-Hong Zhu, Yi Zhang, Run-Xia Tian, Hao Lei, Nanyin Zhang, Xiaoliang Zhang, Hellmut Merkle, Kamil Ugurbil, and Wei Chen PMCID: PMC130609 Perinatal switch from synchronous to asynchronous activity of motoneurons: Link with synapse elimination Mario Buffelli, Giuseppe Busetto, Lorenzo Cangiano, and Alberto Cangiano PMCID: PMC130610 The roles of the external, middle, and inner ears in determining the bandwidth of hearing Mario A. Ruggero and Andrei N. Temchin PMCID: PMC130611 Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice Nathalie Picard-Riera, Laurence Decker, Cécile Delarasse, Karine Goude, Brahim Nait-Oumesmar, Roland Liblau, Danielle Pham-Dinh, and Anne Baron-Van Evercooren PMCID: PMC130612 Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling Ottavio V. Vitolo, Antonino Sant'Angelo, Vincenzo Costanzo, Fortunato Battaglia, Ottavio Arancio, and Michael Shelanski PMCID: PMC130613 Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks Marlene Bartos, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer, Jörg R. P. Geiger, and Peter Jonas PMCID: PMC130614 Synapse formation is associated with memory storage in the cerebellum Jeffrey A. Kleim, John H. Freeman, Jr., Rochelle Bruneau, Brian C. Nolan, Natalie R. Cooper, Alison Zook, and Drew Walters PMCID: PMC130615 Conditional disruption of synaptic transmission induces male–male courtship behavior in Drosophila Toshihiro Kitamoto PMCID: PMC130616 Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes Ricardo Miledi, Fabrizio Eusebi, Ataúlfo Martínez-Torres, Eleonora Palma, and Flavia Trettel PMCID: PMC130617 Pharmacology Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance Li Ma, Piero del Soldato, and John L. Wallace PMCID: PMC130618 Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice Hunter C. Champion, Trinity J. Bivalacqua, Stanley S. Greenberg, Thomas D. Giles, Albert L. Hyman, and Philip J. Kadowitz PMCID: PMC130619 Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/β-catenin-regulated cell proliferation Guangnan Li and Ravi Iyengar PMCID: PMC130620 The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding Sergio E. Martinez, Albert Y. Wu, Natalie A. Glavas, Xiao-Bo Tang, Stewart Turley, Wim G. J. Hol, and Joseph A. Beavo PMCID: PMC130621 Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes Levente József, Christine Zouki, Nicos A. Petasis, Charles N. Serhan, and János G. Filep PMCID: PMC130622 Physiology β2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure Gary Cohen, Zhi-Yan Han, Régis Grailhe, Jorge Gallego, Claude Gaultier, Jean-Pierre Changeux, and Hugo Lagercrantz PMCID: PMC130623 Kir6.2 is required for adaptation to stress Leonid V. Zingman, Denice M. Hodgson, Peter H. Bast, Garvan C. Kane, Carmen Perez-Terzic, Richard J. Gumina, Darko Pucar, Martin Bienengraeber, Petras P. Dzeja, Takashi Miki, Susumu Seino, Alexey E. Alekseev, and Andre Terzic PMCID: PMC130624 Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons Angelita Tottene, Tommaso Fellin, Stefano Pagnutti, Siro Luvisetto, Joerg Striessnig, Colin Fletcher, and Daniela Pietrobon PMCID: PMC130625 Plant Biology Regulation of transgene expression in plants with polydactyl zinc finger transcription factors M. Isabel Ordiz, Carlos F. Barbas, III, and Roger N. Beachy PMCID: PMC130626 Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors Xuen Guan, Justin Stege, Myoung Kim, Zina Dahmani, Nancy Fan, Peter Heifetz, Carlos F. Barbas, III, and Steven P. Briggs PMCID: PMC130627 A new class of regulatory genes underlying the cause of pear-shaped tomato fruit Jiping Liu, Joyce Van Eck, Bin Cong, and Steven D. Tanksley PMCID: PMC130628 The heterotrimeric G protein α subunit acts upstream of the small GTPase Rac in disease resistance of rice Utut Suharsono, Yukiko Fujisawa, Tsutomu Kawasaki, Yukimoto Iwasaki, Hikaru Satoh, and Ko Shimamoto PMCID: PMC130629 Floral responses to photoperiod are correlated with the timing of rhythmic expression relative to dawn and dusk in Arabidopsis Laura C. Roden, Hae-Ryong Song, Stephen Jackson, Karl Morris, and Isabelle A. Carre PMCID: PMC130630 Insect feeding mobilizes a unique plant defense protease that disrupts the peritrophic matrix of caterpillars Tibor Pechan, Allen Cohen, W. Paul Williams, and Dawn S. Luthe PMCID: PMC130631 Rice phosphate transporters include an evolutionarily divergent gene specifically activated in arbuscular mycorrhizal symbiosis Uta Paszkowski, Scott Kroken, Christophe Roux, and Steven P. Briggs PMCID: PMC130632 Population Biology Modeling dynamic and network heterogeneities in the spread of sexually transmitted diseases Ken T. D. Eames and Matt J. Keeling PMCID: PMC130633 Psychology Neural basis of protracted developmental changes in visuo-spatial working memory H. Kwon, A. L. Reiss, and V. Menon PMCID: PMC130634 Social Sciences Anthropology The Neandertal type site revisited: Interdisciplinary investigations of skeletal remains from the Neander Valley, Germany Ralf W. Schmitz, David Serre, Georges Bonani, Susanne Feine, Felix Hillgruber, Heike Krainitzki, Svante Pääbo, and Fred H. Smith PMCID: PMC130635 Economic Sciences Efficiency wages in an experimental labor market Mary L. Rigdon PMCID: PMC130636 Psychology The natural center of chromaticity space is not always achromatic: A new look at color induction Vebjørn Ekroll, Franz Faul, Reinhard Niederée, and Eike Richter PMCID: PMC130637 Corrections Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 13357. Published online 2002 September 18. doi: 10.1073/pnas.212463799.PMCID: PMC130482 Corrects: J. Nagaraju, et al. Genetic analysis of traditional and evolved Basmati and non-Basmati rice varieties by using fluorescence-based ISSR-PCR and SSR markers. Proc Natl Acad Sci U S A. 2002 April 30; 99(9): 5836–5841. Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 13357. Published online 2002 September 20. doi: 10.1073/pnas.212371999.PMCID: PMC130483 Corrects: Jörg Wiedenmann, et al. Cracks in the β-can: Fluorescent proteins from Anemonia
sulcata (Anthozoa, Actinaria). Proc Natl Acad Sci U S A. 2000 December 19; 97(26): 14091–14096. Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 13357. Published online 2002 September 13. doi: 10.1073/pnas.212281299.PMCID: PMC130484 Corrects: Sang-Joon Cho, et al. Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4720–4724. |
