| | This journal provides immediate access to some articles. Commentaries Imaging the progression of Alzheimer pathology through the brain A. David Smith Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4135–4137. doi: 10.1073/pnas.082107399.PMCID: PMC123611 From bacteria to mitochondria: Aconitase yields surprises William E. Walden Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4138–4140. doi: 10.1073/pnas.082108799.PMCID: PMC123612 What are big brains for? Robert M. Seyfarth and Dorothy L. Cheney Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4141–4142. doi: 10.1073/pnas.082105099.PMCID: PMC123613 Whole-genome disassembly Phil Green Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4143–4144. Published online 2002 March 19. doi: 10.1073/pnas.082095999.PMCID: PMC123614 On the sequencing and assembly of the human genome Eugene W. Myers, Granger G. Sutton, Hamilton O. Smith, Mark D. Adams, and J. Craig Venter Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4145–4146. Published online 2002 March 19. doi: 10.1073/pnas.092136699.PMCID: PMC123615 Physical Sciences Applied Physical Sciences Dynamics of self assembly of magnetized disks rotating at the liquid–air interface Bartosz A. Grzybowski, Howard A. Stone, and George M. Whitesides Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4147–4151. doi: 10.1073/pnas.062036699.PMCID: PMC123616 Astronomy Emission lines of [K v] in the optical spectra of gaseous nebulae Francis P. Keenan, Lawrence H. Aller, Brian R. Espey, Katrina M. Exter, Siek Hyung, Michael T. C. Keenan, Don L. Pollacco, and Robert S. I. Ryans Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4152–4155. Published online 2002 March 19. doi: 10.1073/pnas.062032299.PMCID: PMC123617 Chemistry Phosphate backbone neutralization increases duplex DNA flexibility: A model for protein binding Tamara M. Okonogi, Stephen C. Alley, Eric A. Harwood, Paul B. Hopkins, and Bruce H. Robinson Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4156–4160. doi: 10.1073/pnas.072067799.PMCID: PMC123618 Engineering Molecules, muscles, and machines: Universal performance characteristics of motors James H. Marden and Lee R. Allen Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4161–4166. Published online 2002 March 26. doi: 10.1073/pnas.022052899.PMCID: PMC123619 Geology Atmospheric carbon dioxide levels for the last 500 million years Daniel H. Rothman Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4167–4171. Published online 2002 March 19. doi: 10.1073/pnas.022055499.PMCID: PMC123620 Examination of hypotheses for the Permo–Triassic boundary extinction by carbon cycle modeling Robert A. Berner Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4172–4177. Published online 2002 March 26. doi: 10.1073/pnas.032095199.PMCID: PMC123621 Mathematics The Pythagorean Theorem: I. The finite case Richard V. Kadison Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4178–4184. doi: 10.1073/pnas.032677199.PMCID: PMC123622 Biological Sciences Biochemistry Directed evolution of the site specificity of Cre recombinase Stephen W. Santoro and Peter G. Schultz Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4185–4190. Published online 2002 March 19. doi: 10.1073/pnas.022039799.PMCID: PMC123623 Using RNA interference to identify genes required for RNA interference Nathaniel R. Dudley, Jean-Claude Labbé, and Bob Goldstein Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4191–4196. Published online 2002 March 19. doi: 10.1073/pnas.062605199.PMCID: PMC123624 Oligomerization and activation of caspase-9, induced by Apaf-1 CARD Eric N. Shiozaki, Jijie Chai, and Yigong Shi Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4197–4202. Published online 2002 March 19. doi: 10.1073/pnas.072544399.PMCID: PMC123625 The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain Heather Hundley, Helene Eisenman, William Walter, Tara Evans, Yuka Hotokezaka, Martin Wiedmann, and Elizabeth Craig Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4203–4208. doi: 10.1073/pnas.062048399.PMCID: PMC123626 A functional chaperone triad on the yeast ribosome Matthias Gautschi, Andrej Mun, Suzanne Ross, and Sabine Rospert Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4209–4214. doi: 10.1073/pnas.062048599.PMCID: PMC123627 Leukotriene A4 hydrolase: Selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375 Peter C. Rudberg, Fredrik Tholander, Marjolein M. G. M. Thunnissen, Bengt Samuelsson, and Jesper Z. Haeggström Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4215–4220. Published online 2002 March 26. doi: 10.1073/pnas.072090099.PMCID: PMC123628 Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits Adam M. Silverstein, Christina A. Barrow, Anthony J. Davis, and Marc C. Mumby Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4221–4226. Published online 2002 March 19. doi: 10.1073/pnas.072071699.PMCID: PMC123629 Paranodal junction formation and spermatogenesis require sulfoglycolipids Koichi Honke, Yukie Hirahara, Jeffrey Dupree, Kinuko Suzuki, Brian Popko, Kikuro Fukushima, Junko Fukushima, Takashi Nagasawa, Nobuaki Yoshida, Yoshinao Wada, and Naoyuki Taniguchi Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4227–4232. Published online 2002 March 26. doi: 10.1073/pnas.032068299.PMCID: PMC123630 Function of quaking in myelination: Regulation of alternative splicing Jiang I. Wu, Robyn B. Reed, Paula J. Grabowski, and Karen Artzt Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4233–4238. Published online 2002 March 26. doi: 10.1073/pnas.072090399.PMCID: PMC123631 Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro Keng-Boon Lee, Dong Wang, Stephen J. Lippard, and Phillip A. Sharp Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4239–4244. Published online 2002 March 19. doi: 10.1073/pnas.072068399.PMCID: PMC123632 Selenoprotein R is a zinc-containing stereo-specific methionine
sulfoxide reductase Gregory V. Kryukov, R. Abhilash Kumar, Ahmet Koc, Zhaohui Sun, and Vadim N. Gladyshev Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4245–4250. doi: 10.1073/pnas.072603099.PMCID: PMC123633 Transcriptional activation of NtcA-dependent promoters of Synechococcus sp. PCC 7942 by 2-oxoglutarate in vitro Ryohei Tanigawa, Masao Shirokane, Shin-ichi Maeda, Tatsuo Omata, Kan Tanaka, and Hideo Takahashi Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4251–4255. Published online 2002 March 26. doi: 10.1073/pnas.072587199.PMCID: PMC123634 Diversity and evolution of the green fluorescent protein family Y. A. Labas, N. G. Gurskaya, Y. G. Yanushevich, A. F. Fradkov, K. A. Lukyanov, S. A. Lukyanov, and M. V. Matz Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4256–4261. doi: 10.1073/pnas.062552299.PMCID: PMC123635 Assembly of the neutrophil respiratory burst oxidase: A direct interaction between p67PHOX and cytochrome b558 II Pham My-Chan Dang, Andrew R. Cross, Mark T. Quinn, and Bernard M. Babior Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4262–4265. Published online 2002 March 26. doi: 10.1073/pnas.072345299.PMCID: PMC123636 Biophysics Rapid compaction during RNA folding Rick Russell, Ian S. Millett, Mark W. Tate, Lisa W. Kwok, Bradley Nakatani, Sol M. Gruner, Simon G. J. Mochrie, Vijay Pande, Sebastian Doniach, Daniel Herschlag, and Lois Pollack Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4266–4271. doi: 10.1073/pnas.072589599.PMCID: PMC123637 Fluorescence polarization of green fluorescence protein Shinya Inoué, Osamu Shimomura, Makoto Goda, Mykhailo Shribak, and P. T. Tran Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4272–4277. doi: 10.1073/pnas.062065199.PMCID: PMC123638 Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM Piotr E. Marszalek, Hongbin Li, Andres F. Oberhauser, and Julio M. Fernandez Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4278–4283. Published online 2002 March 26. doi: 10.1073/pnas.072435699.PMCID: PMC123639 Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules Harold D. Kim, G. Ulrich Nienhaus, Taekjip Ha, Jeffrey W. Orr, James R. Williamson, and Steven Chu Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4284–4289. doi: 10.1073/pnas.032077799.PMCID: PMC123640 From the Cover: Computational mapping identifies the binding sites of organic solvents on proteins Sheldon Dennis, Tamas Kortvelyesi, and Sandor Vajda Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4290–4295. Published online 2002 March 19. doi: 10.1073/pnas.062398499.PMCID: PMC123641 Conformational flexibility of bacterial RNA polymerase Seth A. Darst, Natacha Opalka, Pablo Chacon, Andrey Polyakov, Catherine Richter, Gongyi Zhang, and Willy Wriggers Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4296–4301. Published online 2002 March 19. doi: 10.1073/pnas.052054099.PMCID: PMC123642 Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution Martin Egli, George Minasov, Li Su, and Alexander Rich Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4302–4307. Published online 2002 March 19. doi: 10.1073/pnas.062055599.PMCID: PMC123643 Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness Boris Martinac and Owen P. Hamill Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4308–4312. Published online 2002 March 19. doi: 10.1073/pnas.072632899.PMCID: PMC123644 Cell Biology Vav3 is regulated during the cell cycle and effects cell division Keiko Fujikawa, Yoshiro Inoue, Masaharu Sakai, Yoshikazu Koyama, Shinzo Nishi, Ryo Funada, Frederick W. Alt, and Wojciech Swat Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4313–4318. Published online 2002 March 26. doi: 10.1073/pnas.052715699.PMCID: PMC123645 FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction Bimal N. Desai, Benjamin R. Myers, and Stuart L. Schreiber Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4319–4324. doi: 10.1073/pnas.261702698.PMCID: PMC123646 PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel Masaru Ishii, Atsushi Inanobe, and Yoshihisa Kurachi Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4325–4330. Published online 2002 March 19. doi: 10.1073/pnas.072073399.PMCID: PMC123647 The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum David G. Breckenridge, Mai Nguyen, Stephan Kuppig, Michael Reth, and Gordon C. Shore Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4331–4336. Published online 2002 March 26. doi: 10.1073/pnas.072088099.PMCID: PMC123648 Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B Donald L. Gillian-Daniel, Paul W. Bates, Angie Tebon, and Alan D. Attie Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4337–4342. Published online 2002 March 19. doi: 10.1073/pnas.072557199.PMCID: PMC123649 From the Cover: The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei Roya Zoraghi and Thomas Seebeck Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4343–4348. doi: 10.1073/pnas.062716599.PMCID: PMC123650 A role for survivin in chemoresistance of endothelial cells mediated by VEGF Jennifer Tran, Zubin Master, Joanne L. Yu, Janusz Rak, Daniel J. Dumont, and Robert S. Kerbel Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4349–4354. Published online 2002 March 26. doi: 10.1073/pnas.072586399.PMCID: PMC123651 The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types Bradley M. Hersh, Erika Hartwieg, and H. Robert Horvitz Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4355–4360. Published online 2002 March 19. doi: 10.1073/pnas.062065399.PMCID: PMC123652 Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A Anja Schmitt and Angel R. Nebreda Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4361–4366. Published online 2002 March 19. doi: 10.1073/pnas.022056399.PMCID: PMC123653 Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2 Marco Rusnati, Chiara Urbinati, Elena Tanghetti, Patrizia Dell'Era, Hugues Lortat-Jacob, and Marco Presta Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4367–4372. Published online 2002 March 26. doi: 10.1073/pnas.072651899.PMCID: PMC123654 Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression Nam-On Ku, Sara Michie, Evelyn Z. Resurreccion, Rosemary L. Broome, and M. Bishr Omary Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4373–4378. Published online 2002 March 26. doi: 10.1073/pnas.072624299.PMCID: PMC123655 Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization Kerby Shedden and Stephen Cooper Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4379–4384. Published online 2002 March 19. doi: 10.1073/pnas.062569899.PMCID: PMC123656 Inhibition of APC-mediated proteolysis by the meiosis-specific protein kinase Ime2 Melanie Bolte, Patrick Steigemann, Gerhard H. Braus, and Stefan Irniger Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4385–4390. Published online 2002 March 26. doi: 10.1073/pnas.072385099.PMCID: PMC123657 Developmental Biology Endothelial cells derived from human embryonic stem cells Shulamit Levenberg, Justin S. Golub, Michal Amit, Joseph Itskovitz-Eldor, and Robert Langer Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4391–4396. Published online 2002 March 26. doi: 10.1073/pnas.032074999.PMCID: PMC123658 In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis Ichiro Sekiya, Jussi T. Vuoristo, Benjamin L. Larson, and Darwin J. Prockop Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4397–4402. Published online 2002 March 26. doi: 10.1073/pnas.052716199.PMCID: PMC123659 Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine Michal Zurovec, Tomas Dolezal, Michal Gazi, Eva Pavlova, and Peter J. Bryant Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4403–4408. Published online 2002 March 19. doi: 10.1073/pnas.062059699.PMCID: PMC123660 Ecology Nitrogen availability alters the expression of carnivory in the northern pitcher plant, Sarracenia purpurea Aaron M. Ellison and Nicholas J. Gotelli Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4409–4412. Published online 2002 March 19. doi: 10.1073/pnas.022057199.PMCID: PMC123661 Renewable and nonrenewable resources: Amino acid turnover and allocation to reproduction in Lepidoptera Diane M. O'Brien, Marilyn L. Fogel, and Carol L. Boggs Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4413–4418. doi: 10.1073/pnas.072346699.PMCID: PMC123662 From the Cover: Algal blooms reduce the uptake of toxic methylmercury in freshwater food webs Paul C. Pickhardt, Carol L. Folt, Celia Y. Chen, Bjoern Klaue, and Joel D. Blum Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4419–4423. Published online 2002 March 19. doi: 10.1073/pnas.072531099.PMCID: PMC123663 Evolution Examination of hypotheses for the Permo–Triassic boundary extinction by carbon cycle modeling Robert A. Berner Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4172–4177. Published online 2002 March 26. doi: 10.1073/pnas.032095199.PMCID: PMC123621 Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates Hideyuki Tanabe, Stefan Müller, Michaela Neusser, Johann von Hase, Enzo Calcagno, Marion Cremer, Irina Solovei, Christoph Cremer, and Thomas Cremer Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4424–4429. doi: 10.1073/pnas.072618599.PMCID: PMC123664 Rate heterogeneity among lineages of tracheophytes: Integration of molecular and fossil data and evidence for molecular living fossils Pamela S. Soltis, Douglas E. Soltis, Vincent Savolainen, Peter R. Crane, and Timothy G. Barraclough Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4430–4435. Published online 2002 March 26. doi: 10.1073/pnas.032087199.PMCID: PMC123665 From the Cover: Social intelligence, innovation, and enhanced brain size in primates Simon M. Reader and Kevin N. Laland Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4436–4441. Published online 2002 March 12. doi: 10.1073/pnas.062041299.PMCID: PMC123666 Sexual selection driving diversification in jumping spiders Susan E. Masta and Wayne P. Maddison Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4442–4447. doi: 10.1073/pnas.072493099.PMCID: PMC123667 Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster Wen Wang, Frédéric G. Brunet, Eviatar Nevo, and Manyuan Long Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4448–4453. Published online 2002 March 19. doi: 10.1073/pnas.072066399.PMCID: PMC123668 Extreme genome reduction in Buchnera spp.: Toward the minimal genome needed for symbiotic life Rosario Gil, Beatriz Sabater-Muñoz, Amparo Latorre, Francisco J. Silva, and Andrés Moya Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4454–4458. Published online 2002 March 19. doi: 10.1073/pnas.062067299.PMCID: PMC123669 Genetics Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damage Ziqiang Li, Wei Xiao, J. Justin McCormick, and Veronica M. Maher Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4459–4464. Published online 2002 March 26. doi: 10.1073/pnas.062047799.PMCID: PMC123670 Large-scale analysis of the human and mouse transcriptomes Andrew I. Su, Michael P. Cooke, Keith A. Ching, Yaron Hakak, John R. Walker, Tim Wiltshire, Anthony P. Orth, Raquel G. Vega, Lisa M. Sapinoso, Aziz Moqrich, Ardem Patapoutian, Garret M. Hampton, Peter G. Schultz, and John B. Hogenesch Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4465–4470. Published online 2002 March 19. doi: 10.1073/pnas.012025199.PMCID: PMC123671 Mutation of melanosome protein RAB38 in chocolate mice Stacie K. Loftus, Denise M. Larson, Laura L. Baxter, Anthony Antonellis, Yidong Chen, Xufeng Wu, Yuan Jiang, Michael Bittner, John A. Hammer, III, and William J. Pavan Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4471–4476. Published online 2002 March 26. doi: 10.1073/pnas.072087599.PMCID: PMC123672 Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development Eiríkur Steingrímsson, Lino Tessarollo, Bhavani Pathak, Ling Hou, Heinz Arnheiter, Neal G. Copeland, and Nancy A. Jenkins Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4477–4482. doi: 10.1073/pnas.072071099.PMCID: PMC123673 The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster Balaji Iyengar, Ningguang Luo, Carol L. Farr, Laurie S. Kaguni, and Ana Regina Campos Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4483–4488. Published online 2002 March 26. doi: 10.1073/pnas.072664899.PMCID: PMC123674 Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes Michael Peitz, Kurt Pfannkuche, Klaus Rajewsky, and Frank Edenhofer Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4489–4494. Published online 2002 March 19. doi: 10.1073/pnas.032068699.PMCID: PMC123675 Mammalian germ-line transgenesis by transposition Adam J. Dupuy, Karl Clark, Corey M. Carlson, Sabine Fritz, Ann E. Davidson, Karra M. Markley, Ken Finley, Colin F. Fletcher, Stephen C. Ekker, Perry B. Hackett, Sandra Horn, and David A. Largaespada Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4495–4499. Published online 2002 March 19. doi: 10.1073/pnas.062630599.PMCID: PMC123676 INAUGURAL ARTICLE by a Recently Elected Academy Member: Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiaeKyungjae Myung and Richard D. Kolodner Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4500–4507. Published online 2002 March 26. doi: 10.1073/pnas.062702199.PMCID: PMC123677 Immunology Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling Angela G. King, Motonari Kondo, David C. Scherer, and Irving L. Weissman Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4508–4513. Published online 2002 March 26. doi: 10.1073/pnas.072087899.PMCID: PMC123678 The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells Thomas Pohl, Raffi Gugasyan, Raelene J. Grumont, Andreas Strasser, Donald Metcalf, David Tarlinton, William Sha, David Baltimore, and Steve Gerondakis Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4514–4519. doi: 10.1073/pnas.072071599.PMCID: PMC123679 Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation Lisa K. McNeil and Brian D. Evavold Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4520–4525. Published online 2002 March 19. doi: 10.1073/pnas.072673899.PMCID: PMC123680 Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation Simona Sivori, Michela Falco, Emanuela Marcenaro, Silvia Parolini, Roberto Biassoni, Cristina Bottino, Lorenzo Moretta, and Alessandro Moretta Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4526–4531. Published online 2002 March 26. doi: 10.1073/pnas.072065999.PMCID: PMC123681 Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination Matthew L. Brown, Daniel Franco, Alexander Bürkle, and Yung Chang Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4532–4537. doi: 10.1073/pnas.072495299.PMCID: PMC123682 Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes Armelle Le Campion, Christine Bourgeois, Florence Lambolez, Bruno Martin, Sandrine Léaument, Nicole Dautigny, Corinne Tanchot, Claude Pénit, and Bruno Lucas Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4538–4543. Published online 2002 March 26. doi: 10.1073/pnas.062621699.PMCID: PMC123683 Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression Makio Iwashima, Masako Takamatsu, Hiroko Yamagishi, Yasue Hatanaka, Yi-Ying Huang, Courtnie McGinty, Sho Yamasaki, and Toru Koike Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4544–4549. Published online 2002 March 26. doi: 10.1073/pnas.082647499.PMCID: PMC123684 MYC overexpression imposes a nonimmunogenic phenotype on Epstein–Barr virus-infected B cells Martin S. Staege, Steven P. Lee, Teresa Frisan, Josef Mautner, Siegfried Scholz, Alexander Pajic, Alan B. Rickinson, Maria G. Masucci, Axel Polack, and Georg W. Bornkamm Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4550–4555. Published online 2002 March 26. doi: 10.1073/pnas.072495599.PMCID: PMC123685 Medical Sciences Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice Kenji Yumoto, Muneaki Ishijima, Susan R. Rittling, Kunikazu Tsuji, Yoko Tsuchiya, Shigeyuki Kon, Akira Nifuji, Toshimitsu Uede, David T. Denhardt, and Masaki Noda Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4556–4561. doi: 10.1073/pnas.052523599.PMCID: PMC123686 HLTF gene silencing in human colon cancer Helen R. Moinova, Wei-Dong Chen, Lanlan Shen, Dominic Smiraglia, Joseph Olechnowicz, Lakshmeswari Ravi, Lakshmi Kasturi, Lois Myeroff, Christoph Plass, Ramon Parsons, John Minna, James K. V. Willson, Sylvan B. Green, Jean-Pierre Issa, and Sanford D. Markowitz Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4562–4567. Published online 2002 March 19. doi: 10.1073/pnas.062459899.PMCID: PMC123687 Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6 Leslie J. Raffini, Diana J. Slater, Eric F. Rappaport, Luca Lo Nigro, Nai-Kong V. Cheung, Jaclyn A. Biegel, Peter C. Nowell, Beverly J. Lange, and Carolyn A. Felix Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4568–4573. doi: 10.1073/pnas.062066799.PMCID: PMC123688 In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure Masaya Takahashi, Felix W. Wehrli, Luna Hilaire, Babette S. Zemel, and Scott N. Hwang Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4574–4579. Published online 2002 March 19. doi: 10.1073/pnas.062037499.PMCID: PMC123689 Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation Keiji Yoshida, Hiroji Oida, Takuya Kobayashi, Takayuki Maruyama, Masaharu Tanaka, Teruaki Katayama, Kojiro Yamaguchi, Eri Segi, Tadao Tsuboyama, Mutsumi Matsushita, Kosei Ito, Yoshiaki Ito, Yukihiko Sugimoto, Fumitaka Ushikubi, Shuichi Ohuchida, Kigen Kondo, Takashi Nakamura, and Shuh Narumiya Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4580–4585. Published online 2002 March 26. doi: 10.1073/pnas.062053399.PMCID: PMC123690 Impaired cardiac hypertrophic response in Calcineurin Aβ-deficient mice Orlando F. Bueno, Benjamin J. Wilkins, Kevin M. Tymitz, Betty J. Glascock, Thomas F. Kimball, John N. Lorenz, and Jeffery D. Molkentin Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4586–4591. Published online 2002 March 19. doi: 10.1073/pnas.072647999.PMCID: PMC123691 INAUGURAL ARTICLE by a Recently Elected Academy Member: Curing metastatic testicular cancer Lawrence H. Einhorn Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4592–4595. Published online 2002 March 19. doi: 10.1073/pnas.072067999.PMCID: PMC123692 Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Gaël Nicolas, Myriam Bennoun, Arlette Porteu, Sandrine Mativet, Carole Beaumont, Bernard Grandchamp, Mario Sirito, Michèle Sawadogo, Axel Kahn, and Sophie Vaulont Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4596–4601. doi: 10.1073/pnas.072632499.PMCID: PMC123693 Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration Hyung-Suk Kim, Gene Lee, Simon W. M. John, Nobuyo Maeda, and Oliver Smithies Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4602–4607. Published online 2002 March 19. doi: 10.1073/pnas.072083799.PMCID: PMC123694 Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines by a “biased agonist” mechanism Daniel Chan, Lajos Gera, John Stewart, Barbara Helfrich, Marileila Verella-Garcia, Gary Johnson, Anna Baron, Jie Yang, Theodore Puck, and Paul Bunn, Jr. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4608–4613. doi: 10.1073/pnas.072077299.PMCID: PMC123695 HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community Barbara L. Triggs-Raine, Robert D. Kirkpatrick, Sherrie L. Kelly, Lisa D. Norquay, Peter A. Cattini, Kazuya Yamagata, Anthony J. G. Hanley, Bernard Zinman, Stewart B. Harris, P. Hugh Barrett, and Robert A. Hegele Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4614–4619. Published online 2002 March 19. doi: 10.1073/pnas.062059799.PMCID: PMC123696 Microbiology A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli Eric Massé and Susan Gottesman Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4620–4625. Published online 2002 March 26. doi: 10.1073/pnas.032066599.PMCID: PMC123697 DnaK dependence of mutant ethanol oxidoreductases evolved for aerobic function and protective role of the chaperone against protein oxidative damage in Escherichia coli Pedro Echave, M. Angel Esparza-Cerón, Elisa Cabiscol, Jordi Tamarit, Joaquim Ros, Jorge Membrillo-Hernández, and E. C. C. Lin Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4626–4631. Published online 2002 March 26. doi: 10.1073/pnas.072504199.PMCID: PMC123698 Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle Michael T. Laub, Swaine L. Chen, Lucy Shapiro, and Harley H. McAdams Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4632–4637. doi: 10.1073/pnas.062065699.PMCID: PMC123699 Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens Hai-Bao Zhang, Lian-Hui Wang, and Lian-Hui Zhang Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4638–4643. Published online 2002 March 19. doi: 10.1073/pnas.022056699.PMCID: PMC123700 The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens Alexei I. Slesarev, Katja V. Mezhevaya, Kira S. Makarova, Nikolai N. Polushin, Olga V. Shcherbinina, Vera V. Shakhova, Galina I. Belova, L. Aravind, Darren A. Natale, Igor B. Rogozin, Roman L. Tatusov, Yuri I. Wolf, Karl O. Stetter, Andrei G. Malykh, Eugene V. Koonin, and Sergei A. Kozyavkin Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4644–4649. doi: 10.1073/pnas.032671499.PMCID: PMC123701 Regulation of PKR and IRF-1 during hepatitis C virus RNA replication Jill Pflugheber, Brenda Fredericksen, Rhea Sumpter, Jr., Chunfu Wang, Felecia Ware, Donald L. Sodora, and Michael Gale, Jr. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4650–4655. Published online 2002 March 19. doi: 10.1073/pnas.062055699.PMCID: PMC123702 Bartonella-associated endothelial proliferation depends on inhibition of apoptosis James E. Kirby and Dawn M. Nekorchuk Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4656–4661. Published online 2002 March 19. doi: 10.1073/pnas.072292699.PMCID: PMC123703 From the Cover: A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: Implications for the evolution of the mitochondrial Krebs cycle Anthony D. Baughn and Michael H. Malamy Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4662–4667. Published online 2002 March 5. doi: 10.1073/pnas.052710199.PMCID: PMC123704 Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks James C. Smoot, Kent D. Barbian, Jamie J. Van Gompel, Laura M. Smoot, Michael S. Chaussee, Gail L. Sylva, Daniel E. Sturdevant, Stacy M. Ricklefs, Stephen F. Porcella, Larye D. Parkins, Stephen B. Beres, David S. Campbell, Todd M. Smith, Qing Zhang, Vivek Kapur, Judy A. Daly, L. George Veasy, and James M. Musser Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4668–4673. Published online 2002 March 26. doi: 10.1073/pnas.062526099.PMCID: PMC123705 Neurobiology Desensitization of μ-opioid receptor-evoked potassium currents: Initiation at the receptor, expression at the effector Christophe Blanchet and Christian Lüscher Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4674–4679. Published online 2002 March 26. doi: 10.1073/pnas.072075399.PMCID: PMC123706 Gene expression analysis in schizophrenia: Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22 Michael L. Mimmack, Margaret Ryan, Hajime Baba, Juani Navarro-Ruiz, Shuji Iritani, Richard L. M. Faull, Peter J. McKenna, Peter B. Jones, Heii Arai, Michael Starkey, Piers C. Emson, and Sabine Bahn Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4680–4685. doi: 10.1073/pnas.032069099.PMCID: PMC123707 Circadian 5-HT production regulated by adrenergic signaling Xing Sun, Jie Deng, Tiecheng Liu, and Jimo Borjigin Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4686–4691. Published online 2002 March 26. doi: 10.1073/pnas.062585499.PMCID: PMC123708 Human receptors for sweet and umami taste Xiaodong Li, Lena Staszewski, Hong Xu, Kyle Durick, Mark Zoller, and Elliot Adler Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4692–4696. Published online 2002 March 26. doi: 10.1073/pnas.072090199.PMCID: PMC123709 A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP Malcolm A. Leissring, M. Paul Murphy, Tonya R. Mead, Yama Akbari, Michael C. Sugarman, Mehrdad Jannatipour, Brigitte Anliker, Ulrike Müller, Paul Saftig, Bart De Strooper, Michael S. Wolfe, Todd E. Golde, and Frank M. LaFerla Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4697–4702. Published online 2002 March 26. doi: 10.1073/pnas.072033799.PMCID: PMC123710 Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI Rachael I. Scahill, Jonathan M. Schott, John M. Stevens, Martin N. Rossor, and Nick C. Fox Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4703–4707. doi: 10.1073/pnas.052587399.PMCID: PMC123711 Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer Deniz Kirik, Biljana Georgievska, Corinna Burger, Christian Winkler, Nicholas Muzyczka, Ronald J. Mandel, and Anders Björklund Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4708–4713. Published online 2002 March 26. doi: 10.1073/pnas.062047599.PMCID: PMC123712 Pharmacology Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei Ana Rascón, Scott H. Soderling, Jonathan B. Schaefer, and Joseph A. Beavo Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4714–4719. doi: 10.1073/pnas.002031599.PMCID: PMC123713 Physiology Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles Sang-Joon Cho, A. K. M. Abdus Sattar, Eun-Hwan Jeong, Mylan Satchi, Jin Ah Cho, Sudhansu Dash, Mary Sue Mayes, Marvin H. Stromer, and Bhanu P. Jena Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4720–4724. Published online 2002 March 26. doi: 10.1073/pnas.072083499.PMCID: PMC123714 Plant Biology Structural requirement of bilin chromophore for the photosensory specificity of phytochromes A and B Hiroko Hanzawa, Tomoko Shinomura, Katsuhiko Inomata, Takashi Kakiuchi, Hideki Kinoshita, Keishiro Wada, and Masaki Furuya Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4725–4729. doi: 10.1073/pnas.062713399.PMCID: PMC123715 The homeobox gene BREVIPEDICELLUS is a key regulator of inflorescence architecture in Arabidopsis S. P. Venglat, T. Dumonceaux, K. Rozwadowski, L. Parnell, V. Babic, W. Keller, R. Martienssen, G. Selvaraj, and R. Datla Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4730–4735. Published online 2002 March 26. doi: 10.1073/pnas.072626099.PMCID: PMC123716 GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering Gabriella Colucci, Fabio Apone, Nicole Alyeshmerni, Derek Chalmers, and Maarten J. Chrispeels Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4736–4741. doi: 10.1073/pnas.072087699.PMCID: PMC123717 Elucidating the biosynthesis of 2-carboxyarabinitol 1-phosphate through reduced expression of chloroplastic fructose 1,6-bisphosphate phosphatase and radiotracer studies with 14CO2 P. John Andralojc, Alfred J. Keys, Jens Kossmann, and Martin A. J. Parry Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4742–4747. Published online 2002 March 26. doi: 10.1073/pnas.072137099.PMCID: PMC123718 Social Sciences Economic Sciences Chaos in learning a simple two-person game Yuzuru Sato, Eizo Akiyama, and J. Doyne Farmer Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4748–4751. doi: 10.1073/pnas.032086299.PMCID: PMC123719 Corrections Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 12. doi: 10.1073/pnas.082093899.PMCID: PMC123606 Corrects: Benjamin B. Davis, et al. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2222–2227. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 12. doi: 10.1073/pnas.082095399.PMCID: PMC123607 Corrects: Christopher J. Benson, et al. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2338–2343. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 12. doi: 10.1073/pnas.082070499.PMCID: PMC123608 Corrects: Hyman Hartman, et al. The origin of the eukaryotic cell: A genomic investigation. Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1420–1425. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 26. doi: 10.1073/pnas.062018699.PMCID: PMC123609 Corrects: Yuka Sasaki, et al. Local and global attention are mapped retinotopically in human
occipital cortex. Proc Natl Acad Sci U S A. 2001 February 13; 98(4): 2077–2082. Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4753. Published online 2002 March 26. doi: 10.1073/pnas.082070899.PMCID: PMC123610 Corrects: William M. Perlstein, et al. Dissociation in human prefrontal cortex of affective influences on working memory-related activity. Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1736–1741. |