| | This journal provides immediate access to some articles. Commentary Reverse transcriptase at bacterial telomeres Neal F. Lue and Sulin Jiang Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14307–14308. Published online 2004 September 28. doi: 10.1073/pnas.0406018101.PMCID: PMC521969 Perspective Exercises in prognostication: Crystal structures and protein folding Jack D. Dunitz and Harold A. Scheraga Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14309–14311. Published online 2004 September 27. doi: 10.1073/pnas.0405744101.PMCID: PMC521964 Biographies INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Erin K. O'Shea Melissa Marino Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14312–14314. Published online 2004 September 28. doi: 10.1073/pnas.0406675101.PMCID: PMC521978 INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Vernon M. Ingram Tinsley H. Davis Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14323–14325. Published online 2004 September 28. doi: 10.1073/pnas.0406677101.PMCID: PMC521979 Physical Sciences Applied Mathematics Entropy of dialogues creates coherent structures in e-mail traffic Jean-Pierre Eckmann, Elisha Moses, and Danilo Sergi Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14333–14337. Published online 2004 September 24. doi: 10.1073/pnas.0405728101.PMCID: PMC521963 Chemistry Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates Alan R. Fersht Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14338–14342. Published online 2004 September 21. doi: 10.1073/pnas.0406091101.PMCID: PMC521971 Probing conformational dynamics in single donor-acceptor synthetic molecules by means of photoinduced reversible electron transfer Mircea Cotlet, Sadahiro Masuo, Guobin Luo, Johan Hofkens, Mark Van der Auweraer, Jan Verhoeven, Klaus Müllen, Xiaoliang Sunney Xie, and Frans De Schryver Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14343–14348. Published online 2004 September 23. doi: 10.1073/pnas.0406119101.PMCID: PMC521947 Bulk-solvent and hydration-shell fluctuations, similar to α- and β-fluctuations in glasses, control protein motions and functions P. W. Fenimore, Hans Frauenfelder, B. H. McMahon, and R. D. Young Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14408–14413. Published online 2004 September 24. doi: 10.1073/pnas.0405573101.PMCID: PMC521939 Chemistry Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy Haitao Li, Xiaojun Ren, Liming Ying, Shankar Balasubramanian, and David Klenerman Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14425–14430. Published online 2004 September 27. doi: 10.1073/pnas.0404295101.PMCID: PMC521954 Biological Sciences Agricultural Sciences Sequence composition and genome organization of maize Joachim Messing, Arvind K. Bharti, Wojciech M. Karlowski, Heidrun Gundlach, Hye Ran Kim, Yeisoo Yu, Fusheng Wei, Galina Fuks, Carol A. Soderlund, Klaus F. X. Mayer, and Rod A. Wing Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14349–14354. Published online 2004 September 23. doi: 10.1073/pnas.0406163101.PMCID: PMC521949 Applied Biological Sciences Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis Juan P. Liuzzi, Jeffrey A. Bobo, Louis A. Lichten, Don A. Samuelson, and Robert J. Cousins Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14355–14360. Published online 2004 September 20. doi: 10.1073/pnas.0406216101.PMCID: PMC521973 Biochemistry From the Cover: Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex Kai Bao and Stanley N. Cohen Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14361–14366. Published online 2004 September 7. doi: 10.1073/pnas.0404386101.PMCID: PMC521936 A poxvirus protein forms a complex with left-handed Z-DNA: Crystal structure of a Yatapoxvirus Zα bound to DNA Sung Chul Ha, Neratur K. Lokanath, Dong Van Quyen, Chun Ai Wu, Ky Lowenhaupt, Alexander Rich, Yang-Gyun Kim, and Kyeong Kyu Kim Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14367–14372. Published online 2004 September 24. doi: 10.1073/pnas.0405586101.PMCID: PMC521960 Identification of a SUMO-binding motif that recognizes SUMO-modified proteins Jing Song, Linda K. Durrin, Thomas A. Wilkinson, Theodore G. Krontiris, and Yuan Chen Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14373–14378. Published online 2004 September 23. doi: 10.1073/pnas.0403498101.PMCID: PMC521952 Molecular dynamics studies of ground state and intermediate of the hyperthermophilic indole-3-glycerol phosphate synthase Devleena Mazumder-Shivakumar and Thomas C. Bruice Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14379–14384. Published online 2004 September 27. doi: 10.1073/pnas.0406002101.PMCID: PMC521968 Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity Tim A. Rand, Krzysztof Ginalski, Nick V. Grishin, and Xiaodong Wang Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14385–14389. Published online 2004 September 27. doi: 10.1073/pnas.0405913101.PMCID: PMC521941 Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein Krzysztof B. Wicher and Erik Fries Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14390–14395. Published online 2004 September 22. doi: 10.1073/pnas.0405692101.PMCID: PMC521962 Long-range intramolecular signaling in a tRNA synthetase complex revealed by pre-steady-state kinetics Nathan T. Uter and John J. Perona Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14396–14401. Published online 2004 September 27. doi: 10.1073/pnas.0404017101.PMCID: PMC521953 Biophysics Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates Alan R. Fersht Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14338–14342. Published online 2004 September 21. doi: 10.1073/pnas.0406091101.PMCID: PMC521971 Different relaxations in myoglobin after photolysis Matteo Levantino, Antonio Cupane, László Zimányi, and Pál Ormos Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14402–14407. Published online 2004 September 22. doi: 10.1073/pnas.0406062101.PMCID: PMC521970 Bulk-solvent and hydration-shell fluctuations, similar to α- and β-fluctuations in glasses, control protein motions and functions P. W. Fenimore, Hans Frauenfelder, B. H. McMahon, and R. D. Young Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14408–14413. Published online 2004 September 24. doi: 10.1073/pnas.0405573101.PMCID: PMC521939 Biophysics New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels Cristiano Viappiani, Stefano Bettati, Stefano Bruno, Luca Ronda, Stefania Abbruzzetti, Andrea Mozzarelli, and William A. Eaton Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14414–14419. Published online 2004 September 22. doi: 10.1073/pnas.0405987101.PMCID: PMC521967 The formation of spherulites by amyloid fibrils of bovine insulin Mark R. H. Krebs, Cait E. MacPhee, Aline F. Miller, Iain E. Dunlop, Christopher M. Dobson, and Athene M. Donald Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14420–14424. Published online 2004 September 20. doi: 10.1073/pnas.0405933101.PMCID: PMC521966 Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy Haitao Li, Xiaojun Ren, Liming Ying, Shankar Balasubramanian, and David Klenerman Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14425–14430. Published online 2004 September 27. doi: 10.1073/pnas.0404295101.PMCID: PMC521954 From the Cover: Systematic investigation of protein phase behavior with a microfluidic formulator Carl L. Hansen, Morten O. A. Sommer, and Stephen R. Quake Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14431–14436. Published online 2004 September 27. doi: 10.1073/pnas.0405847101.PMCID: PMC521965 Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone Christine B. Karim, Tara L. Kirby, Zhiwen Zhang, Yuri Nesmelov, and David D. Thomas Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14437–14442. Published online 2004 September 24. doi: 10.1073/pnas.0402801101.PMCID: PMC521948 Cell Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression Rosa M. Marion, Aviv Regev, Eran Segal, Yoseph Barash, Daphne Koller, Nir Friedman, and Erin K. O'Shea Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14315–14322. Published online 2004 September 7. doi: 10.1073/pnas.0405353101.PMCID: PMC521938 Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation Yiling Hong and Peter J. Stambrook Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14443–14448. Published online 2004 September 27. doi: 10.1073/pnas.0401346101.PMCID: PMC521944 Developmental Biology Foxa2 is required for transition to air breathing at birth Huajing Wan, Yan Xu, Machiko Ikegami, Mildred T. Stahlman, Klaus H. Kaestner, Siew-Lan Ang, and Jeffrey A. Whitsett Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14449–14454. Published online 2004 September 27. doi: 10.1073/pnas.0404424101.PMCID: PMC521955 Evolution From the Cover: Meager genetic variability of the human malaria agent Plasmodium vivax M. C. Leclerc, P. Durand, C. Gauthier, S. Patot, N. Billotte, M. Menegon, C. Severini, F. J. Ayala, and F. Renaud Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14455–14460. Published online 2004 August 24. doi: 10.1073/pnas.0405186101.PMCID: PMC521958 Immunology A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation Sumito Ogawa, Jean Lozach, Kristen Jepsen, Dominique Sawka-Verhelle, Valentina Perissi, Roman Sasik, David W. Rose, Randall S. Johnson, Michael G. Rosenfeld, and Christopher K. Glass Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14461–14466. Published online 2004 September 27. doi: 10.1073/pnas.0405786101.PMCID: PMC521940 IFN-γ enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation Mitsutoshi Matsuo, Yasuhiro Nagata, Eiichi Sato, Djordje Atanackovic, Danila Valmori, Yao-Tseng Chen, Gerd Ritter, Ira Mellman, Lloyd J. Old, and Sacha Gnjatic Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14467–14472. Published online 2004 September 21. doi: 10.1073/pnas.0405947101.PMCID: PMC521945 Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells Helene C. Dujardin, Odile Burlen-Defranoux, Laurent Boucontet, Paulo Vieira, Ana Cumano, and Antonio Bandeira Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14473–14478. Published online 2004 September 27. doi: 10.1073/pnas.0403303101.PMCID: PMC521951 Medical Sciences PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder Jing Chen, Daniel J. DeAngelo, Jeffery L. Kutok, Ifor R. Williams, Benjamin H. Lee, Martha Wadleigh, Nicole Duclos, Sarah Cohen, Jennifer Adelsperger, Rachel Okabe, Allison Coburn, Ilene Galinsky, Brian Huntly, Pamela S. Cohen, Thomas Meyer, Doriano Fabbro, Johannes Roesel, Lolita Banerji, James D. Griffin, Sheng Xiao, Jonathan A. Fletcher, Richard M. Stone, and D. Gary Gilliland Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14479–14484. Published online 2004 September 24. doi: 10.1073/pnas.0404438101.PMCID: PMC521956 Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study Sudha K. Iyengar, Barbara E. K. Klein, Ronald Klein, Gyungah Jun, James H. Schick, Christopher Millard, Rachel Liptak, Karlie Russo, Kristine E. Lee, and Robert C. Elston Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14485–14490. Published online 2004 September 27. doi: 10.1073/pnas.0400778101.PMCID: PMC521942 Microbiology Sword and shield: Linked group B streptococcal β-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense George Y. Liu, Kelly S. Doran, Toby Lawrence, Nicole Turkson, Manuela Puliti, Luciana Tissi, and Victor Nizet Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14491–14496. Published online 2004 September 20. doi: 10.1073/pnas.0406143101.PMCID: PMC521972 Evidence for conservation of architecture and physical properties of Omp85-like proteins throughout evolution Neeraj K. Surana, Susan Grass, Gail G. Hardy, Huilin Li, David G. Thanassi, and Joseph W. St. Geme, III Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14497–14502. Published online 2004 September 20. doi: 10.1073/pnas.0404679101.PMCID: PMC521957 Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule Barbara J. Blanchard, Albert Chen, Leslie M. Rozeboom, Kate A. Stafford, Peter Weigele, and Vernon M. Ingram Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14326–14332. Published online 2004 September 23. doi: 10.1073/pnas.0405941101.PMCID: PMC521943 Molecular profiling reveals synaptic release machinery in Merkel cells Henry Haeberle, Mika Fujiwara, Jody Chuang, Michael M. Medina, Mayuri V. Panditrao, Susanne Bechstedt, Jonathon Howard, and Ellen A. Lumpkin Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14503–14508. Published online 2004 September 24. doi: 10.1073/pnas.0406308101.PMCID: PMC521975 Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis Hiroshi Yamazaki, Mariko Sekiguchi, Masako Takamatsu, Yasuto Tanabe, and Shigetada Nakanishi Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14509–14514. Published online 2004 September 27. doi: 10.1073/pnas.0406295101.PMCID: PMC521974 Spatial memory, recognition memory, and the hippocampus Nicola J. Broadbent, Larry R. Squire, and Robert E. Clark Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14515–14520. Published online 2004 September 27. doi: 10.1073/pnas.0406344101.PMCID: PMC521976 Visual expertise with nonface objects leads to competition with the early perceptual processing of faces in the human occipitotemporal cortex Bruno Rossion, Chun-Chia Kung, and Michael J. Tarr Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14521–14526. Published online 2004 September 24. doi: 10.1073/pnas.0405613101.PMCID: PMC521961 Pharmacology LEAPT: Lectin-directed enzyme-activated prodrug therapy Mark A. Robinson, Stuart T. Charlton, Philippe Garnier, Xiang-tao Wang, Stanley S. Davis, Alan C. Perkins, Malcolm Frier, Ruth Duncan, Tony J. Savage, David A. Wyatt, Susan A. Watson, and Benjamin G. Davis Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14527–14532. Published online 2004 September 24. doi: 10.1073/pnas.0303574101.PMCID: PMC521935 Plant Biology From the Cover: Evidence for landscape-level, pollen-mediated gene flow from genetically modified creeping bentgrass with CP4 EPSPS as a marker Lidia S. Watrud, E. Henry Lee, Anne Fairbrother, Connie Burdick, Jay R. Reichman, Mike Bollman, Marjorie Storm, George King, and Peter K. Van de Water Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14533–14538. Published online 2004 September 24. doi: 10.1073/pnas.0405154101.PMCID: PMC521937 Arabidopsis C-terminal domain phosphatase-like 1 and 2 are essential Ser-5-specific C-terminal domain phosphatases Hisashi Koiwa, Stéphane Hausmann, Woo Young Bang, Akihiro Ueda, Naoko Kondo, Akihiro Hiraguri, Toshiyuki Fukuhara, Jeong Dong Bahk, Dae-Jin Yun, Ray A. Bressan, Paul M. Hasegawa, and Stewart Shuman Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14539–14544. Published online 2004 September 23. doi: 10.1073/pnas.0403174101.PMCID: PMC521950 A specific form of thioredoxin h occurs in plant mitochondria and regulates the alternative oxidase Eric Gelhaye, Nicolas Rouhier, Joelle Gérard, Yves Jolivet, José Gualberto, Nicolas Navrot, Per-Ingvard Ohlsson, Gunnar Wingsle, Masakazu Hirasawa, David B. Knaff, Hongmei Wang, Pierre Dizengremel, Yves Meyer, and Jean-Pierre Jacquot Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14545–14550. Published online 2004 September 22. doi: 10.1073/pnas.0405282101.PMCID: PMC521959 Social Sciences Social Sciences Terror attacks influence driving behavior in Israel Guy Stecklov and Joshua R. Goldstein Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14551–14556. Published online 2004 September 24. doi: 10.1073/pnas.0402483101.PMCID: PMC521946 Correction Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14557. Published online 2004 September 20. doi: 10.1073/pnas.0406534101.PMCID: PMC521977 Corrects: Aymeric de Parseval, et al. Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. Proc Natl Acad Sci U S A. 2004 August 31; 101(35): 13044–13049. |