| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 August 1; 103(31): 11429–11430. doi: 10.1073/iti3106103.PMCID: PMC1544183 Commentaries Enhancing molecular flux through nanopores by means of attractive interactions John J. Kasianowicz, Tam L. Nguyen, and Vincent M. Stanford PMCID: PMC1544184 Genome complexity in a lean, mean photosynthetic machine John M. Archibald PMCID: PMC1544185 Bacterial stalks are nutrient-scavenging antennas Harley H. McAdams PMCID: PMC1544186 Profile Profile of Lonnie G. Thompson Nick Zagorski PMCID: PMC1544187 Physical Sciences Applied Physical Sciences Macromolecular-scale resolution in biological fluorescence microscopy Gerald Donnert, Jan Keller, Rebecca Medda, M. Alexandra Andrei, Silvio O. Rizzoli, Reinhard Lührmann, Reinhard Jahn, Christian Eggeling, and Stefan W. Hell PMCID: PMC1518808 Chemistry From the Cover:
Molecular transport through channels and pores: Effects of in-channel interactions and blocking Wolfgang R. Bauer and Walter Nadler PMCID: PMC1513537 Chemoresponsive monolayer transistors Xuefeng Guo, Matthew Myers, Shengxiong Xiao, Michael Lefenfeld, Rachel Steiner, George S. Tulevski, Jinyao Tang, Julian Baumert, Frank Leibfarth, James T. Yardley, Michael L. Steigerwald, Philip Kim, and Colin Nuckolls PMCID: PMC1544190 A mechanism to signal receptor–substrate interactions with luminescent quantum dots Ibrahim Yildiz, Massimiliano Tomasulo, and Françisco M. Raymo PMCID: PMC1544191 Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases Florence Pojer, Jean-Luc Ferrer, Stéphane B. Richard, Dinesh A. Nagegowda, Mee-Len Chye, Thomas J. Bach, and Joseph P. Noel PMCID: PMC1544197 Engineering Vascularized organoid engineered by modular assembly enables blood perfusion Alison P. McGuigan and Michael V. Sefton PMCID: PMC1544192 Scaling and saturation laws for the expansion of concrete exposed to sulfate attack Paulo J. M. Monteiro PMCID: PMC1544193 Biological Sciences Applied Biological Sciences Vascularized organoid engineered by modular assembly enables blood perfusion Alison P. McGuigan and Michael V. Sefton PMCID: PMC1544192 Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries James Inglese, Douglas S. Auld, Ajit Jadhav, Ronald L. Johnson, Anton Simeonov, Adam Yasgar, Wei Zheng, and Christopher P. Austin PMCID: PMC1518803 Targeting lentiviral vectors to specific cell types in vivo Lili Yang, Leslie Bailey, David Baltimore, and Pin Wang PMCID: PMC1518805 Biochemistry MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability Mei Leng, Doug W. Chan, Hao Luo, Cihui Zhu, Jun Qin, and Yi Wang PMCID: PMC1518802 Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases Florence Pojer, Jean-Luc Ferrer, Stéphane B. Richard, Dinesh A. Nagegowda, Mee-Len Chye, Thomas J. Bach, and Joseph P. Noel PMCID: PMC1544197 DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxia Ryan Burnett, Christian Melander, James W. Puckett, Leslie S. Son, Robert D. Wells, Peter B. Dervan, and Joel M. Gottesfeld PMCID: PMC1544198 Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease Stephanie X. Wang, Kailash C. Pandey, John R. Somoza, Puran S. Sijwali, Tanja Kortemme, Linda S. Brinen, Robert J. Fletterick, Philip J. Rosenthal, and James H. McKerrow PMCID: PMC1544199 Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties Thomas Boldog, Stephen Grimme, Mingshan Li, Stephen G. Sligar, and Gerald L. Hazelbauer PMCID: PMC1544200 Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate Gil Bornstein, Dvora Ganoth, and Avram Hershko PMCID: PMC1544201 CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein Won-Ho Cho, Young-Joo Lee, Soo-Im Kong, Jerard Hurwitz, and Joon-Kyu Lee PMCID: PMC1544202 Biophysics Macromolecular-scale resolution in biological fluorescence microscopy Gerald Donnert, Jan Keller, Rebecca Medda, M. Alexandra Andrei, Silvio O. Rizzoli, Reinhard Lührmann, Reinhard Jahn, Christian Eggeling, and Stefan W. Hell PMCID: PMC1518808 From the Cover:
Molecular transport through channels and pores: Effects of in-channel interactions and blocking Wolfgang R. Bauer and Walter Nadler PMCID: PMC1513537 Free-energy distribution of binary protein–protein binding suggests cross-species interactome differences Yi Y. Shi, Gerald A. Miller, Hong Qian, and Karol Bomsztyk PMCID: PMC1544203 Molecular dynamics analyses of cross-β-spine steric zipper models: β-Sheet twisting and aggregation Luciana Esposito, Carlo Pedone, and Luigi Vitagliano PMCID: PMC1544204 Coil–globule transition in the denatured state of a small protein Eilon Sherman and Gilad Haran PMCID: PMC1544205 Direct observation of DNA rotation during branch migration of Holliday junction DNA by Escherichia coli RuvA–RuvB protein complex Yong-Woon Han, Tomomi Tani, Masahito Hayashi, Takashi Hishida, Hiroshi Iwasaki, Hideo Shinagawa, and Yoshie Harada PMCID: PMC1544206 Cellular asymmetry and individuality in directional sensing Azadeh Samadani, Jerome Mettetal, and Alexander van Oudenaarden PMCID: PMC1544207 Tension-dependent DNA cleavage by restriction endonucleases: Two-site enzymes are “switched off” at low force Gregory J. Gemmen, Rachel Millin, and Douglas E. Smith PMCID: PMC1520314 Single-molecule detection of structural changes during Per-Arnt-Sim (PAS) domain activation Jason Ming Zhao, Haeshin Lee, Rene A. Nome, Sophia Majid, Norbert F. Scherer, and Wouter D. Hoff PMCID: PMC1544209 Cell Biology Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function Chenguang Wang, Zhiping Li, Yinan Lu, Runlei Du, Sanjay Katiyar, Jianguo Yang, Maofu Fu, Jennifer E. Leader, Andrew Quong, Phyllis M. Novikoff, and Richard G. Pestell PMCID: PMC1518800 Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration Cristina Muñoz-Pinedo, Ana Guío-Carrión, Joshua C. Goldstein, Patrick Fitzgerald, Donald D. Newmeyer, and Douglas R. Green PMCID: PMC1518810 N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development Frederique Zindy, Paul S. Knoepfler, Suqing Xie, Charles J. Sherr, Robert N. Eisenman, and Martine F. Roussel PMCID: PMC1518798 A Drosophila model of Barth syndrome Yang Xu, Morgan Condell, Heide Plesken, Irit Edelman-Novemsky, Jinping Ma, Mindong Ren, and Michael Schlame PMCID: PMC1544213 E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system Dennis Flierman, Catherine S. Coleman, Cecile M. Pickart, Tom A. Rapoport, and Vincent Chau PMCID: PMC1520313 Developmental Biology Liprin-α has LAR-independent functions in R7 photoreceptor axon targeting Kerstin Hofmeyer, Corinne Maurel-Zaffran, Helen Sink, and Jessica E. Treisman PMCID: PMC1544215 Liprin-α is required for photoreceptor target selection in Drosophila Kwang-Min Choe, Saurabh Prakash, Ali Bright, and Thomas R. Clandinin PMCID: PMC1544216 An early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survival José M. Brito, Marie-Aimée Teillet, and Nicole M. Le Douarin PMCID: PMC1544217 Robust, bistable patterning of the dorsal surface of the Drosophila embryo David M. Umulis, Mihaela Serpe, Michael B. O’Connor, and Hans G. Othmer PMCID: PMC1544218 Evolution Sympatric speciation under incompatibility selection Yael Artzy-Randrup and Alexey S. Kondrashov PMCID: PMC1518809 Solution structure of Urm1 and its implications for the origin of protein modifiers Junjie Xu, Jiahai Zhang, Li Wang, Jie Zhou, Hongda Huang, Jihui Wu, Yang Zhong, and Yunyu Shi PMCID: PMC1518799 The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer Badam Enkhmandakh, Alexandr V. Makeyev, and Dashzeveg Bayarsaihan PMCID: PMC1544221 Repression and loss of gene expression outpaces activation and gain in recently duplicated fly genes Todd H. Oakley, Bjørn Østman, and Asa C. V. Wilson PMCID: PMC1544222 Genetics Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability Sarah L. Donahue, Qing Lin, Shang Cao, and H. Earl Ruley PMCID: PMC1544223 From the Cover:
Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features Evelyne Derelle, Conchita Ferraz, Stephane Rombauts, Pierre Rouzé, Alexandra Z. Worden, Steven Robbens, Frédéric Partensky, Sven Degroeve, Sophie Echeynié, Richard Cooke, Yvan Saeys, Jan Wuyts, Kamel Jabbari, Chris Bowler, Olivier Panaud, Benoît Piégu, Steven G. Ball, Jean-Philippe Ral, François-Yves Bouget, Gwenael Piganeau, Bernard De Baets, André Picard, Michel Delseny, Jacques Demaille, Yves Van de Peer, and Hervé Moreau PMCID: PMC1544224 The regulatory utilization of genetic redundancy through responsive backup circuits Ran Kafri, Melissa Levy, and Yitzhak Pilpel PMCID: PMC1513536 A family of conserved noncoding elements derived from an ancient transposable element Xiaohui Xie, Michael Kamal, and Eric S. Lander PMCID: PMC1518811 Immunology The Ets factor Spi-B is a direct critical target of the coactivator OBF-1 Boris Bartholdy, Camille Du Roure, Alain Bordon, Dianne Emslie, Lynn M. Corcoran, and Patrick Matthias PMCID: PMC1513538 Direct stimulation of T cells by membrane vesicles from antigen-presenting cells Marek Kovar, Onur Boyman, Xuefei Shen, Inkyu Hwang, Rachel Kohler, and Jonathan Sprent PMCID: PMC1544228 Essential role of TAK1 in thymocyte development and activation Hong-Hsing Liu, Min Xie, Michael D. Schneider, and Zhijian J. Chen PMCID: PMC1544229 DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype Ivana Durinovic-Belló, Silke Rosinger, Jennifer A. Olson, Mauro Congia, Regina C. Ahmad, Mathias Rickert, Johannes Hampl, Hubert Kalbacher, Jan W. Drijfhout, Elizabeth D. Mellins, Sascha Al Dahouk, Thomas Kamradt, Markus J. Maeurer, Carol Nhan, Bart O. Roep, Bernhard O. Boehm, Constantin Polychronakos, Gerald T. Nepom, Wolfram Karges, Hugh O. McDevitt, and Grete Sønderstrup PMCID: PMC1544230 Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells Marcella Ferlito, Kaikobad Irani, Nauder Faraday, and Charles J. Lowenstein PMCID: PMC1544231 Regulation of T cell activation and tolerance by PDL2 Yongliang Zhang, Yeonseok Chung, Caroline Bishop, Betsy Daugherty, Hilary Chute, Paige Holst, Carole Kurahara, Fred Lott, Ning Sun, Andrew A. Welcher, and Chen Dong PMCID: PMC1544232 Medical Sciences Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression Vasudha Sundaravaradan, Shailendra K. Saxena, Rajesh Ramakrishnan, Venkat R. K. Yedavalli, David T. Harris, and Nafees Ahmad PMCID: PMC1544233 Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells John P. Chute, Garrett G. Muramoto, John Whitesides, Michael Colvin, Rachid Safi, Nelson J. Chao, and Donald P. McDonnell PMCID: PMC1544234 B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia Xiao-jie Yan, Emilia Albesiano, Nicola Zanesi, Sophia Yancopoulos, Alan Sawyer, Egidio Romano, Aleksandar Petlickovski, Dimitar G. Efremov, Carlo M. Croce, and Nicholas Chiorazzi PMCID: PMC1518806 Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption Manabu Kinoshita, Nathan McDannold, Ferenc A. Jolesz, and Kullervo Hynynen PMCID: PMC1544236 Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells Xueni Chen, Brian A. Hyatt, Michael L. Mucenski, Robert J. Mason, and John M. Shannon PMCID: PMC1544237 Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy Yan Shou, Zhijun Ma, Taihe Lu, and Brian P. Sorrentino PMCID: PMC1518804 Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis Mei Li, Pierre Hener, Zhikun Zhang, Shigeaki Kato, Daniel Metzger, and Pierre Chambon PMCID: PMC1544239 From the Cover:
T lineage differentiation from human embryonic stem cells Zoran Galić, Scott G. Kitchen, Amelia Kacena, Aparna Subramanian, Bryan Burke, Ruth Cortado, and Jerome A. Zack PMCID: PMC1544240 Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy Rahul N. Kanadia, Jihae Shin, Yuan Yuan, Stuart G. Beattie, Thurman M. Wheeler, Charles A. Thornton, and Maurice S. Swanson PMCID: PMC1544241 Microbiology Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli Tao Wu, Andrew C. McCandlish, Luisa S. Gronenberg, Shu-Sin Chng, Thomas J. Silhavy, and Daniel Kahne PMCID: PMC1544242 Characterization of mycobacterial virulence genes through genetic interaction mapping Swati M. Joshi, Amit K. Pandey, Nicole Capite, Sarah M. Fortune, Eric J. Rubin, and Christopher M. Sassetti PMCID: PMC1544243 Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague Florent Sebbane, Nadine Lemaître, Daniel E. Sturdevant, Roberto Rebeil, Kimmo Virtaneva, Stephen F. Porcella, and B. Joseph Hinnebusch PMCID: PMC1518801 From the Cover:
A nutrient uptake role for bacterial cell envelope extensions Jennifer K. Wagner, Sima Setayeshgar, Laura A. Sharon, James P. Reilly, and Yves V. Brun PMCID: PMC1544245 Neuroscience Modulation of competing memory systems by distraction Karin Foerde, Barbara J. Knowlton, and Russell A. Poldrack PMCID: PMC1544246 From the Cover:
Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1 Oleg Butovsky, Maya Koronyo-Hamaoui, Gilad Kunis, Eran Ophir, Gennady Landa, Hagit Cohen, and Michal Schwartz PMCID: PMC1544247 Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury Yuri Ikeda-Matsuo, Azusa Ota, Tetsuya Fukada, Satoshi Uematsu, Shizuo Akira, and Yasuharu Sasaki PMCID: PMC1518807 Plant Biology Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation Fernanda Agius, Avnish Kapoor, and Jian-Kang Zhu PMCID: PMC1544249 Population Biology Ecological and immunological determinants of dengue epidemics Helen J. Wearing and Pejman Rohani PMCID: PMC1544250 Psychology Spatial remapping of touch: Confusion of perceived stimulus order across hand and foot Tobias Schicke and Brigitte Röder PMCID: PMC1544251 Social Sciences Psychology Modulation of competing memory systems by distraction Karin Foerde, Barbara J. Knowlton, and Russell A. Poldrack PMCID: PMC1544246 Corrections Correction for, In This Issue PMCID: PMC1544252 Corrects: In This Issue. Proc Natl Acad Sci U S A. 2006 June 13; 103(24): 8907–8908. Correction for Banci et al., A hint for the function of human Sco1 from different structures PMCID: PMC1544253 Corrects: Lucia Banci, et al. A hint for the function of human Sco1 from different structures. Proc Natl Acad Sci U S A. 2006 June 6; 103(23): 8595–8600. Correction for Medina et al., Naked corals: Skeleton loss in Scleractinia PMCID: PMC1544254 Corrects: Mónica Medina, et al. From the Cover:
Naked corals: Skeleton loss in Scleractinia. Proc Natl Acad Sci U S A. 2006 June 13; 103(24): 9096–9100. Correction for Palma et al., Anomalous levels of Cl− transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory PMCID: PMC1544255 Corrects: E. Palma, et al. Anomalous levels of Cl− transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proc Natl Acad Sci U S A. 2006 May 30; 103(22): 8465–8468. Correction for O’Toole et al., Two major classes in the M protein family in group A streptococci PMCID: PMC1544256 Corrects: P O'Toole, et al. Two major classes in the M protein family in group A streptococci. Proc Natl Acad Sci U S A. 1992 September 15; 89(18): 8661–8665. |
