Schizophrenia: genetic tools for unraveling the nature of a complex disorder.

How the plague bacillus and its transmission through fleas were discovered: reminiscences from my years at the Pasteur Institute in Paris.

Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase.

The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay.

Origins of the specificity of tissue-type plasminogen activator.

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

A yeast gene required for DNA replication encodes a protein with homology to DNA helicases.

The yeast nuclear import receptor is required for mitosis.

Role of essential light chain EF hand domains in calcium binding and regulation of scallop myosin.

Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.

The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury.

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys.

Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF.

A single GAL4 dimer can maximally activate transcription under physiological conditions.

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

Whole-body protochordate regeneration from totipotent blood cells.

Phenotype correction in retinal pigment epithelium in murine mucopolysaccharidosis VII by adenovirus-mediated gene transfer.

Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1.

Selenophosphate synthetase: detection in extracts of rat tissues by immunoblot assay and partial purification of the enzyme from the archaean Methanococcus vannielii.

Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.

Rapid genome change in synthetic polyploids of Brassica and its implications for polyploid evolution.

Rat growth hormone gene introns stimulate nucleosome alignment in vitro and in transgenic mice.

Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice.

Neoplastic development: paradoxical relation between impaired cell growth at low population density and excessive growth at high density.

High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes.

Modulation of pair bonding in female prairie voles (Microtus ochrogaster) by corticosterone.

Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

The rat suprachiasmatic nucleus is a clock for all seasons.

Polymorphic simple sequence repeat regions in chloroplast genomes: applications to the population genetics of pines.

Proenzyme of Manduca sexta phenol oxidase: purification, activation, substrate specificity of the active enzyme, and molecular cloning.

Nucleotide sequence of the cDNA encoding the proenzyme of phenol oxidase A1 of Drosophila melanogaster.

Molecular cloning of insect pro-phenol oxidase: a copper-containing protein homologous to arthropod hemocyanin.

Interleukin 2 signaling involves the phosphorylation of Stat proteins.

Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.

Light-generated nuclear quantum beats: a signature of photosynthesis.

Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.

A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.

The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.

The two single-strand cleavages at each end of Tn10 occur in a specific order during transposition.

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage.

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

Isolation of a primate embryonic stem cell line.

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene.

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.

Expression of PTPH1, a rat protein tyrosine phosphatase, is restricted to the derivatives of a specific diencephalic segment.

Olfactory transduction is intrinsically noisy.

Frequency encoding in excitable systems with applications to calcium oscillations.

Geographic and climatic control of primate diversity.

Identification of receptor ligands and receptor subtypes using antagonists in a capillary electrophoresis single-cell biosensor separation system.

Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha.

A molecular anchor for stabilizing triple-helical DNA.

14-3-3 proteins associate with cdc25 phosphatases.

Interleukin 1 beta up-regulates the expression of sulfoglucuronosyl paragloboside, a ligand for L-selectin, in brain microvascular endothelial cells.

Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat.

Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.

An automated multiplex oligonucleotide synthesizer: development of high-throughput, low-cost DNA synthesis.

TRAP, the trp RNA-binding attenuation protein of Bacillus subtilis, is a toroid-shaped molecule that binds transcripts containing GAG or UAG repeats separated by two nucleotides.

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase.

Cell-free activation of neutrophil NADPH oxidase by a phosphatidic acid-regulated protein kinase.

Membrane disposition of the M5-M6 hairpin of Na+,K(+)-ATPase alpha subunit is ligand dependent.

The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E).

Features of MotA proton channel structure revealed by tryptophan-scanning mutagenesis.

Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli.

Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein).

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.

Drosophila hormone receptor 38: a second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type.

Interleukin 4 signals through two related pathways.

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

Characterization of a Leishmania tropica antigen that detects immune responses in Desert Storm viscerotropic leishmaniasis patients.

Role of pili and the phase-variable PilC protein in natural competence for transformation of Neisseria gonorrhoeae.

Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells.

Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation.

Molecular cloning and functional characterization of the Xenopus Ca(2+)-binding protein frequenin.

Tonic stimulation of renin gene expression by nitric oxide is counteracted by tonic inhibition through angiotensin II.

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.

Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone.

Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine.

Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors.

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.

Adaptation of Spodoptera exigua larvae to plant proteinase inhibitors by induction of gut proteinase activity insensitive to inhibition.

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.

Diverse transposable elements are mobilized in hybrid dysgenesis in Drosophila virilis.

Gene therapy for long-term expression of erythropoietin in rats.

Construction, purification, and functional incorporation on tumor cells of glycolipid-anchored human B7-1 (CD80).

Apoptosis induced by a human milk protein.

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors.

Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.

Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum