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Scientists

Lothar's Picture

Lothar Hennighausen (Personal Page)

Lothar Hennighausen is a geneticist whose career includes contributions in academia and government. A native off Germany, Lothar performed undergraduate work in Germany and Scotland, and earned his Ph.D. in Genetics from the University of Cologne (Germany) in 1982. He immigrated to the United States in 1983 to join the research group of Dr. Philip Leder at Harvard Medical School.

In 1985 Lothar Hennighausen joined the National Institute of Diabetes, Digestive and Kidney Diseases at the NIH in Bethesda, Maryland and established a research group that explores genetic circuitry in organ development and disease using experimental mouse genetics. His current interest focuses on the mechanisms used by cytokines to control the physiology and patho-physiology of cells. Dr. Hennighausen addresses questions related to mammary development and cancer, hematopoietic stem cells and leukemias as well as the physiology of muscle and liver.

Lothar takes the same enthusiastic approach to activities outside the laboratory as he does inside. He is an avid cross country skier and long distance cyclist (Randonneur) and finisher of the 1200 kilometer event Paris-Brest-Paris. He is married to Dr. Priscilla Furth, a cancer researcher and Professor at the Lombardi Comprehensive Cancer Center at Georgetown University.

Gertraud Robinson

Gertraud Robinson (Personal Page)

Dr. Robinson joined LGP in 1993. Her main interest is the development of mammary glands from the embryo into adult life, lactation and cancer. In particular she studies the role of cytokines that activate the JAK/STAT pathway and mediate hormone signals, which induce cell proliferation, survival and differentiation. Traudl also tries to understand how the different cell types in the epithelium obtain and maintain their specific cell fate as either luminal or myoepithelial cells and how Notch signals are involved in this process. In her capacity as Staff Scientist, together with Dr. Hennighausen, she supervises the ongoing post doc projects in the lab.

Jihoon Yu

Jihoon Yu

Yonatan Feuermann

Yonatan Feuermann

Akiko Kimura

Akiko Kimura

Dr. Kimura received her Ph.D. degree in Medical Science from Kyushu University (Faculty of Medicine) in Japan after graduating from Nagasaki University (Faculty of Pharmaceutical Science) in Japan and Miyazaki Medical College (at present, the Faculty of Medicine, Miyazaki University) in Japan. After her clinical residency, she selected Hematology as her specialty and treated patients with hematological malignant diseases, autoimmune diseases and severe infection etc. She joined LGP in 2006 where she focuses on the role of the transcription factor STAT5 in hematopoietic stem cells and the granulocyte lineage using STAT5 complete knockout and conditional knockout mouse model. This granulocyte project won the Fellows Award for Research Excellence 2008 competition at NIH.

Peter Klover

Peter Klover

Dr. Klover received a doctoral degree in biochemistry from the University of Rochester after studying role of IL-6 in obesity and hepatic insulin resistance. He joined the LGP in 2005 and currently is focused on how the transcription factors STAT5a and STAT5b (STAT5) function to regulate growth and carbohydrate metabolism in the skeletal muscle. Using a conditional knockout model he has found that STAT5 plays an important role in the skeletal muscle for maintenance of normal growth and glucose homeostasis. Dr. Klover has also developed a mouse model to study the role the transcription factor STAT1 in the development of breast cancer.

Marius Henkel

Marius Henkel

Daisuke Yamaji

Dr. Daisuke Yamaji

Daisuke Yamaji received a Ph.D. degree in veterinary medicine from Hokkaido University in Japan after studying roles of adipocyte-secreted factors in mammary epithelial cell morphogenesis. Since his interest is in the biology of mammary gland, he joined LGP in June 2007 as a postdoctoral fellow. In LGP, Dr. Yamaji attempts to elucidate why loss of Stat5 results in a complete block of mammary alveolar development. He also attempts to identify whether Stat5 is required for the initiation and progression of mammary tumor using a transgenic and conditional knockout mouse model.
BingMei Zhu

BingMei Zhu

Dr. Zhu joined our lab after she got her Ph.D. degree in University of Yamanashi, Japan. She has been working on cytokine pathways in hematopoietic system and immune system using knockout mice. She and her coworkers had revealed that the mice in which Signaling Transducer and Activator of Transcription 5 (Stat5) had been deleted from hematopoietic stem cells developed microcytic anemia which was accompanied by increased serum iron levels and hepatic iron deposition. This study demonstrates a direct link between erythropoietin signaling and the iron status of erythroid cells and reveals that loss of Stat5 in hematopoietic stem cells results in impaired iron uptake into erythroid progenitors and the development of microcytic anemia due to insufficient transferring receptor (TfR) 1 expression. This study won the Fellows Award for Research Excellence (FARE) 2008 competition in NIH. Dr. Zhu also focuses on a study that how the Suppressor of Cytokine Signaling (SOCS3) contributes to mouse skin wound healing and immune system by using different conditional SOCS3 knockout mice. She found that wound healing is controlled in keratinocytes by the gp130-SOCS3-STAT3 pathway and an imbalance of this pathway results in delayed wound healing. She is involved some other projects with collaborators to uncover the role of Stats and their negative regulators in tumor development and therapy.

Mark Wickre

Mark Wickre

 Winfried Wels

Winfried Wels

 

Michael Rieger

Michael Rieger
Michael, is a visiting scientist from the Stem Cell Institute in Neuherberg/Munich.  He joined our lab for two months to continue a longstanding collaboration exploring the role of TPO-STAT5 signaling in hematopoietic stem cells. 



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