| | This journal provides immediate access to some articles. Letters Decline in nature-based recreation is not evident Maarten H. Jacobs and Michael J. Manfredo PMCID: PMC2453718 Reply to Jacobs and Manfredo: More support for a pervasive decline in nature-based recreation Oliver R. W. Pergams and Patricia A. Zaradic PMCID: PMC2453695 This Week in PNAS Proc Natl Acad Sci U S A. 2008 July 8; 105(27): 9131–9132. doi: 10.1073/iti2708105.PMCID: PMC2453707 Commentaries Another step toward quantifying spontaneous mutation Alexey S. Kondrashov PMCID: PMC2453708 Immune surveillance obstructed by viral mRNA Shelley R. Starck, Sylvain Cardinaud, and Nilabh Shastri PMCID: PMC2453731 Profile Profile of Claudio Bunster Kaspar Mossman PMCID: PMC2453749 Physical Sciences Applied Physical Sciences Optimal vein density in artificial and real leaves X. Noblin, L. Mahadevan, I. A. Coomaraswamy, D. A. Weitz, N. M. Holbrook, and M. A. Zwieniecki PMCID: PMC2453744 Chemistry Four-color DNA sequencing with 3′-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides Jia Guo, Ning Xu, Zengmin Li, Shenglong Zhang, Jian Wu, Dae Hyun Kim, Mong Sano Marma, Qinglin Meng, Huanyan Cao, Xiaoxu Li, Shundi Shi, Lin Yu, Sergey Kalachikov, James J. Russo, Nicholas J. Turro, and Jingyue Ju PMCID: PMC2442126 Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly W. Seth Horne, Joshua L. Price, and Samuel H. Gellman PMCID: PMC2453709 A unified view of ligand-protected gold clusters as superatom complexes Michael Walter, Jaakko Akola, Olga Lopez-Acevedo, Pablo D. Jadzinsky, Guillermo Calero, Christopher J. Ackerson, Robert L. Whetten, Henrik Grönbeck, and Hannu Häkkinen PMCID: PMC2442568 Atomic level computational identification of ligand migration pathways between solvent and binding site in myoglobin Jory Z. Ruscio, Deept Kumar, Maulik Shukla, Michael G. Prisant, T. M. Murali, and Alexey V. Onufriev PMCID: PMC2453746 Biological Sciences Applied Biological Sciences Four-color DNA sequencing with 3′-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides Jia Guo, Ning Xu, Zengmin Li, Shenglong Zhang, Jian Wu, Dae Hyun Kim, Mong Sano Marma, Qinglin Meng, Huanyan Cao, Xiaoxu Li, Shundi Shi, Lin Yu, Sergey Kalachikov, James J. Russo, Nicholas J. Turro, and Jingyue Ju PMCID: PMC2442126 Biochemistry Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I Duo Lu and James L. Keck PMCID: PMC2453719 Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus Jae-Mun Choi, Anne M. Hutson, Mary K. Estes, and B. V. Venkataram Prasad PMCID: PMC2453692 Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20 Esther Eytan, Ilana Braunstein, Dvora Ganoth, Adar Teichner, James C. Hittle, Tim J. Yen, and Avram Hershko PMCID: PMC2453698 Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import Mary Anne T. Rubio, Jesse J. Rinehart, Bethany Krett, Stéphane Duvezin-Caubet, Andreas S. Reichert, Dieter Söll, and Juan D. Alfonzo PMCID: PMC2453747 Role of hybrid tRNA-binding states in ribosomal translocation Sarah E. Walker, Shinichiro Shoji, Dongli Pan, Barry S. Cooperman, and Kurt Fredrick PMCID: PMC2453706 Spatiotemporal activation of Rac1 for engulfment of apoptotic cells Michio Nakaya, Masahiro Kitano, Michiyuki Matsuda, and Shigekazu Nagata PMCID: PMC2442128 Biophysics Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly W. Seth Horne, Joshua L. Price, and Samuel H. Gellman PMCID: PMC2453709 Atomic level computational identification of ligand migration pathways between solvent and binding site in myoglobin Jory Z. Ruscio, Deept Kumar, Maulik Shukla, Michael G. Prisant, T. M. Murali, and Alexey V. Onufriev PMCID: PMC2453746 Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex Hélène Van Melckebeke, Matthew Devany, Carmelo Di Primo, François Beaurain, Jean-Jacques Toulmé, David L. Bryce, and Jérôme Boisbouvier PMCID: PMC2453701 High-resolution mass spectrometry of viral assemblies: Molecular composition and stability of dimorphic hepatitis B virus capsids Charlotte Uetrecht, Cees Versluis, Norman R. Watts, Wouter H. Roos, Gijs J. L. Wuite, Paul T. Wingfield, Alasdair C. Steven, and Albert J. R. Heck PMCID: PMC2453694 Measuring molecular rupture forces between single actin filaments and actin-binding proteins Jorge M. Ferrer, Hyungsuk Lee, Jiong Chen, Benjamin Pelz, Fumihiko Nakamura, Roger D. Kamm, and Matthew J. Lang PMCID: PMC2453742 Light-dependent regulation of structural flexibility in a photochromic fluorescent protein Hideaki Mizuno, Tapas Kumar Mal, Markus Wälchli, Akihiro Kikuchi, Takashi Fukano, Ryoko Ando, Jeyaraman Jeyakanthan, Junichiro Taka, Yoshitsugu Shiro, Mitsuhiko Ikura, and Atsushi Miyawaki PMCID: PMC2453726 A stringent test for hydrophobicity scales: Two proteins with 88% sequence identity but different structure and function Alexander E. Kister and James C. Phillips PMCID: PMC2453729 Cell Biology Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations Nikola Wenta, Holger Strauss, Stefanie Meyer, and Uwe Vinkemeier PMCID: PMC2453697 Critical regulation of TGFβ signaling by Hsp90 Katharine H. Wrighton, Xia Lin, and Xin-Hua Feng PMCID: PMC2453700 Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner Latif Rachdi, Norman Balcazar, Fernando Osorio-Duque, Lynda Elghazi, Aaron Weiss, Aaron Gould, Karen J. Chang-Chen, Michael J. Gambello, and Ernesto Bernal-Mizrachi PMCID: PMC2453727 Ecology Functional diversity in coral–dinoflagellate symbiosis Michael Stat, Emily Morris, and Ruth D. Gates PMCID: PMC2453720 Identification of bacteria and bacteria-associated chemical cues that mediate oviposition site preferences by Aedes aegypti Loganathan Ponnusamy, Ning Xu, Satoshi Nojima, Dawn M. Wesson, Coby Schal, and Charles S. Apperson PMCID: PMC2443818 Environmental Sciences Optimal vein density in artificial and real leaves X. Noblin, L. Mahadevan, I. A. Coomaraswamy, D. A. Weitz, N. M. Holbrook, and M. A. Zwieniecki PMCID: PMC2453744 Evolution Egg size variation among tropical and temperate songbirds: An embryonic temperature hypothesis Thomas E. Martin PMCID: PMC2453717 From the Cover:
A genome-wide view of the spectrum of spontaneous mutations in yeast Michael Lynch, Way Sung, Krystalynne Morris, Nicole Coffey, Christian R. Landry, Erik B. Dopman, W. Joseph Dickinson, Kazufusa Okamoto, Shilpa Kulkarni, Daniel L. Hartl, and W. Kelley Thomas PMCID: PMC2453693 Geometric constraints on neuronal connectivity facilitate a concise synaptic adhesive code Shalev Itzkovitz, Leehod Baruch, Ehud Shapiro, and Eran Segal PMCID: PMC2453736 Genetics Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites Sven Diederichs, Stephanie Jung, S. Michael Rothenberg, Gromoslaw A. Smolen, Barbara G. Mlody, and Daniel A. Haber PMCID: PMC2442125 Chromosomal transposition of PiggyBac in mouse embryonic stem cells Wei Wang, Chengyi Lin, Dong Lu, Zeming Ning, Tony Cox, David Melvin, Xiaozhong Wang, Allan Bradley, and Pentao Liu PMCID: PMC2440425 A comprehensive assay for targeted multiplex amplification of human DNA sequences Sujatha Krishnakumar, Jianbiao Zheng, Julie Wilhelmy, Malek Faham, Michael Mindrinos, and Ronald Davis PMCID: PMC2442818 Complementary functions of ATM and H2AX in development and suppression of genomic instability Shan Zha, JoAnn Sekiguchi, James W. Brush, Craig H. Bassing, and Frederick W. Alt PMCID: PMC2453730 Immunology Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors Eric Adeeku, Prathyusha Gudapati, Yanice Mendez-Fernandez, Luc Van Kaer, and Mark Boothby PMCID: PMC2453725 Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4 Jyothi M. Ketavarapu, Annette R. Rodriguez, Jieh-Juen Yu, Yu Cong, Ashlesh K. Murthy, Thomas G. Forsthuber, M. Neal Guentzel, Karl E. Klose, Michael T. Berton, and Bernard P. Arulanandam PMCID: PMC2453703 From the Cover:
Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition Judy Tellam, Corey Smith, Michael Rist, Natasha Webb, Leanne Cooper, Tony Vuocolo, Geoff Connolly, David C. Tscharke, Michael P. Devoy, and Rajiv Khanna PMCID: PMC2453702 CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis Jeffrey H. Mills, Linda F. Thompson, Cynthia Mueller, Adam T. Waickman, Sirpa Jalkanen, Jussi Niemela, Laura Airas, and Margaret S. Bynoe PMCID: PMC2453691 Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells Li Wang, Karina Pino-Lagos, Victor C. de Vries, Indira Guleria, Mohamed H. Sayegh, and Randolph J. Noelle PMCID: PMC2442817 Dependence of antibody-mediated presentation of antigen on FcRn Shuo-Wang Qiao, Kanna Kobayashi, Finn-Eirik Johansen, Ludvig M. Sollid, Jan Terje Andersen, Edgar Milford, Derry C. Roopenian, Wayne I. Lencer, and Richard S. Blumberg PMCID: PMC2453734 Medical Sciences From the Cover:
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis Eric A. Murphy, Bharat K. Majeti, Leo A. Barnes, Milan Makale, Sara M. Weis, Kimberly Lutu-Fuga, Wolfgang Wrasidlo, and David A. Cheresh PMCID: PMC2453735 A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells Jenna N. Passman, Xiu Rong Dong, San-Pin Wu, Colin T. Maguire, Kelly A. Hogan, Victoria L. Bautch, and Mark W. Majesky PMCID: PMC2453724 Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex Kazuo Ueda, Carmen Valdivia, Argelia Medeiros-Domingo, David J. Tester, Matteo Vatta, Gianrico Farrugia, Michael J. Ackerman, and Jonathan C. Makielski PMCID: PMC2442127 Microbiology Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment Wei Kong, Soo-Young Wanda, Xin Zhang, Wendy Bollen, Steven A. Tinge, Kenneth L. Roland, and Roy Curtiss, III PMCID: PMC2453710 Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis Georgios Chamilos, Russell E. Lewis, Jianhua Hu, Lianchun Xiao, Tomasz Zal, Michel Gilliet, Georg Halder, and Dimitrios P. Kontoyiannis PMCID: PMC2453716 Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine Ngoc Q. Tran, Lisa F. Rezende, Udi Qimron, Charles C. Richardson, and Stanley Tabor PMCID: PMC2453740 From the Cover:
Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole Jordan L. Cocchiaro, Yadunanda Kumar, Elizabeth R. Fischer, Ted Hackstadt, and Raphael H. Valdivia PMCID: PMC2453745 An in vivo gene deletion system for determining temporal requirement of bacterial virulence factors Yancheng Liu, Ping Gao, Simran Banga, and Zhao-Qing Luo PMCID: PMC2453721 Neuroscience MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function Ana C. Barbosa, Mi-Sung Kim, Mert Ertunc, Megumi Adachi, Erika D. Nelson, John McAnally, James A. Richardson, Ege T. Kavalali, Lisa M. Monteggia, Rhonda Bassel-Duby, and Eric N. Olson PMCID: PMC2453723 Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo Hao Li, Jonathan C. Radford, Michael J. Ragusa, Katherine L. Shea, Scott R. McKercher, Jeffrey D. Zaremba, Walid Soussou, Zhiguo Nie, Yeon-Joo Kang, Nobuki Nakanishi, Shu-ichi Okamoto, Amanda J. Roberts, John J. Schwarz, and Stuart A. Lipton PMCID: PMC2453715 From the Cover:
PET and MRI show differences in cerebral asymmetry and functional connectivity between homo- and heterosexual subjects Ivanka Savic and Per Lindström PMCID: PMC2453705 Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation Alvin W. Lyckman, Sam Horng, Catherine A. Leamey, Daniela Tropea, Akiya Watakabe, Audra Van Wart, Cortina McCurry, Tetsuo Yamamori, and Mriganka Sur PMCID: PMC2453704 Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome Sergey V. Voronov, Samuel G. Frere, Silvia Giovedi, Elizabeth A. Pollina, Christelle Borel, Hong Zhang, Cecilia Schmidt, Ellen C. Akeson, Markus R. Wenk, Laurent Cimasoni, Ottavio Arancio, Muriel T. Davisson, Stylianos E. Antonarakis, Katheleen Gardiner, Pietro De Camilli, and Gilbert Di Paolo PMCID: PMC2453748 Pharmacology Agonist-selective signaling is determined by the receptor location within the membrane domains Hui Zheng, Ji Chu, Yu Qiu, Horace H. Loh, and Ping-Yee Law PMCID: PMC2453714 Detrimental effects of Bartonella henselae are counteracted by l-arginine and nitric oxide in human endothelial progenitor cells Paola Salvatore, Amelia Casamassimi, Linda Sommese, Carmela Fiorito, Alfredo Ciccodicola, Raffaele Rossiello, Bice Avallone, Vincenzo Grimaldi, Valerio Costa, Monica Rienzo, Roberta Colicchio, Sharon Williams-Ignarro, Caterina Pagliarulo, Maria Evelina Prudente, Ciro Abbondanza, Florentia Lamberti, Adone Baroni, Elisabetta Buommino, Bartolomeo Farzati, Maria Antonietta Tufano, Louis Joseph Ignarro, and Claudio Napoli PMCID: PMC2453733 Plant Biology PIF1 directly and indirectly regulates chlorophyll biosynthesis to optimize the greening process in Arabidopsis Jennifer Moon, Ling Zhu, Hui Shen, and Enamul Huq PMCID: PMC2453699 Psychology The natural order of events: How speakers of different languages represent events nonverbally Susan Goldin-Meadow, Wing Chee So, Aslı Özyürek, and Carolyn Mylander PMCID: PMC2453738 Sustainability Science Humid tropical forest clearing from 2000 to 2005 quantified by using multitemporal and multiresolution remotely sensed data Matthew C. Hansen, Stephen V. Stehman, Peter V. Potapov, Thomas R. Loveland, John R. G. Townshend, Ruth S. DeFries, Kyle W. Pittman, Belinda Arunarwati, Fred Stolle, Marc K. Steininger, Mark Carroll, and Charlene DiMiceli PMCID: PMC2453739 Field evidence that ecosystem service projects support biodiversity and diversify options Rebecca L. Goldman, Heather Tallis, Peter Kareiva, and Gretchen C. Daily PMCID: PMC2453743 Social Sciences Psychology The natural order of events: How speakers of different languages represent events nonverbally Susan Goldin-Meadow, Wing Chee So, Aslı Özyürek, and Carolyn Mylander PMCID: PMC2453738 |
