Individual Animal Clinical Chemistry

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Chemical Name:	Acetaminophen (4-hydroxyacetanilide)
CAS Number:	103-90-2
Study Number:	C55801E
Exposure Route:	Gavage
Study Length (Year Completed):	2 Days (2002)
Sex:	Male
Strain and Species:	F344 Rats

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Table Instructions and Notes:

Summary table measurements are dose group mean ± standard error of means

Summary Data | Detail Data | Historical Controls

Clinical Chemistry Summary Table
(Mean ± SEM)
Dose Group (mg/kg bw)	Control Code	BUN (mg/dL)	Creat (mg/dL)	TP (g/dL)	ALB (g/dL)	ALT (IU/L)	SDH (IU/L)	AST (IU/L)	ALP (IU/L)	TBA (umol/L)	Cholesterol (mg/dL)
Hour 6
0	V	11.33 ± 0.211	0.7 ± 0.02	7.1 ± 0.14	4.78 ± 0.075	58.5 ± 4.58	20.33 ± 0.803	86 ± 6	264 ± 9	6.2 ± 1.54	82.0 ± 4.20
50		12.50 ± 0.671	0.7 ± 0.02	7.2 ± 0.10	4.85 ± 0.050	81.2 ± 4.33	23.50 ± 0.719	108 ± 7	286 ± 16	6.5 ± 0.85	85.3 ± 5.97
150		12.00 ± 0.000	0.6 ± 0.02	7.3 ± 0.11	4.83 ± 0.049	72.5 ± 5.25	23.67 ± 1.202	99 ± 7	290 ± 8	6.0 ± 0.73	83.3 ± 2.63
1500		12.33 ± 0.422	0.6 ± 0.03	7.5 ± 0.16	5.05 ± 0.092	127.7 ± 50.38	27.67 ± 7.017	151 ± 48	306 ± 7	5.0 ± 0.45	93.8 ± 2.15
2000		14.50 ± 0.563	0.7 ± 0.00	7.7 ± 0.17	5.20 ± 0.073	185.8 ± 44.16	40.17 ± 10.274	221 ± 41	276 ± 18	4.2 ± 0.40	99.3 ± 1.71
Hour 18
0	V	18.67 ± 0.803	0.7 ± 0.00	7.8 ± 0.10	5.13 ± 0.076	60.7 ± 4.81	17.33 ± 1.606	99 ± 7	394 ± 12	6.0 ± 1.15	89.8 ± 2.17
50		19.00 ± 0.447	0.7 ± 0.02	7.7 ± 0.06	5.13 ± 0.042	114.8 ± 50.94	28.50 ± 10.535	159 ± 58	391 ± 6	6.3 ± 1.52	87.2 ± 2.36
150		16.83 ± 0.401	0.7 ± 0.02	7.6 ± 0.12	5.10 ± 0.068	58.8 ± 4.87	13.83 ± 0.946	93 ± 10	378 ± 13	7.0 ± 1.32	77.5 ± 2.25
1500		22.83 ± 1.108	0.7 ± 0.02	7.9 ± 0.17	5.35 ± 0.089	2,489.5 ± 1,286.59	422.83 ± 311.739	4,593 ± 2,507	391 ± 13	25.5 ± 9.89	75.0 ± 6.44
2000		25.17 ± 0.833	0.7 ± 0.02	7.7 ± 0.08	5.27 ± 0.061	6,812.8 ± 2,104.09	19.83 ± 15.645	13,794 ± 3,628	376 ± 7	45.0 ± 9.88	61.3 ± 3.42
Hour 24
0	V	16.17 ± 1.493	0.7 ± 0.00	7.5 ± 0.08	5.02 ± 0.048	65.2 ± 5.91	18.33 ± 1.520	88 ± 7	324 ± 7	13.5 ± 3.17	78.5 ± 1.61
50		15.50 ± 1.118	0.6 ± 0.02	7.4 ± 0.11	4.95 ± 0.062	63.3 ± 3.16	16.67 ± 1.430	88 ± 5	321 ± 12	7.2 ± 1.90	83.8 ± 1.68
150		16.00 ± 1.354	0.7 ± 0.03	7.5 ± 0.03	4.95 ± 0.029	69.0 ± 3.76	14.20 ± 3.153	143 ± 52	326 ± 7	12.3 ± 3.12	82.3 ± 2.50
1500		22.33 ± 1.054	0.7 ± 0.02	7.7 ± 0.13	5.22 ± 0.048	3,859.2 ± 1,673.91	291.67 ± 158.632	8,440 ± 3,776	383 ± 16	41.5 ± 8.72	67.2 ± 6.64
2000		23.17 ± 1.014	0.7 ± 0.02	7.5 ± 0.28	5.00 ± 0.151	7,217.2 ± 1,734.31	13.83 ± 10.650	16,602 ± 4,054	416 ± 20	57.3 ± 12.38	69.0 ± 6.77
Hour 48
0	V	15.00 ± 0.931	0.7 ± 0.03	7.3 ± 0.06	4.97 ± 0.049	62.2 ± 4.68	23.67 ± 1.022	87 ± 4	308 ± 9	10.2 ± 1.85	80.0 ± 1.51
50		15.67 ± 0.955	0.7 ± 0.03	7.5 ± 0.06	4.98 ± 0.048	65.7 ± 5.79	22.17 ± 1.470	92 ± 6	330 ± 7	13.2 ± 2.48	84.3 ± 1.73
150		15.33 ± 0.989	0.7 ± 0.00	7.3 ± 0.06	4.95 ± 0.050	60.5 ± 2.95	22.83 ± 0.946	83 ± 2	321 ± 10	6.7 ± 1.69	82.5 ± 2.14
1500		16.17 ± 0.749	0.7 ± 0.03	7.0 ± 0.16	4.63 ± 0.117	1,309.8 ± 264.39	197.83 ± 31.422	1,731 ± 350	361 ± 29	39.8 ± 8.03	94.5 ± 3.12
2000		15.67 ± 0.333	0.7 ± 0.02	6.9 ± 0.12	4.57 ± 0.076	1,635.0 ± 321.08	465.00 ± 89.954	3,008 ± 662	335 ± 23	49.8 ± 8.27	99.0 ± 3.71
Abbreviations: NA: Not Available,SEM: Standard Error of Means,V: Vehicle Control,BW: dose is per unit of body wt,BUN: Blood Urea Nitrogen,Creat: Creatinine,TP: Total Protein,ALB: Albumin,ALT: Alanine aminotransferase,SDH: Sorbitol Dehydrogenase,AST: Aspartate Aminotransferase Serum,ALP: Alkaline phosphatase,TBA: Total Bile Acids,Cholesterol: CholesterolWT: Weight

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Historica Controls: if sufficient historical control data is available that matches your sex, strain, endpoint set, and type of feed, you will see summary historical control data for this endpoint set.
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