National Toxicology Program

Photocarcinogenesis Study of Glycolic acid and Salicylic acid in SKH-1 Mice (Simulated solar light and topical application studies) (TR 524)

The Subcommittee accepted unanimously (6 yes, 0 no) the conclusions as written, no alteration of photocarcinogenesis of simulated solar light by glycolic acid and photoprotection by salicylic acid.

Dibromoacetic acid (TR 537)

The Subcommittee accepted unanimously (6 yes, 0 no) the conclusions as written, some evidence of carcinogenic activity of dibromoacetic acid in male and female F344/N rats, and clear evidence of carcinogenic activity of dibromoacetic acid in male and female B6C3F₁ mice. The Subcommittee stated that the increased incidences in mononuclear cell leukemia in male rats may have been related to chemical exposure.

Dichloroacetic acid (GMM 11)

The Subcommittee accepted (5 yes, 1 no) the conclusions as written, no evidence of carcinogenic activity of dichloroacetic acid in p53 haploinsufficient mice.

Bromodichloromethane (GMM 5)

The Subcommittee accepted unanimously (6 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of bromodichloromethane in p53 haploinsufficient mice.

Sodium bromate (GMM 6)

The Subcommittee accepted unanimously (6 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of sodium bromate in p53 haploinsufficient mice.

Divinylbenzene (TR 534)

The Subcommittee accepted (5 yes, 0 no, 1 abstention) the conclusions as written, equivocal evidence of carcinogenic activity of divinylbenzene in male F344/N rats and female B6C3F₁ mice and no evidence of carcinogenic activity in female F344/N rats and male B6C3F₁ mice.

Methyl isobutyl ketone (TR 538)

The Subcommittee accepted unanimously (6 yes, 0 no) the conclusions as written, some evidence of carcinogenic activity of methyl isobutyl ketone in male F344/N rats and in male and female B6C3F₁ mice and equivocal evidence of carcinogenic activity in female F344/N rats.

Diisopropylcarbodiimide (TR 523)

The Subcommittee accepted unanimously (5 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of diisopropylcarbodiimide in male or female F344/N rats or B6C3F₁ mice.

Diisopropylcarbodiimide (GMM 10)

The Subcommittee accepted unanimously (5 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of diisopropylcarbodiimide in p53 haploinsufficient mice.

4-Methylimidazole (TR 535)

The Subcommittee accepted unanimously (5 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of 4-methylimidazole in male F344/N rats, equivocal evidence of carcinogenic activity in female F344/N rats and clear evidence of carcinogenic activity in male and female B6C3F₁ mice.