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Summaries & Associations of Study Results

TR-494 Anthraquinone

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Target Organs and Levels of Evidence
NTP Technical Report Number 494

Produced from Chemtrack Database 05/14/04

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
ANTHRAQUINONE
84-65-1
02/17/04 INTERMEDIATE IN MANUFACTURE OF DYES AND OTHER ORGANICS. ORGANIC INHIBITOR. CATALYST. ACCELERATOR IN NICKEL ELECTROPLATING. IMPROVING ADHESION AND HEAT STABILITY OF TIRE CORD. (NTP EXECUTIVE SUMMARY) Dosed-Feed R: 0, 469, 938, 1875, OR 3750 PPM M: 0, 833, 2500, OR 7500 PPM Battelle Columbus Laboratory
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: SOME EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 1/50 3/50 9/50 5/50 3/50
KIDNEY TRANSITIONAL CELL: PAPILLOMA 0/50 0/50 2/50 0/50 1/50
URINARY BLADDER: TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49
MAY HAVE BEEN RELATED: LIVER: ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50
NON-NEOPLASTIC LESIONS: KIDNEY: HYALINE DROPLET ACCUMULATION; INCREASED SEVERITY OF NEPHROPATHY; PIGMENTATION; MEDULLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
LIVER: CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION; INFLAMMATION; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; CYTOPLASMIC VACUOLIZATION
SPLEEN: CONGESTION; PIGMENTATION; HEMATOPOIETIC CELL PROLIFERATION
BONE MARROW: HYPERPLASIA
OTHER CONSIDERATIONS: HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 25/50 2/50 1/50 5/50 7/50
FR: CLEAR EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49
URINARY BLADDER: TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49
LIVER: ADENOMA 0/50 2/50 6/50 4/50 3/50
NON-NEOPLASTIC LESIONS: KIDNEY: HYALINE DROPLET ACCUMULATION; NEPHROPATHY; PIGMENTATION; MEDULLA MINERALIZATION; TUBULAR CELL HYPERPLASIA; TRANSITIONAL EPITHELIAL HYPERPLASIA
LIVER: CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION; INFLAMMATION; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; ANGIECTASIS
SPLEEN: CONGESTION; PIGMENTATION; HEMATOPOIETIC CELL PROLIFERATION
BONE MARROW: HYPERPLASIA; ATROPHY
OTHER CONSIDERATIONS: HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 18/50 1/50 1/50 2/50 0/50
MM: CLEAR EVIDENCE LIVER: ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49
MAY HAVE BEEN RELATED: THYROID GLAND: FOLLICULAR CELL ADENOMA 0/50 0/50 2/49 2/46
NON-NEOPLASTIC LESIONS: LIVER: CENTRILOBULAR HYPERTROPHY; FOCAL DEGENERATION; HEPATOCYTE ERYTHROPHAGOCYTOSIS; EOSINOPHILIC FOCUS; FOCAL NECROSIS
URINARY BLADDER: INTRACYTOPLASMIC INCLUSION BODY
THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
KIDNEY: PIGMENTATION
FM: CLEAR EVIDENCE LIVER: ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49
MAY HAVE BEEN RELATED: THYROID GLAND: FOLLICULAR CELL ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48
NON-NEOPLASTIC LESIONS: LIVER: CENTRILOBULAR HYPERTROPHY; FOCAL DEGENERATION; EOSINOPHILIC FOCUS
URINARY BLADDER: INTRACYTOPLASMIC INCLUSION BODY
SPLEEN: HEMATOPOIETIC CELL PROLIFERATION