8:30 - 9:00 a.m. | Welcome & Introductions NIH Directors
Duane Alexander, NICHD Kenneth Olden, NIEHS Steven Hyman, NIMH Audrey Penn, NINDS James Battey, NIDCD
Overview Conference Co-Chairs
Jean Lauder, University of North Carolina Marie Bristol Power, NICHD Cindy Lawler, NIEHS
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Autism and Related Disorders ________________________________________________________________ |
8:50 - 9:00 a.m. | Overview |
9:00 -10:20 a.m. | Session 1: Neuropathology of Autism: Chair, Anthony Bailey Neuroanatomical Correlates of Autism Anthony Bailey |
| Dysregulation of Reelin Protein in Autism S. Hossein Fatemi |
| Cerebellar Neuropathology and Autistic Behaviors: Exploration of a Mouse Model System Daniel Goldowitz |
| Reduced Number of Benzodiazepine Binding Sites and Decreased Density of GABAA Receptors in Hippocampal Formation of Autistic Individuals Gene J. Blatt |
10:20 - 10:35 a.m. | Discussion |
10:35-10:50 a.m. | Coffee Break Sponsored by the ASA Foundation |
10:50 - 11:30 a.m. | Session 2: Cognitive and Social Phenotypes in Autism: Chair, Joseph Piven
Human Research |
| Social Intelligence in Normal and Autistic Brain Helen Tager-Flusberg |
| fMRI Evidence for Differences in Social Affective Processing in Autism Robert Schultz |
11:30 - 11:45 a.m. | Discussion |
11:45 - 1:00 a.m. | Working Lunch |
1:00 - 2:00 a.m. | Animal Models Social Interaction Abnormalities in Mice Lacking Dvl1 Anthony Wynshaw-Boris |
| Social Deficits in Oxytocin Knockout Mice Larry Young |
| The Primate Temporal Lobe Structures: Maturation, Early Dysfunction, and Relationships to Human Developmental Disorders Jocelyne Bachevalier |
2:00 - 2:15 p.m. | Discussion |
2:15 - 3:15 p.m. | Session 3: Molecular Genetics of Autism: Chair, Edwin Cook |
| Functional and Positional Candidate Gene Studies of Autism Edwin Cook |
| Evidence Supporting Wnt2 as an Autism Susceptibility Gene Thomas Wassink |
| Rett Syndrome, MECP2 Mutations, and Autism Ignatia Van den Veyver |
3:15 - 3:30 p.m. | Break |
3:30 - 4:30 p.m. | Cellular Substrates of Fragile X Syndrome William T. Greenough |
| Brain Abnormalities in a Mouse Model for Smith-Lemli-Opitz Syndrome: Implications for Autism Heather Baudet and Kathy Sulik |
| Ch 15q 22-23 Deletion in Autism and Evidence for Location of Two Series of Chromosome 15 Specific Duplicons that Predispose to Chromosome Rearrangements Moyra Smith |
4:30 - 4:45 p.m. | Discussion |
4:45 - 5:00 p.m. | General Discussion |
6:30 p.m. | Working Dinner (Session chairs and speakers only - reports) |
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September 7, 2001 |
8:00-9:40 a.m. | Session 4: Neurotransmitters Systems in Autism: Chair, Jean Lauder |
| Abnormal Serotonin Synthesis and GABAA Receptors Measure with PET in Autistic Children Diane C. Chugani |
| Prenatal Serotonin in Rats as an Animal Model of Autism Patricia Whitaker-Azmitia |
| Chronic Elevation of Serotonin and Norepinephrine in MAO-A and MAO-A/B Deficient Mice Daniel Holschneider |
| Control of Central Serotonergic Neuron Phenotype by the ETS Domain Factor PET-1 Evan Deneris |
| Characteristics of Mice Lacking the gabrb3 Gene Timothy DeLorey |
9:40 - 9:55 a.m. | Discussion |
9:55 -10:10 a.m. | Break
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Role of the Environment in Autism ________________________________________________________________ |
10:10 - 12:10 a.m. | Session 5: Environmental Influences as Etiologic Factors in Autism: Chair, Stanley Barone |
| Developing Neurotransmitter Systems as Targets for Pesticide Exposure Jean Lauder |
| Environmental Insults and Early Developmental Genes in Autism Etiology Patricia Rodier |
| Regulation of Neurogenesis by Growth Factors and Neurotoxicants Emanuel DiCicco-Bloom |
| Disruption of Synaptic Neural Cell Adhesion Molecules by Environmental Insults Kenneth Reuhl |
| Multidisciplinary Analysis of the BDV Animal Model of Autism: Neuroanatomical, Neurochemical, Behavioral, and Genetic Features Mikhail Pletnikov |
| Possible Environmental Risk Factors in the Etiology of Autism Isaac Pessah |
12:10 - 12:25 a.m. | Discussion |
12:25 - 1:20 a.m. | Working Lunch Sponsored by the Autism Tissue Program
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Emerging Technologies and Strategies in Autism Research ________________________________________________________________ |
1:20 - 2:40 p.m. | Session 6: Emerging Technologies: Chair, Clarence Schutt |
| Gene-based Mutagenesis for Functional Annotation in the Mouse Terry Magnuson |
| Metabonomics Jeremy Nicholson |
| Microdissection and Laser Capture Micromanipulation Chi'ming Huang |
| Structural Biology in Autism Research Clarence Schutt |
2:40 - 2:55 p.m. | Discussion |
2:55 - 3:10 p.m. | Coffee Break Sponsored by the National Association for Autism Research (NAAR) |
3:10 - 4:00 p.m. | Session 7: Autism Brain Tissue Panel-Progress and Future Strategies: Chair, Jane Pickett |
| Brain and Tissue Donation - Issues Related to Children Ronald Zielke |
| Neuropathology Margaret Bauman |
| Microarrays in Human Tissue/Tuberous Sclerosis/Seizures Peter Crino |
| Tissue Based Data Warehousing to Maximize Collaboration by Divergent Laboratories Harry Haroutunian |
| Immunohistochemistry Robert Lopez |
4:00 - 4:15 p.m. | Discussion |
4:15 - 4:40 p.m. | Reports of Recommendations from Working Groups |
4:40 - 5:00 p.m. | Discussion of Reports from Working Groups
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We would like to thank Jack Bishop, William McMahon, and Ute Schambra for serving as conference discussants
We would like to thank the Autism Tissue Program, The National Association for Autism Research (NAAR), and the ASA Foundation for sponsoring the refreshments for this conference. |