Genetic Modeling of Neural Tumors in Mice |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Wednesday, March 22, 2006, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 01:05:07 |
| NLM Title: | Genetic modeling of neural tumors in mice [electronic resource] / Luis Parada. |
| Series: | WALS |
| Author: | Parada, Luis. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2006] |
| Other Title(s): | WALS |
| Abstract: | (CIT): Neurofibromatosis Type 1 (NF1) is a dominantly inherited disease in which mutation of the NF1tumor suppressor either appears de novo or is transmitted through the germ line. Biochemical and mouse knockout studies have demonstrated that NF1 is a negative regulator of the ras pathway by acting as rasGap. Dr. Parada has used conventional knockouts and cre/loxP based strategies to model tumor formation in these mice. He will discuss the current understanding of neurofibroma formation, a complex peripheral nerve tumor that is prevalent in NF1. |
| Subjects: | Astrocytoma--genetics Disease Models, Animal Mice, Knockout Neurofibroma--genetics Neurofibromatosis 1 |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | QZ 380 |
| NLM ID: | 101289621 |
| CIT File ID: | 13126 |
| CIT Live ID: | 4282 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13126 |