Outer Membrane Biogenesis in Gram-Negative Bacteria |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Wednesday, January 10, 2007, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | The outer membrane (OM) of Gram-negative bacteria functions as a protective barrier. It is unusual because the OM bilayer is asymmetric; the inner leaflet is composed of phospholipids, but the outer leaflet is made of lipopolysaccharide (LPS). Two kinds of proteins are found in the OM.
Lipoproteins are inserted into the inner leaflet of the OM by posttranslationally attached lipid moieties. Integral OM proteins are Beta-barrel proteins (OMPs). All of the components of the OM are synthesized inside the cell. They must be transported to, and assembled in the OM in the correct orientation to maintain barrier function, and all of this takes place outside the cytoplasm where there is no obvious energy source, such as ATP.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | Thomas J. Silhavy, Ph.D., Princeton University |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 13976 |
| CIT Live ID: | 5183 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13976 |
| Podcast information | ||||||
|---|---|---|---|---|---|---|
| Audio Podcasts | Video Podcasts | |||||
| Description | Runtime | Description | Runtime | |||
|
|
Enhanced Audio Podcast | 56:00 |
|
Enhanced Video Podcast | 56:00 | |