PHYSICAL ACTIVITY AND OBESITY ACROSS CHRONIC DISEASES

Release Date:  November 15, 2000

PA NUMBER: PA-01-017

National Institute of Diabetes and Digestive and Kidney Diseases
   http://www.niddk.nih.gov/
National Cancer Institute
   http://www.nci.nih.gov/
National Heart, Lung, and Blood Institute
   http://www.nhlbi.nih.gov/
National Institute on Aging
   http://www.nih.gov/nia/
National Institute of Arthritis and Musculoskeletal and Skin Diseases
   http://www.nih.gov/niams/
National Institute of Child Health and Human Development
   http://www.nichd.nih.gov/
National Institute of Nursing Research
   http://www.ninr.nih.gov/

THIS PROGRAM ANNOUNCEMENT (PA) USES "MODULAR GRANT" AND "JUST-IN-TIME" 
CONCEPTS.  THIS PA INCLUDES DETAILED MODIFICATIONS TO STANDARD 
APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING AN 
APPLICATION IN RESPONSE TO THIS PA.

This Program Announcement is part of a trans-NIH Obesity Initiative, 
which also includes approaches to obesity prevention and the 
neuroendocrinology of obesity.  The above-named Institutes invite 
applications from investigators for research studies that will address 
the relationship between physical activity and obesity.  Three general 
areas of research are encouraged: (1) studies (including observational 
and prospective) examining physical activity and obesity relationships, 
(2) studies to improve methodology of assessment of physical activity 
and energy balance, and (3) studies to test intervention approaches 
that incorporate physical activity for obesity prevention or treatment 
related to chronic diseases.

HEALTHY PEOPLE 2010

The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2010," a 
PHS led national activity for setting priority areas.  This PA, 
Physical Activity And Obesity Across Chronic Diseases, is related to 
one or more of the priority areas.  Potential applicants may obtain a 
copy of "Healthy People 2010" at http://www.health.gov/healthypeople

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic and foreign for-profit and 
nonprofit organizations, public and private, such as universities, 
colleges, hospitals, laboratories, units of State and local 
governments, and eligible agencies of the Federal Government.  
Racial/ethnic minority individuals, women, and persons with 
disabilities are encouraged to apply as principal investigators.

MECHANISM OF SUPPORT

The primary mechanism of support will be the National Institutes of 
Health (NIH) research project grant (R01).  Additional mechanisms of 
support are available through individual Institutes and Centers (ICs).  
Potential applicants are encouraged to contact Program Staff in the 
appropriate ICs (see INQUIRIES, section) for further information about 
the mechanisms available.  Planning, direction, and execution of the 
program will be the responsibility of the applicant.  Any applicant 
planning to submit a new investigator-initiated grant application 
requesting $500,000 or more in direct costs in any one year must 
contact Institute Program Staff before submitting the application.  
Furthermore, the applicant must obtain agreement from Institute staff 
that the Institute will accept the application for consideration for 
award.   Additional information about this policy can be found in the 
NIH Guide Volume 25, Number 14, May 3, 1996.  Responses to Program 
Announcements are subject to this policy.

Applications requesting less than $250,000 in direct costs per year 
must be in modular grant format.  Specific application instructions 
have been modified to reflect "MODULAR GRANT" and "JUST-IN-TIME" 
streamlining efforts being examined by the NIH.  Complete and detailed 
instructions and information on Modular Grant applications can be found 
at http://grants.nih.gov/grants/funding/modular/modular.htm 

RESEARCH OBJECTIVES

Background

An estimated 97 million adults in the U.S. are overweight or obese 
(Body Mass Index {BMI, kg/(MxM} greater than or equal to 25.0).  “The 
Dietary Guidelines for Americans,” (published by the World Health 
Organization) and the 1998 NIH Clinical Guidelines on the 
Identification, Evaluation, and Treatment of Overweight and Obesity in 
Adults (See  http://www.nhlbi.nih.gov/guidelines/obesity/ob_home.htm) 
all use a body mass index (BMI) of  less than 25.0 to define the upper 
limit of the healthy weight range, greater than 50 percent of the adult 
population is above this range.  According to numerous recent reports, 
the prevalence of overweight and obesity in the U.S. is increasing 
dramatically.  Based on the BMI cut-point of 30.0, which defines 
obesity, 20 percent of men and 25 percent of women were obese in 1988-
1994 (NHANES III) compared with 12 percent of men and 16 percent of 
women in 1971-74 (NHANES I).

Overweight is especially prevalent among certain racial and ethnic 
groups.  For example, 66 percent of African-American and Mexican-
American women are estimated to be overweight (NHANES III).  
Furthermore, the increasing prevalence of overweight is not limited to 
adults, but is observed in children, in both genders and in all 
subpopulations.  

Morbidity associated with overweight and obesity is considerable.  
Obesity is a risk factor for Type II diabetes mellitus and for 
cardiovascular disease as well as several other medical conditions.  
The risk of diabetes increases as BMI increases, with the relative risk 
of diabetes increasing by about 25 percent for each unit of BMI over 
22.  Overweight and obesity are also associated with increased 
morbidity and mortality from coronary heart disease (CHD), studies have 
found a three-fold increase in rate of coronary heart disease in women 
with BMIs of 29 or greater compared with women with BMIs less than 21, 
and a 10 percent increase in coronary events in men with each BMI unit 
above 22.  Hypertension prevalence increases from 16-18 percent to 32-
38 percent as BMI goes from less than 25 to greater than 30, and a 
similar relationship, although not as dramatic, is seen between BMI and 
high blood cholesterol.  These problems can be ameliorated, or 
sometimes reversed, through weight loss.  

The relationship between physical activity and obesity appears to be 
complex, and requires further study.  The 1996 Surgeon General’s Report 
on Physical Activity and Health concluded that physical activity is 
important for weight control, primarily because of the positive 
findings from studies testing the effects of physical activity on 
weight loss.  However, the report also stated: “It is commonly believed 
that physically active people are less likely to gain weight over the 
course of their lives and are thus more likely to have a lower 
prevalence of obesity than inactive people: accordingly, it is also 
commonly believed that low levels of physical activity are a cause of 
obesity.  Few data, however, exist to evaluate the truth of these 
suppositions.”  The report called for research to determine the most 
important features of physical activity that confer specific health 
benefits.  For example, what specific combination(s) of type, 
frequency, duration, intensity, and pattern of physical activity best 
contributes to weight control or weight loss. 

The 1998 NIH Clinical Guidelines on the Identification, Evaluation, and 
Treatment of Overweight and Obesity in Adults Report indicates that 
more research is needed on effects on body weight/obesity of different 
lengths of physical activity interventions, different formats and 
intensities of physical activity, and different forms of physical 
activity in combination with diet, as well as effects of physical 
activity on body fat distribution, e.g., abdominal fat.  The 
recommendations of this report for future research includes the need to 
determine the optimal amount of physical activity to promote weight 
loss, maintenance of weight loss, and prevention of obesity, as well as 
strategies to preserve muscle and bone in the face of weight loss.  
Research is needed on the effects of pharmacologic intervention for 
weight loss on cardiorespiratory fitness.  Research is also needed on 
environmental and population-based intervention methods for weight 
control that incorporate physical activity.  These studies should 
address high-risk populations for obesity and low levels of physical 
activity including underserved population segments, e.g., minorities 
and low socioeconomic (SES) groups.

Education about the long-term health consequences and risks associated 
with overweight and how to achieve and maintain a preferred weight is 
necessary.  While many individuals attempt to lose weight, studies show 
that within five years a majority of them regain the weight.  In order 
to maintain weight loss, good dietary habits must be coupled with 
increased physical activity, and these must become permanent lifestyle 
changes.  It is still not clear, however, which behavioral approaches 
are best for achieving these changes, particularly long-term.  A 1998 
NHLBI workshop on Maintenance of Behavior Change in Cardiorespiratory 
Risk Reduction concluded that additional research is needed to examine 
factors associated with long-term maintenance of weight loss, long-term 
maintenance of increased physical activity levels, and the relationship 
between the two.  In addition, the question of whether physical 
activity enhances long-term maintenance of weight loss has not been 
formally examined in randomized trials.

NIDDK, in cooperation with NCI, NHLBI, NIA, NIAMS, and the President’s 
Council on Physical Fitness and Sports, held a conference on the topic 
of Physical Activity and Obesity in 1992.  This conference assessed 
research activities in this area and posed several research questions 
that have yet to be adequately addressed and that are included in this 
PA.

Research Scope

A broad range of specific research questions and study approaches are 
relevant to this Program Announcement.  The following are examples of 
research topics and study approaches that are relevant.  Applicants are 
encouraged to consider these questions, when relevant, in relation to 
persons with and without morbid conditions (such as hypertension, 
diabetes, arthritis).  Likewise, applicants are encouraged to provide a 
rationale for the type of physical activity (e.g., aerobic, anaerobic, 
resistance) that they propose in their applications.

1. Physical Activity and Obesity Relationships 

o Studies to examine the relationships between type and amount of 
physical activity and dietary intake, including caloric expenditure, 
caloric intake and dietary macronutrient composition.

o Studies to examine the relationships between patterns of aerobic, 
anaerobic, and resistance exercise with body weight, body composition, 
and body fat distribution.

o Studies to examine interactions between the genetics of obesity and 
physical activity levels on obesity phenotypes.

o Studies to examine the psychological and quality of life benefits of 
physical activity.

o Studies to examine the determinants (personal, familial, cultural, 
environmental and policy) for engaging in and maintaining physical 
activity and good nutrition practices, particular attention can be paid 
to various subpopulations, defined by gender, age, ethnicity, and/or 
socioeconomic status who may be at risk for developing obesity.

o Prospective studies to examine tracking of dietary intake and eating 
behavior and physical activity patterns, and the relationships between 
the two, from childhood to adulthood.

o Prospective studies to examine the relationship between physical 
activity and obesity or weight gain, particularly focusing on life 
stages where the risk of obesity development is highest  (e.g., 
adolescence, menopause, older age).

2. Assessment Methodology Studies 

o Validation of improved methods for assessment of energy intake and 
expenditure and levels of physical activity, as well as, improvement of 
measures in special population segments based on race/ethnicity and 
socioeconomic status.

o Improved methods for measuring skeletal muscle and adipose tissue 
metabolic processes in response to exercise.

o Improved methods for measuring the type (resistance vs. aerobic) and 
amount of physical activity behavior (frequency, intensity, duration), 
the energy cost associated with physical activity, energy intake, and 
energy balance.

o Improved methods for measuring the impact--both positive and 
negative--of physical activity in subpopulations (defined by gender, 
age, ethnicity, socioeconomic status) on various outcomes such as 
quality of life.

o Improved methods for assessment of energy metabolism, body fat, and 
body fat distribution, including visceral fat.

3. Intervention Studies

o Test the effects on body weight/obesity of different lengths of 
physical activity interventions, different formats and intensities of 
physical activity, and different forms of physical activity in 
combination with diets, as well as, effects of physical activity on 
body fat distribution e.g. abdominal fat

o Examine the effects of physical activity patterns on changes in 
eating practices.

o Determine the long-term effects of various approaches to physical 
activity interventions (including different behavioral approaches as 
well as different type and amount of physical activity) on weight loss 
and maintenance.

o Develop, implement, and evaluate psychobiobehavioral programs for 
parents and their children utilizing nutritional counseling, dietary 
changes, and exercise (preferably games and sports) to prevent or 
attenuate problems of overweight and obesity.

o Evaluate the psychological effects of being overweight or obese at 
different developmental stages of childhood and/ or  the psychological 
effects of participating in successful or unsuccessful weight loss 
programs. 

o Compare peer-oriented weight loss programs for overweight and obese 
children and adolescents with parent-child oriented programs.

o Examine the optimal mixture of physical activity and dietary intake 
for promoting weight loss and  long-term maintenance of weight loss, 
examine whether increased physical activity alone or in combination 
with diet can prevent obesity or weight gain.

o Develop/test interventions to increase physical activity and examine 
their effects on weight, on the changes in risk factors for obesity-
related diseases, and on the use of health care services. These 
interventions can take place in a variety of settings, for example, 
health maintenance organizations, primary care practices, work sites, 
armed services, community groups, schools, etc.

o Test the effects the environmental and population-based intervention 
methods for weight control, including those that incorporate physical 
activity.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups 
and their sub-populations must be included in all NIH-supported 
biomedical and behavioral research projects involving human subjects, 
unless a clear and compelling rationale and justification are provided 
indicating that inclusion is inappropriate with respect to the health 
of the subjects or the purpose of the research. This policy results 
from the NIH Revitalization Act of 1993 (Section 492B of Public Law 
103-43).
All investigators proposing research involving human subjects should 
read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities 
as Subjects in Clinical Research," published in the NIH Guide for 
Grants and Contracts on August 2, 2000 
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html), a 
complete copy of the updated Guidelines are available at 
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: 
The revisions relate to NIH defined Phase III clinical trials and 
require: a) all applications or proposals and/or protocols to provide a 
description of plans to conduct analyses, as appropriate, to address 
differences by sex/gender and/or racial/ethnic groups, including 
subgroups if applicable, and b) all investigators to report accrual, 
and to conduct and report analyses, as appropriate, by sex/gender 
and/or racial/ethnic group differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN 
SUBJECTS
It is the policy of NIH that children (i.e., individuals under the age 
of 21) must be included in all human subjects research, conducted or 
supported by the NIH, unless there are scientific and ethical reasons 
not to include them. This policy applies to all initial (Type 1) 
applications submitted for receipt dates after October 1, 1998.
All investigators proposing research involving human subjects should 
read the "NIH Policy and Guidelines on the Inclusion of Children as 
Participants in Research Involving Human Subjects" that was published 
in the NIH Guide for Grants and Contracts, March 6, 1998, and is 
available at the following URL address: 
http://grants.nih.gov/grants/guide/notice-files/not98-024.html
Investigators also may obtain copies of these policies from the program 
staff listed under INQUIRIES. Program staff may also provide additional 
relevant information concerning the policy.
URLS IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained 
within specified page limitations. Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no 
obligation to view the Internet sites. Reviewers are cautioned that 
their anonymity may be compromised when they directly access an 
Internet site. 

APPLICATION PROCEDURES

Applications are to be submitted on the grant application form PHS 398 
(rev. 4/98) and will be accepted at the standard application deadlines 
as indicated in the application kit. Application kits are available at 
most institutional offices of sponsored research and may be obtained 
from the Division of Extramural Outreach and Information Resources, 
National Institutes of Health, 6701 Rockledge Drive, MSC 7910, 
Bethesda, MD 20892-7910, telephone 301/435-0714, email: 
GrantsInfo@nih.gov.
Applicants planning to submit an investigator-initiated new (type 1), 
competing continuation (type 2), competing supplement, or any 
amended/revised version of the preceding grant application types 
requesting $500,000 or more in direct costs for any year are advised 
that he or she must contact the Institute or Center (IC) program staff 
before submitting the application, i.e, as plans for the study are 
being developed. Furthermore, the application must obtain agreement 
from the IC staff that the IC will accept the application for 
consideration for award. Finally, the applicant must identify, in a 
cover letter sent with the application, the staff member and Institute 
or Center who agreed to accept assignment of the application.  This 
policy requires an applicant to obtain agreement for acceptance of both 
any such application and any such subsequent amendment. Refer to the 
NIH Guide for Grants and Contracts, March 20, 1998 at 
http://grants.nih.gov/grants/guide/notice-files/not98-030.html
Applications requesting less than $250,000 in direct costs per year 
must be submitted in modular grant format.  The modular grant concept 
establishes specific modules in which direct costs may be requested as 
well as a maximum level for requested budgets. Only limited budgetary 
information is required under this approach.  The just-in-time concept 
allows applicants to submit certain information only when there is a 
possibility for an award. It is anticipated that these changes will 
reduce the administrative burden for the applicants, reviewers and 
Institute staff.  The research grant application form PHS 398 (rev. 
4/98) is to be used in applying for these grants, with the 
modifications noted below.

SPECIFIC INSTRUCTIONS FOR MODULAR GRANT APPLICATIONS

BUDGET INSTRUCTIONS

Modular Grant applications will request direct costs in $25,000 
modules, up to a total direct cost request of $250,000 per year. 
(Applications that request more than $250,000 direct costs in any year 
must follow the traditional PHS 398 application instructions.)  The 
total direct costs must be requested in accordance with the program 
guidelines and  the modifications made to the standard PHS 398 
application instructions described below:

PHS 398

o FACE PAGE: Items 7a and 7b should be completed, indicating Direct 
Costs (in $25,000 increments up to a maximum of $250,000) and Total 
Costs [Modular Total Direct plus Facilities and Administrative  (F&A) 
costs] for the initial budget period Items 8a and 8b should be 
completed indicating the Direct and Total Costs for the entire proposed 
period of support.

o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form 
Page 4 of the PHS 398. It is not required and will not be accepted with 
the application.

o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete 
the categorical budget table on Form Page 5 of the PHS 398. It is not 
required and will not be accepted with the application.

o NARRATIVE BUDGET JUSTIFICATION - Prepare a Modular Grant Budget 
Narrative page. (See 
http://grants.nih.gov/grants/funding/modular/modular.htm for sample 
pages.) At the top of the page, enter the total direct costs requested 
for each year.  This is not a Form page.

o Under Personnel, list all project personnel, including their names, 
percent of effort, and roles on the project. No individual salary 
information should be provided. However, the applicant should use the 
NIH appropriation language salary cap and the NIH policy for graduate 
student compensation in developing the budget request.

For Consortium/Contractual costs, provide an estimate of total costs 
(direct plus facilities and administrative) for each year, each rounded 
to the nearest $1,000. List the individuals/organizations with whom 
consortium or contractual arrangements have been made, the percent 
effort of all personnel, and the role on the project. Indicate whether 
the collaborating institution is foreign or domestic. The total cost 
for a consortium/contractual arrangement is included in the overall 
requested modular direct cost amount.  Include the Letter of Intent to 
establish a consortium.

Provide an additional narrative budget justification for any variation 
in the number of modules requested.

o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information 
used by  reviewers in the assessment of each individual"s 
qualifications for a specific role in the proposed project, as well as 
to evaluate the overall qualifications of the research team. A 
biographical sketch is required for all key personnel, following the 
instructions below. No more than three pages may be used for each 
person. A sample biographical sketch may be viewed at:  
http://grants.nih.gov/grants/funding/modular/modular.htm

- Complete the educational block at the top of the form page,
- List position(s) and any honors,
- Provide information, including overall goals and responsibilities, on 
research projects ongoing or completed during the last three years.
- List selected peer-reviewed publications, with full citations,

o CHECKLIST - This page should be completed and submitted with the 
application. If the F&A rate agreement has been established, indicate 
the type of agreement and the date. All appropriate exclusions must be 
applied in the calculation of the F&A costs for the initial budget 
period and all future budget years.

o The applicant should provide the name and phone number of the 
individual to contact concerning fiscal and administrative issues if 
additional information is necessary following the initial review. 
The title and number of the program announcement must be typed on line 
2 of the face page of the application form and the YES box must be 
marked.

Submit a signed, typewritten original of the application, including the 
Checklist, and five signed photocopies in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by the Center for 
Scientific Review.  Applications that are complete will be evaluated 
for scientific and technical merit by an appropriate peer review group 
convened in accordance with NIH peer review procedures.  As part of the 
initial merit review, all applications will receive a written critique 
and undergo a process in which only those applications deemed to have 
the highest scientific merit, generally the top half of applications 
under review, will be discussed, assigned a priority score, and receive 
a second-level review by the appropriate National Advisory Council or 
Board.
 
The goals of NIH-supported research are to advance our understanding of 
biological systems, improve the control of disease, and enhance health.  
In the written review, comments on the following aspects of the 
application will be made in order to judge the likelihood that the 
proposed research will have a substantial impact on the pursuit of 
these goals.  Each of these criteria will be addressed and considered 
in the assignment of the overall score:

1. Significance: Does this study address an important problem?  If the 
aims of the application are achieved, how will scientific knowledge be 
advanced?  What will be the effect of these studies on the concepts or 
methods that drive this field?

2. Approach: Is the conceptual framework, design, methods, and analyses 
adequately developed, well integrated, and appropriate to the aims of 
the project?  Does the applicant acknowledge potential problem areas 
and consider alternative tactics?

3. Innovation: Does the project employ novel concepts, approaches or 
methods?  Are the aims original and innovative?  Does the project 
challenge existing paradigms or develop new methodologies or 
technologies?

4. Investigator: Is the investigator appropriately trained and well 
suited to carry out this work?  Is the work proposed appropriate to the 
experience level of the principal investigator and other researchers 
(if any)?

5. Environment: Does the scientific environment in which the work will 
be done contribute to the probability of success?  Do the proposed 
experiments take advantage of unique features of the scientific 
environment or employ useful collaborative arrangements?  Is there 
evidence of institutional support?

In addition, the adequacy of plans to include both genders and 
minorities and their subgroups as appropriate for the scientific goals 
of the research will be reviewed.  Plans for the recruitment and 
retention of subjects will also be evaluated.

The Scientific Review Group will also examine the provisions for the 
protection of human and animal subjects, the safety of the research 
environment, and conformance with the NIH Guidelines for the Inclusion 
of Women, Minorities, and Children as Subjects in Clinical Research.

AWARD CRITERIA

Applications will compete for available funds with all other 
recommended applications assigned to that Institute.  The following 
will be considered in making funding decisions: quality of the proposed 
project as determined by peer review, availability of funds, and 
program priority.

INQUIRIES

Inquiries are encouraged.  We welcome the opportunity to clarify any 
issues or questions from potential applicants.

Direct inquiries regarding programmatic issues to:

Richard P. Troiano, Ph.D., R.D.
CDR, USPHS
National Cancer Institute, DCCPS, ARP
EPN 4005
6130 Executive Blvd, MSC 7344
Bethesda, MD 20892-7344
Telephone: 301/496-8500, direct 301/435-6822
FAX: 301/435-3710
E-mail:	rt75i@nih.gov or rick_troiano@nih.gov

Denise G.  Simons-Morton, M.D., Ph.D.
Leader, Prevention Scientific Research Group
Clinical Applications and Prevention Program
Division of Epidemiology and Clinical Applications
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 8138, MSC 7936
Telephone:   (301) 435-0384
FAX: (301) 480-1669
Email: simonsd@nhlbi.nih.gov

Chhanda Dutta, Ph.D.
Geriatrics Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 3E-327
Bethesda, MD  20892-9205
Telephone:  (301) 435-3048
FAX:  (301) 402-1784
Email:  DuttaC@exmur.nia.nih.gov 

James S. Panagis, M.D., M.P.H.
Orthopaedics Program
NIAMS
6500 Center Drive - Room 5AS-37K
Bethesda, MD 20892-6500
TEL: 301-594-5055
FAX: 301-480-4543
Email: jpl49d@nih.gov

Susan Yanovski, M.D.
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive Kidney Diseases
6707 Democracy Blvd, Room 612
Bethesda, MD  20892
Telephone:  (301) 594-8882
FAX:  (301) 480-3504
Email:  YanovskiS@extra.niddk.nih.gov

Pamela E Starke-Reed, Ph.D.
NIH, Division of Nutrition Research Coordination
Rockledge 1, Suite 8048, MSC 7973
Bethesda, MD  20892-7973
Telephone:  (301) 594-8805
FAX:  (301) 480-3768
Email:  ps39p@nih.gov

Lynne M. Haverkos, M.D., MPH
Child Development and Behavior Branch
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 4B05B, MSC 7510
Bethesda, MD 20892-7510
Telephone: (301) 435-6881
FAX: (301) 480-7773
E-mail: lh179r@nih.gov
 
Hilary Sigmon, Ph.D. R.N.
Division of Intramural Programs
National Institute of Nursing Research
45 Center Drive, Room 3AN18 MSC 6300
Bethesda, MD 20892-6300
Telephone:  (301) 594-5970
FAX:  (301) 480-8260
Email:  hilary_sigmon@nih.gov

Direct inquiries regarding fiscal and administrative matters to:

Ms. Linda Whipp
Grants and Contracts Management Office
National Institute on Aging
7201 Wisconsin Avenue, Suite 2N212
Bethesda, MD  20892-9205
Telephone:  (301) 496-1472
FAX:  (301) 402-3672
Email:  WhippL@exmur.nia.nih.gov

Melinda B. Nelson
Grants Management Branch
NIAMS
6500 Center Drive - Room 5AS-49F
Bethesda, MD 20892-6500
TEL: 301-594-3535
FAX: 301-480-5450
Email: mn23z@nih.gov

Douglas Shawver
Office of Administrative Management
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 8A07, MSC 7510
Bethesda, MD  20892-7510
Telephone:  (301) 435-6999
FAX:  (301) 402-0915
Email:  ds117g@nih.gov

Sharon Bourque
Division of Extramural Activities
National Institute of Diabetes and Digestive Kidney Diseases
6707 Democracy Blvd, Room 612
Bethesda, MD  20892
Telephone:  (301) 594-8846
FAX:  (301) 480-3504
Email:  BourqueS@extra.niddk.nih.gov

Ms. Sally York
Grants Management Specialist 
National Institute of Nursing Research
45 Center Drive MSC 6300
Bethesda, Maryland 20892-6300
Tel:  301-594-2154
FAX:  301-480-8260
Email sally_york@nih.gov    

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance 
No. 93.393, 93.399, 93.846, 93.865, 93.866, 93.837, 93.847, 93.848, 
93.361, and 93.849.  Awards are under authorization of the Public 
Health Service Act, Title IV, Part A (Public Law 78-410, as amended by 
Public Law 99-158, 42 USC 241 and 285) and administered under PHS 
grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74.  
This program is not subject to the intergovernmental review 
requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to 
provide a smoke-free workplace and promote the non-use of all tobacco 
products.  In addition, Public Law 103-227, the Pro-Children Act of 
1994, prohibits smoking in certain facilities (or in some cases, any 
portion of a facility) in which regular or routine education, library, 
day care, health care, or early childhood development services are 
provided to children.  This is consistent with the PHS mission to 
protect and advance the physical and mental health of the American 
people.

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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