The p53 Tumor Suppressor: A Story of Death and Degradation |
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| Launch in standalone player | |
| Air date: | Tuesday, October 21, 2003, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | A Special Tuesday Lecture
During malignant progression cells are exposed to various types of stress that activate tumor suppressive pathways, thereby preventing further proliferation of the abnormal cell. The p53 protein plays a pivotal role in these responses, in part because stress-induced activation of p53 can lead to the induction of programmed cell death or apoptosis. Most cancer cells only survive because they have acquired genetic alterations that disrupt this apoptotic program. These changes can be thought of as the Achilles heel of cancers, since repairing them would lead to the death of malignant cells, while leaving many normal tissues – which are not exposed to the same stress signals - relatively unscathed. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | Karen Vousden, Ph.D., FRS, Beatson Institute for Cancer Research Glasgow, Scotland |
| Runtime: | 01:02:50 |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 10298 |
| CIT Live ID: | 2850 |
| Permanent link: | http://videocast.nih.gov/launch.asp?10298 |