Coronavirus Receptor Recognition and Entry |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Wednesday, September 10, 2003, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | The spike glycoprotein (S) of coronaviruses is a very large type 1 viral fusion protein that recognizes receptors on host cells and mediates membrane fusion and virus entry. Several coronaviruses can also bind to host cells by a hemagglutinin-esterase (HE) glycoprotein derived from influenza C HE. Most coronaviruses cause disease only in one host species, although several have a broader host range. The S protein is an important determinant of species specificity, tissue tropism and virulence. Receptors for S proteins of three coronaviruses have been identified, and the receptor-binding domains of the corresponding viral S proteins have been identified. The interactions of human and animal coronaviruses with their receptors will be used as examples to consider how the SARS coronavirus may have emerged from an
animal reservoir.
For more information, visit Kathryn Holmes |
| Author: | Kathryn V. Holmes, PhD, University of Colorado |
| Runtime: | 01:03:18 |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 10278 |
| CIT Live ID: | 2510 |
| Permanent link: | http://videocast.nih.gov/launch.asp?10278 |