Cancer Drugs and ON/OFF Switches in Protein Kinases

 


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Air date: Wednesday, June 04, 2003, 3:00:00 PM
Category: Wednesday Afternoon Lectures
Description: The NIH Director's Wednesday Afternoon Lecture

Structural Studies on the Specificity of the CML Drug STI-571/Gleevec

John Kuriyan is interested in the construction, mechanism, and regulation of the molecular machines and switching devices that carry out signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of the component proteins, along with biochemical and biophysical analyses to elucidate mechanisms.

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John Kuriyan
Author: John Kuriyan, Berkeley
Runtime: 01:00:48
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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CIT File ID: 10259
CIT Live ID: 1898
Permanent link: http://videocast.nih.gov/launch.asp?10259