Clinical Trials
Miscellaneous Conditions
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence.
Evaluation study. Alcohol dependence (alcoholism) is a chronic medical illness with a relapsing course and a major public health problem. Ages 18-65. Location in Bethesda, MD.
- Hormone Function in Men Treated for Pain With Opioids or Placebo.
Interventional study. This study will examine hormone function in men with osteoarthritis pain and how it is affected by opioid medication (such as Percocet, Vicodin, MS Contin and morphine) versus placebo. Ages 30-65. Location in Bethesda, MD.
- Effectiveness of Anger Management Treatment in Reducing Anger-Related Behaviors in Female Juvenile Offenders.
Interventional study. This study will evaluate the effectiveness of an anger management treatment program, Juvenile Justice Anger Management for Girls, in reducing anger-related behaviors displayed by girls in the juvenile justice system. Ages 12-19. Location in Philadelphia, PA.
- PET Imaging of Peripheral Benzodiazepine Receptors.
Evaluation study. This study will use positron emission tomography (PET) to measure a receptor in the brain that is involved in inflammation. Ages 18 and over. Location in Bethesda, MD.
- Mirror Therapy for Phantom Limb Pain.
Evaluation study. This study, conducted at the National Institutes of Health (NIH) and at Walter Reed Army Medical Center (WRAMC), will explore the phenomenon of phantom limb pain (a continued feeling of pain in an amputated limb) and will use functional magnetic resonance imaging (fMRI) to investigate the effect of mirror therapy on phantom limb pain. Ages 18-75. Locations in Washington, DC; Bethesda, MD.
- PET Imaging of P-Glycoprotein Function Using [11C]dLop.
Evaluation study. This study will test the use of a radioactive substance called [11C]dLop for measuring P-glycoprotein (P-gp) using positron emission tomography (PET) imaging. Ages 18-50. Location in Bethesda, MD.
- PET Imaging of Cannabinoid CB1 Receptors Using [18F]FMPEP-d2.
Interventional study. The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral disorders. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Cannabinoid CB1 Receptors Using [11C]MePPEP.
Interventional study. The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral disorders. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis.
Interventional study. Inflammation in the vascular wall is important in atherosclerosis and the blockage of the artery. Ages 18-89. Location in Bethesda, MD.
- PET Imaging of Brain mGluR5 Receptors Using [18F]SP203.
Interventional study. The metabotropic glutamate subtype five (mGluR5) receptor is a protein found in the brain and is the target for the excitatory chemical messenger glutimate. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [F-18]FB.
Interventional study. The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28.
Interventional study. The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.... Ages 18-65. Location in Bethesda, MD.
- Effectiveness of Treatment for Relational Aggression in Urban African American Girls.
Interventional study. This study will evaluate the effectiveness of a school-based social cognitive group treatment in reducing aggression (bullying) among relationally aggressive urban African American girls. Location in Philadelphia, PA.
- Abuse-Focused Cognitive Behavioral Therapy for Children Who Have Been Physically Abused.
Interventional study. This study will determine the effectiveness of abuse-focused cognitive behavioral therapy that is provided by a community health clinic in addressing the behavioral and emotional health needs of children and adolescents whose parents have used physical disciplinary action. Ages 5-15. Location in Pittsburgh, PA.
- A Parent-Based Intervention to Reduce Sexual Risk Behavior in Adolescents.
Interventional study. This study will evaluate the effectiveness of a parent-based intervention in reducing sexual risk behavior in high-risk Latino and African-American adolescents. Ages 11-14. Location in New York, NY.
- Functional Neuroanatomy of Emotion Perception, Recognition, Learning, and Memory.
Evaluation study. This study uses magnetic resonance imaging (MRI) to explore the areas of the brain involved in different types of mental processes, in particular, the brain regions involved in perception, recognition, learning, and memory. Ages 20-40. Location in Bethesda, MD.
- Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses.
Interventional study. This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses. Ages 18-70. Location in Baltimore, MD.
- Follow-up Evaluation of Home Nurse Visitation Program for Socially Disadvantaged Women and Their Children.
Interventional study. This study will evaluate the long-term effects of a prenatal and early childhood home nurse visitation program for socially disadvantaged women and their children. Location in Elmira, NY.
- Internet-Based Treatment for Children With Traumatic Brain Injuries & Their Families: Counselor Assisted Problem Solving.
Interventional study. This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among children who have had a traumatic brain injury and their families. Ages 12-17. Locations in Cincinnati, OH; Cleveland, OH.
- PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28.
Interventional study. In this study we will examine where the radioactive tracer [11C]PBR28 is distributed in the body of healthy volunteers to calculate the radiation exposure to organs of the body. Ages 18-65. Location in Bethesda, MD.
- Multi-Family Group Therapy for Reducing Behavioral Difficulties in Youth.
Interventional study. This study will examine the effectiveness of a multiple family group mental health service delivery strategy in improving mental health service use and outcome for urban, low income children of color, ages 7-11 years old with disruptive behaviors and their families. Ages 7 and over. Location in New York, NY.
- Integrated Treatment Program for Hypochondriasis in Primary Care Settings.
Interventional study. This study will evaluate the effectiveness of an integrated three-part treatment program in improving the quality of care and treatment outcomes of people with hypochondriasis in primary care settings. Ages 18-70. Locations in Boston, MA; Cambridge, MA.
- Protein Synthesis in the Brain of Patients With Fragile X Syndrome.
Evaluation study. Biosynthesis of proteins is essential for growth and continued maintenance of the entire neuron including axons, dendrites, and synaptic terminals, and it is clearly one of the important biochemical processes underlying adaptive changes in the nervous system. Ages 18-24. Location in Bethesda, MD.
- Promoting Infant Mental Health in Foster Care.
Interventional study. This study will evaluate the effectiveness of the Promoting First Relationships (PFR) program versus an Early Education Support (EES) program in promoting infant well-being, preventing emotional and behavioral problems, countering developmental delay, and reducing placement instability in young foster care children. Ages 10 Months-20 Months. Location in Seattle, WA.
- Comparing Cognitive Behavioral Therapy, Antidepressant Medication, and Combined Treatment in Individuals With Hypochondriasis.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy, antidepressant medication, and a combination of the two for treating hypochondriasis. Ages 21 and over. Locations in Boston, MA; New York City, NY.
- Safety and Effectiveness of Taking Choline Supplements During Pregnancy for Improving Infant Brain Development.
Interventional study. This study will evaluate the safety and effectiveness of taking choline supplements during pregnancy, and whether choline supplementation has an effect on infant development. Ages 18-45. Location in Denver, CO.
- Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood Disorders.
Evaluation study. The goal of this protocol, broadly stated, is to use targeted manipulations with intranasally administered oxytocin (OT) and arginine vasopressin (AVP) in conjunction with neurocognitive and neuroimaging paradigms to evaluate claims that OT and AVP inhibit and facilitate, respectively, the effective processing of aversive signals. Ages 20-40. Location in Bethesda, MD.
- Effectiveness of the Screen, Test, Immunize, Reduce Risk, and Refer (STIRR) Intervention for People With Both a Mental and Substance Abuse Disorder.
Interventional study. This study will determine the effectiveness of the STIRR (Screen, Test, Immunize, Reduce risk, and Refer) intervention in increasing rates of testing, immunization, referral, and treatment for blood-borne diseases, such as hepatitis and HIV, in people with both a mental disorder and a substance abuse disorder. Ages 18-65. Location in Baltimore, MD.
- PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram.
Interventional study. The purpose of this study is to measure a particular protein in the brain called the phosphodiesterase by using the imaging techniques of positron emission tomography (PET) and magnetic resonance imaging (MRI). Ages 18-65. Location in Bethesda, MD.
- Effectiveness of Behavior Therapy and Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder.
Interventional study. This study will compare the effectiveness of supportive therapy versus habit-reversal therapy for the treatment of Tourette syndrome and chronic tic disorder. Ages 16 and over. Locations in New Haven, CT; Boston, MA; San Antonio, TX.
- Attention and Visual Perception.
Evaluation study. The NIMH is conducting studies aimed at gaining a better understanding of the areas of the brain that are involved in different types of mental processes. Ages 18-80. Location in Bethesda, MD.
- The Role of Norepinephrine in Emotional Processing.
Evaluation study. This study will examine the role of a brain chemical called norepinephrine in thinking, decision-making, and emotional processing. Ages 20-50. Location in Bethesda, MD.
- MRS Measurement of Glutamate and GABA Metabolism in Brain.
Interventional study. This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. Ages 18-65. Location in Bethesda, MD.
- Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study.
Evaluation study. Velocardiofacial syndrome, also known as 22q11.2 syndrome or DiGeorge syndrome, has been associated with many features such as a cleft palate, heart defects, and learning, speech and feeding problems. Ages 18-50. Location in Bethesda, MD.
- Investigating the Role of Serotonin in Emotional Processing Through the Use of Tryptophan Depletion.
Evaluation study. This study will examine the role of serotonin function in the brain. Ages 20-50. Location in Bethesda, MD.
- A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder.
Interventional study. This study will compare the medications fluoxetine (Prozac®) and divalproex (Depakote®) for the treatment of aggressive behavior in individuals with Intermittent Explosive Disorder (IED). Ages 21-55. Location in Chicago, IL.
- Effect of Hydrocortisone on the Brain.
Evaluation study. The purpose of this study is to use brain imaging technology to examine the effect of the hormone hydrocortisone on the brain's response to various facial expressions. Ages 18-50. Location in Bethesda, MD.
- Psychopharmacology of Fear-Potentiated Startle in Humans.
Evaluation study. The purpose of this study is to understand the effects of the drug alprazolam (Xanax ) on anxiety. Ages 18-45. Location in Bethesda, MD.
- PET Scanning in Parkinson's Disease.
Evaluation study. This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine neurochemistry and blood flow in normal volunteers, persons with Parkinson's disease (both familial and sporadic), and those with schizophrenia spectrum disorders. Ages 18 and over. Location in Bethesda, MD.
- Adolescence, Puberty, and Emotion Regulation.
Evaluation study. The purpose of this study is to use brain imaging technology to compare how the brains of adolescents and adults are activated during tasks that involve emotional responses. Ages 9-55. Location in Bethesda, MD.
- Use of Transcranial Magnetic Stimulation (TMS) and Magnetic Resonance Imaging (MRI) to Study Visual Attention.
Evaluation study. The purpose of this study is to learn more about how the brain allows people to focus on important objects and filter out unimportant ones when looking at visual images. Ages 20-65. Location in Bethesda, MD.
- The Effects of Dextroamphetamine on Brain Function.
Evaluation study. The purpose of this study is to determine the effects of the drug dextroamphetamine on the brain function and mood of healthy volunteers. Ages 18-45. Location in Bethesda, MD.
- Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children.
Evaluation study. Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. Location in Bethesda, MD.
- The Effects of Reproductive Hormones on Mood and Behavior.
Evaluation study. This study evaluates the effects of estrogen and progesterone on mood, the stress response, and brain function in healthy women. Ages 18-55. Location in Bethesda, MD.
- Studies of Blood Flow to the Brain During Thought.
Evaluation study. The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks. Ages 18-65. Locations in Baltimore, MD; Bethesda, MD.
