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Biotinylated Alkylating Acridine for Pull-downs of Viral Pre-integration Complexes (PIC) or Other Cytosol Localized DNAs

Background:
The HIV Drug Resistance Program, National Cancer Institute at Frederick is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Research Tools.

Technology:
The invention describes a DNA-binding molecule that allows recovery of viral DNA and associated proteins. An acridine orange based molecule was modified and the resulting alkylating acridine molecule intercalates with viral pre-integration complexes (PIC) or other DNAs localized in cytosol. Because the molecule is also biotinylated, streptavidin beads can be used to purify the molecule and the bound DNA and associated protein can subsequently be eluted and analyzed. The invention provides a useful tool to facilitate the studies for viral PIC and other cytosol DNAs. It is available for non-exclusive licensing as biological material and research tool.

R&D Status: Pre-clinical, in vitro data available

Contact Information:
John D. Hewes, Ph.D., NCI Technology Transfer Center
Phone: 301-435-3121
E-mail: Hewesj@mail.nih.gov

Reference:  #448 KH

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Page Last Updated: 12-17-2008