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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00178087 |
This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression.
Condition |
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Late-Life Depression |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Pathways Linking Late-Life Depression to MCI & Dementia |
Estimated Enrollment: | 344 |
Study Start Date: | August 2005 |
Estimated Study Completion Date: | August 2010 |
The goal of this research study is to investigate the relationships among late-life depression (LLD), cognitive impairment and progressive neurodegeneration. The guiding hypothesis is that LLD patients have evolving cognitive impairments as a consequence of distinct underlying neuropathological changes, which frequently are expressed as Mild Cognitive Impairment (MCI). These neuropathological and cognitive changes are risk modifiers, lowering brain reserve capacity, and in turn, increasing risk of developing Alzheimer's Disease (AD). In order to pursue this goal we will enroll LLD, MCI, and normal control subjects to enrich our existing cohort to include a total of 150 elderly, non-demented, non-depressed subjects, 60 non-depressed MCI subjects and 270 LLD subjects. Using the joint infrastructure of the University of Pittsburgh's Advanced Center for Intervention and Services Research for Late-Life Mood Disorders and the Alzheimer's Disease Research Center, we will complete a detailed neurobehavioral evaluation, including clinical, neuropsychological, neuroimaging and biological markers, using these data to evaluate the factors associated with the development of MCI or dementia. Subjects will be studied annually for at least three years, allowing us to use longitudinal data to evaluate a series of linked hypotheses that postulate the pathways by which elderly, depressed patients develop cognitive impairment, and which may lead some to develop dementia.
Ages Eligible for Study: | 55 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
150 elderly, non-demented, non-depressed subjects, 60 non-depressed mild cognitive impairment subjects and 270 late-life depression subjects
Inclusion Criteria:
Exclusion Criteria:
Contact: Meryl A. Butters, Ph.D. | 412-246-5280 | buttersma@upmc.edu |
Contact: Michelle D. Zmuda, B.S. | 412-246-6487 | zmudamd@upmc.edu |
United States, Pennsylvania | |
UPMC Western Psychiatric Institute and Clinic | Recruiting |
Pittsburgh, Pennsylvania, United States, 15213 | |
Contact: Meryl A. Butters, Ph.D. 412-246-5280 buttersma@upmc.edu | |
Contact: Michelle D. Zmuda, B.S. 412-246-6487 zmudamd@upmc.edu | |
Principal Investigator: Meryl A. Butters, Ph.D. | |
Sub-Investigator: Benoit H. Mulsant, M.D. | |
Sub-Investigator: Robert A. Sweet, M.D. | |
Sub-Investigator: Charles F. Reynolds, III., M.D. | |
Sub-Investigator: James T. Becker, Ph.D. | |
Sub-Investigator: Mark Miller, M.D. | |
Sub-Investigator: Carolyn C. Meltzer, M.D. | |
Sub-Investigator: Howard Aizenstein, M.D., Ph.D. | |
UPMC Late-Life Evaluation and Treatment Center | Recruiting |
Pittsburgh, Pennsylvania, United States, 15213 | |
Contact: Jacqueline A. Stack, MSN,RN,CSN 412-246-6006 stackja@upmc.edu | |
Contact: Jill A. Houle, B.A. 412-246-6003 houleja@upmc.edu | |
Principal Investigator: Meryl A. Butters, Ph.D. | |
Sub-Investigator: Charles F. Reynolds, III., M.D. |
Principal Investigator: | Meryl A. Butters, Ph.D. | University of Pittsburgh |
Responsible Party: | University of Pittsburgh ( Meryl A. Butters, PhD ) |
Study ID Numbers: | R01 MH72947, 9512127, DATR A4-GPT |
Study First Received: | September 13, 2005 |
Last Updated: | October 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00178087 |
Health Authority: | United States: Federal Government |
late-life depression mild cognitive impairment dementia |
Depression Mental Disorders Mood Disorders |
Depressive Disorder Dementia Behavioral Symptoms |