National Toxicology Program

CASRN: 7789-12-0

Related: HEXAVALENT CHROMIUM (18540-29-9)

Formula: CR2 H4 NA2 O9

Synonyms/Common Names:

• DICHROMIC ACID, DISODIUM SALT, DIHYDRATE
• DISODIUM DICHROMATE DIHYDRATE

Known Uses:

INTERMEDIATE; INDUSTRIAL CHEMICAL

Short-Term Toxicity

• 13-WEEK (Dosed-Water)  (C20114B) Report Complete 
  • TOX-72   (Toxicity Peer Review 07/05/2006)
    Toxicity Studies of Sodium Dichromate Dihydrate
  • Mice: BALB/c; Mice: AM3 (C57BL/6); Mice: B6C3F1
  • Dose: MALE MICE: 0, 62.5, 125, OR 250 MG/L
• 13-WEEK (Dosed-Water)  (C20114) Completed 
  •   (Peer Review 05/16/2007) Citation: Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 62.5, 125, 250, 500, OR 1000 MG/L; 10/SEX/SPECIES

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C20114) Report Draft 
  • TR-546   (Peer Review 05/16/2007)
    Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: M/F RATS AND FM: 0, 14.3, 57.3, 172, OR 516 MG/L; MM: 0, 14.3, 28.6, 85.7, OR 258 MG/L

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage/Dosed-water)  (S0941) Completed 
  • Citation: L-J C. Ferguson and J. D. McDonald. Disposition of Oral Doses of Chromium VI and Chromium III in Male Rats and Mice. Lovelace Biomedical and Environmental Research Institute. Final Project Report No. 3. Period Covered in this Report: May 2004 to April 2007. December 30, 2008.
  • F Rats: F344/N
  • Dose: 1-100 mg/kg; 560 mg/L
• Toxicokinetic Study (Dosed-Water)  (S0830) Completed 
  • M Rats: F344/N; M Mice: B6C3F1; M Guinea Pigs: Hartley
  • Dose: 0, 1, 3, 10, 30, 100, and 300 mg Cr/L

Genetic Toxicology

• Micronucleus  (A50434) Completed 
  • Mice: BALB/c
  • Male Negative 
• Micronucleus  (A54983) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A73280) Completed 
  • Mice: AM3 (C57BL/6)
  • Male Positive 
• Micronucleus  (A91250) Completed 
  • Mice: B6C3F1
  • Male Inconclusive 
• Micronucleus  (A94686) Completed 
  • Mice: AM3 (C57BL/6)
  • Male Negative 
• Salmonella  (A06449) Completed 
  •  Positive 

Organ Systems Toxicity

• 28 DAYS Immunotoxicity (Dosed-Water)  (IMM20202) Completed 
  • F Rats/Mice: F344 And SD/B6C3F1
  • Dose: 0, 5, 20, OR 100 MG/L