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Transgenic Mouse Model For Development Of Cancer Therapeutics

The National Cancer Institute's Medical Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the thymidylate synthase transgenic mouse model.

Thymidylate synthase (TS) is an enzyme that is essential for DNA synthesis and repair. Elevated levels of TS protein and mRNA levels are associated with many human cancers. NIH inventors have demonstrated that ectopic expression of catalytically active TS induces a transformed phenotype in mammalian cells manifested by foci formation, anchorage independent growth, and tumor formation in nude mice. Overexpression of human thymidylate synthase (hTS) in murine islets provides a model to study genetic alterations associated with the progression from normal cells to hyperplasia and adenoma.  This mouse model may be useful for cancer prevention and the development of therapeutic strategies.

R&D Status: Thymidylate synthase transgenic mice available under Material Transfer Agreement

IP Status:  Research Tool.  Patent prosecution is not being pursued for this technology.

Value Proposition:

  • Transgenic mouse model to develop cancer therapeutics
  • Ability to conduct drug screening for tumor reduction and prevention

Contact Information:
John D. Hewes, Ph.D.
NCI Technology Transfer Center
Tel: 301-435-3121
Email: hewesj@mail.nih.gov

Please reference advertisement #787

Revised 12/04/2008


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Page Last Updated: 12-17-2008