Our Science – Flanders Website

Kathleen C. Flanders, Ph.D.

Laboratory of Cancer Biology and Genetics Cancer Biology of TGF-beta Section Staff Scientist National Cancer Institute Building 37, Room 5046B 37 Convent Drive, MSC 4255 Bethesda, MD 20892 Phone:   301-496-5453 Fax:   301-496-8709 E-Mail:   flanderk@dce41.nci.nih.gov

Biography

Dr. Kathleen Flanders received a B.S.degree in chemistry from Rensselaer Polytechnic Institute and a Ph.D. in biological chemistry from Indiana University. Following a post-doctoral fellowship at Case Western Reserve University, she joined the National Cancer Institute in the laboratory of Dr. Anita Roberts in 1985. Since then her research has focused on various aspects of transforming growth factor-beta (TGF-beta) biology. She currently works in the tumor suppressor group under the direction of Dr. Lalage Wakefield.

Research

Dr. Flanders developed some of the first isoform-specific antibodies to TGF-beta to be widely used in immunohistochemistry. She has extensive experience in analysis of components of the TGF-beta signaling pathway in tissues relating to many in vivo models of wound healing and disease pathogenesis. Most recently she has been investigating the role of TGF-beta and its signaling intermediate, Smad3, in chornic fibrotic conditions such as radiation-induced fibrosis. She is interested in investigating the mechanisms by which loss of Smad3 inhibits fibrosis and in developing small moecule inhibiotrs of Smad3 for use as potential anti-fibrotic therapeutic agents.

This page was last updated on 7/15/2008.