Our Science – Espey Website

Michael Graham Espey, Ph.D.

Radiation Biology Branch Staff Scientist Molecular and Clinical Nutrition Section, NIDDK Building 10, Room 4D57 10 Center Drive Bethesda, MD 20892 Phone:   301-402-6513 Fax:   Fax Number not listed E-Mail:   sp@nih.gov

Biography

Dr. Espey is a native of Clinton Iowa and received his B.S. at the U. of Iowa in 1987. He is Board certified in Clinical Pathology, Histocompatibility and Immunogenetics. After working in Immunology, Organ transplant and Infectious dis. laboratories at Georgetown Hospital and NIH Clinical Center, he obtained a Ph.D. with distinction for his thesis dissertation on tryptophan biochemistry from Georgetown U. in 1995. Dr. Espey's postdoctoral research at NIH focused on neuroimmunology and retroviral infection. In 2001, he became a NCI Staff Scientist conducting studies primarily in redox biochemistry and cancer. He is currently is on detail to NIDDK.

Research

- Analytical chemistry & biochemistry of redox active species (ascorbate, nitric oxide)
- Cellular immunology of macrophages, neutrophils and dendritic cells
- Intermediate metabolism of cancer, inflammation and chronic infectious disease
- Live cell microscopy and in vivo imaging
- Multi-modality (optical, MRI, EPR) probe development
- Neurochemistry, Neuroimmunology
- Radiation biology and cancer therapeutics
- Whole animal surgery and pharmacology

Our current research focus is on redox metabolism as it relates to cancer biology and infectious disease. An emphasis is placed on detection and imaging of reactive oxygen and nitrogen species. A goal is to understand the relationship between the biochemistry and physiology of redox species in the development of better therapeutic interventions.

This page was last updated on 8/5/2008.