Neuroimaging in Obesity Research, October 27-28, 2008

AGENDA

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Monday, October 27, 2008
7:30 a.m. – 9:00 a.m.	Registration and Coffee
9:00 a.m. – 9:15 a.m.	Welcome and Introduction Dr. Nora Volkow, Director, National Institute on Drug Abuse (NIDA), Deputy Director, NIDDK

Session I. Obesity—What Are the Big Questions Concerning the Role of the Brain? Moderator: Dr. Angelo Del Parigi, Pfizer, Inc.
9:15 a.m. – 9:45 a.m.	The Brain and Obesity: The Clinical Picture Dr. Rudolph Leibel, Columbia University An overview of the clinical picture with emphasis on the brain in obesity; neural complications of obesity, including cognitive ability; monogenic obesities; response to therapy, including intentional weight loss, bariatric surgery; response to antipsychotics; other clinical issues.
9:45 a.m. – 10:15 a.m.	Behavior and the Brain in Obesity Dr. Adam Drewnowski, University of Washington An overview of the behavior phenotypes associated with obesity: decision-making, impulsivity, endophenotypes within hedonics, satiety and hunger, craving, eating disorders, bingeing, etc.
10:15 a.m. – 10:45 a.m.	CNS Pathways Regulating Body Weight and Glucose Homeostasis Dr. Joel Elmquist, University of Texas Southwestern Medical Center An overview of the neural and molecular pathways associated with energy balance and eating; hypothalamic neurotransmitters; leptin, insulin, ghrelin, dopamine, etc.; food intake, energy balance and metabolism; progress in imaging in animal models.
10:45 a.m. – 11:15 a.m.	Panel Discussion Moderator: Dr. Angelo Del Parigi, Pfizer, Inc. What do we want to learn about the brain in obesity? What are imageable biomarkers of obesity in the brain? What studies can best be done in animal models and what should be studied in people?
11:15 a.m. – 11:40 a.m.	Break

Session II. Functional Neuroimaging—What Can It Be Used For? Moderator: Dr. Samuel McClure, Stanford University
These introductory technical talks will convey useful and important information regarding exactly what functional imaging can measure and what it cannot (discriminating the imageable markers of brain function from brain function itself, etc.); how studies should be designed; and important points to consider regarding data analysis and data interpretation, etc.
11:40 a.m. – 12:10 p.m.	Magnetic Resonance Methods for Functional and Anatomical Neuroimaging Dr. Peter Bandettini, National Institute of Mental Health (NIMH)
12:10 p.m. – 12:20 p.m.	MEG Methods for Functional Neuroimaging Dr. David Poeppel, University of Maryland
12:20 p.m. – 12:55 p.m.	PET Methods for Functional Neuroimaging and Data Analysis Dr. Peter Herscovitch, NIH
12:55 p.m. – 1:25 p.m.	A Frank Discussion of Study Design Dr. Russell Poldrack, University of California at Los Angeles How does one design and validate a new study? What extant paradigms are most useful for studies of obesity? “State” measures (metabolism) versus activation paradigms (block design, natural behaviors, etc.).
1:25 p.m. – 2:30 p.m.	Lunch (on your own)
2:30 p.m. – 2:50 p.m.	Adolescent Brain Development and Risk for Psychopathology Dr. B.J. Casey, Cornell University Children have different hardware and study design needs due to size, attention span, need for noninvasive studies, etc. Data interpretation may be complicated by developmental stage.
2:50 p.m. – 3:15 p.m.	Special Considerations for Analysis of fMRI Data Dr. Robert Cox, NIMH Common methods of data analysis of neuroimaging studies; pitfalls and best practices; what can be known from functional neuroimaging studies; novel or experimental data analysis methods.
3:15 p.m. – 3:30 p.m.	Data Interpretation in the Real World Dr. David Poeppel, University of Maryland Considerations when interpreting neuroimaging data to inform our understanding of brain function.
3:30 p.m. – 4:15 p.m.	Panel Discussion Moderator: Dr. Samuel McClure, Stanford University Can we design robust, interpretable neuroimaging studies that can answer the important questions surrounding brain function in the following areas? Energy balance Eating behavior and eating disorders Predisposition to and consequences of obesity
4:15 p.m. – 4:45 p.m.	Break

Session III. Lessons from Neuroimaging—Brain Function in Health and Disease Moderator: Dr. Peter Bandettini, NIMH
4:45 p.m. – 5:10 p.m.	Neuroimaging of Intrinsic Connectivity Dr. Michael Greicius, Stanford University
5:10 p.m. – 5:35 p.m.	Neuroimaging of Drug Abuse Dr. Elliot Stein, NIDA
5:35 p.m. – 6:05 p.m.	Neuroeconomics and Decision-Making Dr. P. Read Montague, Baylor College of Medicine
6:05 p.m. – 6:35 p.m.	Neuroimaging of Genetic Polymorphisms Dr. Daniel Weinberger, NIMH
6:35 p.m. – 7:00 p.m.	Panel Discussion Moderator: Dr. Peter Bandettini, NIMH What lessons can we take from other fields for studies of obesity?
7:00 p.m.	Adjourn

Tuesday, October 28, 2008
7:30 a.m. – 8:30 a.m.	Registration and Coffee
Session IV. Neuroimaging: Obesity and Energy Balance Moderator: Dr. Joel Elmquist, University of Texas Southwestern Medical Center at Dallas
This session reports on neuroimaging studies of energy balance in people and animal models.
8:30 a.m. – 8:50 a.m.	The Senses and Emotion—Taste and Smell Dr. Dana Small, The John B. Pierce Laboratory and Yale University
8:50 a.m. – 9:10 a.m.	Hypothalamic Response to Hormones and Nutrient Ingestion Dr. Jeroen van der Grond, Leiden University Medical Center
9:10 a.m. – 9:30 a.m.	PYY and Hypothalamus to Corticolimbic Switching Dr. Rachel Batterham, University College London
9:30 a.m. – 9:50 a.m.	Leptin, Hypothalamus and Cortical Regulation Dr. Joy Hirsch, Columbia University
9:50 a.m. – 10:30 a.m.	Panel Discussion Moderator: Dr. Joel Elmquist, University of Texas Southwestern Medical Center at Dallas What is needed in terms of biomarkers of energy balance in the brain? What questions can be answered with neuroimaging? How can information from neuroimaging experiments be interpreted? How can neuroimaging inform therapy, etc.? How can this information be used to design new informative experiments?
10:30 a.m. – 10:50 a.m.	Break

*Session V. Neuroimaging: Obesity and Eating Behavior* Moderator: Dr. Cary Savage, University of Kansas Medical Center
This session reports on neuroimaging studies of obesity and eating behavior and related fields in people and animal models.
10:50 a.m. – 11:10 a.m.	Lessons About Obesity from Neuroimaging Dr. Angelo Del Parigi, Pfizer, Inc.
11:10 a.m. – 11:30 a.m.	Diet, Weight Loss, and Maintenance Dr. Cary Savage, University of Kansas Medical Center
11:30 a.m. – 12:00 p.m.	Neuroimaging of Food Addiction Dr. Nora Volkow, NIDA, NIDDK
12:00 p.m. – 12:20 p.m.	Emotion and Cognition Dr. Samuel McClure, Stanford University
12:20 p.m. – 1:30 p.m.	Lunch (on your own)
1:30 p.m. – 1:50 p.m.	Eating Disorders Dr. Walter Kaye, University of Pittsburgh Medical Center
1:50 p.m. – 2:10 p.m.	Food Craving Dr. Marcia Levin Pelchat, University of Pennsylvania
2:10 p.m. – 2:30 p.m.	Neuroimaging of Gut Distention Dr. Allan Geliebter, Columbia University
2:30 p.m. – 3:30 p.m.	Panel Discussion Moderator: Dr. Rudolph Leibel, Columbia University What is needed in terms of biomarkers of eating behavior in the brain? What questions can be answered with neuroimaging? How can information from neuroimaging experiments be interpreted? How can neuroimaging inform therapy, etc.? How can this information be used to design new informative experiments?
3:30 p.m. – 3:45 p.m.	Wrap-Up Dr. Maren Laughlin, NIDDK Dr. Walter Kaye, University of Pittsburgh Medical Center Dr. Malcolm Avison, Vanderbilt University
3:45 p.m.	Adjournment