Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) and
Division of Digestive Diseases and Nutrition (DDN)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Description of the Meeting:
There is a strong need to develop additional tools that can regulate nuclear receptor (NR) signaling through alternative or noncanonical mechanisms. Although many drugs targeted at NRs have made it to market, off-target effects, lack of specificity, and unexpected outcomes have limited their usefulness. A better understanding of the regulation of NR action by ligands, small molecular compounds, and natural products presents opportunities to decouple multiple hormone-induced events to provide selectivity and specificity that result in therapeutic effects with fewer off-target effects. Focused chemical biology efforts aimed at key control points in NR signaling will allow the development of new understandings and tools and lead to new therapeutic approaches.
The overall goal of this workshop is to increase the collaboration of investigators drawn from different disciplines to develop a better understanding of chemical modulation of NR action and to identify future research directions. The specific focus will be on diseases and disorders associated with lipid and carbohydrate metabolism, obesity, and type 2 diabetes (T2D).