Pathology Tables for Peer Review
The National Toxicology Program
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BARIUM CHLORIDE DIHYDRATE
NTP Experiment-Test: 05127-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
Facility: TSI Mason Research
Chemical CAS #: 10326279
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 14 11 9 16
Dead 5 3 2 2
Survivors
Terminal Sacrifice 30 36 39 32
Moribund 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (57) (58) (59) (60)
Intestine Large, Colon (57) (57) (60) (59)
Adenocarcinoma 1 (2%)
Intestine Large, Rectum (57) (57) (60) (59)
Schwannoma Malignant 1 (2%)
Intestine Small, Duodenum (57) (58) (60) (60)
Schwannoma Malignant 1 (2%)
Liver (60) (60) (60) (60)
Adenoma 1 (2%)
Fibrosarcoma, Metastatic 1 (2%)
Hepatocellular Adenoma 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Mesentery (4) (1) (3)
Schwannoma Malignant 1 (100%)
Pancreas (59) (57) (59) (60)
Schwannoma Malignant 1 (2%)
Acinus, Adenoma 1 (2%) 1 (2%)
Salivary Glands (59) (60) (60) (60)
Stomach, Forestomach (60) (60) (60) (60)
Squamous Cell Papilloma 1 (2%) 2 (3%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (59) (58) (60)
Adenoma 1 (2%) 3 (5%) 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Adrenal Gland, Medulla (60) (59) (58) (59)
Osteosarcoma, Metastatic 1 (2%)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 3 (5%) 2 (3%) 1 (2%)
Pheochromocytoma Benign, Two 1 (2%) 1 (2%)
Islets, Pancreatic (59) (58) (59) (59)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 2 (3%)
Pituitary Gland (58) (58) (58) (60)
Pars Distalis, Adenoma 28 (48%) 26 (45%) 28 (48%) 24 (40%)
Pars Distalis, Adenoma, Two 2 (3%) 2 (3%) 2 (3%)
Pars Distalis, Carcinoma 4 (7%) 6 (10%) 4 (7%) 5 (8%)
Thyroid Gland (59) (60) (59) (60)
C-Cell, Adenoma 6 (10%) 8 (13%) 9 (15%) 9 (15%)
C-Cell, Adenoma, Two 1 (2%) 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (59) (60) (57)
Adenoma 1 (2%) 2 (4%)
Carcinoma 1 (2%) 3 (5%) 1 (2%)
Carcinoma, Two 2 (3%)
Ovary (59) (60) (60) (60)
Granulosa Cell Tumor Benign 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Schwannoma Malignant 1 (2%)
Uterus (60) (60) (60) (60)
Polyp Stromal 14 (23%) 8 (13%) 11 (18%) 13 (22%)
Polyp Stromal, Two 1 (2%) 3 (5%)
Sarcoma Stromal 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (36) (37) (43) (32)
Lymph Node (60) (60) (60) (60)
Mediastinal, Schwannoma Malignant 1 (2%)
Lymph Node, Mandibular (59) (58) (58) (59)
Sarcoma, Metastatic 1 (2%)
Lymph Node, Mesenteric (60) (59) (59) (60)
Spleen (60) (60) (60) (60)
Osteosarcoma, Metastatic 1 (2%)
Schwannoma Malignant 1 (2%)
Thymus (54) (55) (54) (56)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (52) (52) (55) (59)
Adenocarcinoma 1 (2%) 1 (2%)
Adenoma 1 (2%) 2 (4%)
Fibroadenoma 15 (29%) 15 (29%) 11 (20%) 8 (14%)
Fibroadenoma, Multiple 4 (8%) 1 (2%) 3 (5%)
Lipoma 1 (2%)
Sarcoma 1 (2%)
Skin (57) (60) (59) (59)
Fibroma 4 (7%) 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%) 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Lipoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2) (1)
Lipoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic 3 (5%) 2 (3%) 1 (2%) 2 (3%)
Ependymoma Malignant 1 (2%)
Page 4
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont
Glioma Malignant 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma Adenosquamous 1 (2%)
Fibrosarcoma, Metastatic 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Sarcoma, Metastatic 1 (2%)
Nose (60) (60) (60) (60)
Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (8) (4) (3)
Sarcoma 1 (13%)
Zymbal's Gland (2) (1)
Carcinoma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (58) (60) (60)
Urinary Bladder (55) (57) (59) (58)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 15 (25%) 13 (22%) 9 (15%) 9 (15%)
Lymphoma Malignant Lymphocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 51 44 48 50
Total Primary Neoplasms 112 116 91 94
Total Animals with Benign Neoplasms 46 39 43 43
Total Benign Neoplasms 81 78 73 72
Total Animals with Malignant Neoplasms 27 27 16 22
Total Malignant Neoplasms 31 38 18 22
Total Animals with Metastatic Neoplasms 3 4 2 2
Total Metastatic Neoplasm 3 11 3 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 19 14 18 14
Dead 9 5 3 3
Survivors
Terminal Sacrifice 21 31 29 33
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (53) (55) (58) (57)
Lipoma 1 (2%)
Intestine Large, Colon (55) (54) (59) (58)
Intestine Small, Ileum (52) (55) (57) (57)
Intestine Small, Jejunum (53) (55) (57) (57)
Liver (59) (60) (60) (60)
Mesentery (5) (6) (10) (4)
Fibrosarcoma 1 (10%)
Pancreas (55) (58) (59) (60)
Acinus, Adenocarcinoma 1 (2%)
Acinus, Adenoma 3 (5%) 4 (7%) 1 (2%) 3 (5%)
Pharynx (2)
Squamous Cell Papilloma 1 (50%)
Salivary Glands (60) (58) (60) (60)
Osteosarcoma, Metastatic 1 (2%)
Stomach, Forestomach (59) (60) (60) (59)
Squamous Cell Papilloma 2 (3%) 1 (2%)
Stomach, Glandular (57) (58) (60) (58)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (60) (59) (60)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (58) (59) (58) (59)
Pheochromocytoma Malignant 2 (3%) 2 (3%) 2 (3%)
Pheochromocytoma Benign 10 (17%) 7 (12%) 9 (16%) 6 (10%)
Pheochromocytoma Benign, Two 1 (2%) 2 (3%) 2 (3%)
Islets, Pancreatic (55) (58) (58) (59)
Adenoma 3 (5%) 2 (3%) 5 (9%) 5 (8%)
Carcinoma 2 (4%) 2 (3%)
Parathyroid Gland (56) (56) (56) (55)
Pituitary Gland (58) (55) (59) (56)
Pars Distalis, Adenoma 23 (40%) 24 (44%) 19 (32%) 23 (41%)
Pars Distalis, Adenoma, Two 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Thyroid Gland (58) (58) (60) (59)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (7%) 5 (9%) 8 (13%) 7 (12%)
C-Cell, Adenoma, Two 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (58) (60) (60) (60)
Preputial Gland (59) (59) (60) (60)
Adenoma 1 (2%) 2 (3%) 2 (3%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (58) (60) (60) (59)
Seminal Vesicle (59) (59) (59) (60)
Testes (59) (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 28 (47%) 33 (55%) 32 (53%) 24 (40%)
Interstitial Cell, Adenoma 15 (25%) 15 (25%) 18 (30%) 20 (33%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (26) (39) (39) (9)
Bone Marrow (55) (59) (60) (59)
Lymph Node (59) (57) (60) (60)
Lymph Node, Mandibular (59) (55) (59) (60)
Lymph Node, Mesenteric (57) (57) (60) (59)
Spleen (59) (58) (60) (59)
Sarcoma 1 (2%)
Thymus (54) (54) (53) (53)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (51) (41) (52) (54)
Fibroadenoma 2 (4%) 3 (7%) 1 (2%)
Skin (60) (60) (58) (58)
Basal Cell Carcinoma 1 (2%) 2 (3%)
Fibroma 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%) 1 (2%) 1 (2%)
Hemangioma 1 (2%) 1 (2%)
Keratoacanthoma 1 (2%) 3 (5%)
Lipoma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Peripheral Nerve (2) (1) (1)
Schwannoma Benign 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Carcinoma, Metastatic 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Nose (60) (58) (60) (60)
Page 9
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Adenoma 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1) (2)
Carcinoma 2 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (57) (59) (59)
Urinary Bladder (52) (55) (57) (58)
Leiomyoma, Two 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 35 (58%) 25 (42%) 26 (43%) 15 (25%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 1 (2%)
Mesothelioma NOS 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 19:05:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 56 57 59 57
Total Primary Neoplasms 146 142 141 120
Total Animals with Benign Neoplasms 52 57 56 52
Total Benign Neoplasms 100 109 102 93
Total Animals with Malignant Neoplasms 39 27 35 25
Total Malignant Neoplasms 45 33 38 26
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 2 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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Web page last updated on November 11, 2004
